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Query: [J] COG0013 Alanyl-tRNA synthetase, from VFDB

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKTMTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTSSEWFEFPAEKLYITYYPADKDTYNRWVEVGVDPTHLVPIEDNFWEIGAGPSGPDTEIFFDRGEVYDPEHVGLKLLAEDIENDRYIEIWNIVLSQFNADPSIPRSEYPELPQKNIDTGMGLERMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTYSPDSENMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLLNLKSEGKDRLEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGSMGAQNETLSSIEVESEFLYEDKTTQGKLLVSIQDDEIVDEVSGKAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVVANVLDVQHAPHGQNLHSVETLSPLKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEMGAMALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAFKDAENTLNEVATMVKAPQTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGLRNLADIWKQKELSDVLVLVAKIGEKVSLLVASKSSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELLAAVAEKLALast
1 -143.000PF01411.19; SYA_HAEIN/6-555; tRNA synthetases class II (A)  ali follow..  42  1.......EIRQSFLDFFHSKGHQVVESSSLVPENDPTLLFTNAGMNQFKDVFLGMDKRPYSRATTAQRCVRPNDLENVGYTARHHTFFEMLGNFSFGDYFKQDAINFAWEYLTSPQWLGLPKEKLWVTVYETDDEAYNIWNKVGVPAERIIRISDNFWAMGTGPCGPCTEIFYDHGDHIW----GGPPGSPEEDGDRYIEIWNVVFMQFNRLA---DGTMEKLPRPSVDTGMGLERISAVLQHVNSNYEIDIFKTLIAKTAEIVGATD---LTNKSLRVIADHIRSCAYLIADGVIPSNEGRGYVLRRIIRRAVRHGHLLGAKESFFYKLVPTLIDVMAEAGKDVKAKQTNVEKLLRLEEEQFARTLERGLSLLDEALSQVKDG---ILSGEVAFKLYDTYGFPLDLTADVCRERNITIDEQAFDRKMEAQRTRAQAASQFGVDYN---SVIRVDGETKFEGYTEVESQAKITALFYDGKSVESAGQSAVVILENTPFYAESGGQIGDSGYLSTQSV--TFNVKDTQKYGQVFGHIGELTQGSLKVGQSVNAIVDAKR.......................................................................................................................................................................................................................................................................................................................... 550
2 -55.700PF02091.15; SYGA_PELCD/3-280; Glycyl-tRNA synthetase alpha subunit  ali follow..  13  2......QELILALQNYWAKQGCIIQQPYDMEK---------GAGTFNPA-TFLRVLGPEPWNVAYVEPSRRPTDGENPNRLQHYYQFQVVMK------PSPTNIQELYLDSLKSFGI----------------------------PSRHDIRFVEDDWESPTGAWGLGWEVWLD------------------------MEITQFTYFQQVGG--------IDLKPVSAEITYGCERIAMYLQGVDNVYDLEWIDGIFDMYEKECSRLAKSQLVLPAYDYVLKASHAFNLLDARGAISVTERAHYIGR--VRNLARLCAEGYVAQ.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 276
3 -8.660PF07973.14; SYT2_BACSU/172-221; Threonyl and Alanyl tRNA synthetase second additional domain  ali follow..  25  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ITLYQQGEF-VDLCRGPHLPSTGMIKAFKLTRVSGANEVLQRV............................................................................................................................................................................... 49
4 -8.370PF02272.19; Y1633_METJA/328-463; DHHA1 domain  ali follow..  12  6....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DASILNMIENPEISTEVMEVLAKAVMNRRVVKGNIALAYVGEISNRDALPKAADFLLKMEGISTTFVFGIVGDEIHISARTKDLRLNLGEILNKAF-----GGGGHQTAAAA--KAVSDKEALRKLVEEAI. 136
5 -7.970PF01780.19; C4M0M9_ENTHI/4-88; Ribosomal L37ae protein family  ali follow..  16  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RTKKVGIVGKYGTRYGASLRIAQHSKYVCPFCCKEAVRRTA-CGIWECKGKKQIAGGAYTLSTISGATVRSTVRRLRD.............................................................................................................................................................. 85
