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Query: [J] COG0012 Predicted GTPase, probable translation factor, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEIGVVGKPNVGKSTFFSAATLVDVEIANYPFTTIDANVGVTYAIAEHPCKELGCKPNPQNYEYREGLALIPVKMIDVAGLVPGAHEGRGLGNKFLDDLRMASALIHVVDVTGKTDAEGQPTENHDPIEDIEFLEREIDYWIYGILSKGWDKFAKRIKLQRIKLESAIAEHLSGIGVTENDVWEAMHRLGLPSDPTLWSQEDLLAFASEIRRINKPMIIAANKADAASEEQINRLIKEGEKRGYIVVPTSAAAELTLRKAAKAGFIDYIPGSSEFKILKDMNERQKKALLMIKEKVLDRFGSTGVQEVINKAVFELLNLIPVYPVQDENKLTDQFGNVLPHVFLMKKGSNPRDLAFKVHTDLGRGFLYAINAKTKRRIGEDYELQFNDIIKIVAVTKLast
1 -130.000[J] COG0012 Predicted GTPase, probable translation factor  ali  100  1MEIGVVGKPNVGKSTFFSAATLVDVEIANYPFTTIDANVGVTYAIAEHPCKELGCKPNPQNYEYREGLALIPVKMIDVAGLVPGAHEGRGLGNKFLDDLRMASALIHVVDVTGKTDAEGQPTENHDPIEDIEFLEREIDYWIYGILSKGWDKFAKRIKLQRIKLESAIAEHLSGIGVTENDVWEAMHRLGLPSDPTLWSQEDLLAFASEIRRINKPMIIAANKADAASEEQINRLIKEGEKRGYIVVPTSAAAELTLRKAAKAGFIDYIPGSSEFKILKDMNERQKKALLMIKEKVLDRFGSTGVQEVINKAVFELLNLIPVYPVQDENKLTDQFGNVLPHVFLMKKGSNPRDLAFKVHTDLGRGFLYAINAKTKRRIGEDYELQFNDIIKIVAVTK 397
2 -95.300[R] KOG1491 Predicted GTP-binding protein (ODN superfamily)  ali follow..  22  21LKAGIVGLANVGKSTFFQAITRCPGNPANYPFATIDPEEARVIV-PSPRFDKLCEIYKKTA-----SEVPAHLTVYDIAGLTKGASAGEGLGNAFLSHIRSVDSIYQVVRCFDDAE-IIHVEGDVDPVRDLEIINQELRLKDIEFAQKALEGAEKIAKRGGQSLEVKQKKE----EMDLITKIIKLLESGQRVANHSWTSKEVEIINSMFLLTAKPCIYLINLSERDYIRKKNKHLLRIKSPGDLIIPFSVSLEERLSHMSPEDAEEE----------------------------LKKLQTISALPKIITTMRQKLDLISFFTC----------GPDEVREWTIRRGTKAPQAAGVIHNDLMNTFILAQAAGKLMQKGKDYVVEDGDIIYFRAGAG 392
3 -46.300[R] COG1163 Predicted GTPase  ali follow..  23  67.SVGFVGFPSVGKSTLLSKLTGTESEAAEYEFTTLVTVPGVIRYK-------------------------AKIQMLDLPGIIDGAKDGRGRGKQVIAVARTCNLLFIILDVN-------------KPLHHKQIIEKELEGVGIRLNKTPPDILIKKKEKGGISITNTVPLTHLGNDEIRAVMSEYRINSAEIAFRCDATVDDLIDVLEASSRRYMPAIYVLNKIDSLSIEELELLYR-----IPNAVPISSGQDWNL-------------------------------------------------DELLQVMWDRLNLVRIYT-----KPKGQIPDFTDPVVLRSDRCSVKDFCNQIHKSLVDDFRNALVYGSSQYVGLSHILEDEDVVTILKK.. 369
4 -45.500[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  23  66.RIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYK-------------------------AKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVL-------------KPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVE---RVYIPCIYVLNKIDQISIEELDIIYK-----VPHCVPISAHHRWNF-------------------------------------------------DDLLEKIWDYLKLVRIYT-------PKGQLPDYTSPVVLPYSRTVEDFCMKIHKNLIKEFKYALVWGLSQKVGKDHTLEDEDVIQIVKK.. 367
5 -44.600[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  19  64.RVALIGFPSVGKSTLLTMLTGTHSEAASYEFTTLTCIPGVIHYN-------------------------TKIQLLDLPGIIEGASEGKGRGRQVIAVAKSSDLVLMVLDAS-------------KSEGHRQILTKELEAVGLRLNKTPPQIYFKKKKTGGISFNTTAPLTHIDEKLCYQILHEYKIHNAEVLFRENATVDDFIDVIE---RKYIKCVYVYNKIDVVGIDDVDRLSR-----QPNSIVISCNLKLNL-------------------------------------------------DRLLARMWDEMGLVRVYSKPQGQQPDFDEPFVLS----DRGGCTVEDFCNHVHRTLVKDMKYALVWGTSQNCGLSQHLEDEDVVQIVKKKE 369
6 -29.900[R] COG0536 Predicted GTPase  ali follow..  26  161.DVGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVNVGHE------------------------TFTMADVPGLIPGASEGKGLGLDFLRHIERTSVLVHVVDTATMDP-------GRDPISDIEALEAELAAYQSALDEDT----------------------------------------------------------GLGDLSQRPRLVVLNKADVPEAEELAEFLKEEKQFGWPVFIISAVARKGLDPLKYK-------------LLEIVQDARKKRPKEKAESVIIKPKAVDHRTKGQFQIKPDPEVQGGFIITGEK----------PERWILQTDFENDEAVGYLADRLAKLGIEDG----LRKAG----AHVGANVTI..... 433
7 -29.400[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  25  341.DLGLIGLPNAGKSTILNKISNAKPKIGHWQFTTLSPTIGTVSLGFGQD----------------------VFTVADIPGIIQGASLDKGMGLEFLRHIERSNGWVFVLDLSNK-----------NPLNDLQLLIEEVGTLE---------------------------------------------------------------------VKTKNILIVCNKVDIDAEKSYLQVEKFSKSQEWDCVPISALRE............................................................................................................................................... 497
