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Query: [W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases, from VFDB

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSPIRNRLQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPIGFRFNAYNRTFHVQLHPIDDSLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHVHGSVFDGVFEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINHRKWRVKRDAENLSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADHKLYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTNFNGIKGLHFVIQRTSIYTPDSCDRGRAKTDSDNPFCEENVDVSNFLNLNSQRNHSAFCLAYALTFRDFVGGTLGLAWVASPQFNTAGGICQVHQRYNEGSRGWVYRSLNTGIVTLVNYGNRVPARVSQLTLAHEIGHNFGSPHDFPAECQPGLPDGNFIMFASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPVDPTRNASPVGIGKRNCFQERTSAFCGNQIYEPGEECDCGFSQADCDQMGDKCCVPHEARGNGGPGPCKRKPGAQCSPSQGYCCNPDTCSLHGKNEEKICRQESECSNLQTCDGRNAQCPVSPPKHDGIPCQDSTKVCSSGQCNGSVCAMFGLEDCFLTEGKADELCFLACIKDGKCTSSVHLPEFSANRTNFLQNMRKDKPGLILHPGSPCNNYKGYCDIFRKCRSVDANGPLARLKNLLFNKRTIETLTQWAQDNWWVVGVGGLVFLVIMALFVKCCAVHTPSTNPNKPPALNIYQTLTRPGTLIRQHRQRHRAAAGSVPPGPGAQPRSGAASAPSRTTPSARPSAPPLVAPQVAVAVPPGVVGPPIPLIATHPGSSSSTPAVIVLEPPPPYTAADPGSAMGGPRRGHRKNKRQTSSDAAGSSGNGGKKKGKLast
1 -99.1006be6_A mol:protein length:449 Disintegrin and metalloproteinase domain-containing protein 10  ali model follow..  43  1...........................................................................................................................................................................................................................................TTSAEKNTCQLYIQTDHLFFKYYG----------TREAVIAQISSHVKAIDTIYQTTDFSGIRQISFMVKRIRINTTAD------EKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSG-SSGGICEKSKLYSDGKK----KSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGKENGNYIMYARATSGDKLNNNKFSLCSIRQISQVLEKKRNNCFVESGQ------------------PICGNGMVEQGEECDCGYSDQ----CKDECCFDANQ---PEGRKCKLKPGKQCSPSQGPCCT-AQCAFKSKSEKCR--DDSDCAREGICNGFTALCPASDPKPQFTDCNRHTQVCINGQCAGSICEKYGLETCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTIT------LQPGSPCNDFRGYCDVFMRCRLVDADGPLG....................................................................................................................................................................................................... 442
2 -80.1003g5c_A mol:protein length:510 ADAM 22  ali model follow..  13  1...........................................................................................................................................................................................................................................NVEEETKYIELMIVNDHLMFKKHRLS---------VVHTNTYAKSVVNMADLIYKDQ-----LKTRIVLVAMETWATDN----KFAISENPLITLREFMKYRRDFIKEKSDA-----VHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGK----------------------------TDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPS-------------KLLDPPECGNGFIETGEECDCGTPAE---CVLEGAE---------CCKKCTLTQDSQCS--DGLCC--KKCKFQPMGTVCR-EAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRD------RQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCG-KDKDTWIQCNKRDVLCGYLLCGTPCGP--QMMCLEHRCLPVASFNLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFHNDDAKTGITLSGNGVAGTN.................................................................................................................................................. 504
3 -73.9003hdb_A mol:protein length:417 AAHIV  ali model follow..  20  2..............................................................................................................................................................................................................................................DPFKYVETVFVVDKAMVTKYNGD---------LDKIKTKMYEAANNMNEMYRYM------FFRVVMVGLIIWTEED----KITVKPDVDYTLNAFAEWRKTYLLAEKKHDN---AQLITGIDFRGSIIGYAYIGSMCHPKRSVG--------------------------IIQDYSPINLVLAVIMAHEMGHNLGIHHDDGYCYCG---GYPCIMGPSISP---EPSKFFSNCSYIQCWDFIMNHNPECIDNEPLGTDII-----------SPPLCGNELLEVGEECDCGTPEN----CQNPCC---------DAATCKLKSGSQCG--HGKCC--EQCKFRTSGTECR-ASMSECDPAEHCTGQSSECPADVFHKNGEPCLDNYGYCYNGNCPIMY------HQCYALFGADIYEAEDSCFESNKKGNYYGYCR--KENGKKIPCASEDVKCGRLYCGTKCAD--GKVCSNGHCVDVTT............................................................................................................................................................................................................ 415
4 -73.8003k7l_A mol:protein length:422 Atragin  ali model follow..  23  1....................................................................................................................................................................................................................................TNTPEQDRYLQAKKYIEFYVVVDNIMYRHYKRD---------QPVIKRKVYEMINTMNMIYRRL------NFHIALIGLEIWSNIN----EINVQSDVRATLNLFGEWREKKLLPRKRNDN---AQLLTGIDFNGTPVGLAYIGSICNPKTSAA--------------------------VVQDYSSRTRMVAITMAHEMGHNLGMNHDRGF---CTCGFNKCVMSTRRTKP----AYQFSSCSVREHQRYLLRDRPQCILNKPLSTDIV-----------SPPICGNYFVEVGEECDCGSPAD----CQSACC---------NATTCKLQHEAQCD--SEECC--EKCKFKGARAECR-AAKDDCDLPELCTGQSAECPTDVFQRNGLPCQNNQGYCYNGKCPIMT------NQCIALRGPGVKVSRDSCFTLNQRTRGCGLCR--MEYGRKIPCAAKDVKCGRLFCGTKCGD--GMVCSNRQCVDVKT............................................................................................................................................................................................................ 420
5 -73.3003dsl_A mol:protein length:419 Zinc metalloproteinase-disintegrin bothropasin  ali model follow..  22  1...........................................................................................................................................................................................................................................QKYNPFRYVELFIVVDQGMVTKNNGD---------LDKIKARMYELANIVNEILRYL------YMHAALVGLEIWSNGD----KITVKPDVDYTLNSFAEWRKTDLLTRKKHDN---AQLLTAIDFNGPTIGYAYIGSMCHPKRSVA--------------------------IVEDYSPINLVVAVIMAHEMGHNLGIHHDTDF---CSCGDYPCIMGPTISN---EPSKFFSNCSYIQCWDFIMKENPQCILNEPLGTDIV-----------SPPVCGNELLEVGEECDCGTPEN----CQNECC---------DAATCKLKSGSQCG--HGDCC--EQCKFSKSGTECR-ASMSECDPAEHCTGQSSECPADVFHKNGQPCLDNYGYCYNGNCPIMY------HQCYALFGADVYEAEDSCFKDNQKGNYYGYCR--KENGKKIPCAPEDVKCGRLYCGTKCAD--GKVCSNGHCVDVAT............................................................................................................................................................................................................ 417