6 -7.880PF17072.5; SPIKE_BRV1/1-1583; Torovirinae spike glycoprotein  ali follow..  12  255........ISSDWVVAFKSKASAIILRSQLIVA--AQKLSRTVGVNPYHYLSLVNFSPNYALFSPLCKSLRQQSA-TYSALSYGSPFFVAQECYNNALYLPD-SILFSWDYQVNNNVLQANETFLQLPTTGYLGQTVSQGRMLNLFKDAIV-YDTKFYRTNDGPGGDISAFRIEQQTGYLAVKCNGVIQATLAPHSRHMSMWSIAAANYFHTLAQPSGPIQQVSMPVLSTGAAIEHWVTLL-AQSSVYQPSMFTPFIQALLSFKQADIDATDVDTVARVIYNQLPEWSYPLFKGGVGDSRKKFLVTTKIHQTASHFPFIAGYLDFLDYKYIPKYLSTMVPSILQVYETPQLFVIIVQCVSTTYSHTIYRSYKLGTICVLVPYSSPTDVYSSFGFF-LPGCVGFVQDSVFTPCHPSGCPVRNSGSSASNYTLRNYYRTTTPVTNVPIEEVPLQLEIPTVSLTSYELKQSESVLLQDIEGG----------IVVDHNTGSIWYPGGQAYDVSFYVSPKLELPSTLANFTSCLDYICFGNQQCRGEAQTFCTSMDYFEQVFNKSLTSLITALQDLHYVLKLVLPETTLELTEDTRRRRRAVDFSDTISLLSESFERFMSPASQAYMANMMWWDEAFDLSSAPSLSSISSW-HSYSSRTPLIS--NVKLSMPKLPKASTLSTIGSVLSSGLSIASLGLSIFSIIEDRRVIELTQQQIMALEDQITILTTKNFEEIQSSLNTLGQQVQDFSQTSALSLQQLSNGFEQITQQLDKSIYYVMAVQQYATYMSSNQLNELSQAVYKTQDMYITCIHSLQSGVLSPNCITPFQICHLYQVAKNLSS................................... 1271
7 -7.240PF06016.11; VP1_AQRVC/1-1298; Reovirus core-spike protein lambda-2 (L2)  ali follow..  358.............................LYWPESPFVPPIGPFYAPFRPVNFPFTTGSYTVVPDASRPLRTITVQQADDAYEDTALSPL----THGFCVTGGVSTSIYDISGDPTAYPPAQLVDTPNDYFDRERMADLFRRLRAPADRSAIKDRAVFDFLASLVNPTTANPV-LDTSFSMAYLGASSAHANADEPVILADIR-------------SGSIPGLPIPRRIVQFGYDVVHGSLLDLSRAVPTGTFGLVYADLDQVED---AGTDMPAANRAAIAMLGTALQMTTAGVLKVNFPTRAFWTQVFNLYATHATTLHLVKPTIVNSSEVFLVFGGRQSNGALRSTTALQRALLSLYARN-AAIDRAVTHINLPSNALASLVSRVVPSSIMFTRVPSNGVSTTIYGKRTFLSNRRRARLRDVPMLITTTLVHQRRFTTPPTFTLFSSEAVPVTTLVAAGYNSFISECRILSLIPPTLQV--------TMSDARPCYSTAGAAAAAAGTDLIAFVQQLIPRIVAAGGTRMWLQLNTPLYEVSSLPDLIDIDLRDRVYRFNGGERVEPYADPVPLQQAIAALLPAAALSWHTLSPTCDWLPYIIGVGSPLNLSDINTAISYSRLTPILHIDTTTPPLRVNPVPTPLNQQQHNGVEVIGGTPGNVISVAGAAALQYILANQEFLLQFTPTLPGIFDVFLTTLGQPPVPRGSFTITPPPTTVVLNMPPPGQLDFTDNDARITCDPYYQLAVCIFKDGQYVRVNPEKASVVTNAPNRDLHFVLDLADNHVLLYLCDVTPSGLGDRIAF.................................................................. 1221
8 -7.020PF04071.12; R5BRD8_9FIRM/12-95; Cysteine-rich small domain  ali follow..  15  3..............SFFCHKNCEYFPCHETKDPENFNCLFCYCPLYALGDKCGGNFRILDGGIKDCSKCMLPHRRENYGYVTGK.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 72
9 -6.810PF05088.12; A4XWG7_PSEMY/77-1608; Bacterial NAD-glutamate dehydrogenase  ali follow..  11  585..PWRDVALLRAYARYLKQIRLGFDLSSTLINHADIAKELVRLFRTRFYLARKLTAEDLEDKQQKLEQAILADNVAVLNEDRILRRYLDLIKATLRTNFFQADASGAAKSYFS----FKLSPRLI------PEIPRPVPKFEIFVYSPRVEGVHLRFGDVARG--G----LRWSDREE-----------------DFRTEVLGLVKAQQVKNAVIVPGAKGGFVPRKMPVGGSRDEVMAEGIACYRIF-LDITDNLKEGEVVPPVNVVRHDADDPYLVVAADKGTA-AFASGGSAGYDHKGMGITAKGGWVSVQRHFRERGIDVQKDNVTVIGIGDMAGDVFGNLSDKLQLVMHIFIDPNPDAAKSFAERKRLFDLPRSSWADYDSKLISEG----IFLRSAKSITITPQMKARFDIAADKLAPTELLNALLKAPNGGIGTYVKSSKESHADVGDKANDALRVDGRELRAKVVG----------EGGNLGMTQLGRVEFGLHGGASDNAGGVDCSDHEVNIKILLGEIVSGGDMTEKQRNKLLAEMTDDVSELVNYKQTQALSLAERRARERVGEYKRLM-NALESAGKLPSDEELNERATNGQGLTRPELSVLESLLKSLVPDDDYLAREMETAEILTEKFGDAMRRHRLKREIVSTQIANDLVNHMGITFVQRLKEAGAYVIVRD-RLPHWWAQIEALDYKVPAELQLQLMDELMRLGRLRSRRNELDAARDVAHFAPRIEALVGRLDELLEGPAREQWLARYQSFVEAGTPEELARVVAGTSH-PIIEAADVTGKDASEVATAYFAVGGQALAREAFRDDLDWQQRAITVSVLQMAEGPQEIEARVALWLEQHHRLVERWKAMLTELRS 1514
10 -6.310PF01409.20; SYFA_BACHD/92-341; tRNA synthetases class II core domain (F)  ali follow..  13  35FSVAEGPQIETDYYNFNLPKDHPARDMQDSFYFTDELLLRTQTSPVQARTMEKYKGKGPI-KIICPGKVFRRDDDD-----ATHSHQFMQIEGLYVDHGVRMSDLKGVLQAFAKSFFGEERSIRLRPSFFPFTEPSVEV------------------------------DVSCGICHGDGCRVCKQ---------TGWIEILGAGMV---HPRVLEMSGFNPNEYSGFAFGMGVERLSMLIDDIRHFYTNDR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 244

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 5 8 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Clustering of highly homologous sequences to reduce the size of large protein databases. Bioinformatics. 2001 Mar;17(3):282-3.