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Query: [H] COG0001 Glutamate-1-semialdehyde aminotransferase, from VFDB

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPGGVSSPVRAFKSVGGQPIVFDHVKGAYIWDVDGNQYIDYVGTWGPAICGHAHPDVIGALHDALEKGTSFGAPSFLENVLAEMVIAAVPSIEMVRFVNSGTEACMAVLRLMRAFTNREKVIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVPKSATSSTLTAPYNDLEAVKALFEENRDQIAGVILEPVVGNAGFITPDAGFLEGLRELTHEHGALLVFDEVMTGFRIAYGGAQEKFGVTPDLTTLGKVIGGGLPVGAYGGRRDIMSMIAPAGPVYQAGTLSGNPLAMTAGIKTLELLQKPGAYEYLERITKKLADGLLQVALETGHAACGGHISAMFGLFFTSGPVHNYEDAKNSDTAKFGRFHRGMLERGVYLAPSQFEAGFTSLAHTDEDIDQTIAIAREVLSSILast
1 -52.500sp|Q9BYV1|AGT2_HUMAN(removed signalp:1-24) Alanine--glyoxylate aminotransferase 2, mitochondrial OS=Homo sapiens GN=AGXT2 PE=1 SV=1  ali follow..  23  61..................PLLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCHPKVNAVAQKQLGR-TSTVFFHPPMHEYAEKLAALLPELKVIFLVNSGSEANELAMLMARAHSNNIDIISFRGAYHGCSPYTLGLTNVGTYKMELPGGTGCQPTMCPDVFRGPWGGIEQFKDTLSTSAKSIAGFFAEPIQGVNGVVQYPKGFLKEAFELVRARGGVCIADEVQTGFRLGS--GFQTHDVLPDIVTMAKGIGNGFPMAAVITTPEIAKSLAKC--LQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAKLRDEFEIVGDVRGKGLMIGIEM----VQDKISCRPLPREEVNQIHEDCKHMGLLVGRGSIFSQTFRIA-TKPEVDFAVEVFRSALTQH 484
2 -51.900sp|P04181|OAT_HUMAN(removed signalp:1-20) Ornithine aminotransferase, mitochondrial OS=Homo sapiens GN=OAT PE=1 SV=1  ali follow..  25  38.................LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRANNVLGEYEEYITK-LFNYHKVLPMNTGVEAGETACKLARKWKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFPFMPGF--------DIIPYNDLPALERALQD--PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLRTGRWLAVDYENVRPDIVLLGKALSGGLPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKDWDAWKVCL-----------RLRDNGLLAKPTHGDIIRFPLVIKEDELRESIEIINKTILSF 419
3 -50.900sp|Q8TBG4|AT2L1_HUMAN Alanine--glyoxylate aminotransferase 2-like 1 OS=Homo sapiens GN=AGXT2L1 PE=2 SV=1  ali follow..  23  30..................PIKIVRAQRQYMFDENGEQYLDCIN--NVAHVGHCHPGVVKAALKQMELNTNSRFLHDNIVEYAKRLSATLPELSVCYFTNSGSEANDLALRLARQFRGHQDVITLDHAYHGHLSSLIEISPYKFQKGKDVKKEFVHVAPTPDTYRGKYREVKKIIEDAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVHGAGGVFIADEVQVGFRVGKSFQMYGEDFVPDIVTMGKPMGNGHPVACVVTTKEIAEAFSSSG-MEYFNTYGGNPVSCAVGLAVLDIIENEDLQGNAKRVGNYLTELLKKQKAKHTLIGDIRGIGLFIGIDLVKD-----HLKRTPATAEAQHIIYKMKEKRVLLSADGPHRNVLKIK-TEEDAKFMVDQLDRILTVL 436
4 -49.700sp|Q8IUZ5|AT2L2_HUMAN Alanine--glyoxylate aminotransferase 2-like 2 OS=Homo sapiens GN=AGXT2L2 PE=2 SV=1  ali follow..  22  31..................PVKIVRAQGQYMYDEQGAEYIDCIS--NVAHVGHCHPLVVQAAHEQNQVNTNSRYLHDNIVDYAQRLSETLPELCVFYFLNSGSEANDLALRLARHYTGHQDVVVLDHAYHGHLSSLI-DISPYKFRNLDGQKEWVHVAPLPDTYRGPYREVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFSQVAEHIRKAGGVFVADEIQVGFRVGKAFQLQGKDFVPDIVTMGKSIGNGHPVACVAATQPVARAFEATG-VEYFNTFGGSPVSCAVGLAVLNVLEKEQLQDHATSVGSFLMQLLGQQKIKHPIVGDVRGVGLFIGVDLIKD-----EATRTPATEEAAYLVSRLKENYVLLSTDGPGRNILKFK-SLDNARQVVAKLDAILTDM 436
