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Query: [H] KOG1370 S-adenosylhomocysteine hydrolase, from VFDB

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSDKLPYKVAAWGRKALDIAENKMPGLMRIWERYSASKPLNGARIPGCLHRTVETAVLMSLITLGTEVQWSSCNIFSTQDHAAAAIAKAGISASTGIPVLPLPRLACLEGRNRRGVPVTGDLTNLIHSEYSQLLLSFRGISKETTIGVHNLYKMMVNGILKVPAIDVNDSATKSKFDNLYGCGIKQATDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKTDPIKALQAAMEGYEVTTMDEACQEGDVFVTTTGCVDIILGQHFEQTKDDTIVCNTGYFDVEMDVKWLNKNTVEKVNVKLQVDPYRLKNGRGIILLAEGRLVNLACAMGHPSFVRSNSFTSQVMAQIKLWTHPDKYPVGVHFLPKKLDESVAEAHLGKLNMKLTKLTEKQAQYLGMSCYCPFKPDHYRYLast
1 -97.000IDP95479 S-adenosylhomocysteinase Q5CPH1 [Cryptosporidium parvum]  ali follow..  42  5.SRIKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEIWCSCNIYSTQDHAAAAVKKNIATVFAWKNETIEDYWVCLSMDLKCMYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPIKVIEVKQNVHKFTFPTQKSVILLCKGRLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKSSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRY 495
2 -89.700IDP92093 adenosylhomocysteinase, putative [Toxoplasma gondii ME49] TGME49_025050 [Toxoplasma gondii ME49]  ali follow..  44  5.SKVKDLTLSAFGRKEIELAEGEMPGLMALRKEFGPRQPLKGAKISGSLHMTVQTAVLIETLKALGAELWCSCNIFSTQDHAAAAIKNNSAAVFAWKGETLEEYWWCTVMEMKVVYKILAEGLQKDPQKWSRMAANLKGVSEETTTGVHRLLQMAKKKELLFPAINVNDCVTKSKFDNVYGCRIMRATDVMLGGKRVVICGFGDVGKGCAAAMKGAGARVVVTEVDPICALQAAMEGYSVSTLESQLATADIFISATGNKDIITARHMSQMKNNAIVGNIGHFDNEVDMAGLLAWPGQKVNIKPQVDRFIFEDNHGVIVLAEGRLLNLGCATGHPSFVMSCSFTNQTLAQLDLWDNTKRYQNDVYLLPKELDEKVARLHLPALGCELTTMSQEQAAYVGIKPEGPYKSASYRY 477
3 -24.400IDP02524 gene: ilvC-2; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1852 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  13  1...........................................................................................................................................................................MKTYYEQ-------DANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLPDEHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYV----DVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALHVALAYAKGVGCTRAGVIET---------TFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYF. 224
4 -17.900IDP02330 gene: ilvC-1; ketol-acid reductoisomerase [Bacillus anthracis str. `Ames Ancestor`] GBAA1419 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  21  10..........................................................................................................................................................................................VTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILLPDEEVYEEEIAPNLQAGNSLVFAHGFNVHFD............................................................................................................................. 114
5 -14.800IDP90757 gene: ilvC; ketol-acid reductoisomerase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0632 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  18  1...............................................................................................................................................................MAITVYYDKDCDLN-----------------LIKSKKVAIIGFGSQGHAHAMNLRDNGVNVTIGLREGSVSAVAKNAGFEVVSVSEASKIADVIMILAPDEDIFNVEIKPNLSEGKAIAFAHGFNIHYG............................................................................................................................. 116
6 -12.100IDP02277 glycerate dehydrogenase [Bacillus anthracis str. `Ames Ancestor`] GBAA1434 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  11  9............................................................................KIPEIGLELLKDHDVEMYDKELISLDELTERVKDKDALLSLLSTKVTKEVIDAAPSLK-----IVANYGAGYDNI-DYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAALGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPEAESEL-EATYVTLEELLQTADFITINCKLHHMIDEEQFKMMKKTAYIVNASRGPI-MHEAALAHALKTNEIEGAALDVFEFEPKITEELKG-----NVVLAPHVGNATFETRDAMAEMAVRNILA.......................................................... 304
