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Query: [E] COG0169 Shikimate 5-dehydrogenase, from VFDB

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASQIDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEGALLast
1 -65.100d1nyta1 c.2.1.7 (A:102-271) Shikimate 5-dehydrogenase AroE {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  44  1.........................................................................................................DGVGLLSDLERLSFIRPGLRILLIGAGGASRGVLLPLLSLDC-AVTITNRTVSRAEELAKLFAHTGSIQALSMDELGHEFDLIINATSSGISGDIPAIPSSLIHPGIYCYDMFYQKGKTPFLAWCEQRGSKRNADGLGMLVAQAAHAFLLWHGVLPDVEPVIKQLQEELS... 170
2 -60.500d2egga2 c.2.1.7 (A:123-297) Shikimate 5-dehydrogenase AroE {Geobacillus kaustophilus [TaxId: 1462]}  ali model 3D-neighbors follow..  31  1.........................................................................................................DGLGYVQALEEENITLDGKRILVIGAGGGARGIYFSLLSTAAERIDMANRTVEKAERLVREGDERRSFSLAEAETRLAEYDIIINTTSVGMHPEVQPLSLERLRPGVIVSDIIYNPLETKWLKEAKARGA-RVQNGVGMLVYQGALAFEKWTGQWPDVNRMKQLVIEALRR.. 175
3 -58.100d3dona2 c.2.1.7 (A:100-269) Shikimate 5-dehydrogenase AroE {Staphylococcus epidermidis [TaxId: 176279]}  ali model 3D-neighbors follow..  30  1.........................................................................................................DGIGYVNGLKQIYEGIEDAYILILGAGGASKGIANELYKIVRPTLTVANRTMSRFNNWSLNINK---INLSHAESHLDEFDIIINTTPAGMNGNTSVISLNRLASHTLVSDIVYNPYKTPILIEAEQRGN-PIYNGLDMFVHQGAESFKIWTNLEPDIKAMKNIVIQKLKGEL 170
4 -56.400d1npya1 c.2.1.7 (A:103-269) Shikimate 5-dehydrogenase-like protein HI0607 {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  23  1.........................................................................................................DYIAIVKLIEK-YHLNKNAKVIVHGSGGMAKAVVAAFKNSGFEKLKIYARNVKTGQYLAALYGYAY-------SLENQQADILVNVTSIGMKGGKLAFPKAFIDNASVAFDVVAMPVETPFIRYAQARGK-QTISGAAVIVLQAVEQFELYTHQRPSDELIAEAAAFART... 167
5 -55.800d3tnla2 c.2.1.0 (A:113-291) automated matches {Listeria monocytogenes [TaxId: 169963]}  ali model 3D-neighbors follow..  21  1.........................................................................................................DGTGYMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIFNRKDDFYANAEKTVEKINSEDHEQLRKEIAESVIFTNATGVGMKPETLLPSADMLRPELIVSDVVYKPTKTRLLEIAEEQGC-QTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEIL........ 178
6 -55.100d5dzsa2 c.2.1.0 (A:101-269) automated matches {Peptoclostridium difficile [TaxId: 272563]}  ali model 3D-neighbors follow..  21  1.........................................................................................................DYFGLDSMFKMANIDVQGKVAVILGTGGASKAALTYFIDSGIEKLYVSTRKKDDKKLLNSKAILID-------ELKHIKGDIILNATPVGMYPGISPVSKSIIQNFDILIDLIYNPGETEFLRIGNSMGK-KTCDGLYMLVGQAIKSQEIWQDTKIDNSILDVIYNELKLEFL 169
7 -54.500d2hk8a2 c.2.1.7 (A:106-266) Shikimate 5-dehydrogenase AroE {Aquifex aeolicus [TaxId: 63363]}  ali model 3D-neighbors follow..  29  1.........................................................................................................DWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGA-KVFLWNRTKEKAIKLAQKFPLEV---VNSPEEVIDKVQVIVNTTSVGLKDEPEIFNYDLIKKDHVVVDIIYKE--TKLLKKAKEKGA-KLLDGLPMLLWQGIEAFKIWNGCEVPYSVAERSVRD...... 161
8 -54.400d1nyta2 c.58.1.5 (A:1-101) Shikimate 5-dehydrogenase AroE {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  59  1....METYAVFGNPIAHSKSPFIHQQFAQQLNIEHPYGRVLAPINDFINTLNAFFSAGGKGANVTVPFKEEAFARADELTERAALAGAVNTLMRLEDGRLLGDNT............................................................................................................................................................................. 101
