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Query: [H] KOG1370 S-adenosylhomocysteine hydrolase, from VFDB

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSDKLPYKVAAWGRKALDIAENKMPGLMRIWERYSASKPLNGARIPGCLHRTVETAVLMSLITLGTEVQWSSCNIFSTQDHAAAAIAKAGISASTGIPVLPLPRLACLEGRNRRGVPVTGDLTNLIHSEYSQLLLSFRGISKETTIGVHNLYKMMVNGILKVPAIDVNDSATKSKFDNLYGCGIKQATDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKTDPIKALQAAMEGYEVTTMDEACQEGDVFVTTTGCVDIILGQHFEQTKDDTIVCNTGYFDVEMDVKWLNKNTVEKVNVKLQVDPYRLKNGRGIILLAEGRLVNLACAMGHPSFVRSNSFTSQVMAQIKLWTHPDKYPVGVHFLPKKLDESVAEAHLGKLNMKLTKLTEKQAQYLGMSCYCPFKPDHYRYLast
1 -94.400PF05221.17; D9SB20_FIBSS/15-498; S-adenosyl-L-homocysteine hydrolase  ali follow..  48  2.YKIKDINLAIEGRKELDLAETEMPGLMALRKEYAGKKPLAGARIMGSLHMTVQTAILIETLVDLGADVWVSCNIFSTQDNAAAAVNPQGVPVFAWKGESLEEYWENTAREWGVFLATCRKIFEKDPKQWTRAREALKGVSEETTTGVHRLYQMAQAKRLKFPAINVNDSVTKSKFDNLYGCRINRATDVMMAGKIAVVCGYGDVGKGCAQSLRGQGARVIITEIDPICALQAAMEGYEVKTLDEVVSYADIFVTTTGNTGIISAAQMEKMKNRAIVGNIGHFDNEIDMAGLKKIPIKRNEIKPQYDEWIFADGHSILVLAEGRLLNLGCATGHPSFVMSASFTNQTIAQIDLWLNAKYESGVVYTLPKILDEKVARLHLEKLGVHLTRLTQAQADYIGVPVEGPYKADHYR. 484
2 -44.600PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  60  2...................................................................................................................................................................LYGCRESLID---------GIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQACMDGYQIVTMETAAPLSNIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNANA-KKDTVKPQVDRYTLANGVHIILLAEGRLVNLGCGTG................................................................................ 161
3 -14.300PF07991.12; ILVC_METAC/15-178; Acetohydroxy acid isomeroreductase, NADPH-binding domain  ali follow..  19  1...............................................................................................................................................................................................LKDKTIAIMGYGSQGHAHARNLHESGLNVVVGLRKGSSSWAAESDGLKVMTVEEAAKAADVIMILLPDESVYYSQIEPSLEAGNALVFAHGF.................................................................................................................................. 96
4 -12.200PF02826.19; Q98GE4_RHILO/107-283; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain  ali follow..  20  32...........................................................................................................................................................................................ANIELAGKTIGIVGLGAVGQAVGHAAHGFDLKVVATT----RSMQPAPEKVGFLSIDALVEQSDIIVLCCETRGLISRERIARMKPNALLINVSRGPV-VDDDALIEALREGRIGGAALDVFS....................................................................................................... 154
5 -11.800PF00389.30; Q9KCG9_BACHD/20-325; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain  ali follow..  14  3.................................................................................VSDAMSEQGLSPLLNDPRVEVADADDLHEYDALLVRSATTVTEELMEKMSSLK-----IIARAGVGVDNI-DIDAATKHGIVVVNAPDGNTISTAEHTFAMICSLLQGTELRGKTLGIIGFGRIGSQIAKRAKAFEMTPYVFDP--LTKARAEKLGVTVASLDDVLQVADIITVTKETKGLLGMKNIGKTKKGVFLINCARGGI-IDEEALKHYLREGHIAGAALDVFEEEPVADEELLA-----NVIATPHIAASTKEAQLNVAEQVSQEVLH.......................................................... 294
6 -10.800PF13241.6; Q2FTK6_METHJ/4-113; Putative NAD(P)-binding  ali follow..  16  5...............................................................................................................................................................................................FTGKKVIIFGGGVIGARKARYFAY-EADVLVYSRSFHPEFQEIPVRTEVCEILRNMIHDASLVIAATSDPELNELIESACAREHIWCNVAAGK................................................................................................................................. 102
7 -10.600PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain  ali follow..  19  15....................................................................................................................................................................................GRGVLPGGVPGVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIF-NAFELEKACLEADLVIGAVKAPKLVTNELVSRMKPGSVLVDIA.................................................................................................................................... 128
8 -10.300PF02882.19; FOLD1_ARATH/184-349; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain  ali follow..  25  28.......................................................................................................................................................................................LLIRTGVEIAGKNAVVIGRSNVGLPMSLLLQRHDATVSTVHA-------------FTKDPEHITRKADIVIAAAGIPNLVRGS---WLKPGAVVIDVGTTPVE............................................................................................................................... 115
9 -10.100PF02254.18; Q92CZ9_LISMO/5-120; TrkA-N domain  ali follow..  11  1....................................................................................................................................................................................................FAVIGLGRFGGSICRSLVEQGMEVLAIDSDEERVNEYMSIATHAVIANSTIRNFEHVIVAIGESSILTTLILKEMGVKYVTAKATNDKHA............................................................................................................................... 102
10 -9.960PF06690.11; D7DUD4_METV3/2-259; Protein of unknown function (DUF1188 topsan)  ali follow..  10  1................................................................................................................................................KYGITENVKTIESKVKVRDIIKKIAEKKANAIKYYLEGE---------EFEQAIIFGAYLSGNYIANTLKADCGEVILIDSQPIKFMDLNTFMLKLRNNKDKEINPD-LIIDVTGLGGVDPNMLKDFDPKVLIIEDPKS.................................................................................................................................. 139
11 -9.020PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  11  1...................................................................................................................................................................................................QIGVVGLAVMGSNLARNFARNGHTVAVYNRSTDKTDKLISDY-TVEDFVAALEKPRRAIVMVQAGAATDAQLADAMEEGDIIIDGGNALYTDTVCREKEMAARGRHVGAGISGGEEGALNGPSIMPGGPKESW..................................................................................... 146

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.