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Query: [K] COG2378 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPTDNVVSVVSPYHMEMYNMRKASRLFEIIQILRLARRPVTAQTIADMLEVTARSVYRDIAALQTMRVPIEGERGVGYILRPGFNLPPLMFSIEETEAIVLALAMVDRSGDAELRQAAKKVSDKIAASLPEPLSKTLSANALHAWGSIAPAPAGIDLATVRRAVRDEERLDLCYSDESGVETQRRIRPIAVIYYSETVNIVAWCELRHAIRNFRSDRVLDCAATGSFFKMEGEKLRRLWMSGWQSGQPGGELGRPISGVTLPLast
1 -34.300PF13280.6; C0ZDF9_BREBN/138-311; WYL domain  ali follow..  19  1..........................................................................................................................................................PYLSLLLDAAIDQKVVRIEYES-KQDKRLRDVQPIGIYASNGFWYCPAYCFHRRDFRLFRCDRVRSVELIERKAVDLTQVHTGNWDSYIEEESPAMELYVELTATGV. 106
2 -20.200PF09182.10; Q8YAD9_LISMO/4-72; Bacterial purine repressor, N-terminal  ali follow..  21  1....................RRSERLIDMTQFLLSHRKLVPLTMFAERYGSAKSSISEDLKTFEDRGIGLETVPGGGVQYI..................................................................................................................................................................................... 69
3 -15.300PF09904.9; A4XY65_PSEMY/5-95; Winged helix-turn helix  ali follow..  13  1.................KTRTSFYRRLYLAWLIDSGQAT-SIPALMAATGMPRRTAQDTLAALEELDIDCRFEQGEGERNNAGH.................................................................................................................................................................................. 66
4 -15.300PF06163.11; A0A070SGS2_ECOLX/1-127; Bacterial protein of unknown function (DUF977 topsan)  ali follow..  14  8...................EQREELKARIIGLVR-KNERMTISQLERATGAGWHSVRRCLVDVLACGD-LYMPGKYGV........................................................................................................................................................................................ 64
5 -14.700PF08279.12; Q82YX2_ENTFA/90-148; HTH domain  ali follow..  21  1........................RVSYIIKRLIEEDQFISTYDLSEELAVSRGTVNKDIKRMKELQVAVVGTPNRGIH....................................................................................................................................................................................... 59
6 -14.500PF08280.11; Q8DP24_STRR6/14-73; M protein trans-acting positive regulator (MGA) HTH domain  ali follow..  22  2....................TKVQRQLRLMETLIQNRNWMKLHELAEKLGCTERILKSDLNELRI..................................................................................................................................................................................................... 46
7 -12.200PF08220.12; ULAR_ECOLI/6-62; DeoR-like helix-turn-helix domain  ali follow..  17  1........................RHQILLEMLA-QLGFVTVEKVVERLGISPATARRDINKLDESGK-LKKVRNGAEAITQQ................................................................................................................................................................................... 57
8 -11.900PF10007.9; A4YIE5_METS5/9-101; Uncharacterized protein conserved in archaea (DUF2250 topsan)  ali follow..  16  1................LKKLIEDKRYLMVLQHLR-KANVDYGKSIMLNTKIPIEEVVIILDKLENLGL-IERVKGATLK....................................................................................................................................................................................... 61
9 -11.500PF03444.15; Q6M165_METMP/2-80; Winged helix-turn-helix transcription repressor, HrcA DNA-binding  ali follow..  25  5....................VQKEILQELISIYREKNKAVKGTEIAVKLSRNPGTIRNQMQALRALNL-VDGVPGGGY........................................................................................................................................................................................ 63
10 -11.500PF04703.12; Q9ADX3_ECOLX/1-62; FaeA-like protein  ali follow..  16  4...........................NILTFLTELKTPCRTTEIAIHFGLSAYQARYYLMNLEKEGKIKRSPVRRG......................................................................................................................................................................................... 53
11 -10.300PF01978.19; Q8TXT4_METKA/25-102; Sugar-specific transcriptional regulator TrmB  ali follow..  8  7...................IKEDEAELYLKLLENSEEAPFTVEDVAEIINRSRSTAQKMLQSLVRVGM.................................................................................................................................................................................................. 55
12 -10.100PF01316.21; ARGR_BACLD/1-70; Arginine repressor, DNA binding domain  ali follow..  29  1...................MNKGQRHIKIREIIT-ANEIETQDELVDILNVTQATVSRDIKELHLVKVP-TNNGSYKYSLPADQRF................................................................................................................................................................................ 70
13 -10.000PF05732.11; O50587_SELRU/6-169; Firmicute plasmid replication protein (RepL)  ali follow..  12  58..........................TRLAFWLINNLNRMTQRKIAEKTGISLETVRQTMKALMESGFLIKINSGA-------YCVNPDAVFKGGKTDRLNVLIQYRKSEQENTKTSEPTSEKDEPSLFNNEQLK............................................................................................................................... 164
14 -9.760PF09339.10; Q89P18_BRADU/21-72; IclR helix-turn-helix domain  ali follow..  19  2......................LERTLGVLELLATNARGMQLFEIADSLHIPRSATHRVLTSLIEHGY.................................................................................................................................................................................................. 47
15 -9.730PF01475.19; FUR_ECOLI/10-130; Ferric uptake regulator family  ali follow..  16  9.......................PRLKILEVLQEPDNHHVSAEDLYKRLEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFE------LTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAK.......................................................................................................................................... 108
16 -9.660PF09012.10; Q6LTA5_PHOPR/2-67; FeoC like transcriptional regulator  ali follow..  14  2.........................LQQLKQYIE-QHGRSSRSNLATHFGMSADGVEAMLAVWIRKG................................................................................................................................................................................................... 42
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.