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Query: [E] KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily, from VFDB

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAFSSSCSSVKAVNSRWTSPSPSPSSRFAVLPAFLHRRYATSVKLTAISAALKTVEQTTLTEDNRFSTVGSDSDEYNPTLPKPRILVTEKLGEAGVNLLREFGDVDCSYDLSPEDLKKKVAESDALIVRSGTKVTREVFEAAKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVFCEEPPSKDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVAGALKGELSATAVNAPMVAPEVLSELTPYIVLAEKLGRLAVQLASGGKGVQSIRVVYRSARDRDDLDTRLLRAMITKGIIEPISDSYVNLVNADFIAKQKGLRISEERMVVDSSPEYPVDSIQVQILNVESNFAGAVSDAGDISIEGKVKYGVPHLTCVGSFGVDVSLEGNLILCRQVDQPGMIGQVGNILGEQNVNVNFMSVGRTVLRKQAIMAIGVDEEPDNKTLERIGGVSAIEEFVFLKLLast
1 -122.0001ygy_A mol:protein length:529 D-3-phosphoglycerate dehydrogenase  ali model follow..  34  2...............................................................................VSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAAAP-KLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCT-DSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGG--VVNEEVAPWLDLVRKLGVLAGVLSDE--LPVSLSVQVRG--ELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESP---NHRSVVDVRAVGA---------DGSVVTVSGTLYGPQQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDL 528
2 -92.6001wwk_A mol:protein length:307 phosphoglycerate dehydrogenase  ali model follow..  42  1...............................................................................MKRMKVLVAAPLHEKAIQVLKDAGEVIYEEYPDEDRLVELVKDVEAIIVRSKPKVTRRVIESAP-KLKVIARAGVGLDNIDVEAAKEKGIEVVNAPAASSRSVAELAVGLMFSVARKIAFADRKMREGVWAKKEAMGIELEGKTIGIIGFGRIGYQVAKIANALGMNILLYDPYPNEERAKEVNGKFVDLETLLKESDVVTIHVPLVESTYHLINEERLKLMKKTAILINTSRGPVVDTNALVKALKEGWIAGAGLDVFEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG.............................................................................................................................................................................................................................................. 307
3 -90.8002g76_A mol:protein length:335 D-3-phosphoglycerate dehydrogenase  ali model follow..  45  18...............................................................................ANLRKVLISDSLDPCCRKILQDGGQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAE-KLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-RDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGV........................................................................................................................................................................................................................................ 329
4 -89.3002ekl_A mol:protein length:313 D-3-phosphoglycerate dehydrogenase  ali model follow..  34  1.............................................................................MAIYTVKALITDPIDEILIKTLREKGQVDYMPEISKEELLNIIGNYDIIVVRSRTKVTKDVIEKGK-KLKIIARAGIGLDNIDTEEAEKRNIKVVYAPGASTDSAVELTIGLMIAAARKMYTSMALAKSGIFKK--IEGLELAGKTIGIVGFGRIGTKVGIIANAMGMKVLAYDILDIREKAEKINAKAVSLEELLKNSDVISLHVTVSKDAKPIIDYPQFELMKDNVIIVNTSRAVAVNGKALLDYIKKGKVYAYATDVFWNEPPKEEWELLKHERVIVTTHIGAQTKEAQKRVAEMTTQNLLNAMKELGM........................................................................................................................................................................................................................................... 312
5 -88.7002d0i_A mol:protein length:333 dehydrogenase  ali model follow..  29  2.................................................................................RPKVGVLLKMKREALEELKKYADVEIILYPSGEELKGVIGRFDGIIVSPTTKITREVLENAE-RLKVISCHSAGYDNIDLEEATKRGIYVTKVSGLLSEAVAEFTVGLIINLMRKIHYADKFIRRGEWESHAKIIESLYGKKVGILGMGAIGKAIARRLIPFGVKLYYWSRHRKVNVEKELKARYMDIDELLEKSDIVILALPLTRDTYHIINEERVKKLE-GKYLVNIGRGALVDEKAVTEAIKQGKLKGYATDVFEKEPVREHELFKYEWETVLTPHYAGLALEAQEDVGFRAVENLLKVLRGEVPEDLVNKEVLEVRPIENVKM........................................................................................................................................................................................................................ 332
6 -85.8002p9c_A mol:protein length:410 D-3-phosphoglycerate dehydrogenase  ali model follow..  28  2.........................................................................AKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAE-KLVAIGAFAIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG--NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALADALASKHLAGAAIDVFPTEPATNTSPLAEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHVGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEA--------------DEDVAEKALQAMKAIPGTIR......................................................................................................................................... 405
7 -85.7001yba_A mol:protein length:410 D-3-phosphoglycerate dehydrogenase  ali model follow..  28  2.........................................................................AKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAE-KLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG--NATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQT--SAQMGYVVIDIEADEDVAEKALQA-MKAIPGTIRAR.................................................................................................................................................. 407
8 -85.6003k5p_A mol:protein length:416 D-3-phosphoglycerate dehydrogenase  ali model follow..  30  6........................................................................TERLSLSRDRINVLLLEGISQTAVEYFKSSGYTNVPKALDKADLIKAISSAHIIGIRSRTQLTEEIFAAAN-RLIAVGCFSVGTNQVELKAARKRGIPVFNAPFSNTRSVAELVIGEIIMLMRRIFPRSVSAHAGGWEKTAIGSREVRGKTLGIVGYGNIGSQVGNLAESLGMTVRYYDTSDKLQYGN--VKPAASLDELLKTSDVVSLHVPSSKSTSKLITEAKLRKMKKGAFLINNARGSDVDLEALAKVLQEGHLAGAAIDVFPVEPASNSTPLQGLENVILTPHIGGSTEEAQERIGTEVTRKLVEYSDVGSTVGAVNFPQVQ------------------------------------------------------------------------------------------------------------------------------------------------LPPRPTGTRFMHVHENRPGILNSLMNVFSHHHINIASQFLQTDGEVGYLVMEADGVGEASDAVLQEIREIPGTIRARLL.. 415
9 -85.4006bii_A mol:protein length:333 Glyoxylate reductase  ali model follow..  37  2.................................................................................KPKVLITRAIPENGIELLREHFEVEVEHEIPREVLLEKVKDVDALVTMLSEKIDREVFDAAP-RLRIVANYAVGYDNIDIEEATKRGIYVTNTPDVLTDATADLAWALLLAAARHVVKGDKFVRSGEWKRKMFLGYDVYGKTIGIVGFGRIGQAIAKRAKGFGMRILYTARSRKPEAEKELGAEFKPLEELLRESDFVVLAVPLTKETYHMINEERLRLMKPTAVLVNVARGKVVDTKALIRALKEGWIAAAGLDVFEEEPY-YDEELFALDNVVLTPHIGSATFGAREGMAELVAKNLIAFKNGEVPPTLVNREVL-----KVRRPGF...................................................................................................................................................................................................................... 333