6 -73.0002e3x_A mol:protein length:427 Coagulation factor X-activating enzyme heavy chain  ali model follow..  21  3.........................................................................................................................................................................................................................................STSAQFNKIFIELVIIVDHSMAKKCNST-----------ATNTKIYEIVNSANEIFNPL------NIHVTLIGVEFWCDRD----LINVTSSADETLNSFGEWRASDLMTRKSHDN---ALLFTDMRFDLNTLGITFLAGMCQAYRSVG--------------------------IVQEQGNRNFKTAVIMAHELSHNLGMYHDGKNCIC---NDSSCVMSPVL---SDQPSKLFSNCSIHDYQRYLTRYKPKCIFNPPLRKDIV-----------SPPVCGNEIWEEGEECDCGSPAN----CQNPCC---------DAATCKLKPGAECG--NGLCC--YQCKIKTAGTVCR-RARDECDVPEHCTGQSAECPRDQLQQNGKPCQNNRGYCYNGDCPIMR------NQCISLFGSRANVAKDSCFQENLKGSYYGYCR--KENGRKIPCAPQDVKCGRLFCGTKCEDGK-VCNNKRQCVDVNT............................................................................................................................................................................................................ 420
7 -72.8002dw0_A mol:protein length:419 Catrocollastatin  ali model follow..  21  1..........................................................................................................................................................................................................................................HQKYNPFRFVELVLVVDKAMVTKNNGD---------LDKIKTRMYEIVNTVNEIYRYM------YIHVALVGLEIWSNED----KITVKPEAGYTLNAFGEWRKTDLLTRKKHDN---AQLLTAIDL-DRVIGLAYVGSMCHPKRSTG--------------------------IIQDYSEINLVVAVIMAHEMGHNLGINHDSGYCSCG---DYACIMRPEI---SPEPSTFFSNCSYFECWDFIMNHNPECILNEPLGTDII-----------SPPVCGNELLEVGEECDCGTPEN----CQNECC---------DAATCKLKSGSQCG--HGDCC--EQCKFSKSGTECR-ASMSECDPAEHCTGQSSECPADVFHKNGQPCLDNYGYCYNGNCPIMY------HQCYDLFGADVYEAEDSCFERNQKGNYYGYCR--KENGNKIPCAPEDVKCGRLYCGTKCAD--GKVCSNGHCVDVAT............................................................................................................................................................................................................ 417
8 -72.8002ero_A mol:protein length:427 vascular apoptosis-inducing protein 1  ali model follow..  21  1..................................................................................................................................................................................................................................QSNLTPEQQRYLNAKKYVKLFLVADYIMYLKYGRN---------LTAVRTRMYDIVNVITPIYHRM------NIHVALVGLEIWSNTD----KIIVQSSADVTLDLFAKWRATDLLSRKSHDN---AQLLTGINFNGPTAGLGYLGGICNTMYSAG--------------------------IVQDHSKIHHLVAIAMAHEMGHNLGMDHDKDT---CTCGTRPCVMAGALSC---EASFLFSDCSQKDHREFLIKNMPQCILKKPLKTDVV-----------SPAVCGNYFVEVGEECDCGSPRT----CRDPCC---------DATTCKLRQGAQCA--EGLCC--DQCRFKGAGTECR-AAKDECDMADVCTGRSAECTDRFQRNGQ-PCKNNNGYCYNGKCPIMA------DQCIALFGPGATVSQDACFQFNREGNHYGYCR--KEQNTKIACEPQDVKCGRLYCGTKCAD--RKACSNGQCVDVTT............................................................................................................................................................................................................ 425
9 -70.9002i47_A mol:protein length:288 ADAM 17  ali model follow..  29  2.......................................................................................................................................................................................................................................KRRADPDPMKNTCKLLVVADHRFYRYMGRG--------EESTTTNYLIELIDRVDDIYRNTAWDGFKGYGIQIEQIRILKSPQEVPGEKHYNMAKSYPNEEKDAWDVKMLLIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPV---GKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECADQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERSN------------------KVCGNSRVDEGEECDPGS......................................................................................................................................................................................................................................................................................................................................................................................................... 282
10 -66.8003k7n_A mol:protein length:397 K-like  ali model follow..  21  1.........................................................................................................................................................................................................................................QDRYLQDKKYIEFYVIVDNRMYRYYNND---------KPAIKIKVYEMINAVNTKFRPL------KIHIALIGLEIWSNKD----KFEVKPAASVTLKSFGEWRETVLLPRKRNDN---AQLLTGIDFNGNTVGRAYIGSLCKTNESVA--------------------------IVQDYNRRISLVASTITHELGHNLGIHHDKASCICI--PGPCIMLKKRTAP-----AFQFSSCSIREYREYLLRDRPQCILNKPLSTDIV-----------SPPICGNYFVEVGEECDCGSPQA-------------------------------CQ---SACCNAATCQFKGAETECR-VAKDDCDLPELCTGQSAECPTDSLQRNGHPCQNNQSYCYNGTCPTLT------NQCITLLGPHFTVSPKGCFNLNMRGDDGSFCR--MEDGTKIPCAAKDVKCGRLYCGTKCGD--GMVCSKGQCVDVQT............................................................................................................................................................................................................ 395
11 -63.2002a8h_A mol:protein length:271 ADAM 17  ali model follow..  27  1.........................................................................................................................................................................................................................................RADPDPMKNTCKLLVVADHRFYRYMGRG--------EESTTTNYLIELIDRVDDIYRNTAWDNFKGYGIQIEQIRILKSPQVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFSKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYY---SPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS-------------------NKVGS...................................................................................................................................................................................................................................................................................................................................................................................................................... 265
12 -62.1002oi0_A mol:protein length:266 TNF- a Converting Enzyme (TACE)  ali model follow..  25  1..........................................................................................................................................................................................................................................ADPDPMKNTCKLLVVADHRFYRYMGRG--------EESTTTNYLIELIDRVDDIYRNTAWDNAKGYGIQIEQIRILKSPQEVKPGEKHYNMEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPV---GKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERSN------------------KVIEGR..................................................................................................................................................................................................................................................................................................................................................................................................................... 266
