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Query: [J] COG0018 Arginyl-tRNA synthetase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNVMQENQIKLIEHIKQAVVQAVGLEETEVPEILLEVPKDKKHGDYSTNIAMQLARVAKKAPRQIAESIVPELKKDTKLIKEVEIAGPGFINFYLDNAYLTDLVPVILTEDKKYGESDFGKGEKFQIEFVSANPTGDLHLGHARGAAIGDSLANIMKMAGFDVSREYYINDAGNQINNLVLSAEARYFEALGLESEFPEDGYRGSDIIALGKDLAAKYGDKYVNASEEERRSVFRVDALAFETGKLRADLEEFRVSFDEWFSETSLYEENKVLPALERLRENGYIYEQDGATWLRTTDFEDDKDRVLIKSDGSYTYFLPDIAYHLNKLERGFDVLIDIWGADHHGYIPRMRAAIEALGYSPNQLEVEIIQLVHLFEDGVQVKMSKRTGKSVTMRDLIEEVGLDATRYFFAMRSSDTHMNFDMSLAKSTSNDNPVYYVQYAHARISSILRSGKEQGLEVSKDANMSLLETEAEYDLLKVLGEFADVVAEAAVKRAPHRIVRYLNDLATAFHRFYNSNKVLDMDNLEVTKARLALIKTAQITLRNGLTLLGVSAPEKMLast
1 -176.000[J] COG0018 Arginyl-tRNA synthetase  ali  100  1MNVMQENQIKLIEHIKQAVVQAVGLEETEVPEILLEVPKDKKHGDYSTNIAMQLARVAKKAPRQIAESIVPELKKDTKLIKEVEIAGPGFINFYLDNAYLTDLVPVILTEDKKYGESDFGKGEKFQIEFVSANPTGDLHLGHARGAAIGDSLANIMKMAGFDVSREYYINDAGNQINNLVLSAEARYFEALGLESEFPEDGYRGSDIIALGKDLAAKYGDKYVNASEEERRSVFRVDALAFETGKLRADLEEFRVSFDEWFSETSLYEENKVLPALERLRENGYIYEQDGATWLRTTDFEDDKDRVLIKSDGSYTYFLPDIAYHLNKLERGFDVLIDIWGADHHGYIPRMRAAIEALGYSPNQLEVEIIQLVHLFEDGVQVKMSKRTGKSVTMRDLIEEVGLDATRYFFAMRSSDTHMNFDMSLAKSTSNDNPVYYVQYAHARISSILRSGKEQGLEVSKDANMSLLETEAEYDLLKVLGEFADVVAEAAVKRAPHRIVRYLNDLATAFHRFYNSNKVLDMDNLEVTKARLALIKTAQITLRNGLTLLGVSAPEKM 556
2 -117.000[J] KOG1195 Arginyl-tRNA synthetase  ali follow..  25  27.DIHHNPVDVYRSYISSELSKINGV-DVSLIYPALETSISKDSADLNLPVPRLRVK---GKPQELAQKWAEAFPK-----DLVEVTANGFLRFNFNGPSLTKLIPIIWEQRENYGRNESGSGKVAVIEFSSPNIAKPFHAGHLRSTIIGSFLANLHESQGWKVHRVNYLGDWGKQFGLLAIGYKKYGDEDQLKSNPIRHDVYVKVNADATEEHDKAREFFKRMEDGDEESLKVWARF-RDLSITKLKDTYDRLNIHYDEYDGESQVSLEL-MNKMVDELRSLNLIEEDGGALLIDLSKHDKKLGAIVQKRDGTTLYLTRDIGTAYKRYEKKFDKSIYVVSSQQDMYFSQLFKIFELMGFDWAKKCVHINY-------GLVQGMSTRKGKAVFLDDIMEVVGKTAIRIQDSTGKRINNYAFDWSRMTSFEGDTG-PYLQYAHSRLSSVRRNVNYTDEEI-MGANLELLTEPDAYDLVRLLGQYPDVLKNAFRFQETSTVVTYLFKLTHAVSKLYDILWVRGRER-DIQLARLALFGAAKQVLNNGMTLLGLTPLERM 618
3 -21.100[J] COG1384 Lysyl-tRNA synthetase (class I)  ali follow..  12  15.........................................................................................................................SGPQRVST-GISPSGPIHVGNMREILTGDILFKAITKRGLESDFIYLCDDMD-PLRKVYPFLSKDYERYVGQPLKNIPAPQGAGKYS-------------------------------DYYLEPFVRVMKEANIPAR-VIKTSDLYESGMLAQACDIAINNR-VISYSYPYAEYACKCGHHGFADIRKAEGKMPWRVEWPA-------FALKVTVEPFGKDHGSYDTGRRIAREVFGIEPP---VPLMYERIILKGKG--AMHSSTGLAIAASEIMEVIPPDLLRYMIARVNPGRHIDFDPGMGILALSDE--------LEKLQDAYFENRASLDEDQAAMVEYSLVNKDRVTLVQIYRTEDEILRAVKKGQPSDFIEADFRKEIEYARRWLERY---VDQKIELSDSDLAILSDFLNGIED............. 441