10 -85.3005aov_A mol:protein length:336 GLYOXYLATE REDUCTASE  ali model follow..  36  2.................................................................................KPKVFITRAIPENGINMLEEEFEVEVEREIPREKLLEKVKDVDALVTMLSERIDQEVFENAP-RLRIVANYAVGYDNIDVEEATRRGIYVTNTPDVLTNATADHAFALLLATARHVVKGDKFVRSGEWKRKWFLGYELYGKTIGIVGFGRIGQAIARRAKGFNMRILYYSRTRKSQAEKELGAEYRPLEEVLKESDFVILAVPLTKETMYMINEERLKLMKPTAILVNIARGKVVDTKALIKALKEGWIAGAGLDVFEEEPY-YNEELFSLDNVVLTPHIGSATFEAREAMAELVARNLIAFKRGEIPPTLVNKEVI-----KIRKPGFN..................................................................................................................................................................................................................... 334
11 -85.2002dbq_A mol:protein length:334 Glyoxylate reductase  ali model follow..  34  2.................................................................................KPKVFITREIPEVGIKMLEDEFEVEVEKEIPREILLKKVKEVDALVTMLSERIDKEVFENAP-KLRIVANYAVGYDNIDIEEATKRGIYVTNTPDVLTDATADLAFALLLATARHVVKGDRFVRSGEWKKRGFLGYDVYGKTIGIIGLGRIGQAIAKRAKGFNMRILYYSRTRKEEVERELNAEFKPLEDLLRESDFVVLAVPLTRETYHLINEERLKLMKKTAILINIARGKVVDTNALVKALKEGWIAGAGLDVFEEEPY-YNEELFKLDNVVLTPHIGSASFGAREGMAELVAKNLIAFKRGEIPPTLVNREVI-----KIRKPGFE..................................................................................................................................................................................................................... 334
12 -84.2004ebf_A mol:protein length:334 Thermostable phosphite dehydrogenase  ali model follow..  28  3.................................................................................LPKLVITHRVHEEILQLLAPHCELITDSTLTREEILRRCRDAQAMMAFMPDRVDADFLQACP-ELRVIGCALKGFDNFDVDACTARGVWLTFVPDLLTVPTAELAIGLAVGLGRHLRAADAFVRSGQFRQPRFYGTGLDNATVGFLGMGAIGLAMADRLQGWGATLQYHAAKLDTQTEQRLGLRQVACSELFASSDFILLALPLNADTLHLVNAELLALVRPGALLVNPCRGSVVDEAAVLAALERGQLGGYAADVFEMEPQQIDPALLAHPNTLFTPHIGSAVRAVRLEIERCAAQNILQALAGERPINAVNRL.................................................................................................................................................................................................................................... 329
13 -83.9001gdh_A mol:protein length:320 D-GLYCERATE DEHYDROGENASE  ali model follow..  31  1.................................................................................KKKILITWPLPEAAMARARESYDVIADPKITIDEMIETAKSVDALLITLNEKCRKEVIDRIPENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGVTVATAEIAMLLLLGSARRAGEGEKMIRTRSWEPLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDIDYFDTHRSSDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVNTARGDLVDNELVVAALEAGRLAYAGFDVFAGEPN-INEGYYDLPNTFLFPHIGSAATQAREDMAHQANDLIDALFGGADMSYALA...................................................................................................................................................................................................................................... 320
14 -83.6002gcg_A mol:protein length:330 Glyoxylate reductase/hydroxypyruvate reductase  ali model follow..  27  5..............................................................................PVRLMKVFVTRRIPAEGRVALARAADCEVDEPIPAKELERGVAGAHGLLCLLSDHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLLAGLRGEPMPSELKL..................................................................................................................................................................................................................................... 330
15 -83.5006cdf_A mol:protein length:373 C-terminal-binding protein 1  ali model follow..  27  3.....................................................................SSSSGLVPRGSHMPLVALLDGRDTVEMPILKDVATVAFDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFK-ALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDATHWASMDPAVVHPELNGAAY............................................................................................................................................................................................................ 367
16 -83.3003wnv_A mol:protein length:330 glyoxylate reductase  ali model follow..  30  1...............................................................................MPSQAALLIGDIVHARWEALSSLVTLKEFPEGGREKFLENCKSYDDVIAIYRSPFDRELISALPKSVKYICHNGAGYDNIDVDAATEAGIAISSTPIAVNNATADVAIFLMIGALRQAYVPITAIRAGEWHGKTTLGHDPNGKTLGILGMGGIGREVARRARAFGMNIIYHNRNKLPP-ELEDGAKYVSFDELLAQSDVFSLNLALNASTRHIIGEKELAKMKDGVVIVNTARGALIDEKALVRALESGKVASVGLDVYENEPQ-VEPGLLNNPRAMLLPHIGTMTYETQKEMELLVLNNLRSAIEKGELLTQVPEQKKR................................................................................................................................................................................................................................. 330
17 -83.1004g2n_A mol:protein length:345 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding  ali model follow..  24  18.............................................................................STHPIQKAFLCRRFTPAIEAELRQRFDLEVDTVLTPSGIASRAHGAEVLFVTATEAITAEVIRKLQPGLKTIATLSVGYDHIDMAAARSLGIKVLHTPDVLSDACAEIAMLLVLNACRRGYEADRMVRSGSWPGTQLLGMGLTGRRLGIFGMGRIGRAIATRARGFGLAIHYHNRTRLSHALEEGAIYHDTLDSLLGASDIFLIAAPGRPELKGFLDHDRIAKIPEGAVVINISRGDLINDDALIEALRSKHLFAAGLDVFANEPA-IDPRYRSLDNIFLTPHIGSATHETRDAMGWLLIQGIEALNQSDVPDNLIS...................................................................................................................................................................................................................................... 339
18 -82.7002cuk_A mol:protein length:311 glycerate dehydrogenase/glyoxylate reductase  ali model follow..  35  1..................................................................................MRVLVTRTLPGKALDRLRERGEVHRGLFLPKAELLKRVEGAVGLIPTVEDRIDAEVMDRAK-GLKVIACYSVGVDHVDLEAARERGIRVTHTPGVLTEATADLTLALLLAVARRVVEGAAYARDGLWKAELLLGLDLQGLTLGLVGMGRIGQAVAKRALAFGMRVVYHART-----PKPLPYPFLSLEELLKEADVVSLHTPLTPETHRLLNRERLFAMKRGAILLNTARGALVDTEALVEALR-GHLFGAGLDVTDPEPLPPGHPLYALPNAVITPHIGSAGRTTRERMAEVAVENLLAVLEGREPPNPV....................................................................................................................................................................................................................................... 310
19 -81.7002ome_A mol:protein length:336 C-terminal-binding protein 2  ali model follow..  32  3.................................................................................HPRPLVALRDCTVEMPILKDLATVAFDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFK-ALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNC..................................................................................................................................................................................................................................... 328
