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Query: [E] COG2902 NAD-specific glutamate dehydrogenase, from VFDB

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGYRNNPKREKQIEKARQQAIAENVQFLDPGILYGRASADDIEYYSAEMLAASAAHSFEALSHWTGDAPHISITTVEGVSPRDIPVTVLTIIGRNMPFLYDSVMGEVTSSYRGLYLAVHPILVRDDEAQGYRLAEPEDDPAENISLIQLHIAPLTPQAASALEERLRFVLTQVQSAYRDWRPMLTKLDEALDELSKRGSSRRKTERTEAVEFLNWLRNDNFTFLGMRDYTYSGKGKNAKIERGDGVGLGSLSDPDVRVLRLGKNAVTTTPEILAFLDGPDFLIVTKANVKSIVHRRAYMDYIGIKRFDEDGNVIGELRIVGLFTATAYTRSVKQIPLLRAKVADVERHFGFDPNSHSGRILQNTLEAYPRDDLFQIETDLLIRFIEQIMELSDRPRVRVLARIDRFDRFVSAIIFVPREEYNSYVREKIGDYLSRVYDGHISAYYPAFPEGAVARVHFIVGRTEGKTPRIAQDKLEDAVSDIAARWIDHFVALSEPGAPVLDVDQAYQEAFTPEEAIGDMPDILAAANGEPVRIEFYQQEGQSDDTLSLKIFHRDGHLPLSRRVPLLENLGFNVISERTFDIGVVSEGEKRDIVLHDMELSVAAGTTLDLPHYGPKLEEAFLAAFSGKVDNDNFNRLILACGLNVREVSVLRAYARYLRQTGIVYSQEHISETLYKYPDISRNIFALFKAGFDPSIEEKKRVKKLAEIHKAIEAALSGVPNLDEDRTLRRYVNAIDATLRTNYFQKNADGTPRDLLAFKFDPKHLDGLPDPRPFREIFVYGTEVEGVHLRFGKVARGGLRWSDRGQDYRTEVLGLVKAQQVKNAVIVPVGAKGGFFPKNLPAGGSRDEVFNAGREAYKTYIRTLLSITDNIVDDAIVPPADTLRLDGDDPYFVVAADKGTATFSDTANGLAHEAGFWLDDAFASGGSAGYDHKKMGITARGAWETVKRHFREMDTDIQTTPFTVAGVGDMSGDVFGNGMLLSEKIRLIAAFDHRDIFIDPDPDTDKSFAERKRLFELPRSSWQDYDRSTLSAGAMIISRSEKSVTLTPEAVAAIGLDKSVATPFEIMTAILKAPTDLLWFGGIGTYIKAAVETNAEVGDRANDPIRVNATELRAKVIGEGANLGITQKGRIAYALAGGRCNSDAIDNSAGVNSSDVEVNIKIALASAVNSGRLTMPKRNQLLASMTPDVAQLVLRNNYQQSLAISLTERLGLANREELGRLMGALEATGQLNRKVETLPNNAEFSERYASGKPLTRPEIGVLLSYAKLTLFDALVASPLPDEPYLQHLLLDYFPAKMQKNYANDIKAHRLHREIVATALANAVVNRGGPGFVQKLADASGLLAADVVKAAVIVEDGFGLKRLWTEVDALDGKVGGQVQNGLYATITRIFSDASRLYLQTGSAGAAAGDMATEIERLKTAIKTLSPAATKYRRELGVTEIDGVPSGLLEELDTLSLLVYVPEIMRIAESAGTTLARAAESYATVSSTFRVARLLDASQRITPADHYESLALLRSQDQISSSRRRIVISALTEYAKEKDPVQAWYAADRVRVNRIVSELGALSESGDTNLARLTVAAGLLGDIVQARLast
1 -18.100d1gtma1 c.2.1.7 (A:181-419) Glutamate dehydrogenase {Pyrococcus furiosus [TaxId: 2261]}  ali model 3D-neighbors follow..  20  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GGSLG----RIEATARGASYTIREAAKVLGWDLKGKTIAIQGYGNA-GYYLAKIMSEDFGMKVVAVSDSKGGIYNPDGLNADEVLKWKN----EHGSVKDFPGATNITNEELLELE------------------------------------------VDVLAPAAIE---------EVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFE------WVQNITGYYWTIEEVRERLDKKMTKAFYDVYNIAKEKNIHM-----RDAAYVVAVQRVYQAMLDRGWVKH................................................................................................................................................................................................................................................................................................................................................................ 239
2 -18.000d1bgva1 c.2.1.7 (A:195-449) Glutamate dehydrogenase {Clostridium symbiosum [TaxId: 1512]}  ali model 3D-neighbors follow..  15  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KARSFGGSLV----RPEATGYGSVYYVEAVMKHENDTLVGKTVALAGFGNVAWGAA--KKLAELGAKAVTLSGPDGYIYDPEGITTEEKINYML--------------------------EMRASGRNKVQDYADKFGVQFFPGEKPWGQ------------KVDIIMPCATQ-NDVDLEQAKKI-----VANNVKYYIEVANMPTTNEARFLMQQPNMVVAPSKAVNAGGVLVSGFE------MSQNSERLSWTAEEVDSKLHQVMTDIHDGSAAAAERYGLGYNL---VAGANIVGFQKIADAMMAQG.................................................................................................................................................................................................................................................................................................................................................................... 252
3 -14.600d1hwxa4 c.2.1.7 (A:209-501) Glutamate dehydrogenase {Cow (Bos taurus) [TaxId: 9913]}  ali model 3D-neighbors follow..  15  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HGRISATGRGVFHGIENFIENASYGFGDKTFAVQGFGNVGLHSM--RYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFKL----QHGTILGFPKAKIYE-----------------------------------GSILEVDCDIL--------IPAASE---------KQLTKSNAPRVKAKIIAEGANGPTTPQADKIFLERNIMVIPDLYLNAGGVTVSYFQILKN--LNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTI-------PIVPTAEFQDRISGASEKDIVHSGLAYTSARQIMRTAMKYNLGLDLRTAAYVNAIEKV............................................................................................................................................................................................................................................................................................................................. 281