5 -45.500sp|P80404|GABT_HUMAN 4-aminobutyrate aminotransferase, mitochondrial OS=Homo sapiens GN=ABAT PE=1 SV=3  ali follow..  16  50VPGPRSQELMQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNPPENFVEKLRQSLLSVAPGMSQLITMACGSCSNENALKTIFMWCPDYSILSFMGAFHGRTMGCLATTHSKAIHKI-SFDWPIAPFPRLKYPLEEFEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGCTGKFWAHEHWGLDADVMTFSKKMMTGGFFHKE--------EFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYQFISRVRGRGTFCSFDTPDDSIRN-------------KLILIARNKGVVLGGCGDKSIRFTLVFRDHHAHLFLNIFSDILADF 499
6 -18.400sp|P23378|GCSP_HUMAN Glycine dehydrogenase [decarboxylating], mitochondrial OS=Homo sapiens GN=GLDC PE=1 SV=2  ali   14  1...............................................................................DLCE-----LTGYDQVCFPNSGAQGEYAGLATIRAYLNQKGVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNI--------------DAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGIRPGDFGSDVSHLNLHK--TFCIPHGGGGPGMGPIGVKKHLAPFLPNHPVIVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYMAKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVD------VAKRLQDYGFH.................................. 291
7 -18.300sp|Q9NUV7|SPTC3_HUMAN Serine palmitoyltransferase 3 OS=Homo sapiens GN=SPTLC3 PE=1 SV=3  ali follow..  17  158.........................VIKDVINMGSYNFLG---------LAAKYDESMRTIKDVLEVGTGVASTLDKHKELEDLVAKFL-NVEAAMVFGMGFATNSMNIP---ALVGKGCLILSDELNHT------------------SLVLGARLSGAT-IRIFKHNNTQSLEKLLRDAVIY-ILILVEGVYSMEGSIVH----LPQIIALKKKYKAYLYIDEA-IGAVGPTGGVTEFFGLDPHMGTFTKSFGGGY----IAGRKDLVDYLRVHSHSAVYAS-SMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNFRQRLQEMGFIIYGNENASVVPLLLY-------------MPGKVAAFARHMLEKKIGVVVEARARFCVSAAHTREMLDTVLEALDEMGDLL 527
8 -18.100sp|O15269|SPTC1_HUMAN(removed signalp:1-41) Serine palmitoyltransferase 1 OS=Homo sapiens GN=SPTLC1 PE=1 SV=1  ali follow..  16  55.........................NGKECINFASFNFLGLL----------DNPRVKAAALASLKKGVGTCGPFDVHLDLEDRLAKFMKTEEAIIY-SYGFATIASAIP---AYSKRGDIVFVDRAAC------------------FAIQKGLQASRSD-IKLFKHNDMADLERLLKEQEIEDQKIVVEGLYMNTGTICP----LPELVKLKYKYKARIFLEESLSGVLGEHGGVTEHYGINIDSANMENALAGGF----CCGRSFVIDHQRLSGQGYCFSA-SLPPLLAAAAIEALNIMENPGIFAVLKEKCGQIHKALQGI---SGLKVVGESLSPAFHLQLEES-----TGSREQDVRLLQEIVDQCMNRSIALTQARYLEVVVTVEQTEEELERAASTIKEVAQAV 430
9 -17.300sp|O15270|SPTC2_HUMAN Serine palmitoyltransferase 2 OS=Homo sapiens GN=SPTLC2 PE=1 SV=1  ali follow..  18  166.........................IIKGVINMGSYNYLG---------FARNTGSCQEAAAKVLEEGAGVCSTLDKHEELEELVARFL-GVEAAMAYGMGFATNSMNIP---ALVGKGCLILSDELNHA------------------SLVLGARLSGAT-IRIFKHNNMQSLEKLLKDAIVY-ILILVEGIYSMEGSIVR----LPEVIALKKKYKAYLYLDEA-IGALGPTGGVVEYFGLDPEMGTFTKSFGGGY----IGGKKELIDYLRTHSHSAVYAT-SLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENFRRRLKEMGFIIYGNEDSPVVPLMLY-------------MPAKIGAFGREMLKRNIGVVVESRARFCLSAAHTKEILDTALKEIDEVGDLL 535
10 -16.000sp|O75600|KBL_HUMAN(removed signalp:1-20) 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens GN=GCAT PE=2 SV=1  ali follow..  21  36..................PHIRVDGVSGGILNFCANNYLGLS----------SHPEVIQAGLQALEEGAGLSSVQSIHKNLEAKIARFHQREDAILY-PSCYDANAGLFE---ALLTPEDAVLSDELNHASIDGIRLCKA--------------------HKYRYRHLDMADLEAKLQEAQKH-RLVATDGAFSMDGDIAP----LQEICCLASRYGALVFMDEC-TGFLGPTGGTDELLGVMDQVSTLGKALGGAS--GYTTGPGPLVSLLRQRARPYLFSN-SLPPAVVGCASKALDLLMSNTIVQSMAAKTQRFRSKMEAA----------------FTISGASHPIC---PVMLGDARLASRMADDMLKRGIFVIGKARIRVQISAVHSEEDIDRCVEAFVEVGRLH 395