20 -81.5003naq_A mol:protein length:357 Formate dehydrogenase  ali model follow..  26  17.........................................................................KANEYATKNPNFLGCVENALGIRDWLESQGHVTDDKEGPDCELEKHIPDLHVLISTHPAYVTAERIKKAK-NLKLLLTAGIGSDHIDLQAAAAAGLTVAEVTGSNVVSVAEDELMRILILMRNFVPGYNQVVKGEWNVAAYRAYDLEGKTIGTVGAGRIGKLLLQRLKPFGCNLLYHDRLQAPELEKETGAKFVDLNEMLPKCDVIVINMPLTEKTRGMFNKELIGKLKKGVLIVNNARGAIMERQAVVDAVESGHIGGYSGDVWDPQPAPKDHPWRYMPNQAMTPHTSGTTIDAQLRYAAGTKDMLERYFKGEDFP-TENYIVKDGELAPQYR......................................................................................................................................................................................................................... 357
21 -81.1001hku_A mol:protein length:358 C-TERMINAL BINDING PROTEIN 3  ali model follow..  29  16.................................................................................HPRPLVALRDCTVEMPILKDVATVAFDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFK-ALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKD................................................................................................................................................................................................................................. 345
22 -81.0005tx7_A mol:protein length:327 D-isomer specific 2-hydroxyacid dehydrogenase family protein  ali model follow..  30  1.................................................................................SMRIVALDGYTDISWAPIEELGELVVHPRTPSDKIIERAAGAHVVLTNK-VPLDMSALQALP-GLRFVSVLATGYDKVDVAAAGVLGIPVSNVPGYGTDSVAQHVFALLLELCRRTALHDHRIRAGAWTQSPSTQEELTGKTMGIVGFGNTGRRVGRIANALGMNVIAYAPRSRFD-PDYRPFEHVGLDELFTSADVVSLHCPLTPETEGLVDARRLASMRPGSYLINTARGPLLDERAVAEALDSGRLAGAGLDVLSQEPPAADNPLLSAKNCLITPHLAWASRTARRTLMDSTAANIRSFIEGT-PVNVVNAAHLRTK............................................................................................................................................................................................................................... 326
23 -80.9003kb6_A mol:protein length:334 D-lactate dehydrogenase  ali model follow..  27  1..................................................................................MNVLFTSVPQEDVPFYQEKDLSLKIYTTDVSKVPENELKKAELISVFVYDKLTEELLSKMP-RLKLIHTRSVGFDHIDLDYCKKKGILVTHIPAYSPESVAEHTFAMILTLVKRLKRIEDRVKKLNFSQDEILARELNRLTLGVIGTGRIGSRVAMYGLAFGMKVLCYDVVKRED-LKEKGCVYTSLDELLKESDVISLHVPYTKETHHMINEERISLMKDGVYLINTARGKVVDTDALYRAYQRGKFSGLGLDVFEDEEILKILELACKDNVIITPHIAYYTDKSLERIREETVKVVKAFVKGDLEQIKGNFVVGPS................................................................................................................................................................................................................................ 334
24 -80.8004lcj_A mol:protein length:349 C-terminal-binding protein 2  ali model follow..  32  17................................................................................SHPRPLVALRDCTVEMPILKDLATVAFDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFK-ALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNC..................................................................................................................................................................................................................................... 343
25 -80.7004lsw_A mol:protein length:318 D-2-hydroxyacid dehydrogensase protein  ali model follow..  26  1...............................................................................MTKPEILQLGPYPAWDQEPLDAAFTVHREADDRAAMLANVGDRIRAIATRGELGASRALIEACP-NLELISVYGVGYDAVDLAACRERGIQVTNTPDVLTGDVADLGVAMMLAQSRGIIGAETWARSGKWAAEGLLKRRVFGRRAGVLGLGRIGFEVARRLAGFDMQISYSDIAPKSYAPD--WTFVEDAVTLARDVDFLFVTLAASAATRHIVGRDVIEALGPEGMLINISRASNIDEEALIAALADGRLGSAALDVFEGEPN-FDPRFRDLPNVLLQPHHASGTIETRKAMGQLLRDNLTAHFAGSPLLTPVVLE.................................................................................................................................................................................................................................... 317
26 -80.1004cuj_A mol:protein length:338 D-LACTATE DEHYDROGENASE  ali model follow..  29  2.................................................................................KLAVYSTKQYDKKYLQQVNEAFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKGVKYIALRCAGFNNVDLDAAKELGLQVVRVPAYSPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMHGKTAGVIGTGKIGVAALRILKGFGMRLLAFDPYPSTA-ALDLGVEYVDLQTLFAESDVISLHCPLTPENYHLLNHAAFDQMKNGVMIINTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDDVFRRLSACHNVLFTGHQAFLTAEALISISETTLQNLSQLEKGEACPNALFKSS................................................................................................................................................................................................................................... 332
27 -80.0004xyb_A mol:protein length:391 Formate dehydrogenase  ali model follow..  25  45................................................................................FVPGELLGCVSGELGLRSYLEDLIVTSDKEGPNSVFEKELPDADIVISQPPAYLTAERIAKAK-KLKLALTAGIGSDHVDLNAAIKAGITVAEETFSNGICVAEHAVMMILALVRNYLPSHKIAEEGGWNIADCVSYDLEGMHVGTVAAGRIGLAVLRRLKPFDVKLHYTARHRSPRAEDELGLTYATAEEMAEVCDVISIHAPLYPATEHLFNAKVLNKMRHGSYLVNTARAEICDRDDIVRALESGQLAGYAGDVWFPQPAPANHPWRNMPHNGMTPHMSGSSLSGQARYAAGTREILECWFENRPIRDEYLIVSNGKLAGTGAKSYGVGEAPKGK.............................................................................................................................................................................................................. 391
28 -79.9002fss_A mol:protein length:365 formate dehydrogenase  ali model follow..  25  13............................................................................KHAADEEKLYGCTENKLGIANWLKDQGHTTSDEEGGNSVLDQHIPDADIIITTHPAYITKERIDKAK-KLKLVVVAGVGSDHIDLDYINQTGISVLEVTGSNVVSVAEHVVMTMLVLVRNFVPAHEQIINHDWEVAAIAAYDIEGKTIATIGAGRIGYRVLERLVPFNPKELLYYDYLPKDAEEKVGARRVNIEELVAQADIVTVNAPLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALESGQLRGYGGDVWFPQPAPKDHPWRDMRNNAMTPHYSGTTLDAQTRYAQGTKNILESFFTGKFDYRPQDIILLNGEYVT--KAYGKHDKK................................................................................................................................................................................................................. 365
29 -79.6003wr5_A mol:protein length:406 Formate dehydrogenase  ali model follow..  24  51.................................................................................TPGQLLGSVSGELGLRKYLEANGHTFDKDGPDSVFEKELVDADVVISQPPAYLTPERIAKAK-NLKLALTAGIGSDHVDLQSAIDRGITVAEVTYCNSISVAEHVVMMILGLVRNYIPSHDWARKGGWNIADCVSYDLEGMTVGSVAAGRIGLAVLRRLAPFDVKLHYTDRHRLPEAVEK-LVWHDTREDMYPHCDVVTLNVPLHPETEHMINDETLKLFKRGAYIVNTARGKLADRDAIVRAIESGQLAGYAGDVWFPQPAPKDHPWRTMKWEGMTPHISGTSLSAQARYAAGTREILECFFEGRPIRDEYLI--VQGGALAGTGAH-------SYSKGNATGG--SEEAAKFKKAG......................................................................................................................................................................................... 406
