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Query: [K] COG2378 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPTDNVVSVVSPYHMEMYNMRKASRLFEIIQILRLARRPVTAQTIADMLEVTARSVYRDIAALQTMRVPIEGERGVGYILRPGFNLPPLMFSIEETEAIVLALAMVDRSGDAELRQAAKKVSDKIAASLPEPLSKTLSANALHAWGSIAPAPAGIDLATVRRAVRDEERLDLCYSDESGVETQRRIRPIAVIYYSETVNIVAWCELRHAIRNFRSDRVLDCAATGSFFKMEGEKLRRLWMSGWQSGQPGGELGRPISGVTLPLast
1 -28.400d1j5ya1 a.4.5.1 (A:3-67) Putative transcriptional regulator TM1602, N-terminal domain {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  29  2..................KTVRQERLKSIVRILERSKEPVSGAQLAEELSVSRQVIVQDIAYLRSLGYNIVATPR-GYVLAGG................................................................................................................................................................................... 65
2 -24.700d1biaa1 a.4.5.1 (A:1-63) Biotin repressor, N-terminal domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  17  1...................MKDNTVPLKLIALLANGE--HSGEQLGETLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPE.................................................................................................................................................................................... 62
3 -21.300d1p41a1 a.4.5.40 (A:2-74) N-terminal domain of Bacillus PurR {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  15  1..................KFRRSGRLVDLTNYLLTHHELIPLTFFSERYESAKSSISEDLQTFEQQGITLLTVPGGGVKYIP.................................................................................................................................................................................... 72
4 -12.800d1jmrb3 a.4.5.33 (B:1-75) Transcriptional regulator IclR, N-terminal domain {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  16  1...................MNTLKKAFEILDFIVKNPGDVSVSEIAEKFNMSVSNAYKYMVVLEEKGF-VLRKKDKRYVP...................................................................................................................................................................................... 60
5 -12.500d3k69a_ a.4.5.0 (A:) automated matches {Lactobacillus plantarum [TaxId: 1590]}  ali model 3D-neighbors follow..  8  9.........................VHSILYLDAHRDSKVASRELAQSLHLNPVMIRNILSVLHKHGY-LTGTVGGGYQLDL----ALADMNLGDLYDLTIPPTISEQADQSPIAANISETLTDLFTVADRQYRAYYHQFTMA....................................................................................................................... 135
6 -12.500d1ylfa1 a.4.5.55 (A:5-142) Hypothetical protein BC1842 {Bacillus cereus [TaxId: 1396]}  ali model 3D-neighbors follow..  11  10.........................VHILSILKNNPSSLCTSDYMAESVNTNPVVIRKIMSYLKQAGF-VYVNRGGGAGLLHEITLLDVYHAVNVVEEDKLFHIHEQPNPDCPIGANIQAVLEIILIQAQSAMEEVLRNITMG....................................................................................................................... 130
7 -12.000d2d1ha1 a.4.5.50 (A:1-109) Hypothetical transcriptional regulator ST1889 {Sulfolobus tokodaii [TaxId: 111955]}  ali model 3D-neighbors follow..  14  25...........................AVLLKMVEIEKPITSEELADIFKLSKTTVENSLKKLIELGL.................................................................................................................................................................................................. 65
8 -11.600d2dt5a1 a.4.5.38 (A:2-77) Transcriptional repressor Rex, N-terminal domain {Thermus aquaticus [TaxId: 271]}  ali model 3D-neighbors follow..  18  1.............KVPEAAISRLITYLRILEELAQGVHRTSSEQLGGLAQVTAFQVRKDLSYFGSYG-----TRGVGYTVPV.................................................................................................................................................................................... 65
9 -11.400d3keoa1 a.4.5.0 (A:6-81) automated matches {Streptococcus agalactiae [TaxId: 216495]}  ali model 3D-neighbors follow..  20  1.............SIPKATAKRLSLYYRIFKRFTDGIEKASSKQIADALGIDSATVRRDFSYFGELG-----RRGFGYDVKK.................................................................................................................................................................................... 65
10 -11.000d2htja1 a.4.5.73 (A:1-73) P fimbrial regulatory protein PapI {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  20  4...........................EILEFLN-RHNGGKTAEIAEALAVTDYQARYYLLLLEKAGMVQRSPLRRG......................................................................................................................................................................................... 52