9 -50.500d3tnla1 c.58.1.0 (A:4-112) automated matches {Listeria monocytogenes [TaxId: 169963]}  ali model 3D-neighbors follow..  30  6ITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQGFRAMNLRGWNVSMPNKTNIHKYLDKLSPAAELVGAVNTVVN-DDGVLTGHIT............................................................................................................................................................................. 109
10 -50.000d3phha2 c.2.1.0 (A:105-263) automated matches {Helicobacter pylori [TaxId: 85962]}  ali model 3D-neighbors follow..  28  1.........................................................................................................DALGFYLSLKQ----KNYQNALILGAGGSAKALACELKKQGL-QVSVLNRSSRGLDFFQRLGCDCFM------EPPKSAFDLIINATSASLHNENKEVLKGYFKEGKLAYDLAYGF-LTPFLSLAKELKT-PFQDGKDMLIYQAALSFEKFSASQIPYSKAFEVMRSVF.... 159
11 -49.000d5dzsa1 c.58.1.0 (A:1-100) automated matches {Peptoclostridium difficile [TaxId: 272563]}  ali model 3D-neighbors follow..  27  1....MNFFGLVGEKLSHSVSPQIHKRVFEILNIESAYKNFEISKEDISKLDGAIKLLGIQGVNVTVPYKERIMKYLDFISPEAKRIGAVNTILL-RENMLYGYNT............................................................................................................................................................................. 100
12 -42.400d1npya2 c.58.1.5 (A:1-102) Shikimate 5-dehydrogenase-like protein HI0607 {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  27  2INKDTQLMSLSGRP--SNFGTTFHNYLYDKLGLNFIYKAFTT--QDIEHAIKGVRALGIRGCAVSMPFKETCMPFLDEIHPSAQAIESVNTIVN-DNGFLRAYNT............................................................................................................................................................................. 102
13 -16.600d1gpja2 c.2.1.7 (A:144-302) Glutamyl tRNA-reductase middle domain {Methanopyrus kandleri [TaxId: 2320]}  ali model 3D-neighbors follow..  24  12..............................................................................................................VELAERELGSLHDKTVLVVGAGEMGKTVAKSLVDRGVRAVLVANRTYERAVELARDLGGEA-VRFDELVDHLARSDVVVSATAIHVDDVREALRKRDRRSPILIIDI............................................................. 122
14 -14.800d1e5qa1 c.2.1.3 (A:2-124,A:392-450) Saccharopine reductase {Fungus (Magnaporthe grisea) [TaxId: 148305]}  ali model 3D-neighbors follow..  16  1.........................................................................................................................ATKSVLMLGSGFVTRPTLDVLTDSG--KVTVACRTLESAKKLSAGVQHSTPISLAALDAEVAKHDLVISLIPYTFH---ATVIKSAIRQKKHVVTTSYVSPAMMELDQAAKDAGITVMNEIGX.................................. 124
15 -12.400d5bsea1 c.2.1.0 (A:3-169) automated matches {Medicago truncatula [TaxId: 3880]}  ali model 3D-neighbors follow..  13  4......................................................................................................................IPADSYTLGFIGAGKMAESIAKGAVRSGPSRIKTAIHSNPARRTAFESIGITV---LSSNDDVVRDSNVVVFSVKPQLLKDVVLKLKPLLTKDKLLVSVAAGIKMKDLQEWAGHERFIRVMPNTAATVGEAASVMSLGGAATEEDANLISQLFGSIGKIW 163
16 -12.000d1xc2a3 c.2.1.6 (A:1-152) Pyrroline-5-carboxylate reductase ProC {Neisseria meningitidis, serogroup B [TaxId: 487]}  ali model 3D-neighbors follow..  14  2............................................................................................................................NVYFLGGGNMAAAVAGGLVKQGGYRIYIANRGAEKRERLEKELG----VETSATLPELHSDDVLI----LAVKPQDMEAACKNIRTNGALVLSVAAGLSVGTLSRGGTRRIVRVMPNTPGKIGLGVSGMYAEAEVSETDRRIADRIMKSVGLTV 149
17 -11.600d1luaa1 c.2.1.7 (A:98-288) Methylene-tetrahydromethanopterin dehydrogenase {Methylobacterium extorquens [TaxId: 408]}  ali model 3D-neighbors follow..  15  1.....................................................................................................GSNTTAAAGVALVVKAGGSVKGKKAVVLAGGPVGMRSAALLAGEGA-EVVLCGRKLDKAQAAADSVNKRFKVNVASRAEAVKGAHFVFTAGAIGL.................................................................................. 104