30 -79.6005dn9_A mol:protein length:364 FDH  ali model follow..  25  12............................................................................KHAADEEKLYGCTENKLGIANWLKDQGITTSDKEGGNSVLDQHIPDADIIITTPPAYITKERIDKAK-KLKLVVVAGVGSDHIDLDYINQTGISVLEVTGSNVVSVAEHVLMTMLVLVRNFVPAHEQIINHDWEVAAIAAYDIEGKTIATIGAGRIGYRVLERLVPFNPKELLYYDYLPKDAEEKVGARRVNIEELVAQADIVTINAPLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALESGQLRGYGGDVWFPQPAPKDHPWRDMRNKAMTPHYSGTTLDAQTRYAEGTKNILESFFTGKFDYRPQDIILLNGEYIT--KAYGKHDKK................................................................................................................................................................................................................. 364
31 -79.6005uog_A mol:protein length:344 NADPH-dependent glyoxylate/hydroxypyruvate reductase  ali model follow..  25  16..............................................................................SMSRPRILVPGKINPRVLERLPEMFETVRIERADAALVTADMRDVSGIAVSG--KLPVPLMDAFP-SLEIVANFGVGYDGVDVSRAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQWLRQGRWVREGLSPLSLRGRTVGLFGLGRIGLAIARRLEAFGVSIAYHTRTPREGLGFTY---HPTLVGMAEAVDTLIVIVPGTASTLKAVNADVLSALGPKGVLINVGRGSTVDEAALVTALQNGTIAGAGLDVFENEPN-VPEALLSFPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFSTGEALTPVAETPFRRRAIQN........................................................................................................................................................................................................................... 338
32 -79.5003gg9_A mol:protein length:352 d-3-phosphoglycerate dehydrogenase oxidoreductase protein  ali model follow..  28  2.................................................................................SLKIAVLDDYQDAVRKLDDHEVKVFNNTVKGVGQLAARVADVEALVIRERTRVTRQLLDRLP-KLKIISQTGRAGGHIDLEACTDKGVVVLEGK-GSPVAPAELTWALVMAAQRRIPQYVASLKHGAWQQSGLIGRVLKGQTLGIFGYGKIGQLVAGYGRAFGMNVLVWGRENSKERARADGFAVASKDALFEQSDVLSVHLRLNDETRSIITVADLTRMKPTALFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLRMENCICTPHIGYVERESYEMYFGIAFQNILDILQGN-VDSVANPTALAPALIRAE.......................................................................................................................................................................................................................... 345
33 -79.5004xkj_A mol:protein length:335 D-lactate dehydrogenase  ali model follow..  26  2.................................................................................KIIMFSVRDDEEAAIREWEKKTQVDINRLELDAETAQLTKGYDGIVIQQRSHISNPAVYEQKNGLRQLTSRTAGYDMIDLEQASERGLVVTNVPAYSPNSVAELALTQTMRLIRNLPLFDARGAEQDFRWAGLMAREIRSLTVGIIGAGRIGGTVARLFKALGATVIANDIVERVEL--KDIVTYVSKEELLQAADVVTLHVPLMDSTTQLIDADALALMKNDAVLINASRGPVVDTDALIAALQNKQIAGAALDTLNGEEHEQLKVLRTLPNVLITPHIGFYTNKAVQNMVEISLNDVLAILKTGTSEHQLNKVAVEN................................................................................................................................................................................................................................ 335
34 -79.4002yq4_A mol:protein length:343 D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE  ali model follow..  22  1...............................................................................MTKIAMYNVSPIEVPYIEDWAKKNEIKTTDQALTSATVDLAEGCSSVSLKPLGPVDEEVVYQSEYGVKCIGLRIVGFNTINFDWTKKYNLLVTNVPVYSPRAIAEMTVTQAMYLLRKIGEFRYRMDHDHDWPSNLISNEIYNLTVGLIGVGHIGSAVAEIFSAMGAKVIAYDVAYNPEF--EPFLTYTDFDTVLKEADIVSLHTPLFPSTENMIGEKQLKEMKKSAYLINCARGELVDTGALIKALQDGEIAGAGLDTLAGESPEDYKTLAKMPNVVITPHSAFYTETSIRNMVQICLTDQLTIAKGGRPRSIVNLTASG................................................................................................................................................................................................................................. 337
35 -79.3002dld_A mol:protein length:337 D-LACTATE DEHYDROGENASE  ali model follow..  26  1...............................................................................MTKVFAYAIRKDEEPFLNEWKEAHDVDYTDKLLTPETAKLAKGADGVVVYQQLDYTADTLQALADGVTKMSLRNVGVDNIDMDKAKELGFQITNVPVYSPNAIAEHAAIQAARVLRQDKRMDEKMAKRDLRWAPTIGREVRDQVVGVVGTGHIGQVFMRIMEGFGAKVIAYDIFKNPE-LEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDKSIAEMKDGVVIVNCSRGRLVDTDAVIRGLDSGKIFGFVMDTYEDEVDKRLADLIDRPNVLVTPHTAFYTTHAVRNMVVKAFNNNLKLINGEKPDSPVALN.................................................................................................................................................................................................................................... 333
36 -79.3004dgs_A mol:protein length:340 Dehydrogenase  ali model follow..  26  15........................................................................QSMLEFRNVKPDLLLVEPMMPFVMDELQRNYSVRLYQAADRPALEAALPSIRAVATGGGAGLSNEWMEKLP-SLGIIAINGVGTDKVDLARARRRNIDVTTTPGVLADDVADLGIALMLAVLRRVGDGDRLVREGRWAAGEPLGHSPKGKRIGVLGLGQIGRALASRAEAFGMSVRYWNRSTLSGVD---WIAHQSPVDLARDSDVLAVCVAASAATQNIVDASLLQALGPEGIVVNVARGNVVDEDALIEALKSGTIAGAGLDVFVNEPA-IRSEFHTTPNTVLMPHQGSATVETRMAMGKLVLANLAAHFAGEKAPNTVN...................................................................................................................................................................................................................................... 334
37 -79.3004s1v_D mol:protein length:332 D-3-phosphoglycerate dehydrogenase-related protein  ali model follow..  23  2..................................................................................MKIAILDDYQNVVRGL-GHDVTVFNDSVSDETVLIERLKPFEALVIRERTPITENLLAHLP-NLKLISQTGKVSNHIDVPLCERYGVTVLEGI-GSPVAPAELCWSLILAASRHLPSYIEQLHAGHWQQNGGLGRTLSGRTLGIWGLGKIGQRIAQFGHVFGMPILVWGSEASRQKALELGYQAADKAEFFAKADVLSLHLRLNDATRGIVTKQDLLAMKPDSLFVNTSRAELVESGALYSVMQANPMRQAAVDVYENEPAPNNEPLLSLPNVLCAPHLGYVEKNSYEIYFQAAFENVVKFAHSAAKASLSDKAL................................................................................................................................................................................................................................... 325
38 -79.2001j49_A mol:protein length:333 D-LACTATE DEHYDROGENASE  ali model follow..  25  1...............................................................................MTKIFAYAIREDEKPFLKEWEDAHEVEYTDKLLTPETVALAKGADGVVVYQQLDYIAETLQALADGITKMSLRNVGVDNIDMAKAKELGFQITNVPVYSPNAIAEHAAIQAARILRQDKAMDEKVARHDLRWAPTIGREVRDQVVGVVGTGHIGQVFMQIMEGFGAKVITYDIFRNPE-LEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKIFGYAMDVYEGEVGARLADLIARPNVLVTPHTAFYTTHAVRNMVVKAFDNNLELVEGKEAETPVKV..................................................................................................................................................................................................................................... 332