13 -55.9005l0q_A mol:protein length:203 Disintegrin and metalloproteinase domain-containing protein 10  ali model follow..  35  4..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LASGQPICGNGMVEQGEECDCGYSDQ----CKDECCYDANQP---EGKKCKLKPGKQCSPSQGPCCT-AHCAFKSKTEKCR--DDSDCAKEGICNGITALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKHGLEECTC-ASSDGKDDKELCHVCCMKKMEPSTCASTGSVQWNKYFLGRTI---TLQPGSPCNDFRGYCDVFMRCRGSASG........................................................................................................................................................................................................... 202
14 -45.0001wni_A mol:protein length:201 Trimerelysin II  ali model follow..  20  3..............................................................................................................................................................................................................................................FPQRYIELAIVVDHGMYKKYNQN---------SDKIKVRVHQMVNHINEMYRPL------NIAISLNRLQIWSKKD----LITVKSASNVTLESFGNWRETVLLKQQNNDC---AHLLTATNLNDNTIGLAYKKGMCNPKLSVG--------------------------LVQDYSPNVFMVAVTMTHELGHNLGMEHDDKDKCKC----EACIMSDVISD---KPSKLFSDCSKNDYQTFLTKYNPQCILNAP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 201
15 -45.0004j4m_A mol:protein length:202 zinc-dependent metalloproteinase  ali model follow..  20  1...........................................................................................................................................................................................................................................QQRFPQRYVMLAIVADHGMVTKYSGN---------SSAITTRVHQMVSHVTEMYSPL------NIATTLSLLRIWSSKD----LITVQSDSSVTLGSFGDWRKVVLLSQQAHDC---AFLNTATALDDSTIGLAYSNGMCDPKFSVG--------------------------LVQDHSSNVFMVAVTMTHELGHNLGMAHDEAGGCAC----SSCIMSPAASS---GPSKLFSDCSKDDYQTFLTNTNPQCILNAP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
16 -44.9001kuf_A mol:protein length:203 metalloproteinase  ali model follow..  19  1..........................................................................................................................................................................................................................................EQQRFPQRYIELAIVVDHGMYTKYSSN---------FKKIRKRVHQMVSNINEMCRPL------NIAITLALLDVWSEKD----FITVQADAPTTAGLFGDWRERVLLKKKNHDH---AQLLTDTNFARNTIGWAYVGRMCDEKYSVA--------------------------VVKDHSSKVFMVAVTMTHELGHNLGMEHDDKDKCKC----DTCIMSAVI---SDKQSKLFSDCSKDYYQTFLTNDNPQCILNAP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 203
17 -44.7004dd8_A mol:protein length:208 Disintegrin and metalloproteinase domain-containing protein 8  ali model follow..  21  1.............................................................................................................................................................................................................................................SRETRYVELYVVVDNAEFQMLGSE----------AAVRHRVLEVVNHVDKLYQKL------NFRVVLVGLEIWNSQD----RFHVSPDPSVTLENLLTWQARQRTRRHLHDN---VQLITGVDFTGTTVGFARVSAMCSHSSGA---------------------------VNQDHSKNPVGVACTMAHEMGHNLGMDHDENVRCQERFEAGRCIMAGSI---GSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLS........................................................................................................................................................................................................................................................................................................................................................................................................................................... 208
18 -44.6001r54_A mol:protein length:214 ADAM 33  ali model follow..  22  1...........................................................................................................................................................................................................................................EARRTRKYLELYIVADHTLFLTRHRN---------LQHTKQRLLEVANYVDQLLRTL------DIQVALTGLEVWTERD----RSRVTQDANATLWAFLQWR-RGLWAQRPHDS---AQLLTGRAFQGATVGLAPVEGMCRAESSGG--------------------------VSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCVEAAAESGGCVMAAAT---GHPFPRVFSACSRRQLRAFFRKGGGACLSNAPSG............................................................................................................................................................................................................................................................................................................................................................................................................................................ 208
19 -44.4001yp1_A mol:protein length:202 FII  ali model follow..  18  1.............................................................................................................................................................................................................................................ASPQVSVTLQLVVDSSMFAKYNGD---------AKKIVTVLDTRVNIMKSIFKPL------LLLITLSGIEMWTSKD----LITVKPAGDLTLSLFADWRQTLLLSRILNDN---AQLQTAVDFRGAVVGLAFVGTMCNAKYSAG--------------------------IIQDFSAIPLLMAVVMAHELGHNLGMLHDDGYSCDC----DVCIMAPSLSS---DPTKVFSNCSLILYEDFLSNEEPDCIDNASNN............................................................................................................................................................................................................................................................................................................................................................................................................................................ 202
20 -44.2001dth_A mol:protein length:203 ATROLYSIN C  ali model follow..  18  1...........................................................................................................................................................................................................................................QQNLPQRYIELVVVADHRVFMKYNSD---------LNTIRTRVHEIVNFINGFYRSL------NIHVSLTDLEIWSNED----QINIQSASSDTLNAFAEWRETDLLNRKSHDN---AQLLTAIELDEETLGLAPLGTMCDPKLSIG--------------------------IVQDHSPINLLMGVTMAHELGHNLGMEHDGKD---CLRGASLCIMRPGLTK---GRSYEFSDDSMHYYERFLKQYKPQCILNKP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 203
21 -43.8001iag_A mol:protein length:202 ADAMALYSIN II  ali model follow..  18  3..............................................................................................................................................................................................................................................LPQRYIELVVVADRRVFMKYNSD---------LNIIRTRVHEIVNIINKFYRSL------NIRVSLTDLEIWSGQD----FITIQSSSSNTLNSFGEWRERVLLIWKRHDN---AQLLTAINFEGKIIGKAYTSSMCNPRSSVG--------------------------IVKDHSPINLLVAVTMAHELGHNLGMEHDGKD---CLRGASLCIMRPGLTP---GRSYEFSDDSMGYYQKFLNQYKPQCILNKP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
