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Query: [E] COG0169 Shikimate 5-dehydrogenase, from VFDB

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASQIDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEGALLast
1 -40.200PF08501.11; ARO1_EMENI/1294-1374; Shikimate dehydrogenase substrate binding domain  ali follow..  28  1.........IFGSPISQSRSPALHNTLFAQVGLPHNYTRLET--TNAQDVQEFIRSPDFGGASVTIPLKLDIMPLLDEVAAEAEIIGAVNTI.......................................................................................................................................................................................... 81
2 -17.000PF01488.20; HEM1_PSEAE/169-304; Shikimate / quinate 5-dehydrogenase  ali follow..  33  9.......................................................................................................................DLHRSQALLIGAGETITLVARHLFEQGVKRIVVANRTLERASLLAEQFGAHA-VLLSEIPEELANSDIVISSTAS.................................................................................... 82
3 -11.900PF03435.18; Q94BZ0_ARATH/41-165; Saccharopine dehydrogenase NADP binding domain  ali follow..  15  1.............................................................................................................................VLVLGGTGVGGSTATALSKLCPEKIVVGGRNREKGEAMVAKLGENSEFDAKMLETSLRDVDLVVHAAGPFQQAPRCTVLEAAIKTKTAYLDVCYAFRAKSLEAEAIAANIPAL........................................ 125
4 -9.560PF07991.12; ILVC_METAC/15-178; Acetohydroxy acid isomeroreductase, NADPH-binding domain  ali follow..  23  1........................................................................................................................LKDKTIAIMGYGSQGHAHARNLHESGL-NVVVGLRKGSSSWAKAES----DGLKVMTVEEAAKAADVIMILLP..................................................................................... 68
5 -9.500PF10727.9; Q743Y6_MYCPA/8-128; Rossmann-like domain  ali follow..  7  6............................................................................................................................KVGIISAGRVGTALGVALERADHVVVACSAISHASRQRAQRRLPDTP---VATPPEVAAGAELLLLAVP..................................................................................... 71
6 -9.360PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  10  14.................................................................................................................KRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGA-RVLVTEIDPINALQACMD-----GYQIVTMETAAPLSNIFVTTTGCRDIVRGEHF--AVMKEDAIVCNIGHFDCEIDVAWLNANAKKDTVKPQVDRYTLANGVHIIL....................... 147
7 -8.740PF02423.15; Q2YIG4_BRUA2/15-320; Ornithine cyclodeaminase/mu-crystallin family  ali follow..  8  75.................................................................LQTVTAFGVLADVGSGYPMLLTEMTILTALRTAATSAVAAKHLA----------PKNARTMAIIGNGAQSEFQALAFKALGVDKLRLYDLDPQATAKCIRNLQGAG-VACKSVEEAVEGADIITTVTAD--KANATILTDNMVGAGVHINAVGGDCSGKTELHGDILRRSDIFVEYPPQTRIEG............................. 249
8 -8.220PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain  ali follow..  11  25.......................................................................................................................GVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDKLREADKIFGTKIQTVVSNAFELEKACLEADLVIGAVLIPGAKAPKLVTNELMKPGSVLVDI............................................................. 127
9 -8.150PF02882.19; FOLD1_ARATH/184-349; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain  ali follow..  14  24............................................................................................................GCVELLIRTGVEIAGKNAVVIGRSNIVGLPMSLLLQRHDATVSTVHA------------------FTKDPEHITRKADIVIAAA-----GIPNLVRGSWLKPGAVVIDVGTTPVEVCYEEALGVASAITPVPGITMLLCNTLEAAK........................ 165
10 -8.040PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  11  1............................................................................................................................QIGVVGLAVMGSNLARNFARNG--TVAVYNRSTDKTDKLISDYATDGNFITKTVEDFVAALEAIVMVQAGAATDAVINQLADAMEEGDIIIDGALYTDTVCREKEMAARGRHFVGAGISGGEEGALNGPSIMPGGPKESWEALGPLLESIAAKV 160
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.