39 -79.0004prk_A mol:protein length:336 4-phosphoerythronate dehydrogenase  ali model follow..  23  2.................................................................................KIAVFSPSESERKLVAATEKKFELKLIDESLSAENVDQVADCDGVLLKPLGNLDDEIVYKADYGIKSIGLRIVGTNTIDFDLAKKYHLTVTNVPVYSPRAIAEMAVTQAMYLNRKIGEFKANMDKGDFTNDSLISNEIYNKTIGLIGVGHIGSAVAQIFSAMGAKVLAYDVIYNPEV--EPYLTYADFDTVLKEADIISLHTPLLKSTENMIGKKQFAEMKNDAILINAARGELVDTAALIEALEKHEIAAAGLDTLAHESPADYKKLAAMPNVIVTPHSAYFTKTSVRNMIEISLRDTIALANGERAHFVVS...................................................................................................................................................................................................................................... 329
40 -79.0004njm_A mol:protein length:309 D-3-phosphoglycerate dehydrogenase, putative  ali model follow..  26  4.................................................................................KIVVITEKPFAENAVKGIREILEVMIEKYKKKEDVIERIKDADGVIVRS-DKIDEEIIKAGE-KVKIIVRAGAGYDNIDIEACNQGKIVVMNTPGQNRNGVAELCIGMMIFGFRKGFKE-------------GKGRELKDKTLGICGCGYVGKRVKEIAEGIGMKIKVYDPFITTE------NQVKKIEELFEECQVISLHLPLTKETKGKIGYELIKKLPYGGMICNTARKEIIDEEGLIRIMREREDLIYITDVAPTSKVFNNEFK---GRFFATPKIGAETEESNINAGMAAASQICDFFTNGTVKFQVNKFL................................................................................................................................................................................................................................... 302
41 -78.9002go1_A mol:protein length:401 NAD-dependent formate dehydrogenase  ali model follow..  23  36.......................................................................TLPTPKAIDFTPGQLLGSVSGELGLRKYLESNGHTLDKDGPDSVFERELVDADVVISQPPAYLTPERIAKAK-NLKLALTAGIGSDHVDLQSAIDRNVTVAEVTYCNSISVAEHVVMMILSLVRNYLPSHEWARKGGWNIADCVAYDLEAMHVGTVAAGRIGLAVLRRLAPFDVHLHYTDRHRLPESEKELNLTWATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAYIVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPAPKDHPWRTMPYNGMTPHISGTTLTAQARYAAGTREILECFFEGRPIRDEYLIVQGGALAGTGAHSYSKGNATGGSEEAAKFKKA..................................................................................................................................................................................................... 400
42 -78.7002gsd_A mol:protein length:402 NAD-dependent formate dehydrogenase  ali model follow..  25  46.................................................................................TPGALLGSVSGELGLRKYLESQGHELSKDGPDSELEKHLHDAEVIISQPPAYLTAERIAKAP-KLKLALTAGIGSDHVDLQAAIDNNITVAEVTYCNSNSVAEHVVMMVLGLVRNYIPSHDWARNGGWNIADCVSYDVEGMHVGTVAAGRIGLRVLRLLAPFDMHLHYTDRHRLPEAEKELNLTWATREDMYGACDVVTLNCPLHPETEHMINDETLKLFKRGAYLVNTARGKLCDRDAIVRALESGRLAGYAGDVWFPQPAPNDHPWRTMPHNGMTPHISGTSLSAQTRYAAGTREILECYFEGRPIRDEYLIVGAHSYSKGNATGGSEEAAKYEKLDA........................................................................................................................................................................................................... 402
43 -78.4004hy3_A mol:protein length:365 phosphoglycerate oxidoreductase  ali model follow..  18  27...............................................................................SAPEPRSLDLIFSDEARAALHSKYEIVEADPENIAGLGDDILGRARYIIGQ-PPLSAETLARMP-ALRSILNVESNLNNMPYEVLFQRGIHVVTTGQVFAEPVAEIGLGFALALARGIVDADIAFQEGTELEGNASARLIAGSEIGIVGFGDLGKALRRVLSGFRARIRVFDPWLPRSMLEENGVEPASLEDVLTKSDFIFVVAAVTSENKRFLGAEAFSSMRRGAAFILLSRADVVDFDALMAAVSSGHIV-AASDVYPEEPLPLDHPVRSLKGFIRSAHRAGALDSAFKKMGDMVLEDMDLMDRGLPPMRCKRAERETVSRM-RSKPVA...................................................................................................................................................................................................................... 357
44 -78.2003ba1_A mol:protein length:333 Hydroxyphenylpyruvate reductase  ali model follow..  24  5.....................................................................SSGLVPRGSHMEAIGVLMMCPMSTYLEQELDKRFKLFRTQPAQRDFLALQAESIRAVVGNSNAGADAELIDALP-KLEIVSSFSVGLDKVDLIKCEEKGVRVTNTPDVLTDDVADLAIGLILAVLRRICECDKYVRRGAWKFGDFLTTKFSGKRVGIIGLGRIGLAVAERAEAFDCPISYFSRSKKPNTN---YTYYGSVVELASNSDILVVACPLTPETTHIINREVIDALGPKGVLINIGRGPHVDEPELVSALVEGRLGGAGLDVFEREPE-VPEKLFGLENVVLLPHVGSGTVETRKVMADLVVGNLEAHFSGKPLLTPV....................................................................................................................................................................................................................................... 326
45 -78.2001dxy_A mol:protein length:333 D-2-HYDROXYISOCAPROATE DEHYDROGENASE  ali model follow..  24  1..................................................................................MKIIAYGARVDEIQYFKQTGNTLEYHTEFLDENTVEWAKGFDGINSLQTTPYAAGVFEKHAYGIKFLTIRNVGTDNIDMTAMKQYGIRLSNVPAYSPAAIAEFALTDTLYLLRNMGKVQAQLQAGDYEKATFIGKELGQQTVGVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMKG--DHPDFDYVSLEDLFKQSDVIDLHVPGIEQNTHIINEAAFNLMKPGAIVINTARPNLIDTQAMLSNLKSGKLAGVGIDTYEYETEPLWDELLGMPNVVLSPHIAYYTETAVHNMVYFSLQHLVDFLTKGETSTEVTGPA................................................................................................................................................................................................................................... 332
46 -78.1003wx0_A mol:protein length:345 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding  ali model follow..  29  12.................................................................................KLAVYSTKQYDKKYLQQVNESFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFDQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL....................................................................................................................................................................................................................................... 338
47 -77.8003wwy_A mol:protein length:358 D-lactate dehydrogenase  ali model follow..  25  2...............................................................NHKVIEGRHMELGTLEMQKTKIIFFDDYDKEFFKKYGADYEMTFLKVRLTEETANLTKGYDVVCGFANDNINKETIDIAENGIKLLAMRCAGFNNVSLKDVNE-RFKVVRVPAYSPHAIAEYTVGLILAVNRKINKAYVRTREGNFSINGLMGIDLYEKTAGIIGTGKIGQILIKILRGFDMKVIAYDLFPNQKVADELGFEYVSLDELYANSDIISLNCPLTKDTKYMINRRSMLKMKDGVILVNTGRGMLIDSADLVEALKDKKIGAVALDVYEEEENDILGRLLSFYNVLITSHQAYFTKEAVGAITVTTLNNIKDFVEGRPLVNEVPQN.................................................................................................................................................................................................................................... 351
48 -77.5001xdw_A mol:protein length:331 NAD+-dependent (R)-2-Hydroxyglutarate Dehydrogenase  ali model follow..  21  2.................................................................................KVLCYGVRDVELPIFEACNKEFGYDIPDYLNTKETAEMAAGFDAVILRGNCFANKQNLDIYKKGVKYILTRTAGTDHIDKEYAKELGFPMAFVPRYSPNAIAELAVTQAMMLLRHTAYTTSRTAKKNFKVDAMFSKEVRNCTVGVVGLGRIGRVAAQIFHGMGATVIGEDVFEIKGI--EDYCTQVSLDEVLEKSDIITIHAPYIKENGAVVTRDFLKKMKDGAILVNCARGQLVDTEAVIEAVESGKLGGYGCDVLDGEAPLFEKLVDLYPRVLITPHLGSYTDEAVKNMVEVSYQNLKDLAETGDCPNKIK...................................................................................................................................................................................................................................... 331
