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Query: [C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst DPDIPEGTEMVMTTVREALRDAMAEEMRADEKVFVMGEEVAEYQGAYKITQGLLQEFGERRVIDTPITEHGFAGIGVGAAMTGLKPIVEFMTFNFAMQAIDQIVNSAAKTLYMSGGQMGAPMVFRGPSGAAARVGAQHSQCYAAWYSHIPGLKVVMPYTAADAKGLLKAAIRDPNPVIFLENEILYGQSFEVPKLDDFVLPIGKARIHRKGKDATIVSFGIGMTYAIKAVAELEKLGIDVELIDLRTIRPMDLPTVIESVKKTGRLVTVEEGFPQSSVGDFIANQVMRAAFDYLDAPILTIAGKDVPMPYAANLEKLALPNVDEVVQAVKTVCYKLast
1 -110.000[C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit  ali  100  1DPDIPEGTEMVMTTVREALRDAMAEEMRADEKVFVMGEEVAEYQGAYKITQGLLQEFGERRVIDTPITEHGFAGIGVGAAMTGLKPIVEFMTFNFAMQAIDQIVNSAAKTLYMSGGQMGAPMVFRGPSGAAARVGAQHSQCYAAWYSHIPGLKVVMPYTAADAKGLLKAAIRDPNPVIFLENEILYGQSFEVPKLDDFVLPIGKARIHRKGKDATIVSFGIGMTYAIKAVAELEKLGIDVELIDLRTIRPMDLPTVIESVKKTGRLVTVEEGFPQSSVGDFIANQVMRAAFDYLDAPILTIAGKDVPMPYAANLEKLALPNVDEVVQAVKTVCYK 335
2 -99.400[C] KOG0524 Pyruvate dehydrogenase E1, beta subunit  ali follow..  57  26KRYSSSSNGVKEMTVRDALNSAMEEEMKRDDRVFLIGEEVAQYNGAYKISRGLLDKFGPKRVIDTPITEMGFTGLATGAAFAGLRPICEFMTFNFSMQAIDHIVNSAARTLYMSGGIQACPIVFRGPNGPAAAVAAQHSQHFAPWYGSIPGLKVVSPYSAEDARGLLKAAIRDPNPVVVLENEILYGKTFPIALSEDFVLPFGLAKVERPGKDITIVGESISVVTALEAADKLADYGVEAEVINLRSIRPLDINTIAASVKKTNRIVTVDQAYSQHGIGSEIAAQIMESAFDYLDAPVERVSMADVPMPYSHPVEAASVPNADVVVAAAKKCLY. 364
3 -44.000[G] COG3958 Transketolase, C-terminal subunit  ali follow..  18  3..KLAPAGLKDDIEMRKVYAGFIAGQIEAGSPIIALEADLMSSMAMDSVARDY-----PQHVINCGIMEANVIGTAAGLALTGRKPFVHTFTAFASRRCFDQLFMALD-------QRNNVKVISDAGVTACHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFADILRQLMDLDGFYWL----RTIRKQARSIYAPGSTFTIGKGNVLREGDDITLIANGIMVAEALEAARQLEQEGVSAAVIDMFTLKPIDRMLVKNYAEKTRRIVTCENHSIHNGLGSAVAEVLVENC----PVPMRRVGVKERYGQVGTQLQKEYGLTAEAIVEAAKSLL.. 317
4 -35.000[HI] COG1154 Deoxyxylulose-5-phosphate synthase  ali follow..  20  307SSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKF-----PDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAI-YSTFLQRAYDQVIHDVA----------KLPVMFAIDAGIVGADGQTHQGAFDSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPR--GNAQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAE-----ALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHR---KPVPVLNIGLPDFFIPQGTEARAELGLDAAGIEAKIKAWLA. 620
5 -21.800[G] COG0021 Transketolase  ali follow..  14  347.......AKAETIATRKASQNSIEILAKELPELVGGSADLTPSNLTDWSNSVSVTRDKGGNYIHYGVREFGMGAIMNGLVLHGGVKPFGATFLMFSEYERNAL---------RMAALMKINPVFHDSIGLGEDGPTHQPIEQTATLRLIPNMDVWRPCDTAESLVAWAEAVKAADHPSCLIFSRQNLKFQARSEQQLNDIKRGGYVISEGNAQAVIIATGSEVELALEAQKALAAQNIAVHVVSMPSTNVFDRQDTQAAVLPESLPRIAVEAGHADGWYKYVGLNGAVVGINRFGES-------------ADLLFKAFGFTVDNVVDTVKSVL.. 659