7 -12.000IDP90820 gene: pdxB; erythronate-4-phosphate dehydrogenase [Salmonella typhimurium LT2] STM2370 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  10  35..................................................................................................................LNHADALMVRSVTKVNESLLSGTINFVGTATAGTDHV-DEAWLKQAGIGFSAAPGCNAIAVVEYVFSAMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCD------RAARGDEGDFRTLDELVQEADVLTFHTKTLHLADETLIRRLKPGAILINACRGPV-VDNAALLARLNAGQPLSVVLDVWEGEPDLNVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETLLPAPEFGRITLHGPLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNY 343
8 -11.600IDP90773 erythronate-4-phosphate dehydrogenase [Vibrio cholerae O1 biovar eltor str. N16961] VC2108 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  15  41..................................................................................................................LIDVDALMIRSVTKVNDALLAK-LKFVGTATAGMDHV-DQALLRERGIFFTAAPGCNKVGVAEYVFSVVLAQQQGFSVFDKTVGIIGAGQVGSYLAKCLSGIGMKVLLNDP-----KQAQGDEREFTELETLLKQADVITLHTPTHHLIDAAILEQLRSDQILINAARGPV-VDNAALKARLQQGDGFTAVLDVFEFEPQVDMELLP............................................................................................ 253
9 -11.400IDP00460 gene: serA; D-3-phosphoglycerate dehydrogenase YPO0914 [Yersinia pestis CO92]  ali follow..  12  5....................................SLEKDRIKFLLVEGVHQSA---VDNLRAAGYSNIEYHKGALDAESLKASIRDAHFIGIRSRTHLSED-----------VFAAAEKLV----------------AVGCFCIGTNQV-DLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMFGSFEARGKKLGIIGYGHIGTQLGILAESIGMKVFFYDI----NKLSLGNAQQVRQLSDLLNMSDVVSLNHTTKNMIGAEQLAQMKPGALLINASRGTV-VDIPALCDALSSNHLSGAAIDVFP....................................................................................................... 267
10 -11.400IDP91791 gene: vanH; vancomycin resistance protein [Enterococcus faecium] AAA24789 [Enterococcus faecium]  ali follow..  15  16..............................................................................ADAFHALSPRFGVMATIINANVSESNAKSAPFNQCISVGHKSEISASILLALKRA----VKYISTRSIGCNHI-DTTAAKRMGITVDNVAYSP-DSVADYTMMLILMAVRGKVLSDMTVGVVGTGQIGKAVIERLRGFGCKVLAYSRSR-------SIEVNYVPFDELLQNSDIVTLNTDTHYIISHEQIQRMKQGAFLINTGRGPL-VDTYELVKALENGKLGGAALDVLE....................................................................................................... 258
11 -11.200IDP04474 gene: pdxB; putative D-isomer specific 2-hydroxyacid dehydrogenase [Yersinia pestis CO92] YPO2763 [Yersinia pestis CO92]  ali follow..  12  35..................................................................................................................LVDADALMVRSVTKVNEALLHG-IGFVGTATAGTDHV-DDTWLRQQGIGFSAAPGCNAIAVVEYVFSAMMAERDGFQLRDKTVGIIGVGNVGSRLNARLQALGVRTLLCDP-----RADRGDNEAFWPLEKLVREADVLTFHTQSLHMADDELLAALPDGRILINACRGAV-VDNAALLRALEKGKKLSVVLDVWEPEPDLSLPLLA............................................................................................ 246
12 -10.100IDP00951 gene: ycdW; putative oxidoreductase STM1135 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  11  60............................................................................................................................................VFVLGAGVDAILSKLNAHP-SIPLFRLEDTGMGLQMQEYAVSQVLHWFRRFREEFSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSR-KSWPGVESYVGREELRAFLNQTRVLINTAQTVGIINSELLDQLPDGAYVLNLARGV----------------------------------HVQEADLLAALDSGKLKGAMLDVFSQEPLPQESPLWRHPRVA----HIAAVTRPAEAIDYISRTIGEPVTGQVDRARGY................ 312
13 -9.680IDP90565 ketol-acid reductoisomerase [Vibrio cholerae O1 biovar eltor str. N16961] VC0162 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  12  8....................................................................................................................................................................LNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKTSVVNAVMPLMKQGAALG....................................................................................................................................... 129
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Veeramalai M, Ye Y, Godzik A. TOPS++FATCAT: fast flexible structural alignment using constraints derived from TOPS+ Strings Model. BMC Bioinformatics. 2008 Aug 31;9(1):35