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Query: [S] COG4344 Uncharacterized protein conserved in archaea, from VFDB

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEYEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNTSIKRTEAKLKKSAEVHKHHTYYQINKKAEAVLKEITPKLYVHHLKSADLQMLCSRKERKENPEACSSLLRMGLIDKCYDLTDLGREVFDTARRMQILHCEDRNLast
1 -42.900PF10007.9; A4YIE5_METS5/9-101; Uncharacterized protein conserved in archaea (DUF2250 topsan)  ali follow..  41  1.......LKKLIEDKRYLMVLQHLRKANVDYGKSIMLNTKIPIEEVVIILDKLENLGLIERVKGATLKNTEAKFKLSSEVHKHHTYYSLTRAGDHLLRYL.................................................................... 93
2 -25.600PF06163.11; A0A070SGS2_ECOLX/1-127; Bacterial protein of unknown function (DUF977 topsan)  ali follow..  10  1...MAKPFTHEQREELKARIIGLVRKNERMTISQLERATGAGWHSVRRCLVDVLACGDLYMPGKYGVFTSEQVYRVWRKAAE--------KATDQTLIRKLPDGEIRRYDRQQNIICGECRKSEVMLRVL------AFYQGNFQ........................ 127
3 -21.600PF08220.12; ULAR_ECOLI/6-62; DeoR-like helix-turn-helix domain  ali follow..  14  1...............RHQILLEMLAQLGFVTVEKVVERLGISPATARRDINKLDESGKLKKVRNGAEAITQQ................................................................................................ 57
4 -17.700PF09012.10; Q6LTA5_PHOPR/2-67; FeoC like transcriptional regulator  ali follow..  10  3.................QQLKQYIEQHGRSSRSNLATHFGMSADGVEAMLAVWIRKGLIGKELVGC...................................................................................................... 51
5 -17.200PF00455.22; A9CFA5_AGRFC/78-235; DeoR C terminal sensor domain  ali follow..  6  2.............................................................................................NIDKKRAIARKAVDLCNDGDAIILNGGTTTFQMVHYMAA-RRLQVMTNSFAIAEHLVKHCNVNVPGGAIYRDQSL 77
6 -15.000PF14947.6; E6N974_9ARCH/5-85; Winged helix-turn-helix  ali follow..  19  6..............KIIADILESINQQGHAKPTKILLDANLSYDRLVKYLDMLVEKKLVERVENS------------------ETMYVLTEKGLEFLMEY.................................................................... 73
7 -14.900PF13601.6; Q7MSY5_PORGI/4-83; Winged helix DNA-binding domain  ali follow..  9  2................RLAIMSVLMSVEEADFLYLKEVTGATSGNISVQLDKLSTAGYIEI-------------EKGYNGKRPRTTCRATDAGREAFSAHFEA................................................................. 75
8 -14.400PF01978.19; Q8TXT4_METKA/25-102; Sugar-specific transcriptional regulator TrmB  ali follow..  6  1...LSCVFGIKEDEAELYLKLLENSEEAPFTVEDVAEIINRSRSTAQKMLQSLVRVGMVER........................................................................................................... 58
9 -14.100PF03444.15; Q6M165_METMP/2-80; Winged helix-turn-helix transcription repressor, HrcA DNA-binding  ali follow..  13  2............LTIVQKEILQELEKNKAVKGTEIAVKLSRNPGTIRNQMQALRALNLVDGVPG........................................................................................................ 58
10 -13.700PF09904.9; A4XY65_PSEMY/5-95; Winged helix-turn helix  ali follow..  13  7..............YRRLYLAWLIDSGQATSIPALMAATGMPRRTAQDTLAALEELDIDCRFEQG....................................................................................................... 57
11 -13.600PF02295.17; DSRAD_HUMAN/295-359; Adenosine deaminase z-alpha domain  ali follow..  9  2............MAEIKEKICDYLFNVSDSSALNLAKNIGLKARDINAVLIDMERQGDVYRQGTT....................................................................................................... 55
12 -13.400PF04703.12; Q9ADX3_ECOLX/1-62; FaeA-like protein  ali follow..  16  1...............MKDNILTFLTELKPCRTTEIAIHFGLSAYQARYYLMNLEKEGKIKRSPVR....................................................................................................... 51