6 -21.300[G] KOG0523 Transketolase  ali follow..  15  442..........PGDATRNLSQQCLNALAKVVPGFLGGSADLASSNMTLKAFGDFQKATPEERNLRFGVREHGMGAICNGIALHGLIPYCA-TFFVFTDYMRGAM---------RISALSEAGVIYHDSIGLGEDGPTHQPIEHIASFRAMPNTLMFRPADGNETAGAYKIAVTKRKTPSIL---ALSRQKLPHLPGTSIEGVEKGGYTISDDSDVILIGTGSELEIAAQAAEVLRKDGKTVRVVSFVCWELFDEQSD-SVLPSDVSARVSIEAASTFGWGKIVGGKGKSIGINSFGAS-------------APLLYKEFGITVEAVVDAAKSFF.. 754
7 -18.700[C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component  ali follow..  12  492.KATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFG----MEGLFRQVGTGQVLQEGINEAGAMCDWIAAATSYMIPFYIY-YSMFGIQRIGDLCWAAGDMRSRG-------LLGGTAGRTTLNGGLQHEDHSHVYHAAIPNCISYDPTFQYELAVVMQDGLREQEDVYYYLTVMNENYEHPEMPAGAEADIIKGMYLFKKAPRVQLLGSGTIFREVIAAAELLKKDGVESDLWGCPSFTELAREGNAAARWNLHPTDAPRESHVEKMLKGVRGPVIASTDYAFVPRRYVVLGTDGFGRS-REKLRHFFEVDRYWVTVASLKALAD 868
8 -16.900[G] COG3957 Phosphoketolase  ali follow..  9  386NVTEPGAIEAQSTKILGDFLRDVMKLNETEKNFRIFGPDETASNRLGSVLEATNRVWAADGRVMEVLSEHLCQGWLEGYLLSGRHGFF-SCYEAFIHIIDSMFNQHAKWLQVARKPISSLNYLLTSHVWRQDHNGFSHQDP--VANKSADIARVYFPPDANTLLWVGDHCLKTWNRVNVIEPQWLTMAEAEKHCEAGLGIWEWAGTEDGLEPDIVMACAGDVPMETLAAVDLLRQSLPHLRIRDLMVLQSPHQHPHGISDEEFDRMFTTNRPVIFAYHGPYLIHRLVYKRTNHSNFHVRGFIEQGTTTTPFDMTVLNEL-DRFHLAMEAVERLPL 750
9 -14.500[C] COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes  ali follow..  14  581SDRALMASGEKPFDWGGAETLAYATLVDEGIPIRLSGEDAGKNGSVYVPLSNIHSGQGDFQVWDSVLSEEAVLAFEYGYATAEPRTLTEAQFGDFANGAIDQFISSGEQKWGRMCG-----LVMLLPHG---GQGPEHSSARLERYLQLQNMQVCIPSTPAQVYHMIRRQALRGRPLIVMSPKSLLRHPDELANGSFLPAIGEIDELDPKGIKRVVMCSGKVYYDLLEQRRKNGQTDVA--IVRIEQLYPFPHQAVQSVLEQVHDFVWCQEEPLNQGAWYCSQHNFREVIPF--GASLRYAGRPASASP-AVGYLSVHQKQQQALVNDALNV... 934
10 -14.000[C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit  ali follow..  14  2.............................KKMKTMDGNTAAAHIAIYPITQGRKNLFGQKVKIMEMQSEAGAAGAVHGSLQAGALTTTYTASQGLLL--MIPNMYKIAGEL--------LPGVFHVSARALATHSNIYGDHQDVMAARQTGCALLAEGSVQEVMDLSAVAHLVAIPFINFFDGFRTSHEIQKVEVMDYEDPVQRGSNEGEDADRVIIAMGSICDTIEETIDYLRAKGEKVGVLKVHLYRPFSVEHFLKYIPKTAKKIAVLDRTKEAGSQADVVKAFYNSD--VIVGGRFGLGLKDT--------------LPVHIYSVYENLKLD 383
11 -13.900[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  14  4DVVRDAEGEKVFLLGNEAIARGAIEA-------VFAAYPGTPSSEIADTLSDACRLLRGKMYMEYSANEKVAFEVAVGASLAGKRAMATMKHVGV----------NVAADPLFSFAYVGARGGFVLVTADDPSMHSSQNEQDNRWYGKAAKLPVVEPSSVQEAKDYAKLCFDLSEPMILRSYTRLSHASGVVELGKIPEKEFSRVEWERHPGDVGIIACGLSYAYTKEALENL---NLNLPVLKLSSMHPLPERLIENFVSQMKKVIVVEEVDPF--VELHVRAMGLAEVYGKMNGYMPMNY................................. 332
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Kolodny R, Sitbon E, Li Z, Godzik A. Using an alignment of fragment strings for comparing protein structures. Bioinformatics. 2007 Jan 15;23(2):e219-24.