current user: public
If you have questions about the server, please let us know.

Query: [J] COG0013 Alanyl-tRNA synthetase, from VFDB

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650    .  660    .  670    .  680    .  690    .  700    .  710    .  720    .  730    .  740    .  750    .  760    .  770    .  780    .  790    .  800    .  810    .  820    .  830    .  840    .  850    .  860    .  870
# Score Template Links and tools%idFirst MKTMTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTSSEWFEFPAEKLYITYYPADKDTYNRWVEVGVDPTHLVPIEDNFWEIGAGPSGPDTEIFFDRGEVYDPEHVGLKLLAEDIENDRYIEIWNIVLSQFNADPSIPRSEYPELPQKNIDTGMGLERMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTYSPDSENMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLLNLKSEGKDRLEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGSMGAQNETLSSIEVESEFLYEDKTTQGKLLVSIQDDEIVDEVSGKAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVVANVLDVQHAPHGQNLHSVETLSPLKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEMGAMALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAFKDAENTLNEVATMVKAPQTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGLRNLADIWKQKELSDVLVLVAKIGEKVSLLVASKSSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELLAAVAEKLALast
1 -99.200sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   40  3.STLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHSRAANTQKCIRANDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLT--QEFGIPIERLYVTYFGGDLECKQIWQNLGLDDTKILPGKDNFWEMGTGPCGPCSEIHYDRIGGRDAA------HLVNQDDPNVLEIWNLVFIQYNREA---DGILKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGK---VGAEDADGIDMAYRVLAD................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
2 -92.500sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   38  1......................................................................................................................................ECKQIWQNLGLDDTKILPGKDNFWEMGTGPCGPCSEIHYDRIGGRDAA------HLVNQDDPNVLEIWNLVFIQYNREA---DGILKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYAEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSL--GDSKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQ........................................................................................................................................................................................................................................................................................................................................................................................................................................................ 299
3 -91.000sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   39  34PPAAKASAVRAAFLNFFRDRGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRFRRVANSQKCVRANDLEDVGRDLSHHTFFEMLGNWAFGEYFKEEACNMAWELLT--QVYGIPEERLWISYFDGDLETRDIWLSLGVPASRVLSFQENFWEMGTGPCGPCTEIHYDLAG--------------GVGAPQLVELWNLVFMQHNREA---DGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIQQGC................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 300
4 -89.000sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   34  1..........................................................................................................MAWELLT--QVYGIPEERLWISYFDGDLETRDIWLSLGVPASRVLSFQENFWEMGTGPCGPCTEIHYDLAG--------------GVGAPQLVELWNLVFMQHNREA---DGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIQQGCRAPPDEGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRRILRRAVRFSEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
5 -76.600sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   30  2.....................................................................................................................................................................................................................................................................................................................................................................................................................SQGKGAGGEDLIMLDIYAIEELRARGLEVTDDSPKYNY------------HLDSSGSYVFENTVATVMALRREKMFVEETGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSTEFTVKNAQVRGGYVLHIGTI-YGDLKVGDQVWLFIDEPRRRPIMSNHTATHILNFALRSVLG-EADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIGLRAVFDETYPDPVRVVSIGVTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIR................................................................................................................................................................................. 300
6 -72.900sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   24  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLS-LGSRDVAEALRLSKDIGRLIEAVETAVMPQWQRRELLATVKMLQ--RRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKV................................................... 299
7 -72.300sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   26  1.....................................................................................................................................................................................................................................................................................................................................................................................................................DMVELMLEEKGVQLDSAGLERAQEEAQHRARQAEPVQKQGPTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVASGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAHALDPASQAALQ................................................................................................................................................................................................... 293
8 -71.900sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   31  1..........................................................................................................................................................................................................................................................................................HARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHELNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSL--GDSKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLVTDDSPKYNYHLDSSGSYVFENTVATVMALRREKMFVEETGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEFTVKNAQVRGGYVLHIGTI-YGDLKVGDQVWLFIDEPRRRP....................................................................................................................................................................................................................................................................................................................... 300