11 -15.700sp|P22557|HEM0_HUMAN(removed signalp:1-15) 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Homo sapiens GN=ALAS2 PE=1 SV=2  ali follow..  18  172.........................ASKDVSVWCSNDYLGMS----------RHPQVLQATQETLQRGAGAGGTSKFHVELEQELAE-LHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAA--------------------KFVFRHNDPDHLKKLLEKSNPKIPKIVAETVHSMDGAICP----LEELCDVSHQYGALTFVDEV-VGLYGSRGGIGERDGIMHKIGTLGKAFGGGY----IASTRDLVDMVRSYAAGFIFTT-SLPPMVLSGALESVRLLKGEELRRAHQRNVKHMRQLLMDR-----------------GLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAEELLRLAPSPHHSPQMMEDFVEKLLLAWTAV 528
12 -15.500sp|P13196|HEM1_HUMAN 5-aminolevulinate synthase, nonspecific, mitochondrial OS=Homo sapiens GN=ALAS1 PE=1 SV=2  ali   16  2..........................................................................................GKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVP--------------------KYIFRHNDVSHLRELLQRSDPSVPKIVAETVHSMDGAVCP----LEELCDVAHEFGAITFVDEV-VGLYGARGGIGDRDGVMPKMGTLGKAFGGGY----IASTSSLIDTVRSYAAGFIFTT-SLPPMLLAGALESVRILKSAELRRQHQRNVKLMRQMLMDA-----------------GLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAEELLRIAPTPHHTPQMMNYFLENLLVTWKQV 297
13 -13.000sp|Q16719|KYNU_HUMAN Kynureninase OS=Homo sapiens GN=KYNU PE=1 SV=1  ali follow..  12  70.....................................YFL------GNSLGLQPKMVKTYLEEELDKWAKIAAYGTGDESIVGLMKDIVGAEKEIALMNALTVNLLLMLSFFKPTPKRYKILLEAKAFPSDH-------------ESQLQLHGLNIEESMRMIKPREGEIEDILEVIEKEGDSIAVILFSGVHFYTGQHFN----IPAITKAGQAKGCYVGFD-----------LAHAVGNVELYLHDWGKYLNAG-GIAGAFIHEKHAHTIKPGVCGFRISN---PILLVCSLHASLEIFKQATM-KALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPSFHDVYKFTNLLTSILDS. 460
14 -12.500sp|Q4AC99|1A1L2_HUMAN 1-aminocyclopropane-1-carboxylate synthase-like protein 2 OS=Homo sapiens GN=ACCSL PE=2 SV=3  ali follow..  11  153....................YNAYQKDKYHKDKNTLGFINLGTSENKLCMDLMTERLQESDMNCIEDTLLQYPDWRGQPFLREEVARFLTDPENV-VVLNGCCSVFCALAMVLCDPG-EAFLVPAPFYGGFAFSSRLYAKVELIPVHLESEV---TVTNTHPFQLTVDKLEEALLEARLEGKKVRGLVLINPQNPLGDIYSPDS-LMKYLEFAKRYNLHVIIDEIYM--LSVFDESITFHSILS-IWGTSKDFGSGFRFGALYTHNKEVASAVSAFGYLHS-------ISGITQHKLCQLLQNTEWIDKLPTNCYRLREAITAELKALEIPFHNRSSGLYVWINLKK--------LDPCTFEEERLLYCRFLDNKLLLSRGKTYMC-LIFADELPRLKLAMRRFCDVLQEQ 553
15 -12.300sp|Q96QU6|1A1L1_HUMAN 1-aminocyclopropane-1-carboxylate synthase-like protein 1 OS=Homo sapiens GN=ACCS PE=2 SV=1  ali follow..  11  92...............................DKNPSGIINLGTSENKLCFDLLSWRLSQRDMQRVEPSLLQYADWRGHLFLREEVAKFLSRPENV-VVLNGGASLFSALATVLCEAG-EAFLIPTPYYGAITQHVCLYGNIRLAYVYLDSEV---TGLDTRPFQLTVEKLEMALREAHSEGVKVKGLILISPQNPLGDVYSPEE-LQEYLVFAKRHRLHVIVDEVYM--LSVFEKSVGYRSVLS-MWATSKDFGSGLRFGTLYTENQ--DVATAVASLCRYHGLSGLVQYQMAQLLRDRDWINQVYLPENHARLKAAHTYVSEELRALGIPFLSRGAGFFIWVDLRK--------LPKGTFEEEMLLWRRFLDNKVLLSFGKAFEC-FVFSDQVHRLCLGMQRVQQVLAGK 481
16 -11.800sp|Q6YP21|KAT3_HUMAN Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1  ali follow..  12  55....................................EFTKLAADPSVVNLGQGFPDKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIVTVGAYGSLFNTIQALIDEG-DEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTL----DPQELESKFN---SKTKAIILNTPHNPLGKVYNREE-LQVIADLCIKYDTLCISDEVYEWLHLKIATFPGMWERTITIGSAGKTFS-GWKLGWSIGPNHLIKHLQ---TVQQNTIYTCATPLQEALAQAFWI-DPECYFNSLPKELEVKRDRMVRLLESVGLKPIVPD-GGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSA----FCFIKKDSTLDAAEEIIKAWSVQK 453