4 -20.000[J] KOG1247 Methionyl-tRNA synthetase  ali follow..  11  1..........................................................................................................MEDDGKSSPKLPIPGKRNILITSALPYVNNVPHLGNIIGCVLADVYARYCRLRGYNAIYICGTDEYGTATETKA------------------------------------------------LEENCTPKEICDKYHAIHKEVYDWFGISFDKFGRTSTPEQTEVCQAIFNKLWDNKWLSEDTDHLFIELPLLKDRRQRCITRDKDKVFYVWFDAPIGYVSITSCYTELYQFMGKDNVPFHTVMFPSTQLGTEENWTLMKTISVTEYLNYEDG--KFSKSKGVGVFGNDVKDTIPVEVWRYYLLTNRPVSDTSFSWTDLQAKLNGELLSNLGNFVNRVLSFIAKPDNAGYGSVIPDAHDAESHSLTKSLAEKVEKFVAEYVEAMEKVKLKQGLKTAMLISSEGNYYLQASQKLYKEDKPLCAVVIRTAAGLVHLLAQLLEPFMPSFSCEV 526
5 -18.500[J] COG0143 Methionyl-tRNA synthetase  ali follow..  15  2......................................................................................................................TQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKA------------------------------------------------QQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYTRLKENGFIKNDSEHFFFDLPSFSEMLQAWTFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKELYHFIGKDIVYFHSLFWPAMLEGSN-NGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINK----------RFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTY........ 491
6 -16.200[J] KOG0436 Methionyl-tRNA synthetase  ali follow..  11  189...........................................................................................................................EELDDSCSTEP----HIGHAYTAVLCDVAHRWLKHPGAQAQFSIGTDEHGSKIFQAALAAKSTPKQF------------------------------------------------CDRVSSKFSDLFTDLELSHTNFIRTTDPAHLEAVQHFWMKIQDNGYIYKEEENYMFRLSEFREKVAEWINRENITSLEMSEDLSISRSRSRLSWTQTIYVWLDALVNYLTVT-PTCQVIGKDITKFHLYYWPAFLMAAG-DNVKMSKSLGNVVNPSEAITKFTAEGLRYFLLKHGNSYDCSFNWNSCLQTINSDLVNNVGNLLNRSTVEKINKEGM----------------PKMEIEDIEAEIRENAKKLMEMVEESRGTAEITTWSAEKREKSGKFPIWKLFWRKIGCRARSF....................... 621
7 -14.000[J] COG0215 Cysteinyl-tRNA synthetase  ali follow..  14  245........................................................................................................................DPKNVRMYVCGMTVYDYCHLGHARVMVVFDMIARWLRECGYPLTYVRNITDIDDKIIARAAENGETIGELT------------------------------------------------ARFIQAMHEDADALGVLRPDIEPKATENIPQMIA-MIETLIQNGKAYPANGDVYYAVREFSDPLDFVLWKANGRPGWHIECSAMSENLFGNTFD--IHGGGADHENEIAQSVGATTHHGQSIASHVKYWLHNGFIRVDGE--KMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHL--DDAKGALTRLYTTLKNTPAAEFDLSENVNDYTRRFYAAMNDDFGTVEAVAVLFELAGEVNKTNDAQLAGCLKALGGIIGLLQRDPTEFLQGGAASDGLSNEEIEDLIAAESDRIRDLLNEHKIILEDN. 690
