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Query: [W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases, from VFDB

Results of FFAS03 search in NEW_HUMAN_DOMAINS
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSPIRNRLQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPIGFRFNAYNRTFHVQLHPIDDSLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHVHGSVFDGVFEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINHRKWRVKRDAENLSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADHKLYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTNFNGIKGLHFVIQRTSIYTPDSCDRGRAKTDSDNPFCEENVDVSNFLNLNSQRNHSAFCLAYALTFRDFVGGTLGLAWVASPQFNTAGGICQVHQRYNEGSRGWVYRSLNTGIVTLVNYGNRVPARVSQLTLAHEIGHNFGSPHDFPAECQPGLPDGNFIMFASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPVDPTRNASPVGIGKRNCFQERTSAFCGNQIYEPGEECDCGFSQADCDQMGDKCCVPHEARGNGGPGPCKRKPGAQCSPSQGYCCNPDTCSLHGKNEEKICRQESECSNLQTCDGRNAQCPVSPPKHDGIPCQDSTKVCSSGQCNGSVCAMFGLEDCFLTEGKADELCFLACIKDGKCTSSVHLPEFSANRTNFLQNMRKDKPGLILHPGSPCNNYKGYCDIFRKCRSVDANGPLARLKNLLFNKRTIETLTQWAQDNWWVVGVGGLVFLVIMALFVKCCAVHTPSTNPNKPPALNIYQTLTRPGTLIRQHRQRHRAAAGSVPPGPGAQPRSGAASAPSRTTPSARPSAPPLVAPQVAVAVPPGVVGPPIPLIATHPGSSSSTPAVIVLEPPPPYTAADPGSAMGGPRRGHRKNKRQTSSDAAGSSGNGGKKKGKLast
1 -11.600sp|Q9BXP8|PAPP2_HUMAN Pappalysin-2 OS=Homo sapiens GN=PAPPA2 PE=1 SV=4  ali   15  275..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................APYCGDGKVSEGEECDDGDLVS-----GDGC-----------SKVCELEEGFNCVGEPSLCEGDGICE-----------PFERKTSIVDCGIYTPKGYLDQWATRAYSSHEDKKKCPVSLVTGEPHSLICTSYHPDLPNHRPLTGWFPCVASEN.................................................................................................................................................................................................................................................................. 406
2 -11.300sp|Q5T1R4|ZEP3_HUMAN Transcription factor HIVEP3 OS=Homo sapiens GN=HIVEP3 PE=1 SV=1  ali   8  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFA.. 137
3 -11.300sp|Q6PJF5|RHDF2_HUMAN Inactive rhomboid protein 2 OS=Homo sapiens GN=RHBDF2 PE=1 SV=2  ali   12  15..............................................................................................................................................................................................................................................................................................................................................................................GLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTTFVHVIITLLVICTYGIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSSIDLIHLGA-KFSPCKDGQIEQLVLRER-----DLERDSGCCVQNDHSGCIQTQRKDCSETLATSGAVC-CEEPASSGAHTKWPICTEQARSNHTGFLHM------DCEIKGRPCCTKGSCEIT---------TREYCE---FMHGY--------FHEEATLCSQVH--CLDKVC................................................................................................................................................................................................................................................................................................... 285
4 -11.000sp|Q96CC6|RHDF1_HUMAN Inactive rhomboid protein 1 OS=Homo sapiens GN=RHBDF1 PE=1 SV=2  ali   11  5..............................................................................................................................................................................................................................................................................................................................................................................GLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTVGFSQHETVDSVLRNRGVYENVKYVIG-HLGAKFSP---CMRQDPQ-----VHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHFGSVCH----QDPRVCDEPSSEDPHEWPEDPICTKNSAGNHTNH------PHMDCVITGRPCC-KGRCEIT---------SREYCD---FMRGY--------FHEEATLCSQVH--CMDDVC................................................................................................................................................................................................................................................................................................... 272
5 -9.820sp|Q9H0E3|SP130_HUMAN Histone deacetylase complex subunit SAP130 OS=Homo sapiens GN=SAP130 PE=1 SV=1  ali   10  1.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALS... 150
6 -9.610sp|O75553|DAB1_HUMAN Disabled homolog 1 OS=Homo sapiens GN=DAB1 PE=1 SV=3  ali   14  3.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLA.. 104
7 -8.420sp|Q3V5L5|MGT5B_HUMAN Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B OS=Homo sapiens GN=MGAT5B PE=2 SV=2  ali   9  6.................................LDLMGSGKESLIFMKKRTKRLTAQWALA-------------QRLAQKLGATQRDQKQILVHIGFLTEESGDVFSPRVLKGGPLGE------MVQWADILTALYVLGHGLRVTVSLKELQSNLGVPPGRGSCPLTMPLPFDLIYTDYHGLQQMKRHMGLSFKKYRCRIRVIDTFGTEPA------NHEEYATLHGYRTNWGYWNLNPKQFMTMFPHTPDNSFMGFVSEELNETEKRLIKGGKASNMAVVYGKEASIWKLQGKEKF--LGILNKYMEIHGTVYYESQRPPEVPAFVKNHGLLPQPEFQQLLRKAK------------------FIGFGF-APLEAIANGCIFLQSRFSPPHSSLNHEFFRGKPTSREVFSQHPYAENFIGKPHVWTVDYNNSEEFEAAIKAIMRTQVDPYLPYEYTCEGMLERIHAYIQHQDFCRAPDPALPEAHAPQSPFVLAPNATHLEWARNTSLAPGA----LAVPGRACT------------DTCCEPSF--PFLNSQDAFLKLQVPCD---------STESEMNHLYPAFAQPGQECYLQKSCAGSNTKCP----------CRDQVALCQG--C................................................................................................................................................................................................................................................................................................... 556
8 -8.230sp|Q6ZRI0|OTOG_HUMAN Otogelin OS=Homo sapiens GN=OTOG PE=2 SV=3  ali   13  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................VPRALGETW---NSSLSGCCQHQCQAPDTIVPVDLGCPSPRP---ESCLRFGEVALLLPTKDPCC------------LGTVCV---NQTLC-----GLAPTCRPG-HRLLTHFQEDSCCPSYSC--ECDPDLCEAELVPSCRQLGDSCCTSYFCACGDCPDSIPECQEGECCPLYQCVCENFRCPQVQCGLGDIHCEANQEYC--GSCRNVSCLFTFPNGTTSLFLPGASWIADCCSSTPLG----------------AVLVRSPISCPPLNE-TECAKVGGSVVPSLEC................................................................................................................................................................................................................. 389
9 -8.120sp|O75592|MYCB2_HUMAN Probable E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens GN=MYCBP2 PE=1 SV=3  ali   12  5.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CNV-----GNLCTCGRTKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEACRFCGSRSGLSAVGSVCSDADCQEYAKIACSKTHPC---------------GHPC---GGVKNEEHCLP--C----LHGC...................................................................................................................................................................................................................................................................................... 143
10 -8.000sp|Q92750|TAF4B_HUMAN Transcription initiation factor TFIID subunit 4B OS=Homo sapiens GN=TAF4B PE=1 SV=2  ali   10  2.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QPEKPVVSGTAVTLSLPAVTFGETSGAAICLPSVKPVVSSAGTTSDKPVIGTPVQIKLAQPGPVLSQPAGIPQAVQVKQLVVQQPSGGNEKQVTTISHSSTLTIQKCGQKTMPVNTIIPTSQFPPASILKQITLPGNK... 139
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.