22 -43.7002aig_P mol:protein length:202 ADAMALYSIN II  ali model follow..  18  1............................................................................................................................................................................................................................................XNLPQRYIELVVVADRRVFMKYNSD---------LNIIRTRVHEIVNIINEFYRSL------NIRVSLTDLEIWSGQD----FITIQSSSSNTLNSFGEWRERVLLTRKRHDN---AQLLTAINFEGKIIGKAYTSSMCNPRSSVG--------------------------IVKDHSPINLLVAVTMAHELGHNLGMEHDGKD---CLRGASLCIMRPGLTP---GRSYEFSDDSMGYYQKFLNQYKPQCILNKP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
23 -43.7001nd1_A mol:protein length:202 BaP1  ali model follow..  20  3..............................................................................................................................................................................................................................................FSPRYIELAVVADHGIFTKYNSN---------LNTIRTRVHEMLNTVNGFYRSV------DVHAPLANLEVWSKQD----LIKVQKDSSKTLKSFGEWRERDLLPRISHDH---AQLLTAVVFDGNTIGRAYTGGMCDPRHSVG--------------------------VVRDHSKNNLWVAVTMAHELGHNLGIDHDTGS---CSCGAKSCIMASVL---SKVLSYEFSDCSQNQYETYLTNHNPQCILNKP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
24 -43.6004q1l_A mol:protein length:202 Snake venom metalloproteinase leucurolysin-A  ali model follow..  19  3..............................................................................................................................................................................................................................................FSPRYIELVVVADHGMFKKYNSN---------LNTIRKWVHEMLNTVNGFFRSM------NVDASLVNLEVWSKKD----LIKVEKDSSKTLTSFGEWRERDLLPRISHDH---AQLLTVIVFDEETIGIAYTAGMCDLSQSVA--------------------------VVMDHSKKNLRVAVTMAHELGHNLGMRHDGNQ---CHCNAPSCIMADTL---SKGLSFEFSDCSQNQYQTYLTKHNPQCILNKP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
25 -43.6003gbo_A mol:protein length:200 Zinc metalloproteinase BmooMPalfa-I  ali model follow..  18  2...............................................................................................................................................................................................................................................SPRHIELVVVADHGMFKKYNSN---------LNTIRKWVHEMVNSMNGFYRSV------DVTASLANLEVWSKKD----LINVQKDSRETLKSFGEWRERDLLPRISHDN---AQLLTTIVFDGHVIGRAFTGGMCDPRHSVG--------------------------VVMDHSPKNLQVAVTMAHELGHNLGMHHDGNQ---CHCDAASCIMADSL---SQVLSYEFSDCSQNQYQTYLTKHNPQCILNEP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 200
26 -42.9001bsw_A mol:protein length:197 PROTEIN (ACUTOLYSIN A)  ali model follow..  22  2................................................................................................................................................................................................................................................QRYMEIVIVVDHSMVKKYNGD---------SDSIKAWVYEMINTITESYSYL------KIDISLSGLEIWSGKD----LIDVEASAGNTLKSFGEWRAKDLIHRISHDN---AQLLTATDFDGATIGLAYVASMCNPKRSVG--------------------------VIQDHSSVNRLVAITLAHEMAHNLGVSHDEGS---CSCGGKSCIMSPSI---SDETIKYFSDCSYIQCRDYIAKENPPCILN................................................................................................................................................................................................................................................................................................................................................................................................................................................ 197
27 -42.5001qua_A mol:protein length:197 ACUTOLYSIN-C  ali model follow..  19  2..............................................................................................................................................................................................................................................APQTSIELFLIVDHSMYAKYNSN---------SSKITTTLKARVNIMNAIYSSL------NLVITLSGIEMWSAAD----LITVQSSSRNTLKLFASWRETDLLKRTSNDN---AQLLTATNFNGNTVGLAYLKTMCNSKYSVG--------------------------LIQDHSAIPLLMAVTMAHELGHNLGMNHD-GAGCSC----ATCIMAPVL---SSGPAKSFSDCSKHDYQSFLTIHKPQCLLN................................................................................................................................................................................................................................................................................................................................................................................................................................................ 197
28 -38.1002rjq_A mol:protein length:378 ADAMTS-5  ali model follow..  16  1............................................................................................................................................................................................................................................SISRARQVELLLVADASMARLYGRG------------LQHYLLTLASIANRLYSHASIEN--HIRLAVVKVVVLGDKD---KSLEVSKNAATTLKNFCKWQHQHNQLGDDHEHYDAAILFTREDLSCDTLGMADVGTICSPERSCAVIE----------------DDGLHA-------------AFTVAHEIGHLLGLSHDDSKFCEEGSTEDKRLMSSILTS--IDASKPWSKCTSATITEFLDDGHGNCLLDLPR-------------KQILGPEELPGQTYDATQQCNLTFGPEYSVCPDVCARLWCAVVRQGQMVCLTKEGTPCGKGRICL-KKKYYSTSSHGNWGSWGSWGQCSRS--CGGAYRHCNNPAPRNNGRYCTGKRRSCSLMPCPPNG-KSFGSAWSHPQFEK................................................................................................................................................................................................................................................................................ 378
29 -36.8003hy7_A mol:protein length:221 A disintegrin and metalloproteinase with thrombospondin motifs 5  ali model follow..  17  2...........................................................................................................................................................................................................................................ASISRARQVELLLVADASMARKYGRG------------LQHYLLTLASIANRLYSHASIEN--HIRLAVVKVVVLGDKD---KSLEVSKNAATTLKNFCKWQHQHNQLGDDHEHYDAAILFTREDLSCDTLGMADVGTICSPERSCAVIE----------------DDGLHA-------------AFTVAHEIGHLLGLSHDDSKFCEEGSTEDKRLMSSILTS--IDASKPWSKCTSATITEFLDDGHGNCLLDLPRK............................................................................................................................................................................................................................................................................................................................................................................................................................................ 219
