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Query: [E] COG0006 Xaa-Pro aminopeptidase, from VFDB

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNQNPIKRLQDSLVERALDAFLIEKDEDISYFLQDQARSGVLLITRDEAVLFVSPLDKDLYARIQDVVLVSYSKSVDQELGSYIENTGLKTIGFDSEYTPYGIAQKRMNSGYAFSPQSLVAEKLRCVKSTEEIQKMTRAAEIGSAGYDFVLAALRPGITEKELVRMLHVFWANLGIEKVSFPPIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGATPEQQLLDGYVAVAEAQRAAIEFCRAGVPCRDVHKEAVRILRAHGMEKAFIHGLGHGVGREVHEYPRLSPFSDATLQLNMAVTVEPGVYFPGVGGIRIEDTIMIGVNENLNLTNRKVSSEIIIILast
1 -107.000IDP00677 proline dipeptidase SACOL1588 [Staphylococcus aureus subsp. aureus COL]  ali follow..  32  2...SRITQVHRILEQKHLDAIIILSDYNRRYLSGFTGTSGALIISKDKQYLITDFRYIDQATKQANYEIINRKSTIIGEIKELLHQENFENVGFEGHHVSYDTYLELNKSRISLISISNTVDKIRDVKDADEIALIQKAANIVDETYEYILTVVKAGMTEKELKAILESKMLELGADGPSFDTIVASGHRGALPHGVASDKIIEKGDMITLDFGAYYNGYCSDITRTFAIGE-PDPKLKEIYQIVLESQMKAINEIRPGMTGAEADAISRNYLESKGYGKEFGHSLGHGIGLEIHEGPMLARTIQDKLQVNNCVTVEPGVYIEGLGGIRIEDDILITENGCQVFTKCT--KDLIVL 352
2 -106.000IDP01139 gene: pepQ-1; proline dipeptidase BA_4422 [Bacillus anthracis str. Ames]  ali follow..  32  2...EKIERLRSAFDEAGIDGILLTNEHSRRYMANFTGTAGVVLISKKRAQFITDFRYVEQASKQAGYEIVQHAGLIIDEVAKQVKELGIQKLGFEQDTLTYSSYSAHKEADAEFIPTSGLVEKLRLIKTDSEIKILKEAAQIADAAFEHILSFIRPGVSEIEVSNELEFFMRKQGATSSSFDIIVASGLRSALPHGVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAVGE-PSDKLKEIYNIVLEAQLRGVNGIKAGLTGREADALTRDYITEKGYGEYFGHSTGHGIGLEIHEAPGLAFRSDTVLEPGMAVTVEPGIYIPGIGGVRIEDDIIVTSEGNEVITKSP--KELIIL 353
3 -106.000IDP02816 proline dipeptidase, putative [Bacillus anthracis str. `Ames Ancestor`] GBAA4014 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  30  2..TLKINKIQNQLQNYEIDGLLITKKENRQYATGFTGSAGVVLITADAAVFITDFRYVDQANSQINAEIIMHKGNLEKEIANQVSKLNIQKLGIEENNMTLQQYKNLQKYHTEMVQVCEIIENIRLIKDTHEIETMKIAAHIADEAFHHIITFLKPGISENDVRDELEFFMRKKGATSSSFQIIVASGVRSSLPHGVASNKIIERGDIVTLDFGALYDGYCSDITRTVAIGE-PSEEFKKIYNVVREALKRGTEAIKPGETAKSIDDVTRNYITDCGYGQYFGHSTGHGLGLEIHEPLRLSQESKATLEEGMVVTVEPGIYIPNWGGCRIEDDIVITKDGYEVITKSN--RDLIII 354
4 -97.600IDP00681 gene: pepQ; proline dipeptidase SACOL1756 [Staphylococcus aureus subsp. aureus COL]  ali follow..  30  2...TKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHLLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFS--LYPQTINKLLIESEHLTVARQKQLISNVNSFGDVDLTIKQLRNIKSEDEISKIRKAAELADKCIEIGVSYLKEGVTECEVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGE-PSKEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGYEVLTHYEK....... 351
5 -97.100IDP02830 gene: pepQ-2; proline dipeptidase [Bacillus anthracis str. `Ames Ancestor`] GBAA4861 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  27  2..NARLENLMQWLKEKNVEAAFLTSTPNVFYMTNFHCEPGMFVFQEKEPILICPKMEEGQARNAGEIIGFTDTDRPWDMIAKAIKDRGINAVAIEKELLNVERYEELTKPNAAFTSAEEKVRELRLIKDEKELSILREAAKMADYAVEVGVNAIKEDRSELEVLAIIEHELKTKGIHKMSFDTMVLAGANSALPHGIPGANKMKRGDFVLFDLGVIIDGYCSDITRTVAFGE-ISEEQTRIYNTVLAGQLQAVEACKPGVTLGAIDNAARSVIADAGYGDFFPHRLGHGLGISVHEYPDVKAGNESPLKEGMVFTIEPGIYVPNVGGVRIEDDIYITKDGSEILTKFP--KELQFV 364