11 -10.800d1v4ra1 a.4.5.6 (A:1-100) Transcriptional repressor TraR, N-terminal domain {Streptomyces sp. [TaxId: 1931]}  ali model 3D-neighbors follow..  18  27................................LAPGDTLPSVADIRAQFGVAAKTVSRALAVLKSEGL-VSSRGALGTVVEK.................................................................................................................................................................................... 75
12 -10.700d5nl9a1 a.4.5.0 (A:1-145) automated matches {Leptospira interrogans [TaxId: 267671]}  ali model 3D-neighbors follow..  11  12..............LEDAGINVTVQRLQMANLLLSKPQHLTADQVFQLINASRATIFNNLKLFAEKGIVNLLELKSGITLYDSNVIHHHHAIDEKTGEIY.................................................................................................................................................................. 102
13 -10.700d3mwma_ a.4.5.0 (A:) automated matches {Streptomyces coelicolor [TaxId: 1902]}  ali model 3D-neighbors follow..  22  2....................RATRQRAAVSAALQEVEEFRSAQELHDMLAVGLTTVYRTLQSLADAGEVDVLRTAEG......................................................................................................................................................................................... 63
14 -10.600d4lmya_ a.4.5.0 (A:) automated matches {Streptococcus pyogenes [TaxId: 198466]}  ali model 3D-neighbors follow..  17  19.............HLREKHIRITETRKAIISYMIQSTEHPSADKIYRDLNMSLATVYNNLKVLVDEGFVSELKISND......................................................................................................................................................................................... 87
15 -10.400d4mtea_ a.4.5.0 (A:) automated matches {Escherichia coli [TaxId: 83333]}  ali model 3D-neighbors follow..  15  14..............CAQRNVRLTPQRLEVLRLMSLQDGAISAYDLLDLLQAKPPTVYRALDFLLEQGFVHKVESTNSYVLCH---------THTSAMFICDRCGAVKEECAEGVEDIMHTLAAK.......................................................................................................................................... 124
16 -10.400d2xiga_ a.4.5.0 (A:) automated matches {Helicobacter pylori [TaxId: 85962]}  ali model 3D-neighbors follow..  13  18..............IKKNGLKNSKQREEVVSVLYRSGTHLSPEEITHSINTSISSVYRILNFLEKENFISVLETSKSGRRYE------IAAKEHHDHIICLHCGKIIEFADPEIENRQNEVVKK.......................................................................................................................................... 126
17 -10.300d1sfua_ a.4.5.19 (A:) 34L {Yaba-like disease virus, YLDV [TaxId: 132475]}  ali model 3D-neighbors follow..  13  2...............TVNDAEIFSLVKKEVLSLN-TNDYTTAISLSNRLKINKKKINQQLYKLQKEDT.................................................................................................................................................................................................. 53
18 -10.300d4raya1 a.4.5.0 (A:1-134) automated matches {Magnetospirillum gryphiswaldense [TaxId: 1430440]}  ali model 3D-neighbors follow..  13  9..............CIDKGMKMTDQRRVIAQVLSDSADHPDVEEVYRRARISIATVYRTVRLFEEESILERHDFGDGRARYE------EAPSEHHDHLIDVNSARVIEFTSPEIEALQREIARK.......................................................................................................................................... 117
19 -10.200d1ulya_ a.4.5.58 (A:) Hypothetical protein PH1932 {Pyrococcus horikoshii [TaxId: 53953]}  ali model 3D-neighbors follow..  22  13................IKVMLEDTRR-KILKLLR--NKEMTISQLSEILGKTPQTIYHHIEKLKEAGL.................................................................................................................................................................................................. 61
20 -10.100d2heoa_ a.4.5.19 (A:) automated matches {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  13  6...........................KILQVLSDDGGPVAIFQLVKKCQVPKKTLNQVLYRLKKEDR-VSSPSPKYWSI...................................................................................................................................................................................... 57
21 -10.100d3bwga1 a.4.5.6 (A:5-82) Transcriptional regulator YydK {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  20  16................................LQQGDKLPVLETLMAQFEVSKSTITKSLELLEQKGA-IFQVRGSGIFVRK.................................................................................................................................................................................... 64
