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Query: [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair, from VFDB

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARKFGVRSAMPTGMALKLCPHLTLLPGRFDAYKEASNHIREIFSRYTSRIEPLSLDEAYLDVTDSVHCHGSATLIAQEIRQTIFNELQLTASAGVAPVKFLAKIASDMNKPNGQFVITPAEVPAFLQTLPLAKIPGVGKVSAAKLEAMGLRTCGDVQKCDLVMLLKRFGKFGRILWERSQGIDERDVNSERLRKSVGVERTMAEDIHHWSECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFDDFQQTTQEHVWPRLNKADLIATARKTWDERRGGRGVRLVGLHVTLLDPQMERQLVLGLLast
1 -97.500d1jx4a2 e.8.1.7 (A:1-240) DinB homolog (DBH) {Sulfolobus solfataricus, DNA polymerase IV [TaxId: 2287]}  ali model 3D-neighbors follow..  33  2..IVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGDSGAVATANYEARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGINKLVDTLSIEFDKLKGMIGEKAKYLISLARDEYNEPIRTR.................................................................................................................. 240
2 -93.500d3gv7b1 e.8.1.7 (B:26-299) DNA polymerase iota {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  35  3.RVIVHVDLDCFYAQVEMISNPELKDKPLGVQ----QKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVERLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGSVAQRIQKLSFGEDNSPVILSGP................................................................................................................ 273
3 -84.500d1t94a2 e.8.1.7 (A:75-407) DNA polymerase kappa {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  42  27.NTIVHIDMDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSTSWHYFLHISLGLGSTHL..................................................................................................................... 333
4 -69.700d1jiha2 e.8.1.7 (A:1-389) DNA polymerase eta {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  23  24.ACIAHIDMNAFFAQVEQMRCGLSKEDPVVCV----QWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIKVSLEPYRRESRKALKIFKSACDLVERASIDEVFLDLGRICFILALGSQVCKGIRDSIKDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDKFEITSFWTLGGVLGKELDVLDLPHENSIKHIRAGQLKEFLDDLAEKLFKLSRGRYGLPLSSR.................................................................................................................. 389
5 -43.300d1unnc1 d.240.1.1 (C:243-351) DNA polymerase IV {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  100  1..................................................................................................................................................................................................................................................VGVERTMAEDIHHWSECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFDDFQQTTQEHVWPRLNKADLIATARKTWDERRGGRGVRLVGLHVTLLDPQMERQLVLGL 109
6 -32.100d1t94a1 d.240.1.1 (A:411-515) DNA polymerase kappa {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  25  2..............................................................................................................................................................................................................................................ERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQ--KERLKGRTVTIKLKNVNFEVKTRASTVVVSTAEEIFAIAKELLKTEIDPLRLRLMGVRISS............. 105
7 -31.400d1jx4a1 d.240.1.1 (A:241-341) DinB homolog (DBH) {Sulfolobus solfataricus, DNA polymerase IV [TaxId: 2287]}  ali model 3D-neighbors follow..  16  2...............................................................................................................................................................................................................................................RKSIGRIVTMKRNSRNLEEIKPYLFRAIEESYYKLDKRI----PKAIHVVAVTEDLDIVSRGRTFGISKETAYSESVKLLQKILEEERKIRRIGVRFSKF............ 100
8 -24.700d3gv7b2 d.240.1.1 (B:300-414) DNA polymerase iota {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  12  1................................................................................................................................................................................................................................................QSFSEEDSF-KKCSSEVEAKNKIEELLASLLNRVC--QDGRKPHTVRLIIRRYSYGRESRQCPIPYDVMTPMVDILMKLFRNMVNVKHLTLLSVCFCNLK........... 115
9 -21.400d1jiha1 d.240.1.1 (A:390-509) DNA polymerase eta {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  12  4................................................................................................................................................................................................................................................KSMMSNKNLGKSCNSIVDCISWLEVFCAELTSRIQDLNKIVIPRTVSISLKTKSYEVYRKSGPVAYKGSHELLKVGIKFVTDLDIKGPLTKLSMTITNFDI.......... 119
10 -9.590d3ldaa1 a.60.4.1 (A:78-144) DNA repair protein Rad51, N-terminal domain {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  21  1..........................................................................................................................................................................GSFVPIEKLQVNGITMADVKKLRESGLHTAEAVAYAPRKDLLEIKG....................................................................................................................................... 46
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Igarashi Y, Eroshkin A, Gramatikova S, Gramatikoff K, Zhang Y, Smith JW,Osterman AL, Godzik A. CutDB: a proteolytic event database. Nucleic Acids Res. 2007 Jan;35(Database issue):D546-9. Epub 2006 Nov 16.