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Query: [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases, from VFDB

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNLAWLQGLSLGLLSPPAPALLIFRSFTMAKVLVSDSIDQVGIDILKQVAQVDVKTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQAGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTAIETAQIGGAALDVFAQEPLGESRLREFSNVILTPHLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAVNIPGLTPDVMEKLRPYLKLAETLGTLVGQLAGGRIDRLTVCLQGDLAEYTNSQPLVVAAIKGLLSQALRERVNYVNAAIEAKERGIRVIETKDASVRDYSGSLHLKATGTMGEHSATGALLSNGEIRITDVDEFPINVPPNNYMLFTLHRDMPGIIGKIGSLLGSFNVNIASMQVGRKIVRGDAIMALSLDDPLPDGLLSEITKVAGIRDAYTVKLLast
1 -132.000sp|O43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase OS=Homo sapiens GN=PHGDH PE=1 SV=4  ali follow..  36  2........................AFANLRKVLISDSLDPCCRKILQDGGQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQGTSLKN-AGNCLSPAVIVGLLKEASKQDVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLALAGAPYQAVGLVQG-TTPVLQGLNGAVFRPEDLPLLLFRTQTSDPAMLPTMIGLLAEAGVRLLSYQTSLVS-DGETWHVMGISSLLPSLEA----WKQHVTEAFQFHF 533
2 -92.800sp|P56545|CTBP2_HUMAN C-terminal-binding protein 2 OS=Homo sapiens GN=CTBP2 PE=1 SV=1  ali follow..  23  22.................RPQIMNGPLHPRPLVALLDGRDTVEMPILKDLATVAFDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNC--VNKEFFVTSAPWSVIDQQAI-------HPELNGATYRYPPGIVGVAPG--GLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNRE....................................................................................................................... 440
3 -92.400sp|Q13363|CTBP1_HUMAN C-terminal-binding protein 1 OS=Homo sapiens GN=CTBP1 PE=1 SV=2  ali follow..  25  13..............LGVRPPIMNGPLHPRPLVALLDRDCTVEMPILKDVATVAFDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNK---------DHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGV-APTGIPAAVEGIVPSAMLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQ.................................................................................................................... 439
4 -88.700sp|Q9UBQ7|GRHPR_HUMAN Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1  ali follow..  27  2........................RPVRLMKVFVTRRIPAEGRVALARAADCEVDEPIPAKELERGVAGAHGLLCLLSDHVDKRILDAAANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPPTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLLAGLRGEPMPSELKL...................................................................................................................................................................................................................... 328
5 -13.300sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   16  6........................................................................MILDDGGDLTHWIYKKYPNMFIVEESVTGVHRLQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGL--------------KRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEI-ICALQACMDGFRLVKLNEVIRQVDIVIT----CTGNKNVVTREHLDRMKNSCIVCNMGHSNTIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLL-----STVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVAS--LHLPTFDAHLTELTDEQAKYLGL................................................................................................................................................................................ 298
6 -13.300sp|P23526|SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens GN=AHCY PE=1 SV=4  ali follow..  15  88.................................AAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLISEETTTGVHNLKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRA--------------TDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITE--INALQAAMEGYEVTTMDEACQEGNIFVT----TTGCIDIILGRHFEQMKDDAIVCNIGHFDVIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLV---GCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAE--AHLGKLNVKLTKLTEKQAQYLGMSCDGPF.......................................................................................................................................................................... 425
7 -12.900sp|O43865|SAHH2_HUMAN Putative adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2  ali follow..  13  186.................................VAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFIVEESVTGVHRLQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGL--------------KRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITE--ICALQACMDGFRVVKLNEVIRQVDVVIT----CTGNKNVVTREHLDRMKNSCIVCNMGHSNTIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLL-----STVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVA-----LPSFDAHLTELTDDQAKYLGLNKNGPF.......................................................................................................................................................................... 523
8 -11.900sp|Q96HN2|SAHH3_HUMAN Putative adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1  ali   14  117.................................VAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFIVEESVTGVHRLYLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRT--------------TDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEI-ICALQACMDGFRLVKLNEVIRQVDI.......................................................................................................................................................................................................................................................................................................................................... 300
9 -8.520sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2  ali follow..  16  40.......................................................................................................................................................................TPVGFIGLGNMGNPMAKNLMKHGYPLIIYDPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANLKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAV---MDA-----PVSGGVGAARSGNLTFMVGGDEFAAAQELLGCMGSNVVYC-TGQAAKICNNM--LLAISMIGTAEAMNLGIRLGLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGL--AQDSATSTKSPI................................................................................................................................ 300
10 -6.830sp|Q13423|NNTM_HUMAN NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3  ali   15  1.............................................................................................LISFIYPAQNPELLNKLSQRKTTVLAMDQVPRVTIAQGY---ALSSMANIAGYKAVVLAANHFGRFFTGQKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTYAKEMSKEFIEAEMKLFAQQCKEVDILTALIP-GKKAPVLFNKEMIESMKEGSVVVDLAAGGNFETTKPGELYIHKGITHIGYTDLPSRMATQASTLYSNNIT--KLLFDVKDDFDFGTMGHVIRGTVVMKDGKVIFPAP........................................................................................................................................................................................................................ 289
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.