22 -10.100d4etsa_ a.4.5.0 (A:) automated matches {Campylobacter jejuni [TaxId: 32022]}  ali model 3D-neighbors follow..  9  16..............LRQGGLKYTKQREVLLKTLYHSDTHYTPESLYMEINVGIATVYRTLNLLEEAEMVTSISFGSAGKKYE------LANKPHHDHMICKNCGKIIEFENPIIERQQALIAKE.......................................................................................................................................... 126
23 -10.000d1qbja_ a.4.5.19 (A:) Z-alpha domain of dsRNA-specific adenosine deaminase, ADAR1 {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  3..................YQDQEQRILKFLEELG-EGKATTAHDLSGKLGTPKKEINRVLYSLAKKG................................................................................................................................................................................................... 50
24 -9.950d2fe3a_ a.4.5.0 (A:) automated matches {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  17  10..............LKETGVRITPQRHAILEYLVNSMAHPTADDIYKALNMSVATVYNNLRVFRESGLVKELTYGDA......................................................................................................................................................................................... 77
25 -9.950d1xnpa_ a.4.5.64 (A:) Transcriptional regulatory protein PF1790 {Pyrococcus furiosus [TaxId: 2261]}  ali model 3D-neighbors follow..  18  10.................DVLGNETRR-RILFLL--TKRPYFVSELSRELGVGQKAVLEHLRILEEAGL.................................................................................................................................................................................................. 57
26 -9.660d4awxb1 a.4.5.62 (B:1-79) automated matches {Klebsiella pneumoniae [TaxId: 573]}  ali model 3D-neighbors follow..  14  4.........................LMEVRDMLA-LQGRMEAKQLSARLQTPQPLIDAMLERMEAMG................................................................................................................................................................................................... 44
27 -9.510d2hr3a1 a.4.5.28 (A:2-146) Probable transcriptional regulator PA3067 {Pseudomonas aeruginosa [TaxId: 287]}  ali model 3D-neighbors follow..  11  1.PTNQDLQLAAHLRSQVTTLTRRLR-LVVLGAIDRLGGDVTPSELAAAERMRSSNLAALLRELERGGL-RVSLSSEGRRNLYGNRAKRECLDESERALLAAAGPLLTRLAQFE..................................................................................................................................................... 144
28 -9.470d2foka3 a.4.5.12 (A:287-386) Restriction endonuclease FokI, N-terminal (recognition) domain {Flavobacterium okeanokoites [TaxId: 244]}  ali model 3D-neighbors follow..  22  23........................RRALILEILI-KAGSLKIEQIQDNLDEVIETIENDIKGLINTGIFIEIKGR-FYQLKDQFVIPNRLGKPDLV...................................................................................................................................................................... 100
29 -9.460d1mzba_ a.4.5.42 (A:) Ferric uptake regulation protein, FUR {Pseudomonas aeruginosa [TaxId: 287]}  ali model 3D-neighbors follow..  16  1........MVENSELRKAGLKVTLPRVKILQMLSAEQRHMSAEDVYKALDVGLATVYRVLTQFEAAGLVVRHNFDGGHAVFE------LADSGHHDHMVCVDTGEVIEFMDAEIEKRQKEIVRE.......................................................................................................................................... 116
30 -9.070d3eyya_ a.4.5.0 (A:) automated matches {Streptomyces coelicolor [TaxId: 1902]}  ali model 3D-neighbors follow..  14  7.............DLRQRGYRLTPQRQLVLEAVDTLEH-ATPDDILGEVGINISTVYRTLELLEELGLVSHAHLGHG......................................................................................................................................................................................... 74
31 -9.040d1hw1a1 a.4.5.6 (A:5-78) Fatty acid responsive transcription factor FadR, N-terminal domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  10  9......................EEYIIESIWRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGW-LTIQHGKPTKVNN.................................................................................................................................................................................... 69
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.