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Query: [W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases, from VFDB

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSPIRNRLQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPIGFRFNAYNRTFHVQLHPIDDSLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHVHGSVFDGVFEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINHRKWRVKRDAENLSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADHKLYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTNFNGIKGLHFVIQRTSIYTPDSCDRGRAKTDSDNPFCEENVDVSNFLNLNSQRNHSAFCLAYALTFRDFVGGTLGLAWVASPQFNTAGGICQVHQRYNEGSRGWVYRSLNTGIVTLVNYGNRVPARVSQLTLAHEIGHNFGSPHDFPAECQPGLPDGNFIMFASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPVDPTRNASPVGIGKRNCFQERTSAFCGNQIYEPGEECDCGFSQADCDQMGDKCCVPHEARGNGGPGPCKRKPGAQCSPSQGYCCNPDTCSLHGKNEEKICRQESECSNLQTCDGRNAQCPVSPPKHDGIPCQDSTKVCSSGQCNGSVCAMFGLEDCFLTEGKADELCFLACIKDGKCTSSVHLPEFSANRTNFLQNMRKDKPGLILHPGSPCNNYKGYCDIFRKCRSVDANGPLARLKNLLFNKRTIETLTQWAQDNWWVVGVGGLVFLVIMALFVKCCAVHTPSTNPNKPPALNIYQTLTRPGTLIRQHRQRHRAAAGSVPPGPGAQPRSGAASAPSRTTPSARPSAPPLVAPQVAVAVPPGVVGPPIPLIATHPGSSSSTPAVIVLEPPPPYTAADPGSAMGGPRRGHRKNKRQTSSDAAGSSGNGGKKKGKLast
1 -60.700d2ddfa_ d.92.1.10 (A:) TNF-alpha converting enzyme, TACE, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  25  3..............................................................................................................................................................................................................................................PMKNTCKLLVVADHRFYRYMGRG--------EESTTTNYLIELIDRVDDIYRNTAWDNFKGYGIQIEQIRILKSPQEVKPGEKHYNMEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPRANSHGGVCPKAYYSPV---GKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 257
2 -44.500d1r55a1 d.92.1.9 (A:208-409) ADAM33 {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  22  1...............................................................................................................................................................................................................................................TRKYLELYIVADHTLFLTRHRN---------LQHTKQRLLEVANYVDQLLRTL------DIQVALTGLEVWTERD----RSRVTQDANATLWAFLQWR-RGLWAQRPHDS---AQLLTGRAFQGATVGLAPVEGMCRAESSGG--------------------------VSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCVEAAAESGGCVMAAAT---GHPFPRVFSACSRRQLRAFFRKGGGACLSNAP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
3 -43.800d2w15a_ d.92.1.9 (A:) Snake venom metalloprotease {Terciopelo (Bothrops asper), bap1 [TaxId: 8722]}  ali model 3D-neighbors follow..  20  3..............................................................................................................................................................................................................................................FSPRYIELAVVADHGIFTKYNSN---------LNTIRTRVHEMLNTVNGFYRSV------DVHAPLANLEVWSKQD----LIKVQKDSSKTLKSFGEWRERDLLPRISHDH---AQLLTAVVFDGNTIGRAYTGGMCDPRHSVG--------------------------VVRDHSKNNLWVAVTMAHELGHNLGIHHDTGS---CSCGAKSCIMASVL---SKVLSYEFSDCSQNQYETYLTNHNPQCILNKP.............................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
4 -36.600d4wk7a_ d.92.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  17  1................................................................................................................................................................................................................................................SRFVETLVVADDKMAAFHGAG------------LKRYLLTVMAAAAKAFKHPSIRN--PVSLVVTRLVILGSGE---EGPQVGPSAAQTLRSFCAWQRGLNTPEDSDDHFDTAILFTRQDLTCDTLGMADVGTVCDPARSCAIVE----------------DDGLQS-------------AFTAAHELGHVFNMLHDNSKPCISPLSTSRHVMAPVM--AHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAP........................................................................................................................................................................................................................................................................................................................................................................................................................................... 215
5 -22.200d4r5ra_ g.20.1.1 (A:) Kistrin (rhodostomin) {Agkistrodon rhodostoma [TaxId: 8717]}  ali model 3D-neighbors follow..  35  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKECDCSSPE-------NPCC---------DAATCKLRPGAQCG--EGLCC--EQCKFKKKRTICR--IPRGDMPDDRCTGQSADCPRY........................................................................................................................................................................................................................................................................................................................ 67
6 -15.100d2echa_ g.20.1.1 (A:) Echistatin {Saw-scaled viper (Echis carinatus) [TaxId: 40353]}  ali model 3D-neighbors follow..  22  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECE--SGPCC--RNCKFLKEGTICK--RARGDDMDDYCNGKTCDCPRNPHKGPAT................................................................................................................................................................................................................................................................................................................. 49