30 -36.6002jih_A mol:protein length:300 ADAMTS-1  ali model follow..  19  3..............................................................................................................................................................................................................................................SSHRYVETMLVADQSMAEFHGSG------------LKHYLLTLFSVAARLYKHPSIRN--SVSLVVVKILVIHDEQ---KGPEVTSNAALTLRNFCNWQKHNPPSDRDAEHYDTAILFTRQDLTCDTLGMADVGTVCDPSRSCSVIE----------------DDGLQA-------------AFTTAHELGHVFNMPHDDAKQCASGVNQDSHMMASMLSNLD--HSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLP------------GTSYDANRQCQFTFGED----------------------------SKHCPDAASTCSTL-------------------CTGT---SGGVLVCQTKFPWADGTSCGEG-KWCINGKCVN................................................................................................................................................................................................................................................................................................. 295
31 -35.8004wk7_A mol:protein length:235 A disintegrin and metalloproteinase with thrombospondin motifs 4  ali model follow..  17  2.............................................................................................................................................................................................................................................ASLSRFVETLVVADDKMAAFHGAG------------LKRYLLTVMAAAAKAFKHPSIRN--PVSLVVTRLVILGSGE---EGPQVGPSAAQTLRSFCAWQRGLNTPEDSDDHFDTAILFTRQDLTCDTLGMADVGTVCDPARSCAIVE----------------DDGLQS-------------AFTAAHELGHVFNMLHDNSKPCISPLSTSRHVMAPVM--AHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEA............................................................................................................................................................................................................................................................................................................................................................................................................................................ 218
32 -32.6002rjp_A mol:protein length:316 ADAMTS-4  ali model follow..  17  2.............................................................................................................................................................................................................................................ASLSRFVETLVVADDKMAAFHGAG------------LKRYLLTVMAAAAKAFKHPSIRN--PVSLVVTRLVILGSGE---EGPQVGPSAAQTLRSFCAWQRLNTPEDSDPDHFDTAILFTRQDLTCDTLGMADVGTVCDPARSCAIVE----------------DDGLQS-------------AFTAAHQLGHVFNMLHDNSKPCISLNSTSRHVMAP--VMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFP------------GKDYDADRQCQ--------------------------------PDSRHCPQLPPPCAAL-------------------CSGH---LNGHAMCTKHSPWADGTPCGPA-QACMGGRCLHMDQL............................................................................................................................................................................................................................................................................................. 300
33 -29.4002mop_1 mol:protein length:83 Disintegrin bitistatin  ali model follow..  35  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SPPVCGNKILEQGEDCDCGSPAN----CQDRCC---------NAATCKLTPGSQCN--YGECC--DQCRFKKAGTVCR-IARGDWN-DDYCTGKSSDCPWN........................................................................................................................................................................................................................................................................................................................ 82
34 -25.4001l3x_A mol:protein length:73 platelet aggregation inhibitor disintegrin  ali model follow..  37  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAGEECDCGSPG-------NPCC---------DAATCKLRQGAQCA--EGLCC--DQCRFMKEGTICR--RARGDDLDDYCNGISAGCPRNPFH..................................................................................................................................................................................................................................................................................................................... 72
35 -24.8003uci_A mol:protein length:72 disintegrin  ali model follow..  34  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AEFGKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR--IARLDDLDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 71
36 -24.0002m7h_A mol:protein length:79 Zinc metalloproteinase/disintegrin  ali model follow..  34  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFGKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR-IARGDWN-DDRCTGQSADCPRNPWN..................................................................................................................................................................................................................................................................................................................... 72
37 -23.9002m7f_A mol:protein length:79 Zinc metalloproteinase/disintegrin  ali model follow..  33  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFGKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR-IARGDWN-DDRCTGQSADCPRNGLY..................................................................................................................................................................................................................................................................................................................... 72
38 -23.8001fvl_A mol:protein length:70 FLAVORIDIN  ali model follow..  37  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GEECDCGSPS-------NPCC---------DAATCKLRPGAQCA--DGLCC--DQCRFKKKRTICR--IARGDFPDDRCTGLSNDCPRWNDL..................................................................................................................................................................................................................................................................................................................... 70