49 -77.4004zgs_A mol:protein length:386 Putative D-lactate dehydrogenase  ali model follow..  28  23......................................................................ELTPQEAAKVATTRCICYSQYVKDFLAGPMQKVDTYFVEPPLDKDTAQLARGYDVAVLFVNDRADASVIKEAKAGVKLIALRCAGFDRVDLHACAEHGVRVVRVPTYSPESVAEHAVALIFALNRHLTDAYIRVRMGNYSLSGLVGVEMRHKVVGVVGTGAIGQQAARILKGIGCKVFAYDIKPNPA-VEAMGIPYVSLDELLAMSDIVTLHCPLLPSTRQLINKESIQKMKKGVMLINVSRGGLIDSAALFDALESGQIGALGLDVYENEGGRQFRTLLSYPQVLVTPHTAFLTEEALNNICTTTIQNIADYVLDRPLGNEVKAQPAPAGKTLE........................................................................................................................................................................................................................... 380
50 -77.3003wwz_A mol:protein length:345 D-lactate dehydrogenase (Fermentative)  ali model follow..  26  2.......................................................................NHKVIEGRHMRILFFSSQAYDSESFQASNHRHELHFQQAHLQADTAVLAQGFEVVCAFVNDDLSRPVLERAAGGTRLVALRSAGYNHVDLAAAEALGLPVVHVPAYSPHAVAEHAVGLILTLNRRLHRAYNRTREGDFSLHGLTGFDLHGKRVGVIGTGQIGETFARIMAGFGCELLAYDPYPNPR-IQALGGRYLALDALLAESDIVSLHCPLTADTRHLIDAQRLATMKPGAMLINTGRGALVNAAALIEALKSGQLGYLGLDVYEEEADDVLARLLSFPNVVVTAHQAFLTREALAAIADTTLDNIAAWQDGT-PRNRVRA..................................................................................................................................................................................................................................... 339
51 -75.7002w2k_A mol:protein length:348 D-MANDELATE DEHYDROGENASE  ali model follow..  27  1...............................................................................MPRPRVLLLGDPARHLDDLWSQKFEVIPANLTTHDGFKQRYGDFEAIIKLAVEPWNADLISHLPSSLKVFAAAGAGFDWLDLDALNERGVAFANSRGAGDTATSDLALYLILSVFRLASYSERAARTGDPETFNRSAHNPRGHVLGAVGLGAIQKEIARKAHGLGMKLVYYDVAADAETEKALGAERVSLEELARRSDCVSVSVPYMKLTHHLIDEAFFAAMKPGSRIVNTARGPVISQDALIAALKSGKLLSAGLDVHEFEPQ-VSKELIEMKHVTLTTHIGGVAIETFHEFERLTMTNIDRFLLQGKPLTPAGKVFAPSS............................................................................................................................................................................................................................... 346
52 -75.0003gvx_A mol:protein length:290 Glycerate dehydrogenase related protein  ali model follow..  26  4.......................................................................................................YVNFPADGHVREIAKTVLDGFDLHYDAEAQVIKDRYVLGK-RTKMIQAISAGVDHIDVNGIPENVVLC-SNAGAYSISVAEHAFALLLAHAKNILENNELMKAGIFRQ--SPTTLLYGKALGILGYGGIGRRVAHLAKAFGMRVIAYTRSSVDQ---NVDVISESPADLFRQSDFVLIAIPLTDKTRGMVNSRLLANARKNLTIVNVARADVVSKPDMIGFLKERSDVWYLSDVWWNEPEITETNL---RNAILSPHVAGGMSGEIMDIAIQLAENVRNFFEGE............................................................................................................................................................................................................................................. 283
53 -72.0001qp8_A mol:protein length:303 FORMATE DEHYDROGENASE  ali model follow..  20  1..................................................................................MELYVNFELPPEAEEELRKYFKI---------VRGGDLGNVEAALV---SRITAEELAKMP-RLKFIQVVTAGLDHLPWESIPP-HVTVAGNAGSNADAVAEFALALLLAPYKRIIQYGEKMKRGDYGRD-VEIPLIQGEKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKEGP----WRFTNSLEEALREARAAVCALPLNKHTRGLVKYQHLALMAEDAVFVNVGRAEVLDRDGVLRILKERPQFIFASDVWGRNDFAKDAEFFSLPNVVATPWVAGGNERVWRQMVMEAVRNLITYATGGRPRNIAKREDYIGS............................................................................................................................................................................................................................... 303
54 -65.6002o4c_A mol:protein length:380 Erythronate-4-phosphate dehydrogenase  ali model follow..  24  1..................................................................................MRILADENI-PVVDAFFADQGSIRRLPG--RAIDRAALAEVDVLLVRSVTEVSRAALAGS--PVRFVGTCTIGTDHLDLDYFAEAGIAWSSAPGCNARGVVDYVLGCLLAMAEV------------------RGADLAERTYGVVGAGQVGGRLVEVLRGLGWKVLVCDPPRQAR---EPDGEFVSLERLLAEADVISLHTPLNRDTRHLLDEPRLAALRPGTWLVNASRGAVVDNQALRRLLEGGADLEVALDVWEGEPQA--DPELAARCLIATPHIAGYSLEGKLRGTAQIYQAYCAWRGIAERVSLQDVLPETWLAGLQLNPGCDPAWALATLCRAVYDPRSDDAAFRRSLTGDSATRRAAFDALR............................................................................................................................................................................ 346
55 -65.1005mh5_A mol:protein length:308 D-2-hydroxyacid dehydrogenase  ali model follow..  28  1...............................................................................MHIERLAVDESVG-------RAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASFGHRDAFL-DADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVAGYMLTFARRLHAYRDAQHDHAWDLPRYEPFTLAGERVCVVGLGTLGRGVVDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLTDETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALDVFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATGDELTNRV....................................................................................................................................................................................................................................... 307
56 -64.2003oet_A mol:protein length:381 Erythronate-4-phosphate dehydrogenase  ali model follow..  26  2................................................................................NAMKILVDENM-PYARELFSRLGEVKAVPG--RPIPVEELNHADALMVRSVTKVNESLLSGT--PINFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERD------------------GFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAAR---GDEGDFRTLDELVQEADVLTFHTPLYKDTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPD-LNVALLEAVD-IGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQLETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDA..................................................................................................................................................................................................... 327
57 -64.2003evt_A mol:protein length:324 Phosphoglycerate dehydrogenase  ali model follow..  25  2..................................................................................SLVLMAQATKPEQLQQLQTTYP-DWTFKDAAAVTAADYDQIEVMYGNH-PLLKTILARPTN-QLKFVQVISAGVDYLPLKALQAAGVVVANTSGIHADAISESVLAAMLSVVRGYHAAWLNQRGARQWALPMTTSTLTGQQLLIYGTGQIGQSLAAKASALGMHVIGVNTTGHPADHFHETVAFTATADALATANFIVNALPLTPTTHHLFSTELFQQTKQQPMLINIGRGPAVDTTALMTALDHHQLSMAALDVTEPEPLPTDHPLWQRDDVLITPHISGQIAHFRATVFPIFAANFAQFVKGTLVRNQVDLN.................................................................................................................................................................................................................................... 313