13 -12.800PF07381.11; L0KZ10_METHD/19-105; Winged helix DNA-binding domain (DUF1495 topsan)  ali follow..  16  1.......IRSLMRSEVRKSILLYLYDIYPLYPAEIARRVNANPINVIGAISSLLHLGIISVIEDN-----------------GLKFYQISETGIELAK...................................................................... 86
14 -12.400PF13814.6; F4CP25_PSEUX/33-234; Replication-relaxation  ali follow..  14  1....................LALLAEHKVLTTNQIAAIEFLSVRRAQDRLRHLRELGVVFAFRESYVRGG-----------TSQTRYALGYLGARLIAA..................................................................... 68
15 -12.200PF07789.12; Q8X8R9_ECO57/105-259; Protein of unknown function (DUF1627 topsan)  ali follow..  11  1.......................IEQRGPQTADELATLFGTTSRKVASTLAMAISKGRLIRVNQN....................................................................................................... 42
16 -11.900PF01047.22; YDGJ_BACSU/52-110; MarR family  ali follow..  17  1............ISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRRK........................................................................................................ 52
17 -11.800PF05732.11; O50587_SELRU/6-169; Firmicute plasmid replication protein (RepL)  ali follow..  18  53............IGNQKTRLAFWLINN---TQRKIAEKTGISLETVRQTMKALMESGFLIKINSGAY..................................................................................................... 113
18 -11.700PF13412.6; Q88AX2_PSESM/7-53; Winged helix-turn-helix DNA-binding  ali follow..  12  1............LDRIDINILVELQKDGRMTNVSLADAVGLSASPCLQRVKRLESAGYI............................................................................................................. 47
19 -11.300PF05491.13; R7FLP2_9CLOT/266-337; RuvB C-terminal winged helix domain  ali follow..  11  1.........SLGLDEIDRKYLECLIVRRPVGLNAIASAIGEEATSLEDVYEPLIKEGLINRTSRGRMATLK................................................................................................. 66
20 -11.200PF04492.13; E6WEN5_PANSA/20-114; Bacteriophage replication protein O  ali follow..  14  14.NELYEELIGANLTRNQAKVAHAVKKLDRISDSQISELTKLPRQKVNKAKNELIAMRVLVREGM........................................................................................................ 84
21 -11.100PF17782.1; A0A142LH30_9PROT/300-360; DprA winged helix domain  ali follow..  13  10............VEDDAAPLLLALGF-DPVSIDEISNRTTLSASSLVAQLMELEINGRVAQLPGG....................................................................................................... 61
22 -10.800PF02002.17; TFE_THEPD/5-109; TFIIE alpha subunit  ali follow..  13  1..EALAEIAGKMFGDNAKKVMMVLASNVEVSDEDLAKDLKMDPPELRKLLNDLFEARLVK............................................................................................................ 58
23 -10.600PF03297.15; Q57XX0_TRYB2/10-110; S25 ribosomal protein  ali follow..  16  38..........MFDKETMDKLMKEVPKYKVITPSIISDRLKISVALAGKGLQHLCRQGLIRLVSCS....................................................................................................... 92
24 -10.600PF02334.16; A0A0F5HS56_9BACI/7-119; Replication terminator protein  ali follow..  15  11................KLFMIKFVEEYGMQAMDELKATFKPNHSEIYRSLHELIDDGILKR----------QKKLQEGAKYKEVVIYQFDDYEKAKLYKKQVKADLD............................................................. 99
25 -10.600PF01022.20; O28971_ARCFU/24-70; Bacterial regulatory protein, arsR family  ali follow..  21  1.............NESRRRILQLLSR-KPCYVSEISYYLGMAPKAVLEHLDKLVKAGIVS............................................................................................................ 46
26 -10.300PF00392.21; A6T6K9_KLEP7/13-76; Bacterial regulatory proteins, gntR family  ali follow..  21  28................................AELVAQFGFSRMTINRALRELTDEGLLVRLQG........................................................................................................ 59