39 -23.6003p24_A mol:protein length:397 BFT-3  ali model follow..  13  1MKNVKLLLMLGTAALLAACTTSIDAPVTASIDLQSVSYTDLATQLNDVSDFGK-------------MIILKDNGFNRQVHVSMDKRTKIQLDN------------ENVRLFNGR---DKDSTNFILGDEFAVLRFYRNGESISYIAYKEAQMMNEIAEFYAAPFKKTRAINEKEAFECIYDSRTRSAGKYP----VSVKINVDKAKKILNLPECDYINDYIKTPQVPHGITESQTRAVPSEPKTVYVICLREN---------------GSTVYPNEVSAQMQDAANSVYAVHGLKRYVNLHFVLYTTEYACPSG----------NADEGLDGFTASLKANPKAEGYDDQ--IYFLIRWGTWDNNILGISWLNSYNVNTAS--------------------------DFKASGMSTTQLMYPGVMAHELGHILGANHADDPKD---------LMYSKYTG----YLFHLSEKNMDIIAKNLGWEIAD.................................................................................................................................................................................................................................................................................................................................................................................................................................................... 395
40 -23.3004r5u_A mol:protein length:68 Disintegrin rhodostomin  ali model follow..  34  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICE--IPRGDMPDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
41 -23.2002pjg_A mol:protein length:68 Rhodostoxin-disintegrin rhodostomin  ali model follow..  34  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR--IPRGEMPDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
42 -23.2001j2l_A mol:protein length:70 Disintegrin triflavin  ali model follow..  38  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GEECDCGSPS-------NPCC---------DAATCKLRPGAQCA--DGLCC--DQCRFKKKRTICR--IARGDFPDDRCTGQSADCPRWNGL..................................................................................................................................................................................................................................................................................................................... 70
43 -23.1002ljv_A mol:protein length:68 Disintegrin rhodostomin  ali model follow..  34  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR--IPRLDMPDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
44 -23.1001n4y_A mol:protein length:68 KISTRIN  ali model follow..  34  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR--IPRGDMPDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
45 -23.1002pji_A mol:protein length:68 Rhodostoxin-disintegrin rhodostomin  ali model follow..  34  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR--IARGDMPDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
46 -23.1004m4c_A mol:protein length:68 Zinc metalloproteinase/disintegrin  ali model follow..  34  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR--IARGDPPDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
47 -23.0002m75_A mol:protein length:76 Zinc metalloproteinase/disintegrin  ali model follow..  34  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EFGKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR-IARGDWN-DDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 69
48 -22.2004r5r_A mol:protein length:68 Disintegrin rhodostomin  ali model follow..  35  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFKKKRTICR--IPRGDMPDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
49 -21.9001q7j_A mol:protein length:68 Hemorrhagic protein-rhodostomin  ali model follow..  34  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFSRAGKICR-IAKGDWN-DDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
50 -20.0003c05_B mol:protein length:64 Disintegrin acostatin-beta  ali model follow..  29  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DAPANPCC---------DAATCKLTTGSQCA--DGLCC--DQCKFMKEGTVCR--RARGDDLDDYCNGISAGCPRNPFH..................................................................................................................................................................................................................................................................................................................... 64
51 -20.0001z1x_A mol:protein length:64 disintegrin  ali model follow..  23  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SVHPCC---------DPVKCEPREGEHCI--SGPCC--RNCKFLNAGTICK--RAMLDGLHDYCTGVTSDCPRNRYNH.................................................................................................................................................................................................................................................................................................................... 64
52 -18.9003c05_A mol:protein length:62 Disintegrin acostatin alpha  ali model follow..  27  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PKNPCC---------DAATCKLTPGSQCA--EGLCC--DQCKFIKAGKICR--RARGDNPDYRCTGQSGDCPRKHF...................................................................................................................................................................................................................................................................................................................... 62
53 -18.7001tej_B mol:protein length:64 disintegrin chain B  ali model follow..  25  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SVNPCC---------DPQTCKPIEGKHCI--SGPCC--ENCYFLRSGTICQ-RARGDGN-NDYCTGITPDCPRNRYN..................................................................................................................................................................................................................................................................................................................... 63
54 -18.6001rmr_A mol:protein length:64 Disintegrin schistatin  ali model follow..  24  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SVHPCC---------DPVICEPREGEHCI--SGPCC--ENCYFLNSGTICK-RARGDGN-QDYCTGITPDCPRNRYN..................................................................................................................................................................................................................................................................................................................... 63
55 -18.5001tej_A mol:protein length:64 disintegrin chain A  ali model follow..  25  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SVNPCC---------DPVICKPRDGEHCI--SGPCC--NNCKFLNSGTICQ-RARGDGN-HDYCTGITTDCPRNRYN..................................................................................................................................................................................................................................................................................................................... 63
