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Query: [K] COG2378 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPTDNVVSVVSPYHMEMYNMRKASRLFEIIQILRLARRPVTAQTIADMLEVTARSVYRDIAALQTMRVPIEGERGVGYILRPGFNLPPLMFSIEETEAIVLALAMVDRSGDAELRQAAKKVSDKIAASLPEPLSKTLSANALHAWGSIAPAPAGIDLATVRRAVRDEERLDLCYSDESGVETQRRIRPIAVIYYSETVNIVAWCELRHAIRNFRSDRVLDCAATGSFFKMEGEKLRRLWMSGWQSGQPGGELGRPISGVTLPLast
1 -36.200IDP90978 hypothetical protein y0549 [Yersinia pestis KIM 10] y0549 [Yersinia pestis KIM10+]  ali follow..  13  1................MLLSTKQFRHYTLALLLA-SGKPVDADDIYDKLSCSGPTLTRALKELRETNAEIRYSKSHSYQLTE---KGTLTPKVLRHIKDAIASHMIIKSHEELVASHVILDKEKKRSISLSLRMSVIRK--IDRVVNQLEITRSEAVEILVNTYISELMLSVSQPPKGKKS................................................................................. 161
2 -17.400IDP01519 hypothetical protein VC2149 VC2149 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  1................MELSPVFARRLYLALLVE-SLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDGRRHNDGYYQL................................................................................................................................................................................ 69
3 -12.500IDP01167 capsule synthesis trans-acting positive regulator, putative, (pxo2-53) GBAA_pXO2_0060 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  18  3....................KDIKRQIQILEIITSEEKWFTTIEISKILRCCNKTIMKDISFIKDEDWHIKIKKGKGVRIYLPYNITFLLFRESLTFRILQHLFERETKTIATLAERLYIQVPSILPAL-KRVENYLKKFGLKL...................................................................................................................... 133
4 -12.300IDP01169 gene: atxA; transcriptional activator atxa, (pxo1-119) GBAA_pXO1_0146 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  12  9....................KEHIRLINLLHFINEQNRWFTIKELSDYLQVADKTVRKYLKLLEDPSWNLLVQKGKGIYLKESLSFVESKILRKSLNLQICEELVFKKNSMQSLAQKLHLQVGALYPII-NQINYDIQSSHLNI...................................................................................................................... 138
5 -12.000IDP90933 gene: birA; biotin--protein ligase [Yersinia pestis CO92] YPO3759 [Yersinia pestis CO92]  ali follow..  1...................MKDIRVPLRLVSILSDGF--HSGEQLGETLGMSRAAINKHMQTIRDWGLDVFTVPGKGYSLPTSIQL----LDEQKILSYLPTGHVTVLPVVDSTNQYLLDRITELKSGDACVAEYQQAGRGRRGRQWVSPFGANLYLSMYWRLEQGPAAAM-GLSLVVGIVMAEVLQNLGAEKVRVKW................................................................ 173
6 -11.900IDP01168 capsule synthesis trans-acting positive regulator, (pxo2-64) GBAA_pXO2_0084 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  14  3....................KDISRKIDLLNILIEEKRWFTLFELEKNLNCSSKTIRKDISIINDLTIFIHSKKGKGVKLSQNQSISEAISNLLKKSLTFLAIQQLLEERSNTVTSSTNIVLKRVSKYIKK................................................................................................................................... 128
7 -11.800IDP90948 gene: mga; trans-acting positive regulator [Streptococcus pyogenes MGAS5005] M5005_Spy_1720 [Streptococcus pyogenes MGAS5005]  ali follow..  12  1..............MYVSKLSQQWRELKLISYVTENADAVKDKELSKALNISMLTLQTCLTNMQFM---GITYKNGYITIW------HQHCGLQEVYQKALR----------------HSQSFKLLETLFFRDFNSLEELAEEL--FVSLSTLKRLIKKTNAYLMHTFGITILTSPVQVSGDEHQIRLFYLKYFSEAYKISEW........................................................... 171
8 -11.600IDP02409 hypothetical protein Cj0883c [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0883c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  13  1................MLFTKASEYALLSLIYISQKETPQDVDSLALELDIPKSFLAKILQTLAKDGL-LKSFKGGGFVLIK----EPSQYTIKEIVNSAEK................................................................................................................................................................ 83
9 -11.600IDP02176 gene: birA; birA bifunctional protein [Coxiella burnetii RSA 493] CBU_1002 [Coxiella burnetii RSA 493]  ali follow..  16  1...................MKNSQNHLAQIVALLNDRRFHPGTAIGQALNISRTAVWKTVQKLKKYEIPITADKSKGYRLERPFLLLDPQKIKNAVQAEPVRIDLFEQINSTNEYLKRVNHPQQLNICLAEMQTQ............................................................................................................................... 116
