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Query: [F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTTIGTPLTPKATKVMMLGSGELGKEVVIELQRLGVEVIAVDRYANAPAQQVAHRAYTISMLDGEALKALVEKEKPDYIVPEVEAIATATLVELEQAGFTVIPTAKATQLTMNREGIRRLAAEELGLPTSNYQFVDNFDDFKRAVEKIGIPCVVKPIMSSSGHGQSILKSVEQIPSAWEYAQQGGRAGAGRVIVEGFVKFDYEITLLTVRHVHGTSFLAPIGHIQIDGDYRESWQPQAMSAVALEKAQAIAEKITGALGGRGIFGVEMFVCGDEVIFNEVSPRPHDTGMVTLISQELSEFALHARAILGLPIPDITLISPSASKAIVVEGKSTQVVFGQLAEVLAEPHTNLRLFGKGEVDGHRRMGVILARDISVEKALEKARRAYDKLEIALLast
1 -103.000[F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)  ali  100  1MTTIGTPLTPKATKVMMLGSGELGKEVVIELQRLGVEVIAVDRYANAPAQQVAHRAYTISMLDGEALKALVEKEKPDYIVPEVEAIATATLVELEQAGFTVIPTAKATQLTMNREGIRRLAAEELGLPTSNYQFVDNFDDFKRAVEKIGIPCVVKPIMSSSGHGQSILKSVEQIPSAWEYAQQGGRAGAGRVIVEGFVKFDYEITLLTVRHVHGTSFLAPIGHIQIDGDYRESWQPQAMSAVALEKAQAIAEKITGALGGRGIFGVEMFVCGDEVIFNEVSPRPHDTGMVTLISQELSEFALHARAILGLPIPDITLISPSASKAIVVEGKSTQVVFGQLAEVLAEPHTNLRLFGKGEVDGHRRMGVILARDISVEKALEKARRAYDKLEIAL 393
2 -87.900[F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)  ali follow..  26  1.MTKNVMAKTNNLTIGIIGGGQLGRMLAMAAARLNHRTIVLEPQADCPAAQVCNDQIVAEYDDEKALAELASR--CDVVTYEFENVPVAAAEKLSAS-VPVYPPAQALSASQDRLTEKRFL-NGCGIPTADFRAVDSQDELEAALTAFGGKGVLKTRRGYDGKGQRLFRGGENLTGAFAAL------GGVPLILESFVAFEREISIIAARFQDGTVTCYDAENVHLNGILHTSTVPAALSDAAKAVAVQSAEKLLAALEYVGVIGIEFFVLPDGLVANEMAPRVHNTGHWTEAACAISQFEQHIRAVSDLAPGSTDRHSDCVMTNLIGDD------INDVPAWLSKKDCLVHLYGKTEARPGRKMGHVTELLHTGKA................ 363
3 -66.800[F] KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase  ali follow..  24  2..........DSRTVGILGGGQLGRMIVEAANRLNIKTVILDA-ENSPAKQISNDHVNGSFSNPLDIEKLAEK--CDVLTIEIEHVDVPTLKNLQVKKLKIYPSPETIRLIQDKYIQKEHL-IKNGIAVTQSVPVEQASSLLNVGRDLGFPFVLKSRTAYDGRGNFVVKNKEMIPEALEVL------KDRPLYAEKWAPFTKELAVMIVRSVNGLVFSYPVETIHKDNICDLCYAPARVPDSVQLKAKLLAENAIKSFPGCGIFGVEMFYLETGLLINEIAPRPHNSGHYTIDACVTSQFEAHLRSILDLPMPKNFITTNAIMLNVLGDKHTKDKELETCERALATPGSSVYLYGK-ESRPNRKVGHINIIASSMAECEQRLNYITGRTDIP. 386
4 -45.600[I] COG0439 Biotin carboxylase  ali follow..  17  3............KKILIANRGEIALRVIRTAREMGIQTVVVYSTADEKSLPVADESVCVSYLNIPNILSAALMTGAEAIHPGYGFMAENPAEMCREHGIVFIGPTPESMRALGSKAGGREIAAQSNVPTVPTGVLESVDAALLAAKQIGYPVLLKASAGGGGRGQKVIRTQEELQKGFNQAQEEARLGDPAIIMEKFLEEFRHIEVQVMGDGQGHVIHIGERDCSIQRRNQKLIAPSTLPESLRQEILAAGVRLAQFVNYAGAGTLEFIMDRDGYYFMEMNTRIQVEHCVSEMISSLDLVRLQIEIAAGLGLNDVKLHGHAIECRINAEDPDKDPAAGKIDDAHFAGGAGVRV-YSIPPHYDSLIGKLIVWHEDRDKAVSRMKRALEETVIQ. 411