58 -64.0005dt9_A mol:protein length:387 Erythronate-4-phosphate dehydrogenase  ali model follow..  28  2.............................................................................PQIPTMKILIDENM-PYAQALFSQLGEVILKPG--RTLTADDLIDVDALMIRSVTKVNDALLAKAN-RLKFVGTATAGMDHVDQALLRERGIFFTAAPGCNKVGVAEYVFSVLMVLAQQQ------------------GFSVFDKTVGIIGAGQVGSYLAKCLSGIGMKVLLNDPPKQAQ---GDEREFTELETLLKQADVITLHTPITRGTHHLIDAAILEQLRSDQILINAARGPVVDNAALKARLQQGDGFTAVLDVFEFEPQ-VDMELLPL-LAFATPHIAGYGLEGKARGTTMIFNSYCEFLGSAHCANPASLLPKAPVPKVYLERAWD-EETLRTLTQIIYDVRKDDAQFR.............................................................................................................................................................................................. 334
59 -53.1003hg7_A mol:protein length:324 D-isomer specific 2-hydroxyacid dehydrogenase family protein  ali model follow..  23  1.............................................................................MSLSQRTLLLLSQDNAHYERLLKAAHHLRILRADNQSDAEKLIGEAHILM--AEPARAKPLLAKAN-KLSWFQSTYAGVDVL-LDARCRRDYQLTNVRGIFGPLMSEYVFGHLLSLMRQLPLYREQQKQRLWQSHPY--QGLKGRTLLILGTGSIGQHIAHTGKHFGMKVLGVSRSGRERAGFDQVYQLPALNKMLAQADVIVSVLPATRETHHLFTASRFEHCKPGAILFNVGRGNAINEGDLLTALRTGKLGMAVLDVFEQEPLPADSPLWGQPNLIITPHNSAYSF--PDDVAQIFVRNYIRFIDGQPLDGKID...................................................................................................................................................................................................................................... 311
60 -51.1004zqb_A mol:protein length:316 NADP-dependent dehydrogenase  ali model follow..  20  3..............................................................................SMSRIALVTSPEAEAHWAGHLARALP-GERIDGFRELSPAERAEVDIAIV----NPDPADLAELP-NLVWIHSLWAGVERLVAELGHLARPIVRLVDPELARTMAEAALAWTYYLFRDMPAYAAQQRARVWKGLPY--KRPERTTVGVLGLGELGAAAALRLRDAGFDVHGWSRSPKEIAGVTCHAGEETLERMLGQVEILVCLLPLTGETRGLLDARRLACLPEGAQIVNFARGPILDSAALIEALDSGRIGHAVLDVFEVEPLPEASPFWGHPKVTVLPHISAATD--PETASAIVGAHVADYRATGRIPPSVD...................................................................................................................................................................................................................................... 311
61 -50.7004weq_A mol:protein length:341 NAD-dependent dehydrogenase  ali model follow..  25  15...........................................................................QSMPAKSPVIVDLKFIPEEVEAALAGAFGREVIDLADPAHQERDLSGIDYAVV----KSAPDLFSRAP-DLKVVFSGGAGVDHVLTLPGLPDVPLVRFVDRTLTTRMSEWVMMQCLLHLRQHRAYEALAKKHEWRDLSQ--PEAADVTVGIMGMGVLGQDAARKLAAMGFKVIGWSRSKRVIEGVET-YDAAGLDAFLGRTDFLVGLLPLTPDTRGIFNAALFAKLSRNGVFINAGRGGSQVEADILECLDSGVLGGASLDVFEREPLSPESRFWDMPNVYVTPHVAASSD--VRALFVHVEHQIARFESGLPLEHVVD...................................................................................................................................................................................................................................... 330
62 -50.4005vg6_A mol:protein length:341 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding  ali model follow..  23  15........................................................................QSMNEQASGALVFYSAVDIGQDWKSALQAAHGLDVRIARAGDGHVEDPEEVRYALV----KPPHGFFARFP-NLKLVINLGAGVDALVARDDLPDVPVTRLSDPNMSQMMASFVLFCVLRHARDIPTFERAQREGRWHYVHP--RTAAEIRVGVLGLGDLGAAAALELARHGFDVRGWSRTPKALEGVSCFHGLEALPGFLAGSEIVVVMLPLTPETRGLMNAERLAHLPRGAKFINVARGPVVDEAALIAALRSGHIAEATLDVFEVEPLPVGSPLWAMDNVLVTPHLASIAI--PRTAAPQIVENIRRIEAGEPVLNQVD...................................................................................................................................................................................................................................... 330
63 -50.4005bqf_A mol:protein length:322 NADP-dependent 2-hydroxyacid dehydrogenase  ali model follow..  23  2...........................................................................QSMSVRPPVLVDIKFNPEGVDRVLKTAFDRGSINLADPANRERDFSETEYALL----KPDADLFRRAP-NLKVIFSGGAGVDHIIGMAGLPDIPIVRFVDRSLTTRMSEWVVMQCLMHLRGQYGHDSHQRRREWAKLIA--PEAAEVTVGVMGLGILGQDAVAKLKVMGFNVIGWSRTRKTIEGVET-FDAGELDRFLAKTDILVGLLPLTPETTGFYDSELFKKLRRDGALINAGRGKSQIETDIVSAVREGTLGGASLDVFEVEPLATDSPLWELENVFITPHDAAVSEE--NALFRHVEMQIARFERGEPLQFVID...................................................................................................................................................................................................................................... 317
64 -49.9004n18_A mol:protein length:332 D-isomer specific 2-hydroxyacid dehydrogenase family protein  ali model follow..  20  36.................................................................................................................CAALQQFPDVTALLPHHQAARDAQYA-SRSPGLKLIQAASAGVDHLPPALFASEIPLCRVIDEDFRHGMFEYALWSVLWFQRHFDRALAHQRTQTWKLYPQ--RAAADFHIGIMGLGEIGGYIADQLARLGYRVSGWSRSEKQLAGVTCYRGEEALDHFLGSLDGLINLLPLTAQTRGILAAPLFNRLPAGAVLINCGRGEHMVNDDVLAALESGQLAGAVLDVFPQEPLPADDPLWRHPQVVITPHMASAAP--AEVIARQLLENIQRQRRGLPLKNLVN...................................................................................................................................................................................................................................... 321
65 -48.5003kbo_A mol:protein length:315 Glyoxylate/hydroxypyruvate reductase A  ali model follow..  21  20.................................................................................................................NALEKALPHARVREWKVGDNNPADYA-LAGRRLKAVFVLGAGVDAI--PEMLDASIPLFRLEDGMGLQMQEYAVSQVLHWFRRFDDYQALKNQALWKPLPE--YTREEFSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGVESYVGREELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAALDSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTR--PAEAIDYISRTITQLEKGEPVTGQVD...................................................................................................................................................................................................................................... 310
66 -27.4005w3k_A mol:protein length:340 Ketol-acid reductoisomerase (NADP(+))  ali model follow..  15  2.............................................................................................................................................................................................................TTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIR-RSFDKAKEDGFDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQP----------PADVDVFLVAPKGPGHLVRRFVEGSAVPSLFGIQQDASGQARNIALSYAKGIGATRAGVIETTF-----KEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEGGM-------ENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEFY.................................................................................................. 302
