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Query: [K] COG1709 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVNINMFEKEKEILAKRIAGEIVLSPDPGKTMRKWREIFGISQTELADYLGVSSSVISDYEGGRRKSPGASTIRKFVEALIEIDEKRGGNVIKAFSRTFSSEIPTSAILDIREFDIPVTVKDIVDAVKGEIVANPDLIDRKIYGYTVVDSIQAILEMSAEEFLKLYGWTTERALVFTKVTTGRSPMIAVRVQGLKPAMVVLHGVKRLDELAVKIAEKERVPLVVSKAENETELITGLRRLVTSILast
1 -29.600d2bnma1 a.35.1.3 (A:5-76) Hydroxypropylphosphonic acid epoxidase Fom4, N-terminal domain {Streptomyces wedmorensis [TaxId: 43759]}  ali model 3D-neighbors follow..  15  2......................TASTGFAELLKDRREQVKMDHAALASLLGETPETVAAWENGEGGELTLTQLGRIAHVLTSIGALTPPAG......................................................................................................................................................... 71
2 -25.200d1x57a1 a.35.1.12 (A:8-85) Endothelial differentiation-related factor 1, EDF1 {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  28  3.......................VTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESG-RAIPNNQVLGKIERAILKLRGKDIGKPIEK...................................................................................................................................................... 73
3 -24.700d1r69a_ a.35.1.2 (A:) 434 C1 repressor, DNA-binding domain {Bacteriophage 434 [TaxId: 10712]}  ali model 3D-neighbors follow..  22  1..........................SISSRVKSKRIQLGLNQAELAQKVGTTQQSIEQLENGKT--KRPRFLPELASALVSVDWLLNGT.......................................................................................................................................................... 63
4 -24.700d2ofya1 a.35.1.3 (A:3-84) Putative transcriptional regulator RHA1_ro04071 {Rhodococcus sp. RHA1 [TaxId: 101510]}  ali model 3D-neighbors follow..  24  8....................ELERGQRLGELLRSAR--GDMSMVTVAFDAGISVETLRKIETGRIATPAFFTIAAVARVLLSLDDVA............................................................................................................................................................. 73
5 -24.400d3jxbc_ a.35.1.2 (C:) P22 C2 repressor, DNA-binding domain {Salmonella bacteriophage P22 [TaxId: 10754]}  ali model 3D-neighbors follow..  25  2........................TQLMGERIRARRKKLKIRQAALGKMVGVSNVAISQWERS-ETEPNGENLLALSKALCSPDYLLKGD.......................................................................................................................................................... 67
6 -24.000d2xi8a_ a.35.1.3 (A:) Putative transcription regulator CylR2 {Enterococcus faecalis [TaxId: 1351]}  ali model 3D-neighbors follow..  25  2...........................IINNLKLIREKKKISQSELAALLEVSRQTINGIEKNKYN-PSLQLALKIAYYLTPLEDIFQWQP......................................................................................................................................................... 65
7 -24.000d1y9qa1 a.35.1.8 (A:4-82) Probable transcriptional regulator VC1968, N-terminal domain {Vibrio cholerae [TaxId: 666]}  ali model 3D-neighbors follow..  21  1...................TDVMFKSQIANQLKNLRKSRGLSLDATAQLTGVSKAMLGQIERGESS-PTIATLWKIASGL.................................................................................................................................................................... 60
8 -23.800d1b0na2 a.35.1.3 (A:1-68) SinR repressor, DNA-binding domain {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  28  2...........................IGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSIQFLEKVSAVL.................................................................................................................................................................... 54
9 -23.500d3f52a_ a.35.1.0 (A:) automated matches {Corynebacterium glutamicum [TaxId: 1718]}  ali model 3D-neighbors follow..  28  1....................EPLLREALGAALRSFRADKGVTLRELAEASRVSPGYLSELERGRKE-VSSELLASVCHAL.................................................................................................................................................................... 59
10 -22.900d3vk0a_ a.35.1.0 (A:) automated matches {Neisseria meningitidis [TaxId: 122586]}  ali model 3D-neighbors follow..  31  1..........KLTLPAELPDEQDLRAVLAYNMRLFRVNKGWSQEELARQCGLDRTYVSAVERKRWN-IALSNIEKMAAAL.................................................................................................................................................................... 69
11 -22.500d4i6ra_ a.35.1.0 (A:) automated matches {Enterobacter sp. [TaxId: 211595]}  ali model 3D-neighbors follow..  21  3.......................LLSKVSFVIKKIRLEKGMTQEDLAYKSNLDRTYISGIERNSRN-LTIKSLELIMKGL.................................................................................................................................................................... 58
12 -22.300d1s4ka1 a.35.1.6 (A:1-119) Putative cytoplasmic protein YdiL {Salmonella typhimurium [TaxId: 90371]}  ali model 3D-neighbors follow..  16  4............................ALELQALRRIFDMTIEECTIYITNNSATWQRWEAGDIPISP-EIIARLKEMKARRQRRI............................................................................................................................................................. 63