7 -11.300d1c7ka_ d.92.1.1 (A:) Zinc protease {Streptomyces caespitosus [TaxId: 53502]}  ali model 3D-neighbors follow..  19  4...............................................................................................................................................................................................................................................................................................................................................................VTYDPSNAPSFQQEIANAWNSSVRN-RAGGNADFSYYEGNDSRGSYAQTDGHGRGYIFLDYQQNQQYDSTRVTAHETGHVLGLPDHYQGPCSE-------LMSGGG-PGPSCTNPYPNAQERSRVNALWANG....................................................................................................................................................................................................................................................................................................................................................................................................................................................... 132
8 -11.200d2w9wa_ g.20.1.1 (A:) automated matches {Trimeresurus jerdonii [TaxId: 135726]}  ali model 3D-neighbors follow..  27  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AMDCT--TGPCC--RQCKLKPAGTTCW-KTSVSSH---YCTGRSCECPSYP....................................................................................................................................................................................................................................................................................................................... 43
9 -10.700d1lmla_ d.92.1.3 (A:) Leishmanolysin {Leishmania major [TaxId: 5664]}  ali model 3D-neighbors follow..  10  3..............................................................................................................................................................................................................................................RDVNWGALRIAVSTEDLTDPAYHCARVGQHVKDHAGAIVTCTAEDILTNEKRDILVKHLIPQAVQLHTERLKVQQVQGKWKVTDMVGDICGDFKVPQAH-----ITEGFSNTDFVMYVASVPSEEGVLAWA-----------TTCQTFSDGHP-----------VGVINI-ANIASRYDQLVTRVVTHEMAHALGFSGPIVANVPNVRGKNFDVPVINSSTAVAKAREQYG-CDTLEYLEVEDQGGAGSAGSHIKMRNAQDELMAPAAAAGYYTALTMAIFQ-----DLGFYQADFSKAEV-CCMEQSVTQWPAMFCNESEDAIRCPTSRGAC--MDYCPVVVP-------SDGSCTQRASEASDAARCIDGAFRPKAT---DGIVKSYAGLCANVQCDTATRTYSVQVHGSNDYTN---CTPGLRVELSTVSNAFEGG-------------------GYTCPPYVEVCQGNVQAAK............................................................................................................................................................................................................... 474
10 -10.400d5d7wa1 d.92.1.0 (A:4-246) automated matches {Serratia marcescens [TaxId: 615]}  ali model 3D-neighbors follow..  15  51...............................................................................................................................................................................................................................................QPVKLTFSFPDYKFSSTNVAGDTGLSKFSAEQQQQAKLSLQSWADVANIFTEVAAGQKANITFGNYSQD------------------------------------------------RPGHYDYGTQAYAFLPN--TIWQGQDLGGQTWYNVNQSNVKHPATED----------------GRQTFTHEIGHALGLSHPGDYNAGEGNPTYNDVTYAE-------DTRQFSLMSYWS............................................................................................................................................................................................................................................................................................................................................................................................................................................................... 215
11 -9.600d1n8yc3 g.3.9.1 (C:166-322) Protooncoprotein Her2 extracellular domain {Norway rat (Rattus norvegicus) [TaxId: 10116]}  ali model 3D-neighbors follow..  16  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NRSRAC---------PPCAPACCWGE------SPEDCQILTGTICTSGPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGIC---ELHCPALVTYNTDTTCPYNYLSTEVGSCTLV-CAEDGTQRCE----KCSKPCARVCY...................................................................................................................................................................................................................................................................... 157
12 -9.220d4r3va_ d.92.1.0 (A:) automated matches {Tannerella forsythia [TaxId: 203275]}  ali model 3D-neighbors follow..  12  23.............................................................................................................................................................................................................................................................................NKTTLKYYIYNSSSHLTTTERENAIRSAFALWSDKSTLSFIQVYNPNQADIK-----------------IKWEKGNHGDGYPF-------DGNTGILAHAFYPPPAGGNYAG--------------------HLHFDGDENWSINGSGIDLITVAAHAIGHLLGIEHSNVSSA---------LMYPY----YTGIKRQLDNDDCLAVWDLY.......................................................................................................................................................................................................................................................................................................................................................................................................................................................... 176
FFAS is supported by the NIH grant R01-GM087218-01
1 4 1 5 6 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.