4 -14.000d1c1da2 c.58.1.1 (A:1-148) Phenylalanine dehydrogenase {Rhodococcus sp., M4 [TaxId: 1831]}  ali model 3D-neighbors follow..  17  26...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VIRLDSTQLGPAAGGTRAAQNLADALTDAGKLAGAMTLKMAVLPMGGGKSVIALPAPRHSIDPST-WARILRIHAENIDKL------------------------SGNYWTGPDVNTNS--ADMDTLNDTTEFVFGRSLERGGAGS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 148
5 -13.100d1gtma2 c.58.1.1 (A:3-180) Glutamate dehydrogenase {Pyrococcus furiosus [TaxId: 2261]}  ali model 3D-neighbors follow..  15  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ADPYEIVIKQLERAAQYMEISEEALEFLKRPQRIVEVTI--KVFTGFRVQHNWATKGGIRWHPEET--LSTVKALAAWMTWKTAVLPYGGGKGGIIVDP------KKLSDREKERLARGYIRAIYDVISPYED-------------------IPAPDVYTNPMAWMMDEYETISRRKTPAGIITGKPLSI............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 178
6 -13.100d3vpxa1 c.58.1.0 (A:1-133) automated matches {Sporosarcina psychrophila [TaxId: 1476]}  ali model 3D-neighbors follow..  21  28...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IIAIHDTTLGPALGGTRMWTSEEEAIEDALRLARGMTYKNAALNLGGGKTVIIGNP------KTDKNDEMFRAFGRYIEGL------------------------NGRYITAEDVGTTE........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 120
7 -12.500d1bgva2 c.58.1.1 (A:1-194) Glutamate dehydrogenase {Clostridium symbiosum [TaxId: 1512]}  ali model 3D-neighbors follow..  15  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKYVDRVIAEVEKKYADEPEFVQTVEEVLSSLGPVVDAHPEYEEVALLERMVI--ERVIEFRVPWEDDNGKVHVNTGYRVQ--------------------------FNGAIGPYKGGLRFAPSVN--LSIMKFLGFEQAFKDSLLPMGGAKGGSDFDP------NGKSDREVMRFCQAFMTELYRHIGPDID-------------------VPAGDLGVAREIGYMYGQYRKIVGGFYNGVLTG.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 194
8 -11.600d1c1da1 c.2.1.7 (A:149-349) Phenylalanine dehydrogenase {Rhodococcus sp., M4 [TaxId: 1831]}  ali model 3D-neighbors follow..  12  4........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TTAVGVFEAMKATVAHRGLSLDGLTVLVQGLGAVGGSLA--SLAAEAGAQLLVADTDTERVAHAV-----------------------------------------------------ALGHTAVALEDVLST------------PCDVFAPCA----------GGVITTEVARTLDCSVVAGAAN--ADEAASDILHARGILYAPDFVANAGGAIHLVGR-----------EVLGWSESVVHERAVAIGDTLNQVFEISDNDGVTPDEAARTLAGRRARE................................................................................................................................................................................................................................................................................................................................................................................ 199
9 -10.900d3vpxa2 c.2.1.0 (A:145-363) automated matches {Sporosarcina psychrophila [TaxId: 1476]}  ali model 3D-neighbors follow..  14  5........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VTAYGIYYGMKAAAKEAF-SLAGKTVAVQGVGNVAYALC--EYLHEEGAKLIITDINEEAVQRAVDAFGATAVGINEIYSQE----------------------------------------------------------------ADIFAPCA----------GAIINDETIPQLKAKVIAGSANNQLKETRHGDIHEMGIVYAPDYVINSGGVINVADELD------------GYNRERALKRVEGIYDVIGKIFAISKRDNIPTYVAADRMAEERIARVANT............................................................................................................................................................................................................................................................................................................................................................................ 205
10 -10.700d1hwxa3 c.58.1.1 (A:1-208) Glutamate dehydrogenase {Cow (Bos taurus) [TaxId: 9913]}  ali model 3D-neighbors follow..  17  5...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DDPNFFKMVEGFFD---------RGASIVEDKLVEDLKTRQTQEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQ--------------------------HSHQRTPCKGGIRYSTDVS--VDEVKALASLMTYKCAVVPFGGAKAGVKINP------KNYTDEDLEKITRRFTMELA-------------KKGFIGPGVD----VPAPNMSTGEMSWIADTYASTIGHY--HACVTGKPISQG----GI........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 208

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.