6 -81.100IDP00207 putative peptidase YPO1950 [Yersinia pestis CO92]  ali follow..  20  9.LEAVSRKARVVMEREGIDALVVTVCDNFYYLTGFASFFMYTFRHTGAAVIIMNEFEAASTHFDMPNSVLKTVEAVFSLVKNALEDAGVKTIAIELQAMSNGGKGVLDKPGLKLVDSTALFNEIRMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSFPETNFSRFNLISVGDNFS-PKIIADTTPAKVGDLIKFDCGIDVAGYGADLARTFVLGE-PDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSGLPHYNRGHLGHGDGLGLEEVPFVSTQATETFCPGMVLSLETPYYGIGVGSIMLEDMILITDSGFEFLSKLDRDLRRYF. 405
7 -63.800IDP01115 xaa-pro aminopeptidase, putative BA_1901 [Bacillus anthracis str. Ames]  ali follow..  21  5FFAQNRERLVNTLPDESITILFFVPNRNFYYVTGIDEPNVIFMLKKFEETLFIEKS-NEEAEKISGIKKVIYLDSFEKTMSNIFFTENVKHLYLDLECLAFAKHVREQYPHVTIGNVYPNICELRVFKTDEEIEIIKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHYEDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLNALKETTEIIKPGLKFAALNEHAKKVLAEGELSKYYYHGVSHFLGLDTHD---VGTYKDRVLEEGMVITIEPGLYIEEESGIRIEDDILVTKDGHENLSK.......... 399
8 -61.600IDP00418 gene: pepP; proline aminopeptidase P II YPO0910 [Yersinia pestis CO92]  ali follow..  25  5EYQNRRQALLAKMAPGSAAIIFYRQNSDFSYLTGFNEPEAVLILVKSHSVLFNRIR-QEAAPTKLAVDRALPFDEINEQLYLLLNRLDVIYHAQGQYEKLRHGFRKNLRAPATLTDWRPWLHEMRLFKSAEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEILHEFTRHGARYPAYNTIVGGGENGCILHYTENECELRDGDLVLIDAGCEYRGYAGDITRTFPVNGKFTPAQRAVYDIVLAAINKSLTLFRPGTSIREVTEEVVRIMVVG-HRPFFMHGLSHWLGMDVHDVGDYGSSDRGILEPGMVLTVEPGLYIAP--GIRIEDDIVITATGNENLTA.......... 420
9 -55.900IDP04491 gene: pepQ; proline dipeptidase [Yersinia pestis CO92] YPO3765 [Yersinia pestis CO92]  ali follow..  23  13..STLQQRTRDVLERHQLDALLIHVNPQFKAWVPVTEVPNCWLWVNTPKLWFYSPVDYSFWTKNIDVQPLLNADDIAQQLPVQRERVAYIGYAQQRAQAL-----GFSAENINPQPVLDYLHYYRSYKTDYELACMREAQKTAVVGHRAAYEAFQSGMSEFDINLAYLMATGHRDTD-VPYDNIVALNEHSAVLHTILQHQPPAEIRSFLIDAGAEYNGYAADLTRTYTADR--DSDFAALISDLNTEQLALIDTIKSGERYTDYHVQMHQRIAKL-TCPFLPHGLGHPLGLQVHDTAGFMQDDKRVLQPRMVLTIEPGLYFIPYGGIRIEDNIVIHDKRVENMTR.......... 438
10 -49.800IDP92112 methionine aminopeptidase, putative [Toxoplasma gondii ME49] TGME49_057730 [Toxoplasma gondii ME49]  ali follow..  16  2............LTQNRVPGLVTSRRTYCAKSHATDGLKPGSIAENRLEWTHSKPNSARKPVPAARLISEGGIARKQLRTNSLEPAQACRSQLFVKPLRPRTCDRSARCSTGQADRGFDTSDTPGEVQTPDALKKIRAAATVAANALKLGLDAAREGVTTEDLDKIVHEYIVSVGAYPANFPKAVCASVNEAVCHGIPDLRPLQDGDIVTLDCTAYVDGFFGDCAGTAMVGSV-TEAHRTLVETTKDCLDEAIKLLYPGLPIKEVGRCITALAEQRGFS-VVREFCGHFIGRKMHLPPLIPNDTQGVFRVGQTFTIEPILCEDGGRAAQFEHTILMTPEGAEVLTKPT........ 386
11 -47.600IDP02506 peptidase, M24 family protein [Francisella tularensis subsp. tularensis SCHU S4] FTT0609 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  23  171..ASKIEELRRTMKQTRSDFYVDSKLDHIAWLLNIRARDSYLFVSLDKIILYVNDRKITPAIKKDNHIQTRDYYQFYQDLEATTGKYLLDGANINYKVPLSIN--KNQNSSCYFLMIDSPVGLSKALKNPVEINGSKEAHRKDAAAFISWWHWIEQGVDEIEAAAKLREFRAQQGYVEDSFSYIVGHAANGAIIHYMAKKKKIDDQAPLLCDSGGQYREGTTDITRVLHFGK-PSKEHRKYYTLVLKGHLGLGRAVFPGTTGSQLDVLAREHLWHFCAD--YAHGTGHGVGLGVHEGPRINSVSKVELMPGMILSNEPGAYFPGEFGIRIENLCYIKQRCFEDLTLVPYEYKLI.. 552