5 -42.300[R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase  ali follow..  14  1........MSKMEEILVIGVN--TRPVVESAFRLGYRVYSAGYYCTADFKHYTERRCILRERSGESCGRFHENFSQEKLLEAASDFIERALTGAPPLPGEKVLGNSRVDHVEDKYRLYRRI--RNSYPTPETHLISDPAEAMEIVAAGEKKYIAKPVSGAGGFGVTEFREGDG-----------------EFLLQEYIEGVPVSASVLSTGEDAITVLTSRQDRGVPGFEGQFVYAGNMTPGPSGEIEDLASDLILDLSLRGSNGVDLIMRDSELYVIEVNPRIQGTFECAEASLGINMVDAHIRACMGELIEKPDPVSYAVKRILYAPARCRVGEIKT-MGVHDLPVP------GTIIEEGEPLLTVLASHNSMEAAENLASNICSRVKKEL 364
6 -40.900[I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit  ali follow..  20  2............KKVLIANRGEIAVRIIRACRDYGLQSVAVYADPDQDALFVADEAYALTYLDISKLIAIAKRAGADAVHPGYGFLSERAAQAVIDAGLIIGPDPDVIEALGDKVMARR-IATGVGAPLVAGSDVSSAAEVTAFAEQHGLPVAIKAAHGGGGRGLKVAWKMEEIAELYESAVREATVGRGECFLERFLDRPRHIEAQVIADKHGNVLVLGTRDCSLQRRNQKLIAPAPLSDEQRQKIHDAAKAICAAAGYSGAGTVEFLLGVDGISFLEVNTRLQVEHPVTEETTGIDLVIEQFRIAEGHKLRTPEPRGHSMEFRINAEDPGRGPTPGLISVFDAPSGPGIRM-GSSIPGVFDSLAKLIVTGVDRDQVLRRARRALREFRIE. 411
7 -35.900[IE] KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit  ali follow..  18  39.TVGIDYNEPKFDKILIANRGEIACRVIKTARAMGIKTVAVHSDVDSNSLHVADEAVCVSYLRADRILQAVEDTGAQAVHPGYGFLSENTAAELEKAGAKIGPNSKAILDMGDKIHSKK-IATAARVSMIPGYEIADEDMCVKVSRDIGYPVMIKASAGGGGKGMRVAWNDKQAREGYRLSKQEAASSFGDMLVEKFIDNPRHIEMQVLCDKHGNALWLNERECSIQRRNQKVIAPSSVPPEMRRKMGEQAVQLAKAVGYDSAGTVEFLVDSQRFYFLEMNTRLQVEHPITECITGIDIVQQMLRVSYGHPLPQVPLNGWAFESRVYAEDPYKGFGLPSVGRLYVEPKHVDGVRCDSGIREGSEICKLVTHGDNREQALNRMQEALDNYVI.. 461
8 -35.300[C] COG1038 Pyruvate carboxylase  ali follow..  19  14.VLACGETVLKISKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLSLHRADESYQVSYLSIEEVIRVAKLSGADAIHPGYGLLSESPVEACNKAGITIGPTPDTMRQLGNKVAARN-LAISVDVPVVPATNPDDIAEVERMAEEIGYPVMLKASWGGGGRGMRAIRKKEDLAREVTEAKREAKAGKDEVYLEKLVERARHVESQILGDTHGNVVHLFERDCSIQRRNQKVVAPAPLSEAQRQELAAYSLKIAAATNYIGAGTVEYLMDADKFYFIEVNPRIQVEHTVTEVVTGIDIVKAQIHILEGAAIGDIRLNGHALQCRITTEDPEHNPDYGRITAYRSASGFGIRLYTGAVITRDPLLVKVTAWAPEPDEAISRMDRALREFRIR. 450
9 -33.500[EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)  ali follow..  18  2......PKRTDIQKIMVIGSGPIGTQACLSLKEEGYEVVLVNSNPATIMTEIADKVYIEPIT-LEFVTRILRKEGPDALLPTLGGMELSKNGILDELGVELLTKLSAIDQAEDRDLFKQ-LMEELEQPIPESEIVNTVEEAVAFAATIGYPVIVRPAFTLGGTGGGMCANEKELREITENGLKLS--PVTQCLIERSIAGFKEIEYEVMRDSADNALVV-FDPVGIHTGDSIVFAPAQMSDYENQMLRDASLSIIRALKIEGGCNVQLALDPNKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEVINPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERRL-----GTQMKATGEVMAIGRNIEESLLKACRSLE...... 401