67 -26.2003d4o_A mol:protein length:293 Dipicolinate synthase subunit A  ali model follow..  14  3...............................................................................LTGKHVVIIRKLSTFDAKIS-DQLDDGFIGVTKMRIDEVDWNTVDAILLPISGTNEAGKVDT------IFSNESIVLTEEMIEKTPNHCVVYSGISNTYLNQCMKKTNRTLVKLMERDDIAIYNSIPTAEGTIQHTDFTIHGANVAVLGLGRVGMSVARKFAALGAKVKVGAR-DLLARIAEMGMEPFHISKALRDVDVCINTIP-----ALVVTANVLAEMPSHTFVIDLASGGTDFRYAEKRGIKALLVPGLPGIVA---PKTAGRILAD................................................................................................................................................................................................................................................................................. 283
68 -22.8002rir_A mol:protein length:300 Dipicolinate synthase, A chain  ali model follow..  14  1...........................................................................SNAMLTGLKIAVGDARQLEIIRKLTEQQADIYLVGFDQLDDEIPFQQIDSIILPVSATTGEGVV------STVFSNEEVVLKQDHLDRTPAHCVIFSGISNAYLENIAAQAKRKLVKLFERIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVLGLGRTGMTIARTFAALGANVKVGARSSAHARITEMGLVPFHTDELVKDIDICINTIP-----SMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLP--IVAPKTAGQILAN................................................................................................................................................................................................................................................................................. 285
69 -20.9004tsk_A mol:protein length:350 Ketol-acid reductoisomerase  ali model follow..  16  5................................................................................................................................................................................................................YYDADISIQPLADKRIAVIGYGSQGHAHAQNLRDSGFDVVIGLR-SSWAKAEADGFRVMAVGEAVEESDVIMILLP-DERQPAVYEREIRPYLTAGKALAFAHGFNIHFSQIQPPK---------DVDVFMVAPKGPGHLVRRYEAGGGVPALIAVHQDASGQ-----AKDLALAYARGIGAGRAGILTTTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPEIAYFECLHEMKLIVDLIYEGGLE-------YMRYSISDTAQWGDFTSGPRIINEETKKEMRRILADIQSGAFAKSWILENQANRPMFN.................................................................................................. 302
70 -12.5003mtg_A mol:protein length:444 Putative adenosylhomocysteinase 2  ali model follow..  16  100......................................................................................VAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKIVEESVTGVHRLQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRT--------------TDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEI-ICALQACMDGFRVVKLNEVIRQVDVVIT----CTGNKNVVTREHLDRMKNSCIVCNMGHS---NTEIDVTSLRTPELTGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPS-AHLTELADDQAKYLGPF....................................................................................................................................................................................................................... 437
71 -12.3001b3r_A mol:protein length:431 PROTEIN (S-ADENOSYLHOMOCYSTEINE HYDROLASE)  ali model follow..  15  87......................................................................................AAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSISEETTTGVHNLYMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGI--------------KRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITE--INALQAAMEGYEVTTMDEACKEGNIFVTTT----GCVDIILGRHFEQMKDDAIVCNIGHFDVIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAE--NLGCAMGHPSFVMSNSFTNQVMAQIELWT.................................................................................................................................................................................................................................................. 373
72 -12.1005axa_A mol:protein length:432 Adenosylhomocysteinase  ali model follow..  15  88......................................................................................AAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKYPQLLSISEETTTGVHNLYMMSNGILKVPAINVNDSVTKSKFDNLYGCRESLIDGI--------------KRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEI-INALQAAMEGYEVTTMDEACKEGNIFVTTT----GCVDIILGRHFEQMKDDAIVCNIGH----DVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIIL-NLGCAMGHPSFVMSNSFTNQVMAQIELWT.................................................................................................................................................................................................................................................. 374
73 -12.1003nj4_A mol:protein length:435 Adenosylhomocysteinase  ali model follow..  16  91......................................................................................AAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPISEETTTGVHNLKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRA--------------TDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITE--INALQAAMEGYEVTTMDEACQEGNIFVTTT----GCIDIILGRHFEQMKDDAIVCNIGHFDVIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAE--NLGCAMGHPSFVMSNSFTNQVMAQIELWT.................................................................................................................................................................................................................................................. 377
74 -11.9003gvp_A mol:protein length:435 Adenosylhomocysteinase 3  ali model follow..  14  95......................................................................................VAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKIVEESVTGVHRLQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRT--------------TDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTE--ICALQACMDGFRLVKLNEVIRQVDIVITCT----GNKNVVTREHLDRMKNSCIVCNMGHSNTIDVASLRTPELTWERVRSQVDHVIW--PDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVA---LHLPTFDAHLTELTDEQAKY--LGLNKNG......................................................................................................................................................................................... 430
75 -11.9002ziz_A mol:protein length:495 Adenosylhomocysteinase  ali model follow..  15  177.................................................................................................................PPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAEVTEETTTGVLRLQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRG--------------TDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTE--INALQAMMEGFDVVTVEEAIGDADIVVT----ATGNKDIIMLEHIKAMKDHAILGNIGHFDNIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLL---NLGNATGHPSFVMSNSFANQTIAQLWTKNDEYDNEVYRLPKHLDEKVAR----VEALGGHLTKLTKEQAE................................................................................................................................................................................................... 478
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Zhang B, Godzik A. Fold prediction by a hierarchy of sequence, threading, and modeling methods. Protein Sci. 1998 Jun;7(6):1431-40.