17 -11.400sp|P13196|HEM1_HUMAN 5-aminolevulinate synthase, nonspecific, mitochondrial OS=Homo sapiens GN=ALAS1 PE=1 SV=2  ali   22  91.........................TKKQVSVWCSNDYLGMS----------RHPRVCGAVMDTLKQGAGAGGTSKFHVDLERELAD-LHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVP--------------------KYIFRHNDVSHLRELLQRSDPSVPKIVAETVHSMDGAVCP----LEELCDVAHEFGAITFVDEV-VGLYGARGGIGDRDGVMPKMGTLGKAFGC............................................................................................................................................................ 299
18 -11.200sp|Q16773|KAT1_HUMAN Kynurenine--oxoglutarate transaminase 1 OS=Homo sapiens GN=CCBL1 PE=1 SV=1  ali follow..  13  25................................ASEHDVVNLGQGFPDF---PPPDFAVEAFQHAVSGDFMLNQYTKTFGPLTKILASFIDPLRNVLVTVGGYGALFTAFQAL--VDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQL---DPMELAGKFT---SRTKALVLNTPNNPLGKVFSREE-LELVASLCQQHDVVCITDEVYQWMHISIASLPGMWERTLTIGSAGKTFS-GWKVGWVLGPDHIMKHLR---TVHQNSVFHCPTQSQAAVAESFER-QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNGLVAIPVSI----FCFVKDEATLQAMDEKLRKWKVEL 422
19 -9.490sp|O95470|SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 OS=Homo sapiens GN=SGPL1 PE=1 SV=3  ali follow..  13  162......................................................KAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCVTSGGTESILMACKAYRDLAFEKGIIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEV--------------DVRAMRRAISR---NTAMLVCSTPQFPHGVIDP----VPEVAKLAVKYKIPLHVDACLGGFLIVF-RVKGVTSISAD-----KYGYAPKGSSLVLYSKKYRNYQFFVDTDWQGGIYSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSN--------------LMTAKGWNLNPPSIHFCITLLHARKRVAIQFLKDIRESVTQI 511
20 -9.360sp|P17735|ATTY_HUMAN Tyrosine aminotransferase OS=Homo sapiens GN=TAT PE=1 SV=1  ali follow..  13  69.................................PNKTMISLSIG-DPTVFGNTDPEVTQAMKDALDSGKYNGAPSIGFLSSREEIASYYHEAKDVILTSGCSQAIDLCLAV----------LANPG------QNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEDLKQLEYLIDEKTACL--IVNNP--SNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPIL--SCGGGWRLGWILIHDRRGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIR---VVITVPEVMMLEACSRIQEFCEQH 441
21 -9.040sp|Q8TD30|ALAT2_HUMAN Alanine aminotransferase 2 OS=Homo sapiens GN=GPT2 PE=1 SV=1  ali follow..  12  135........................................................ARRILQACGGNSLGSYSASQGVNCIREDVAAYITDPDNIYLTTGASDGISTILKLVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENC---------------NVNELRRAVQEAKDHCVLCIINP--GNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQ--DNVYSPDCRFHSFKK-FHSTSKGYMGGYRGGYMEVINLHPEIKGQLVK--LLSVRLCPPVSGQAAMDIVVSREKESVLGNLAKKAKLTEDLFNQV---PGIHCNPLQ-GAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEEGICVVPGS-----MTILPPVEKLKTVLQKVKDFHINF 518

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 6 2 8   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Godzik A., Rychlewski L. A support vector machine approach to the identification of phosphorylation sites. Cell Mol Biol Lett. 2005;10(1):73-89.