8 -23.900[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  21  170.TVLICGYPNVGKSSFMNKVTRADVDVQPYAFTTKSLFVGHTDYK-------------------------LRYQVIDTPGILDRPFEDRNCSITALAHLRAAVLFFLDISGSCGYTIA-------QQAALFHSIKSLF--------------------------------------------------------------------------MNKPLVIVCNKTDLMPMENISEEDRKLIEEEQVLLKMSTLTDEGVMSVKNA...................................................................................................................................... 344
9 -23.800[R] COG1084 Predicted GTPase  ali follow..  21  164.TVVIAGFPNVGKSTLLRTLTGAEPEVADYPFTTKGIQIGHLER--------------------------KRIQVIDTPGLLDRPEDMNNIELQAMVALENADVIMFIFDASETCGYT--------------------------------------------------------------------------------LESQYSLYLGIRSVFDIPVVTVFNKMDL----ENVKYLEEYINMVEDPLKVSAFEGRGVSKIIKK...................................................................................................................................... 320
10 -16.400[P] COG0370 Fe2+ transport system protein B  ali follow..  19  4NTYCILGNPNTGKTSLFNALTGSYEYVGNWSGVTVEKKVGTLR---------------------------KTGKLIDLPGILNPISRDETVVTRFLLE-EKFDCMLNIV--------------------DSSQIERNLN------------------------------------------------------------------LTVQLLEYGAPVVMGLNMIDVAAGRGIHNIQNLAKKLRIPILPVVARSGKGTEDILST...................................................................................................................................... 156
11 -15.900[R] COG3596 Predicted GTPase  ali follow..  11  39PVIGIMGKTGAGKSSLCNALFAGESPVSDVAACTRDPLRFRLQI--------------------------HFMTIVDLPGVGESGVRDTEYAALYREQLPRLDLILWLIKA-----------------------DDRALATDEHFYRQVIGEAYR-----------------------------------------------------------HKMLFVISQSDKAEPTSGGNILSTEQKQNHPVCAVSVRLQWGLRVMAER-MIKCLPREPSSPVVALLQEQARDDFGETVDTILDTVSTFPLIPAPVRTIIQAVRSSVVSVARA...................................................................... 283
12 -15.200[R] COG1159 GTPase  ali follow..  18  11..IAIVGRPNVGKSTLLNKLLGQKISTSRKAQTTRHRIVGIH------------------------TEGPYQAIYVDTPGLHMEEKRNRLMNKAASSSIGDVELVIFVVEGTRWT-------------------------------------------------------------------------------------PDDEMVLNKLRDGKAPVILAVNKVDNVQEKVDLLPHLQFLASQLDIVPISAETGMNVDTIAGIVRKHLPEAIHHFPEDYITDRSQR-ASEIIREKLMRFLGAE-EIERFVTNERGGYDINGLILVEREGQKKMVIG---------NKGAKIKTIGIEARKDMQEMFEAPVHLELWVKVKSGWADDERALRSLGYVDD 300
13 -13.600[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  15  57.TVLLSGLSGSGKTVLFYQLRDGSSHQGAVT--SMEPNEGTFVL---------------HNENNTKKGKVKPVHLIDVPG--------SRLISKLEEYLPRAAAVVFVVDALEFLPNIRAASEYLDILTNASVIKNKTPVLLCEFIRKQMEKEIDKLRVSRSAISTADIANDFTLGIEGEVFSFSHCHNKVTVAEASGLTGETDQVQEFIREHVKP..................................................................................................................................................................................... 260
14 -12.900[R] KOG2486 Predicted GTPase  ali follow..  14  137.EFALVGRSNVGKSSLLNSLVRRKALTSKKPGKTQCINH----------------------------RINDKWYLVDLPGY-ELKQDWNKFTKDYFLNRSTLVSVFLLV----------------DASIPVKPIDLEYA--------------------------------------------------------------------SWLGQNQVPMTLIFTKCDKRKKKKNGGKKPEANIKEPPWIMTSSVTNQGRDEI......................................................................................................................................... 304
15 -12.200[E] COG4917 Ethanolamine utilization protein  ali follow..  12  3.RIAFVGSVGAGKTTLFNALQGNYTLARK-----------------------------------TQAVEFNDKGDIDTPGEY----NHPRWYHALITTLQDVDMLIYVHGANDPESRLPAGLLDIGVSKRQIAVISKT-----DMPDADVAATRKLLLETGFEEPMFELNSHDPQSVQQLVDYLASLTKQEEAGEKTHHSE.................................................................................................................................................................................................... 159