12 -46.000IDP06103 gene: map; methionine aminopeptidase [Helicobacter pylori J99] NP_223937 [Helicobacter pylori J99]  ali follow..  26  4.............................................................................................................................SIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAGFPNSVCMSLNEVVIHGIPTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGAI-SPQDEKLLACSKESLMHAISSIRVGMHFKELSQILEGAITERGFV-PLKGFCGHGIGKKPHEEPEIKANSGPKIKEGMVFCLEPMVCQDGLNTSHHEHTIAIVGNKAVILTE.......... 252
13 -45.200IDP01931 peptidase, M24 family protein [Coxiella burnetii RSA 493] CBU_0073 [Coxiella burnetii RSA 493]  ali follow..  23  173..EDKLAALRQTLQKESADAIVLNTLDAIAWLFNIRGNDSYAVITQNEASLFVDPHKITEGDRSYFKKIPVHIEPYEGIGKLL--ESLSGSVWLDPGATNLWLRDQLK-NTASLILKPSPITLAKALKNPVEQKGAREAHIIDAIAMIQFLHWLESGVSEISAAEKLEFFRRGDRCLDLSFPSISGFGPHGAIVHYSATDATINDSAPYLIDSGGQYHYGTTDITRTIHLGT-PTEEEKRLYTLVLKGHLAIRQAVFPGTCGEHLNALAHQFLWREALD--YGHGTGHGVGLCVHEGPQ-SRYTGIPLQPGMIVSNEPGVYLTHKYGIRIENLCLVTEKSFEDLTLVPYCRKLI.. 553
14 -45.200IDP02071 gene: map; methionine aminopeptidase, type I [Coxiella burnetii RSA 493] CBU_1388 [Coxiella burnetii RSA 493]  ali follow..  24  4.............................................................................................................................SIKTPEELEKMRIAGQLAAEVLEMIEPYVKAGITTNELNAICHDYITQTQKAIPAFPKSICTSVNHVVCHGIPNDKKLKEGDIINIDITVIKNGYHGDTSKMFAVGKI-PSHAQRLVRITQECLYIGISMVKPGTPLGDIGAAIQAHAEKNHYS-VVREYCGHGIGSIFHEPELQRPGTGAVLRPGMTFTIEPMINADRRLSAQWEHTLAVTETGYEVFTLRKDEKISV.. 258
15 -45.100IDP02686 gene: map; methionine aminopeptidase [Francisella tularensis subsp. tularensis SCHU S4] FTT0393 [Francisella tularensis subsp. tularensis SCHU S4]  ali follow..  23  5.............................................................................................................................IIKTPQEIEKMRVAGRLAAEVLEMITPFVKEGVTTAELDKICHEYIVKEQDAYPAFPKSICASINHVVCHGIPADKKLKNGDILNIDITVKKDGYHGDTSKMFMIGEP-SVMAKKLVEVTHECLWKGIEVVKPGNHFGDIGAAIEKHAKKFGYS-IVDAFCGHGIGANFHEPPHVKAGTGAMFEEGMIFTIEPMINIDRSLSAQWEHTILVTKDGYEVLTLREEEKN.... 256
16 -44.700IDP92114 methionine aminopeptidase, putative [Toxoplasma gondii ME49] TGME49_011330 [Toxoplasma gondii ME49]  ali follow..  20  12.............................................................................HYAEEDDGRAKAKREAMLSAELQLRRCEGDEMKARLARFHPVAEREMEWIKPQAEVEGVRRACEVTREVLQVAVDFVKAPLTTEDIDRVVHEETMKRGAYPSNFPKSVCTSTNEIVCHGIPDDRPLQRGSICSIDVSCFLDGFHGDCARTVPIGGFESPPLRRLLVSAREATLEGIRVCAPGRRLSVIGDAIEEFLTRRGYS-TIHDFCGHGIGRNFHEEPFVSNNMPGRMLPGMCFTIEPVVCMDGKPTAQFEHTVLITDTGVEVLTDCPDGETDM.. 321