27 -10.100PF12793.7; A6TCP6_KLEP7/5-116; Sugar transport-related sRNA regulator N-term  ali follow..  13  1.............EAHFRRLHARYGQTHELQMQEIAAIFGCSVRNCRIALKKMHQEKWLDWQPQRG--------------RGKRSRLHLLTSPEKLFSQNVNKLLEK............................................................. 82
28 -9.810PF12802.7; Q28UG0_JANSC/25-85; MarR family  ali follow..  13  3............INRTVGQIYALL-SSTPLNAEQITEGLGVSRSNTSMGLKELQAWNLVRLRH......................................................................................................... 54
29 -9.800PF16864.5; H2SKX6_TAKRU/11-102; Dimerisation domain  ali follow..  14  12........SKAIFSACELGVFDLLLKSEPLSAQQIAQELDTSVDGAERLLDTLVGIEILEV---------------ETCDGTEAALYSSTDVANLYLARGSAK................................................................. 92
30 -9.780PF09681.10; A5I6C3_CLOBH/18-137; N-terminal phage replisome organiser (Phage_rep_org_N)  ali follow..  17  56...............................EEMLSTIFNRPLNSLRFALKVLRDFGMIQIQEDKLIKIANWSKHQNIEGMEKVRQQTRERVAK.......................................................................... 118
31 -9.730PF01726.16; LEXA_HAEIN/1-65; LexA DNA binding domain  ali follow..  18  4............LTARQQEVLDLLKRH-PPTRAEISRELGFSANAAEEHLKALSRKGAIEIIPGAS...................................................................................................... 63
32 -9.700PF14394.6; C9RNG9_FIBSS/101-266; Domain of unknown function (DUF4423 topsan)  ali follow..  11  7VRVVEGDLFEFYESWRNPVLRELAPLMPGATPGELAKMCYVSAADIKQSLDFLVKAGFLKKEGENTYSQTETSIKGSPEATK------------------------LAIRDMHREMAKIAANSLDLARTERNFTGVTMGISKDSYEQIVKELDECRRKIVSIAAGDKN 152
33 -9.680PF12840.7; B8EL50_METSB/15-76; Helix-turn-helix domain  ali follow..  14  5.........RALSDKTRYEILKRLAQTDALACVSVRDCMGVNPATLSHHMKELELAGLIDVTREG....................................................................................................... 61
34 -9.670PF13463.6; M9R4U4_9RHOB/56-120; Winged helix DNA-binding domain  ali follow..  12  4................QALLLFNIGD-NEVTAGELKSRGYYQGSNVSYNLKKLVEMDYMHHQRC--------------EIDRRSVRVRLTEKG........................................................................... 65
35 -9.530PF16221.5; D8PH49_9BACT/341-418; winged helix-turn-helix  ali follow..  15  21.RTIGGNVTGRSAEMALLWVLNLSD--GDHTLLKIAERAGLPFLTIKLAADALEGQGLLRP........................................................................................................... 78
36 -9.480PF03551.14; Q9HI09_HALSA/20-89; Transcriptional regulator PadR-like family  ali follow..  14  1...................LLYVIAGLDEPHGLAVKAEMEIHHGRLYPNLDTLVDKGLVEKGKLD----------------QRTNSYALTRRGQREIA...................................................................... 69
37 -9.360PF14502.6; Q6LNG6_PHOPR/24-71; Helix-turn-helix domain  ali follow..  14  9...............................IDSLAEEFELSVGLVQKALKKIEADGVIALSRQG....................................................................................................... 42
38 -9.350PF07848.12; Q89R82_BRADU/18-87; PaaX-like protein  ali follow..  20  28.................................EFFESLDIDSGVVRTAMSRLAADGWLTREKVG-----------------RNSFYRLADKG........................................................................... 70
39 -9.140PF03428.13; F2J6Y5_POLGS/13-187; Replication protein C N-terminal domain  ali follow..  16  29FQHIREARELIGATDRSLSILNALLSF-PSNEQLAARANGMPATTLRRHIAVLVDCGLIIRRDSPNGKRFARK............................................................................................... 115
40 -9.130PF13730.6; A5D5X8_PELTS/22-76; Helix-turn-helix domain  ali follow..  14  3............LTTLQKLVYIYFCRRANNSYDDIAKDCGCHRSSAIEAVNTLGKMGLV............................................................................................................. 55
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.