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Query: [K] COG3432 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTYGYNIFTVIKFSDNVYKLQLIYYSMQLERRKRGTMEIMFDILRNCEPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDRKIYEITEKGKLLRTHIEEFIKIRENLYSAKEKVSELLRTDSELast
1 -28.900PF14947.6; E6N974_9ARCH/5-85; Winged helix-turn-helix  ali follow..  27  1................................YRSKTKIIADILESIQGHAKPTKILLDANLSYDRLVKYLDMLVEKKLVERV-ENSETMYVLTEKGLEFLMEYKRFERFAA.................. 81
2 -15.900PF07381.11; L0KZ10_METHD/19-105; Winged helix DNA-binding domain (DUF1495 topsan)  ali follow..  15  1..........................IRSLMRSEVRKSILLYLYDIYPLSSYPAEIARRVNANPINVIGAISSLLHLGIISVIEDNGLKFYQISETGIELAK............................ 86
3 -15.700PF14277.6; R6C342_9CLOT/9-170; Domain of unknown function (DUF4364 topsan)  ali follow..  17  4......................................IVLYMLNRVTFPLTRNQITDFI-TNFFTLQQVMAELIDTGLVTAKTVRNRTLLDITDEGLETLRFFEN-DAIKKDIDNYLSEKELELRDEVS 101
4 -14.800PF13601.6; Q7MSY5_PORGI/4-83; Winged helix DNA-binding domain  ali follow..  16  1......................................LRLAIMSVLVEEADFLYLKEVTGATSGNISVQLDKLSTAGYIEIEKGRPRTTCRATDAGREAFSAHFEALKSY................... 79
5 -12.900PF07848.12; Q89R82_BRADU/18-87; PaaX-like protein  ali follow..  17  24..................................................GTLLEFFESLDIDSGVVRTAMSRLAADGWLTREKVGRNSFYRLADKG................................. 70
6 -12.600PF01978.19; Q8TXT4_METKA/25-102; Sugar-specific transcriptional regulator TrmB  ali follow..  22  8................................KEDEAELYLKLLEN-EAPFTVEDVAEIINRSRSTAQKMLQSLVRVGMVERERPGGGRRYLYRPAPWE............................... 78
7 -12.500PF04703.12; Q9ADX3_ECOLX/1-62; FaeA-like protein  ali follow..  20  5.......................................ILTFLTELKTPCRTTEIAIHFGLSAYQARYYLMNLEKEGKIKRSPVRRGA......................................... 54
8 -12.500PF16864.5; H2SKX6_TAKRU/11-102; Dimerisation domain  ali follow..  20  23.......................................VFDLLLKSPEPLSAQQIAQELDTSVDGAERLLDTLVGIEILEVETCDGTELYSSTDVANLYLAR........................... 88
9 -12.400PF14557.6; V6EX65_9PROT/2-176; Putative AphA-like transcriptional regulator  ali follow..  9  4..............................NTLTPKEAVRLCALGMIRQCMRYSELAGAVRPQIDLMGMSIELLRYEGLVQAVGGEGNAQLTITEAGSRELHAL.......................... 89
10 -12.300PF13814.6; F4CP25_PSEUX/33-234; Replication-relaxation  ali follow..  15  1...........................................LALLAE-LTTNQIAAIEFLSVRRAQDRLRHLRELGVVFARGGTSQTRYALGYLGARLIAA........................... 68
11 -12.000PF03444.15; Q6M165_METMP/2-80; Winged helix-turn-helix transcription repressor, HrcA DNA-binding  ali follow..  11  2............................LTIVQKEILQELISIYREKNKAVKGTEIAVKLSRNPGTIRNQMQALRALNLVDGVPGPKG--YIPTSLTYRSL............................. 73
12 -12.000PF13463.6; M9R4U4_9RHOB/56-120; Winged helix DNA-binding domain  ali follow..  12  8..........................................LFNIGDNEVTAGELKSRGYYQGSNVSYNLKKLVEMDYMHHQIDRRSVRVRLTEKG................................. 65
13 -11.400PF11313.8; W7C283_9LIST/1-84; Protein of unknown function (DUF3116 topsan)  ali follow..  20  2................................WRPTDEEQKMVLSFILDPFVLINMQQKMTISKNEFLRVLYWLEQENFLIRLKPYNQKKYFLTDKGDLLYRKLS......................... 83
14 -11.400PF10711.9; Q5WIB5_BACSK/4-95; Hypothetical protein (DUF2513 topsan)  ali follow..  13  1.................................ERDMELIRDLLIEFKG----YQAGSSVTADDEKEDYHIYLLLEAGLIEAEIRNYMDNLHITTAGHDFIDAAKN--------ETVWKKTKDVLKQK.. 89
15 -11.300PF09904.9; A4XY65_PSEMY/5-95; Winged helix-turn helix  ali follow..  13  1...............................KTRTSFYRRLYLAWLIDQATSIPALMAATGMPRRTAQDTLAALEELDIDCRFEQGEGEHYLIHDWGRWIAAHLQQIKTTL................... 91
16 -11.200PF02334.16; A0A0F5HS56_9BACI/7-119; Replication terminator protein  ali follow..  10  5...............................KQRAFLKLF--MIKFVEENKLYGQAMDELKPNHSEIYRSLHELIDDGILKRQKYKEVVIYQFDDYEKAKLYKKQVKADLDRSMGLLRKALEDVY..... 113