13 -21.600d2auwa1 a.35.1.10 (A:88-154) Hypothetical protein NE0471 C-terminal domain {Nitrosomonas europaea [TaxId: 915]}  ali model 3D-neighbors follow..  21  3............................HEMFGDWMHRNNLSLTTAAEALGISRRMVSYYRTAHKIIPRTIWLA.......................................................................................................................................................................... 48
14 -21.500d1y7ya1 a.35.1.3 (A:5-73) Restriction-modification controller protein C.AhdI {Aeromonas hydrophila [TaxId: 644]}  ali model 3D-neighbors follow..  27  1..................HDHYADLVKFGQRLRELRTAKGLSQETLAFLSGLDRSYVGGVERGQRN-VSLVNILKLATAL.................................................................................................................................................................... 61
15 -21.100d3kz3a_ a.35.1.2 (A:) lambda C1 repressor, DNA-binding domain {Bacteriophage lambda [TaxId: 10710]}  ali model 3D-neighbors follow..  16  6....................QLEDARRLKAIWEKKKNELGLSYESVADKMGMGQSAVAALFNGINA-LNAYNAALLAKIL.................................................................................................................................................................... 64
16 -21.000d1dw9a1 a.35.1.4 (A:1-86) Cyanase N-terminal domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  17  11........................RLDLADAILLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQA-LPADAARLVGAKLLDEDSIL............................................................................................................................................................. 73
17 -18.700d2o38a1 a.35.1.13 (A:28-116) Hypothetical protein RPA3824 {Rhodopseudomonas palustris [TaxId: 1076]}  ali model 3D-neighbors follow..  16  3..................AEERQTKLRLAYALNAVIDRARLSQAAAAARLGINQPKVSALRNYKLEGFSVERLMTLLNAL.................................................................................................................................................................... 64
18 -18.600d2awia1 a.35.1.11 (A:2-66) PrgX {Enterococcus faecalis [TaxId: 1351]}  ali model 3D-neighbors follow..  22  2..........................KIGSVLKQIRQELNYHQIDLYSGI-MSKSVYIKVEADSRP-ISVEELSKFSERLVNFFEILNRA.......................................................................................................................................................... 64
19 -17.100d2a6ca1 a.35.1.13 (A:1-69) HTH-motif protein NE1354 {Nitrosomonas europaea [TaxId: 915]}  ali model 3D-neighbors follow..  15  1.....................MKMRSQLLIVLQEHLRNSGLTQFKAAELLGVTQPRVSDLMRGKIDLFSLESLIDMITSI.................................................................................................................................................................... 59
20 -15.700d2ppxa1 a.35.1.3 (A:30-91) Uncharacterized protein Atu1735 {Agrobacterium tumefaciens [TaxId: 358]}  ali model 3D-neighbors follow..  17  2.............................PRIKIIRRALKLTQEEFSARYHIPLGTLRDWEQGRSE-PDQPARAYLK....................................................................................................................................................................... 48
21 -14.100d1ic8a2 a.35.1.1 (A:87-180) Hepatocyte nuclear factor 1a (LFB1/HNF1) {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  26........................PWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPM-KTQKRAALYTWYVR.................................................................................................................................................................. 82
22 -12.400d2icta_ a.35.1.3 (A:) Antitoxin HigA {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  15  10............................GDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAAL-TPEMAIKLSVVI.................................................................................................................................................................... 60
23 -12.400d4mcxa_ a.35.1.3 (A:) Antitoxin HigA {Proteus vulgaris [TaxId: 585]}  ali model 3D-neighbors follow..  22  10............................GEMIARDLEDMGVSGRRFAHNIGVTPATVSRLLAGKTAL-TPSLSIRIAAALGSTPEFWLRLQSNYDLRQLENQIDTSGIVLYGE................................................................................................................................... 93
24 -10.500d2ebya_ a.35.1.0 (A:) automated matches {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  19  6............................GDILLYYLEPLDLKINELAELLHVHRNSVSALINNNRKL-TTEMAFRLAKVF.................................................................................................................................................................... 57
25 -9.100d1e3oc2 a.35.1.1 (C:1-75) Oct-1 {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  20  5....................DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGFSQTTISRFEALNLSFKNMSKLKPLLE...................................................................................................................................................................... 68
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Damiano JS, Stehlik C, Pio F, Godzik A., Reed JC. CLAN, a novel human CED-4-like gene. Genomics. 2001 Jul;75(1-3):77-83.