8 -13.900[J] KOG2007 Cysteinyl-tRNA synthetase  ali follow..  15  46........................................................................................................................DGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLDYFKFDVFYCMNITDIDDKIIKRANHLFEQYREKRPEAAQLLEDVQAALKPFSVKLNETTDPDKKQMLERIQHAVQLATEPLEKAVQGDFHRDMEALNVLPPDVLTRVSEY--PEIVNFVQKIVDNGYGYVSNGSVYFDTAKFASSEKHSYGKQEGEGDLSISADRLSEKRSPNDFAL----WGKGRPGHIECSAMAGTLLGFENDCWVRYFLHTGHLTIAG--CKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQ---------YEKFLNEFFLNVKDILRAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKACDNVDTRTVMEEMRALVSQCNLY------MAARKAVRKRPNQALLENIALYLTHMLKIFGAVEEDS. 565
9 -12.200[J] KOG1149 Glutamyl-tRNA synthetase (mitochondrial)  ali follow..  17  32...............................................................................................................SKKIKEDIHPSLPVRTRF-APSPTGFLHLGSLRTALYNYLLAR--NTNGQFLLR---LEDTDQK-RLIEGAEENIYEILKWCNINYDE----TPIKQSERKLIYDKYVKILLSSG-----KAYRCFCSKERLNDLRHSAMELKPSYDR--EEIKSKLAQGIPFTVRFKSPERYPTFTDGQINLQPQNDKRYDDLILVKSDKLPTY---HLANVVDDHLMGITHVI---GEEWLPSTPKHIALYNAFGWACPKFI------IPLLTTVGDKKLSKRKGDM-ALINFCALFG-ELETIFNLNGLTKGNAKVDDKKLWFFNKH----FLQKRILNPSTLRELVDDIMPSLESIYNTSTISREKVAKILLNCGG-NDAVTKFLSKNESRHIAHLLKKLGQFQEGTDAQESMVETMYYENGFSRKVTYQAMRFALAAMIDILGIK..... 518
10 -10.400[J] COG0060 Isoleucyl-tRNA synthetase  ali follow..  13  249.............................................MPSNRAIAVNADLEYNLVQLAAELVESVAKAVGIVKGDDLELSRFHHVILGDHVTTDGGTGLVHTAPDHGLDDFIVGKQYDLPMAGLSNDGKFTTEFFAGKGVFEAVIEKLQEVGNLLKVESYPHCWRHKTPIIFRATPQWFIGMETQGLR--------------QQALGEIKQVRWIPDWGQARIEKMVENRPDWCISRQRTWGVPMTLFVHKETEELHPRTLDLLEEVAKRVERAGIDLDEKELLGADAETYRKVPDTLDVWFDSGSTYSS---VVANRLEFNGQDIDMYLEGSDQHRGWFMSSLMLSTATDSKAPYKQVLTHGFTVDGQGR--KMSKSIGNIVTPQEVMDKFGGDILRLWVASTDYTGEMTVSDEILKR---------AADSYRRIRNTAR-ANLNGFDPKRDLVKPEKMISLDRWAVACALDAQNEIKDAYDNYQFHTVVQRLMRCSVEMGSFYDRQYTTKADSLARRSCQTALWHIAEALVRWMAPILSFTADE.. 774
11 -10.200[J] COG0751 Glycyl-tRNA synthetase, beta subunit  ali follow..  10  224.......................................................ALILAKSQEKATALGGVADIEDDLLDEVTVEYPNVLAAKFEERFLAEALVYTMKGDQKYFPIYDKDGK-IFVSNINPDDPSKIIEGNEKRPRLTDALKQRLEDQLPRLETVLFQQQLGTLRDKT-------------------------ARIEQLAGEIAKQIGAD--EVKAKRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEDEEVAVALNEQYMPRFAGDELPKSLVASAV----ALADKFDTLT--GIGQQPKGSAD-PFALRRAALGALRII--VEKNLPLDLAEIVKKSSALFGDKLTNANVVEDVVEFMLGRFRAWYQDEGIAVDVIQAVLA-----------RRPTKPSDFDARVRAVSHFRALEAAEALAAANKRVSNILAKVEG---ELPANIDTTLCAEAAEKVLAEQVIALQAELAPLFAKGEYQVALDRLAALREPVDTFFDNV-MVNAENPQLRQNRLAILNNLRNLFLQVADISLLQ..... 689
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Bossy-Wetzel E, Barsoum MJ, Godzik A., Schwarzenbacher R, Lipton SA. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol. 2003 Dec;15(6):706-16. Review.