10 -11.600IDP00219 probable deoR-family transcriptional regulatory protein YPO1938 [Yersinia pestis CO92]  ali follow..  15  1...................MIPIERHQKILALVA-ERGVVSIAELTERLGVSHMTIRRDVQKLEEQGA-VLSVSGGVRSTQRLAIEPSHMMFSRQKQAIGTSAALHIPRNSCIYLDAGTTTLALARQL...................................................................................................................................... 111
11 -11.600IDP90597 biotin--protein ligase [Vibrio cholerae O1 biovar eltor str. N16961] VC0319 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  17  1...................MKEHSAKLAILKQLADGD--HSGEVLGAQLGISRAAISKHIQGIRDWGVDVFRVQGKGYQLAQAMTL----LDQSVIQSQV.................................................................................................................................................................. 76
12 -11.400IDP90992 DNA-binding transcriptional regulator IscR [Yersinia pestis KIM 10] y1333 [Yersinia pestis KIM10+]  ali follow..  14  22................MRLTSKGRYAVTAMLDVHSQDGPVPLADISERQGISLSYLEQLFSRLRKNGL-VASVRGGGYLLGK----DASAIAVGAVITAVDEVDATRCQGKEGCQGGNRCLTHTLWRDLSERISSFLNNITLA....................................................................................................................... 148
13 -11.100IDP91266 birA bifunctional protein [Bacillus anthracis str. Sterne] NT05BA1576 [Bacillus anthracis str. Sterne]  ali follow..  18  1...................MQSTIRKQLLQVFSEADGEFVSGQTISDKLGCSRTAVWKHMEDLRNEGYELEAVRRLGYRIAS----KPDKVTANEIQLGLQTKHIGRTVYFEESVESTQHIAAKLAY....................................................................................................................................... 104
14 -10.900IDP90979 hypothetical protein y0636 [Yersinia pestis KIM] y0636 [Yersinia pestis KIM10+]  ali follow..  18................VQLTSFTDYGLRALIYMLPDGQMTSISQVTEVYGVSRNHMVKIINQLSRVGL-VTAVRGGGIRLGDQILIGDVVRQMEPLTLVNCSSDFCHITPACRLKQVLNQAVQSFLKELDNYTLADM............................................................................................................................. 144
15 -10.700IDP00414 gene: deoR; DNA-binding transcriptional repressor YPO1322 [Yersinia pestis CO92]  ali follow..  25  2..................ETRRAERINKLIQALK-RSDKIHLKDAANLLRVSEMTIRRDLSAEPTSVILLGGYVV........................................................................................................................................................................................... 57
16 -10.200IDP00725 transcriptional regulator, Fur family SACOL1919 [Staphylococcus aureus subsp. aureus COL]  ali follow..  15  19..............LRQAGVRITPQRQAILRYLISSHTHPTADEIYQALNISVATIYNNLRVFKDIGIVKELTYGDS......................................................................................................................................................................................... 86
17 -9.870IDP01032 gene: yhgG; putative cytoplasmic protein STM3507 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  19  4.........................LIQVRDLLA-LRGRMEATQISHTLHAPQPMIDAMLNQLEIMG................................................................................................................................................................................................... 44
18 -9.470IDP95129 DNA-binding transcriptional repressor AllR [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] YP_002918201 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]  ali follow..  10  15.............PSAQKGAQALERGIAILQYLEKSGGSSSVSDISLNLDLPLSTTFRLLKVLEGADFVYQDSQLGWWHI---------------LGAFNIGSAYIHNR---DVLSVGGPFMRRLMLMSGETVN................................................................................................................................ 118
19 -9.130IDP90975 hypothetical protein y0011 [Yersinia pestis KIM 10] y0011 [Yersinia pestis KIM10+]  ali follow..  10  19......................AEKIGQRIL-YEAGSILPGEIELGEQFGVS-RTAVREVKMLAAKGM-LLPRPRIGTRVMPQTNLDQELLT--ILRTSL-ACYLAATHANEKQRELLASLVAEMRALHSNFNREQWIQVDTQFHKLIYEASGNPFLISFANLFSSVYYSYFRAITGDEVIK................................................................................ 198

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.