56 -17.6004k0v_A mol:protein length:529 TEK tyrosine kinase variant  ali model follow..  14  55.........................................................................................................................................................................................................................................................................................................................................................DVTREWAKKVVWKREKASKINGAYF----CEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRR------------------------------CEAQK---GPECN------------HLC------------TAC--MNNGVCHEDTGEC----ICPPGFMGRTC----EKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGC---SCAT---------------GWKGLQCNEACHPGF---------------------------------GPDC---------KLRCS--------------CNNGEMCDRFQGCLCSPGWQGLQCERE....................................................................................................................................................................... 321
57 -16.6003wsx_A mol:protein length:734 Sortilin-related receptor  ali model follow..  54..........................................SAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVHLLGSEQQSSVQLWVSFGRKPMRAARHPINEYYIADASEDQVFVCVSHSNNRTNLYISEA--EGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYATLINGSMNEENMRSVITFDK---GGTWLSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHY----GDHGGIIT--AIAQGMETNELKYS--KPVFVYGLLTEPGEKTIFGSNKENVHSWLILQVNATDALGVPCTENDYKRGNECLLGHKTVFKRRTPHATCNGEDFDRPVVVSNC------SCTREDYEC-SLEVCVPDPEFSGKSYSPPVPCP-----VGSTYRRTRGYRKISGDTCSGGDV-----PCPSRL............................................................................................................................................................................................................................................................................................... 728
58 -16.5003m0c_C mol:protein length:791 Low-density lipoprotein receptor  ali model follow..  14  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................WGWKLRWTVALLLAAAGTAV-----------------DRCERNEF----QCQDGKCI--------------------SYKWVC-----DGSAECQDGSDESQETCLSVTCCDQVDCDNGSDEQGCPPKTDGKCISRQFVCDSDRDCLDGSDEASCPGPASFQCN-SSTCIPQLWACDNDPDCEDGSPCSAFEFHCLSGECIHSSWRCDGGPDCVATCRPDEFQCSDQCDREYDCK---DMSDEVGCVNVTLCEGPNKFKC----HSGECITLDKVCNMARDCRDWS............................................................................................................................................................................................................. 303
59 -16.1002m2f_A mol:protein length:88 Disintegrin and metalloproteinase domain-containing protein 17  ali model follow..  25  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GSSSSGL----VPRGSHMDDDDKFC---------EREQQLESCAC--NETDNSCKVCCRDLSG---------------RCVPYVDAEQKNLFLRKGKPC--TVGFCDMNGKCE................................................................................................................................................................................................................ 82
60 -16.0002ygq_A mol:protein length:324 WNT INHIBITORY FACTOR 1  ali model follow..  12  67..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDVLKPQNAIFFKTCQQAECP----GGCR-NGGFCNERRICECPDHGPHCECMNGGLCVTPGFC-----ICPPG----YGVNCDKASTTCFNGTCFYP-------GKCICPPGLEGEQCEISK------------------------------------CPQPCRNG-GKCIGKSKCK-QGDLCSKPVCEPGCGAHGTCHEPNKCQCQEGWHGRHCNK........................................................................................................................................................................ 308
61 -15.4004cbz_A mol:protein length:312 PROTEIN JAGGED-1  ali model follow..  21  155................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TCDDYYY--GFGCN-------------KFCRPRDDFF--GHYACDQNGNKTCMEGMGPECNRAICRQGC------SPKHGSCKLPGDCR-----CQYG----QGLYCDKPHPGCVHGICNEPW-------QCLCETN----------------------------------------------GGQLCDKDLNYCGTHQPCL----------------NGGTCSNTGQCSCPEGYSGPNCEIV....................................................................................................................................................................... 305
62 -15.4004xbm_A mol:protein length:531 Delta-like protein 1  ali model follow..  16  134....................................................................................................................................................................................................................................................................................................................................................................................................................................................TVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGER----------GEKVCNPGWKGPYCQHGFCDKPGECKCGWQGRYCDECIRYPGCLHGTCQQPWQCNCQ--GGLFCNQDLNYCTHHKPCKTGQGSYTCSCRPPSPCKNGGSCNSYSCTCPPG----YGKICELSAMTCADGPCNGGRCSDDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAG--------SGRHCDDNVDDCASSGTCRDGVSAPVSRCEHAPCHNGATCHQRGHCECARSYGGPNCQF........................................................................................................................................................................ 498
63 -15.3005mvx_A mol:protein length:309 Delta-like protein 4  ali model follow..  21  148................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ICSDNY--YGDNCS-------------RLCKKRND--HFGHYVCQPDGNLSCLPGTGEYCQQPICLSGC------HEQNGYCSKPAECL-----CRPG----QGRLCNEPHNGCRHGTCSTPW-------QCTCDEG----------------------------------------------GGLFCDQDLNYCTHHSPCK----------------NGATCSNSGTCTCRPGYTGVDCEL........................................................................................................................................................................ 297
64 -15.2004xlw_B mol:protein length:261 Delta-like protein  ali model follow..  24  149................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VCSDNYY--GDSCS------------RLCKKRDDHFGHY---ECQPDGSPSCLPGTGKYCDQPICLSGC------HEQNGYCSKPDEC-----NCRPG----QGPLCNEPHKGCRHGTCTIP--------QCACDEGWGGLFCDQAA....................................................................................................................................................................................................................................................................... 261
65 -15.1002ech_A mol:protein length:50 ECHISTATIN  ali model follow..  22  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECE--SGPCC--RNCKFLKEGTICK--RARGDDMDDYCNGKTCDCPRNPHKGPATX................................................................................................................................................................................................................................................................................................................ 50
66 -14.7005mw5_A mol:protein length:293 Protein jagged-2  ali model follow..  19  171................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RCDENYY--SATCN------------KFCRPRNDFFGHY---TCDQYGNKACMDGMGKECKEAVCKQGC------NLLHGGCTVPGEC-----RCSYG----QGRFCDEPYPGCVHGSCVEP--------QCNCETNWGGLLCDK......................................................................................................................................................................................................................................................................... 280