17 -44.100IDP04144 gene: map; methionine aminopeptidase [Yersinia pestis CO92] YPO3337 [Yersinia pestis CO92]  ali follow..  22  5.............................................................................................................................KIHSPAEIEMARAAGQAAAKVLEMIKPYVLAGITTDEIDRLCHDYIVNELKVIPAYTRTVCTSVNHVVCHGIPSDKKLKNGDIVNIDVAIIKEGWYGDTSRMYFVGEP-SVRAKRLVDITYQSMVAGIKAVRPGATLGDIGASIQQLAEGAGFS-VVREYCGHGVGQEYHTAPQVIAQTGMLLKPGMIFTIEPMINADRSLSAQWEHTIAVTESGYDLLTPWPEG...... 254
18 -43.300IDP06298 methionine aminopeptidase [Streptococcus pneumoniae TIGR4] NP_345557 [Streptococcus pneumoniae TIGR4]  ali follow..  21  1...........................................................................................................................MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGSGGLADSCWAYAVGTP-SEEVKNLMDVTKEAMYKGIEQAVVGNRIGDIGAAIQEYAESRGYG-VVRDLVGHGVGPTMHEEPMVIAGRGLRLREGMVLTIEPMINTDGGLSCQYEHQFVITKDGPVILTSQGEE...... 283
19 -42.500IDP01338 methionine aminopeptidase VC2261 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  23  4.............................................................................................................................KIKNAVEIEKMRVAGRLAAEVLEMIEPHVKAGVTTEELDQICHKYITEVQGAIPAFPKSICTSINHIVCHGIPASEDLRDGDILNIDITVIKDGYHGDTSKMFLIGDV-SIEDKRLCHVAQECLYLALKQVKPGVQLGEIGTTIEKHIKTNNKNSIVRDYCGHGIGAEFHEEPQVKNSDRTVLREGMIFTIEPMINADGKKSAQWEHTILVTATGCEILTLRSEE...... 271
20 -41.700IDP04451 gene: ampM; methionine aminopeptidase [Yersinia pestis CO92] YPO1043 [Yersinia pestis CO92]  ali follow..  27  4.............................................................................................................................SIKTPEDIQKMRVAGRLAAEVLEIIEPYVKPGVTTGELDRICHDHITNHQQAISAFPKSVCISVNEVICHGIPSDEKLKEGDIVNIDVTVIKDGFHGDTSKMFIVGKP-TILGERLCRVTQESLYLAIKMVKPGIRLRTLGKAIQKFVEAENFS-VVREYCGHGIGEGFHEEPQVADDGGVVLQAGMAFTIEPMVNADRNLSAQYEHTIVVTDNGCEIMTLRKDD...... 254
21 -40.200IDP92115 methionine aminopeptidase, putative [Toxoplasma gondii ME49] TGME49_048850 [Toxoplasma gondii ME49]  ali follow..  25  149.........................................................................................................................KSNVHVHSEEEIQRLRETCLLGRRALDYAHSLVKPGVTTEEIDAKVHAFIVDNGGYPSQFPKSCCTSVNEVICHGIPDFRPLQDGDIVNIDITVFFKGMHGDLNETYCVGDNVDEDSKRLIKGAYECLMEAVKQCRPGMMYRDVGRIVSDVADKYNLS-VVRSYCGHGIGELFHTTPNIRNKAIGVMKPGHVFTIEPMINADGRRSAQFEHTLLVTETGVEILTKRLPCS..... 403
22 -29.300IDP92099 methionine aminopeptidase, type II, putative [Toxoplasma gondii ME49] TGME49_105460 [Toxoplasma gondii ME49]  ali follow..  18  155..............................................................................................................................RLEAVDIQAIRQAAECHRQVRRYIQGVARPGVKLVDLCRSLEAKSKELIAAGWGFPTGCSL--NNCAAHYTPDNRVLEQGDICKLDFGVQVGGRIIDCAFSIAFD----EKFDSLIQATQDGTNVGISHAGADARLSEIGGFIQEAIESYEMEKSIRNLTGHSID-RIHAGKSVSHAPSNIMEEGEVYAIET-FASTGRAHVSAQFAALRLKSAKDLLKVIDDN...... 411
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.