9 -69.800sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   27  1..................................................................................................................................................................................................................................................................RAPPYLGRVGDEGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRRILRRAVRFSMELKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRARQAEPVQKQGTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVAKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEVLFPVARAQVCGGFI................................................................................................................................................................................................................................................................................................................................................... 300
10 -65.500sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   26  1.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IMSNHTATHILNFALRSVLG-EADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIGLRAVFDETYPDPVRVVSIGVTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAKVKAQTAPNK--DVQREIADLGEALATAVIPQWQK------------DELRETLKSLKKVMDDLDRASKADVQKRVLEKTKQFIDSNPNQPLVILEMESG---SAKALNEALKLFKMHSPQTSAMLFTVDNEAGKI............ 299
11 -59.400sp|Q9BTE6|AASD1_HUMAN Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens GN=AARSD1 PE=1 SV=2  ali follow..  21  13..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFTTTVVSCCPAELQTEEVLSGFQVVLEDTVLFPEGGGQPDDRGTIND------ISVLRVTRRGEQADH---FTQTPLDPGSQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKT--TSWELGRFRSAIEL-DTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEEQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLSDLQVIKILGTEKGKKNRTNLIFLSGNRVLKWMERSHGTEKALTALLKCG-AEDHVEAVKKLQNSTKILQKNNLNLLRDLAVHIAHSLRNSPD---WGGVVILHRKEGDSEFMNIIANEIGSEETLLFLTVGDEKGGGLFLLAG---PPASVETLGPRVAEVLEGKGAGKKGRFQGKATKMSRRMEAQALLQDYIS 406
12 -42.400sp|Q5JTZ9|SYAM_HUMAN Alanyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=AARS2 PE=1 SV=1  ali   15  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGPQWQRRELLATVKMLQRRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLLLSPQPMGKVLCACQVAQTFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTT-DLEAALSIAQTYAL 232
13 -36.900sp|P26639|SYTC_HUMAN Threonyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=TARS PE=1 SV=3  ali   13  6...................................................................................................................................................................................................................................................................................................................................................................................................................ASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIY----TRLEMYNILKAEHDSILAEKAEKDSKPIK---VTLPDGKQVDAESWKTTPYQIACGISQG--LADNTVIAKVNNVVWD----LDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYL-EEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRILNEKVTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTMETLQRIYGI............................................................................................................................................................................ 300
14 -31.300sp|P49588|SYAC_HUMAN Alanyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=AARS PE=1 SV=2  ali   22  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RIVAVTGAEAQKALRKAESLKKCLSVMEAKVKAQTAPNQKDELRETLKSLKKVMDDLDRASKADVQKRVLEKTSNPNQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVEAGKITCLCQVPQNGLKASEWVQQVSGLMDGKGGGKDVSAQATGKNVGCLQEALQLATSFAQ 210
15 -20.300sp|Q9BW92|SYTM_HUMAN Threonyl-tRNA synthetase, mitochondrial OS=Homo sapiens GN=TARS2 PE=1 SV=1  ali   16  2.............................................................................................................................................................................................................................................................................................................ALYQRWRCLRLQGLQACRLHTAV---------------STPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKI----------SLPGGQKIDAVAWNTTPYQLARQISST------------------------------------------------------------------------------LADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVF--------------------------------HSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPVLERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLGPTATVYGCGTL-VDLCQGPHLRHTGQIGGLKLLSNSSSPETLQRVSGIS........................................................................................................................................................................... 280
16 -12.300sp|A2RTX5|SYTC2_HUMAN Probable threonyl-tRNA synthetase 2, cytoplasmic OS=Homo sapiens GN=TARSL2 PE=1 SV=1  ali   14  18....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWDLDRPLEGDSSLELLTFDNEEAQAVY-------------------------------WHSSAHILGEAMELYYGGHLCYGPPIEN-GFYYDMFIEDRAVSSTELSALENICKAIIKEKQPFERLEVSKEILLEMFKYNKFKCRITATTTVYRCGPL-IDLCKGPHVRHTGKIKTIKIFKNSSTMETLQRIYGISFPDNKMMRDAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREE.................................................................................................................... 292
17 -11.800sp|P26639|SYTC_HUMAN Threonyl-tRNA synthetase, cytoplasmic OS=Homo sapiens GN=TARS PE=1 SV=3  ali   19  5.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HSSAHIMGEAMERVYGGCLCYGPPI--ENGFYYDMYLEEGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAM-KCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTMETLQRIYGIS--PDPKMLKEWEKFQEEAKN....................................................................................................................................................... 170
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 2 8 5   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.