18 -10.700d2ahra2 c.2.1.6 (A:1-152) Pyrroline-5-carboxylate reductase ProC {Streptococcus pyogenes [TaxId: 1314]}  ali model 3D-neighbors follow..  13  2............................................................................................................................KIGIIGVGKMASAIIKGLKQTP-HELIISGSSLERSKEIAEQLALPY---AMSHQDLIDQVDLVI----LGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATFGQDLPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRDLTDSFGSTF 148
19 -10.400d3tria1 c.2.1.0 (A:2-162) automated matches {Coxiella burnetii [TaxId: 777]}  ali model 3D-neighbors follow..  15  1.........................................................................................................................NTSNITFIGGGNMARNIVVGLIANGPNRICVTNRSLDKLDFFKEKCGVHT---TQDNRQGALNADVVVLAVPHQIKMVCEELKDILSETKILVISLAVGVTTPLIEKWGKASRIVRAMPNTPSSVRAGATGLFANETVDKDQKNLAESIMRAVGLVI 158
20 -10.300d4ypoa1 c.2.1.0 (A:1-180) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  14  12........................................................................................................................IQGRKVGVIGYGSQGHAHSLSLRDSGV-QVRVGLKQGSRSRPKVEE----QGLDVDTPAEVAKWADVVMVLAP..................................................................................... 79
21 -10.000d1vl6a1 c.2.1.7 (A:155-376) Malate oxidoreductase (malic enzyme) {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  14  11...........................................................................................................AAFLNALKLTEKKIEEVKVVVNGIGAAGYNIVKFLLDLGVKNVVAVDRKGILNENDPET-ITNPERLSGDLETALEGADFFIGVSRGNILKPEW---IKKMSRKPVIFALA-NPVPEIDPELAREAGAFIVATGRSDHPNQVNNLL-IMKGAVEKRSKITKNMLLSAVEAI 190
22 -9.700d1omoa_ c.2.1.13 (A:) Archaeal alanine dehydrogenase {Archaeoglobus fulgidus [TaxId: 2234]}  ali model 3D-neighbors follow..  12  78.................................................................LPTVMALMILNSPETGFPLAVMDATYTTSLRTGAAGGIAAKYLA----------RKNSSVFGFIGCGTQAYFQLEALRRFDIGEVKAYDVREKAAKKFVSYCEDRGISASVQPAEEASRCDVLVTTTPSADGPGKQELDVEILKKAKIVVDDLEQAKHGGEINVAVSKGVEDVHATIGEVI................................ 272
23 -9.200d2izza1 c.2.1.0 (A:1-164) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  11  2............................................................................................................................SVGFIGAGQLAFALAKGFTAAGAHKIMASSPDMDLATVSAL--RKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCT 160
24 -9.180d3guya1 c.2.1.0 (A:2-220) automated matches {Vibrio parahaemolyticus [TaxId: 419109]}  ali model 3D-neighbors follow..  14  1.............................................................................................................................IVITGASGLGAELAKLYDAEG-KATYLTGRSESKLSTVTNCLSNNVGYRARDLEQLDSIPSTVVHSAGSGYFGLLQEQDPEQIQT-LIENNLSSAINVLRELVKRYKDQPVNVVMIMSTAAQQPKAQESTYCAVKWAVKGLIESVRLELKGK. 161
25 -9.160d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  13  1......................................................................................................DNLYGCRIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGA-RVIITEIDPINALQAAME-----GYEVTTMDEACQEGNIFVTTTGCIDIILGRHF--EQMKDDAIVCNIGHFDVEIDV.................................................... 119
26 -9.100d2qq5a_ c.2.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  2.......................................................................................................................PMNGQVCVVTGASGIGRGIALQLCKAGA-TVYITGRHLDTLRVVAQEAQSLGSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPG-VPYGVGKAACDKLAADCAHELRR.. 181
27 -9.050d1bg6a2 c.2.1.6 (A:4-187) N-(1-D-carboxylethyl)-L-norvaline dehydrogenase {Arthrobacter, strain 1c [TaxId: 1663]}  ali model 3D-neighbors follow..  12  1..........................................................................................................................SKTYAVLGLGNGGHAFAAYLALKG-QSVLAWDIDAQRIKEIQDAGTAHPDLLTSDIGLAVKDADVILIVVPAIHHASIAANIASYISEGQLII............................................................... 103
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.