67 -14.5005mw7_A mol:protein length:332 Protein jagged-2  ali model follow..  17  171................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RCDENYY--SATCNKFCRPRNDFFGHYTCCMDGWMGKECKEAVCK----QGCNLLHGGCTVPGECRCSYQGRFCDECVPYPGCVHGSCEPWQCNCETN----GGLLCDKDLNYCGSHHCNGGTCINAEPDRCTCPDGYSGRNCEK......................................................................................................................................................................................................................................................................... 320
68 -14.4005uk5_B mol:protein length:318 Protein jagged-1  ali model follow..  20  159................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TCDDHYY--GFGCN-------------KFCRPRDDFF--GHYACDQNGNKTCMEGMGPECNKAICRQGC------SPKHGSCKLPGDC-----RCQYGWQGLYCDKCIPHPG-CVHGTCNEPW-------QCLCETN----------------------------------------------GGQLCDKDLNYCGTHQPCL----------------NRGTCSNTGQCSCPEGYSGPNCEA........................................................................................................................................................................ 308
69 -14.1003ghn_A mol:protein length:419 A disintegrin and metalloproteinase with thrombospondin motifs 13  ali model follow..  15  3.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACT--FAREHLDMCQALSCHTDPL----DQSSCSRLDGTECG--VEKWCSKGRCRSLVEGRWSSWGPRSPCSRS--CGGRRRQCNNPRPAFGGRACVGADEMCNTQACEKTQ-LEFMSQQCARTDGQGDALCRHMCRAIGESFIMKRGD--------------------SFLDGTRCMPSGPRLCVLGSCRTFGCDGRMDSVWDRC-DNSTCSPRKGSFTAG................................................................................................................................................................................. 281
70 -14.0006eho_A mol:protein length:723 Sortilin  ali model follow..  55.........................................RVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFH----VPLVIMTFGQSK--------LYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPE---NSGKVVLTAEVSGGSRGGRIFRSSD---------FAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALETSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTMHVDEPGDTGFGTIFTSDDRGIVHLYTTTGGETDFTNVTSLRGVYITSVLTMITFDQ---GGRWNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGG--IIVAIEHSSRPINVIKFS--CWQTYTFTRDPIYFTGLASEPGARSMNIS-----FKDILERNCEEKDYTIEDGCILGYKEQFLRLRKSSMCNGRDYVVTKQPSIC------LCSLEDFLC---------------RPENDSKCDLEFCLYGREEHLTTNGYRKPGDKCQGGVNPVREVKDLKKKCTSNFLSP....................................................................................................................................................................................................................................................................................... 714
71 -14.0004yu5_A mol:protein length:756 Immune inhibitor A, metalloprotease  ali model follow..  1.................................................................................................................NLIQEDRLAEALKE-----RGTI---NPASSKEETKKAVEKYIEKKQGDQANKEILPA-----DTAKEASDFVKKVKEKKMEEKEKVKKPEKNVSPEQKPEPNKKQLNGQVPTSKAKQAPYKGSVRTDKVLVLLV-SDYKHNNIDQTPGYMYSNDFSREHYQKMLFG-VKTFKQYYEEQSGGSY-TTDGYVTE--LTVPGKASDYGADGSSGHDNKGPKGARDLVKEALHAAAEKGLDLSQFDQFDRYDTNSDGVIHAGVGQEAGGGKLGDDAIWSHRSKLAIDPVAIEGTKSKVDYFGGKVAAHDYTIVFAHAFGHDLGLPYDTKYTGTGSPVEAWSLMSGGSWTGKIAGTEPTSFSPQNKD.............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 382
72 -13.8005nni_A mol:protein length:732 Sortilin  ali model follow..  68.....................................................THQHVFDDLSGSVSLSWVGDSTGVILVLTTFQVVSFGQSKLYRSEDYGKNFKD----ITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFAKNPLTQMMYSPQNVSKNFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCKADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANEDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLITSTLSEDNSIQSMITFDQ------GGRW-KNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWAKMLEGPHYYTILDSGG--IIVAIEHSNRPINVIKFS--CWQSYVFTQEPIYFTGLASEPGARSMNIS-----FKDILERNCEEDDYTTKDGCILGYKEQFLRLRKSSVCNGRDYVVAKQPSVCP------CSLEDFLC---------------RPENASECELEFCLYGKEEHLTTNGYRKPGDKCQGGMNPAREVKDLKKKCTSNFLNPTKQNSKSNAAA............................................................................................................................................................................................................................................................................ 726
73 -13.7005es4_B mol:protein length:727 Integrin beta-2  ali model follow..  13  56..................................................................................................................................................................................................IMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMD---------SYSMLDDLRNVKKLGGDLLRALNEITESGR-------IGFGSFVDKTVLFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVADGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFA---KSAVGELSEDSSNVVQLIKNAYNKLSSRVSNGVTHRNQPRGDCD-VPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECGKGFLECGIRCDTGYIGKNCE-----CQTQGRSSQELEGSCRKDNNSIICS-GLGDCCGQCLCHTSDVPGKLIYGQYCECDTINKCEGSACQCERTT-NPRRVEC-SGRGRCRCNVCE---CHS---PLC-----QECPGCPSPCGKYISCAECLKFEKGPF--------------------GKNCSAA---PVKGRTCKERDSEG-TLEQQDGMDRYLIYVD-ESRECVDGCGLENLY......................................................................................................................................................................... 683
74 -13.5002vj2_A mol:protein length:169 JAGGED-1  ali model follow..  23  14................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TCDDYYY--GFGCNDFFGHYACDQNGNKTCMEGWMGPECNRAICR----QGCSPKHGSCKLPGDCRCQYQGLYCDKCIPHPGCVHGICEPWQCLCETN----GGQLCDKDLNYCGTHQCNGGTCSNTGPDQCSCPEGYSGPNCEI......................................................................................................................................................................................................................................................................... 163
75 -13.3002w9o_A mol:protein length:46 SHORT DISINTEGRIN JERDOSTATIN  ali model follow..  26  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AMDCT--TGPCC--RQCKLKPAGTTCW----RTSVSSHYCTGRSCECPSYPGN..................................................................................................................................................................................................................................................................................................................... 45

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.