17 -11.100PF03551.14; Q9HI09_HALSA/20-89; Transcriptional regulator PadR-like family  ali follow..  21  28.............................................................IHHGRLYPNLDTLVDKGLVEKGKDQRTNSYALTRRGQREIAA........................... 70
18 -11.000PF09202.11; F7D8R8_XENTR/9-91; Rio2, N-terminal  ali follow..  16  10.........................................RVLTAVEMGMKNHEIASIASLKHGGCNKILRELVKHKLIAYERTKTVQGYRLIYGGYDYL............................. 75
19 -10.800PF08222.11; CODY_STRA5/201-261; CodY helix-turn-helix domain  ali follow..  17  1..............................................LEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTY....................................... 45
20 -10.800PF16221.5; D8PH49_9BACT/341-418; winged helix-turn-helix  ali follow..  14  22.........................TIGGNVTGRSAEMALLWVLNLSDGDHTLLKIAERAGLPFLTIKLAADALEGQGLLRP................................................ 78
21 -10.700PF05732.11; O50587_SELRU/6-169; Firmicute plasmid replication protein (RepL)  ali follow..  12  56..................................QKTRLAFWLINNLNRDMTQRKIAEKTGISLETVRQTMKALMESGFLIKINSG---AYCVNPD.................................. 118
22 -10.600PF07789.12; Q8X8R9_ECO57/105-259; Protein of unknown function (DUF1627 topsan)  ali follow..  13  4...............................................RGPQTADELATLFGTTSRKVASTLAMAISKGRLIRVNQNGKFRYCIPGDNLP............................... 55
23 -10.500PF12793.7; A6TCP6_KLEP7/5-116; Sugar transport-related sRNA regulator N-term  ali follow..  7  5....................................RRLHARYGAGQTHELQMQEIAAIFGCSVRNCRIALKKMHQEKWLDWQPRGKRSRLHLLTSPEKLFQDYGNVLRFIGNDKYLLDRLSLWR..... 106
24 -10.500PF14338.6; E6U8Z8_ETHHY/6-92; Mrr N-terminal domain  ali follow..  18  3.....................................EFMKPLLVCLSDGETHKNLAEYFHLTDEDRQELLTYLKKAGLISSPARS---IMQITDTGRQVVRE........................... 87
25 -10.400PF12840.7; B8EL50_METSB/15-76; Helix-turn-helix domain  ali follow..  17  11..................................TRYEIL-KRLGAQTDALACVSVRDCMGVNPATLSHHMKELELAGLIDVTREGK........................................... 62
26 -10.400PF10007.9; A4YIE5_METS5/9-101; Uncharacterized protein conserved in archaea (DUF2250 topsan)  ali follow..  16  13..........................................VLQHLRNVDYGKSIMLNTKIPIEEVVIILDKLENLGLIERVKGAHHTYYSLTRAGDHLLRYL.......................... 93
27 -10.300PF09639.10; R6M2H2_9FIRM/8-101; YjcQ protein  ali follow..  20  1........................................YKILKVLESAMDCDEVAENFKITENRFENIIRMLAKEEYITGVIIVDMI--RITLKGLEYLSENSLMKKAANLAKSIKE........... 93
28 -10.200PF03428.13; F2J6Y5_POLGS/13-187; Replication protein C N-terminal domain  ali follow..  11  42................................TDRSLSILNALLSFHPETSNEQLAARANGMPATTLRRHIAVLVDCGLIIRRDSPNGKRFARKGRGGEIEQAY-DLSPIVARADEFRDLVEALQAEKKA 152
29 -10.100PF08461.10; O27611_METTH/14-79; Ribonuclease R winged-helix domain  ali follow..  17  3.......................................ILRILAEHDDVLGAKIIASELNLGERAVRYHMRILDEKGFTERVGYAGRR---ITEKGLQEI............................. 66
30 -10.000PF01638.17; YYBR_BACSU/22-112; HxlR-like helix-turn-helix  ali follow..  15  11..........................................FYHMIDGKKRFNEFRRICSITQRMLTLQLRELEADGIVHREQVPPKVEYSLTEFGRTLEPIVLQMKEWGESNRDVLE........... 91
31 -9.990PF06163.11; A0A070SGS2_ECOLX/1-127; Bacterial protein of unknown function (DUF977 topsan)  ali follow..  10  1.......................MAKPFTHEQREELKARIIGLVRK-NERMTISQLERATGAGWHSVRRCLVDVLACGDLYMP............................................... 59
32 -9.650PF12802.7; Q28UG0_JANSC/25-85; MarR family  ali follow..  10  10.......................................IYALLFLSSTPLNAEQITEGLGVSRSNTSMGLKELQAWNLVRLRHVPNDR......................................... 59
33 -9.550PF03501.15; B3S5Q3_TRIAD/3-96; Plectin/S10 domain  ali follow..  8  3................................KKNLILVYERLFNVAKKEFNAPKHPELETVPNLQVIKACQSLKSRGYVKEQFAWRHYYWSLTNEGIDFLRNYLHL....................... 81
34 -9.190PF09012.10; Q6LTA5_PHOPR/2-67; FeoC like transcriptional regulator  ali follow..  8  1......................................ILQQLKQYIHGRSSRSNLATHFGMSADGVEAMLAVWIRKGLIGKELVGC........................................... 51
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.