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Query: [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair, from VFDB

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARKFGVRSAMPTGMALKLCPHLTLLPGRFDAYKEASNHIREIFSRYTSRIEPLSLDEAYLDVTDSVHCHGSATLIAQEIRQTIFNELQLTASAGVAPVKFLAKIASDMNKPNGQFVITPAEVPAFLQTLPLAKIPGVGKVSAAKLEAMGLRTCGDVQKCDLVMLLKRFGKFGRILWERSQGIDERDVNSERLRKSVGVERTMAEDIHHWSECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFDDFQQTTQEHVWPRLNKADLIATARKTWDERRGGRGVRLVGLHVTLLDPQMERQLVLGLLast
1 -77.200PF00817.20; Q74KV6_LACJO/16-168; impB/mucB/samB family  ali follow..  43  1......IDMDAFYASVEMRDNPSIRNKAVLIGGDPKGHGVVATANYIARSYGAHSAMPTAKAVRLIPKLVIIQPNFEKYRAVSAEIHQLMHKITDRVESVALDEAYLDVTENKLNLTDPVRIAALLQERIYQRIGLTSSFGVSYNKFLAKMGSE..................................................................................................................................................................................................... 153
2 -14.400PF14229.6; C7RPT7_ACCPU/9-129; Domain of unknown function (DUF4332 topsan)  ali follow..  20  1...........................................................................................................................QGATPTISEKLK---EAGITNNEQLLAAAAAPAQRKALA-CDPRVILELANRADLARIKGVSGVYSDLLEKAGVDTVKELATRRPDNLHAKIIDTNTSEQVSKQPPTLAMVES-QQAKDL............................................................................................................ 121
3 -11.600PF11731.8; B3ENR7_CHLPB/7-91; Pathogenicity locus  ali follow..  24  7................................................................................................................................................................................KLTDLPNIGPAIAADLRLLGINNPDDLSGQSPVELYHKLSE...................................................................................................................................... 47
4 -11.500PF11798.8; DPO4_TREDE/168-199; IMS family HHH motif  ali follow..  37  1.....................................................................................................................................................................AGEEIDFMKSLPLKDVWGVGGKTRERLIAAGL.......................................................................................................................................................... 32
5 -11.300PF11799.8; B6QQ86_TALMQ/339-497; impB/mucB/samB family C-terminal domain  ali follow..  8  2.........................................................................................................................................................................................................................................MEARAVPTQISIEDSY-RGLEHFEDVRKQLQLLSTSLIKRMRTTRWIAHPRTLRLSTRRRSNGRTSRSGPVPKYAEKLVDDCLVSMFRKLHPDKELSLINVAVTNMVETAGDN..... 156
6 -10.900PF18182.1; A0A0F3GNU5_9BACT/377-494; minimal CRISPR polymerase domain  ali follow..  16  23..........................................................................DEEEVQMRSNILREAINKLKKLIKKTTKDHKSIIFAEGDNILF-DNTLLNEIQSVYKKETGLSSSIGYGKTLRDVMIALRLAKAKNGESL........................................................................................................................................................................................... 115
7 -9.220PF04994.13; Q7MJ56_VIBVY/114-195; TfoX C-terminal domain  ali follow..  14  1.............................................................................................................................................................................KPERLKDLPNLRLATERMLKKAGIETVEQLESQGAVRAYEAI........................................................................................................................................ 42
8 -7.430PF10391.9; G0RCE3_HYPJQ/462-510; Fingers domain of DNA polymerase lambda  ali follow..  35  3.................................................................................................................................................................................FLGIYGVGNKVAEQWIAQGWRTLDDVRKHAKLTPSQRIG....................................................................................................................................... 41
9 -7.110PF17191.4; A8F350_PSELT/110-273; RecG wedge domain  ali follow..  12  1................................................................................................................................................................................EIKYAKRVGPRKEAILKKLGISTLGDL------------------IFYFPRDYEDRRKIIPISEISFEGKLT----------TRGKVVNVETKKIGSMTITAAVLADGVSQLLLKWFNQEYLHKGLQVLKNKTIYATGLVKH................................. 114
10 -5.530PF08004.11; F7XQB5_METZD/1-130; Protein of unknown function (DUF1699 topsan)  ali follow..  14  7...................................SSKEEINTLGPDEEIVHLASNTDIFSLVMKCPDVKALHIPSSYKKTISKSAQMYL-------SMQGIDLLEGDVWGHRKDINEYSEVSRNVFNRIIE----LRSEGLAEDVIADKMAKETRLSQDFI............................................................................................................................................................................................. 125
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.