16 -11.400[R] KOG0410 Predicted GTP binding protein  ali follow..  19  312..VSLVGYTNAGKSTLLNQLTGANVLAENRLFATLDPTTRRVQMQNGKE-----------------------FLLTDTVGFIQKLPTT--LVAAFLEEIAESSLLVHVVDISHPLAE--------QQIEAVEKVMSEL-------------------------------------------------------------------------VSSIPKLVVWNKVDRVDDPQKVKLEAEETGD---TICISALTGEGLDDFCNAVHEKLKDSMVWVEALLPFDKGDLLSTIHKVGMVKETEYTENGTLIRAHVPLRFAQLLKPMRHLVKDTSISQRG............................................................. 540
17 -11.300[R] COG2262 GTPases  ali follow..  27  200..VSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVADVGE-----------------------TVLADTVGFIRHLPHD--LVAAFLQETRQATLLLHVIDAADVRVQ--------ENIEAVNTVLEEIDAHEIPTL........................................................................................................................................................................................................................................................... 313
18 -11.100[R] COG1160 Predicted GTPases  ali follow..  13  5.VVALVGRPNVGKSTLFNRLTRTRALVADFPGLTRDRKYGHAHIA-------------------------YDFIVIDTGGIDGTEEG-EKMAEQSLLAIDEADIVLFLVDARAG-----------------------------------------------------------------------------------LTAADIGIANYLRQRQNKITVVVANKTDGIDADSHCAEFYQLG---GEIEQIAASQGRGVTQL--EQVLAPFAEKMENADENDRTSEEEQDEWEQEFDFDSEEDTALIDDALDEELEEEQDKNIKIAIVGRPNVGKST---LTNRILGEDRVVVFDMPGTTRDSIGQQYTLIDTAGVRKRGKVHQAIQDANVVLLTIDAR 308
19 -11.000[R] COG0218 Predicted GTPase  ali follow..  17  27.EIALAGRSNVGKSSFINTMLNRKARTSGKPGKTQLLNF----------------------------NIDDKMRFVDVPGY-KEREKWGCMIEEYLTTRENLRAVVSLVDLRHDPSAD-----------DVQMYE-KYYEIPVIIVATKADKIPRGKWNKHESAIKKKLN................................................................................................................................................................................................................................... 166
20 -9.990[R] KOG2485 Conserved ATP/GTP binding protein  ali follow..  16  142LLVMVVGVPNVGKSALINSIHQIAAARFPVQ-ATVGPLPGVTQDIAGFKIAH-------------------SIYVLDSPGVLVPSIPDIETGDSVVGEERIAQYFLAILNIRGTPLHWKYLVEGINEGPHADCIDK..................................................................................................................................................................................................................................................................... 274
21 -9.610[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  19  21MELTLVGLQFSGKTTFVNVIASGQFAEDMIP--TVGFNMRKITRG-------------------------VTIKVWDIGG-------QPRFRSMWERYCRGVNAIVYMVDA-----------------ADLDKLEA--------------------------------------------------------------SRNELHSLLDKPQLAGIPVLVLGNKRDLPGALDETGLLSSIQDREICCYSISCKEKDNIDI.......................................................................................................................................... 172
22 -9.590[T] KOG3886 GTP-binding protein  ali follow..  12  42.KVLLMGKSGSGKTSMRSIIFANYIARDTRRLATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSH-LVLNLWDCGG--QDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELE-----------KDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREE------DLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVVSDPSIPSAATLI........................................................................... 349
23 -9.370[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  63PRILLMGLRRSGKSSIQKVVFH---KMSPNETLFLESTNKI-------------------CREDVSNSSFVNFQIWDFPGQIDFFDPTFDYEMIF----RGTGALIFVIDSQDDYMEA-TRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIYGLKEDGAGTPYDKESTAIIKLNNTTVLYLKEVTKFLALVCFVREESFERKGLIDYNFHCFRKAIHEVFEV------MKVVKSRKVQNRLQKKKRATPNGTP............................................... 396

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Godzik A. Fold recognition methods. Methods Biochem Anal. 2003;44:525-46. Review.