10 -32.500[R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)  ali follow..  13  2.............KLFLFEFATCGERIEDSTAVEGFKSAFDGFKNYYEITGFVRPEFSCLFTLPDSMEKYLEKSDAFIIAPEDDFLLYTLTKKAEKYCENLGSSSRAIAVTSDKWELYKKLRGEVQVP-------------QTSLRPLDCKFIIKPRTACAGEGIGFSDEVPD-----------------GHIAQEFIE--INLSVSLAVGEDVKCLSV-NEQIINNFRYAGAVVPARISDEVKREVVEEAVRAVECVGLNGYVGVDIVYS-DQPYVIEINARLTTPVVAFSRAYGASVADLLAGGEVKHVRRQMVRKSKSAEKPYV.................................................................. 291
11 -23.900[R] COG3919 Predicted ATP-grasp enzyme  ali follow..  15  2..........TIPGVVIIGGAHGTLALARSLGVLNVPVYYLTHDSPLPGSRFVRETIRWAGPHDDGEMAEKPGLKGCLLVPSGDGLVSQHREELSALYKIILPEWTNLQWLCEKPLLYK-RAAELGVSIPRTYALTSAADIDGL--DVMFPVILKPHMGGGNTSVIRADDREELKAAFVDASGEI--GPDNVVVQELIP-GESQFSYAALWLNGEPIAEFTARRARQYPVDFGYTSTRVEVVDNRQAIEAARKILKSAGHSGLVEVEFKLDDGALKLLDVNPRPWSWFGLCS-AAGINLGGLLWRVANDMPTGQAVIARQGTSWSYLVRD............................................................... 333
12 -23.600[R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)  ali follow..  12  15..........DKDKITIGVIGS-ALDIADGAKEEGLPTLVVRKTRDGLVKGFIDEVIVLDFAQIIEIQEELRKRNVIFVPNRSFVVYTGIDRVENEFLVPMFGTRSRTEERSEEKSYYWLL-EKAKLPYPEPVSPEEIDD------VGLVIVKLPHAKKRLERGFFTAASYKEFKEKSEKLIRLGVITRAKARIERYIIGPVETSLDGHVRLPAAQQLTLPEWQFEPEYTVCGHASSTLRESLLEKVFDMAEKYVEATGIIGPFTLQTAVDKDLFYIYDVAPRTGGGTNIHMAM-GHPYGNSLWRKPMSTGRRIALEIKRAIELDELEK................................................................ 377
13 -22.700[M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes  ali follow..  17  2.............KIAVLYGGT-GKGIMEALKANGHEVIGIDFHPDDLDVDLVFIGLHGRLGEDGKVQALLDLLNIPYV-----------------------TGVQGSALAMDKAKAKL-FFEKAGIRVAEEVVLHSFTDANAFNFTGTYPVVVKPNQEGSTIGLTVAETEEELLQGIEEAFRHDD----TILIEEFIA--TEVTVAVLGNKGEERSLPVVEIVPKNKLYDEHIVPARISEEHTAYVQQAAVRAHQALGCDVYSRVDFIVPNDGPVILKVNTLPG---------TPTSLYPDAAKGV-GMSYEEM.............................................................................. 294
14 -20.800[F] KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS)  ali follow..  16  5.............IALLIGNGTIAWKLCESPLISKVYVAPGNGGTASNGAESKMENVNIGVCDFEQLVKFALDKDVNLVIPGPELLVEGIEGHFRRVGIPCFGPSALAARMEGSKVFSKDFMHRNNIPTAVYKSFSNYDHAKSFLDTCTFDVVIKADGLAAGKGVIIPKTKKEAFEALESIMLNEEFGSANVVIEELLE--EELSILTFSDGYTCRSLPPAQDHKR----MGCYAPTPASPKLLETVQSTIIQPTEGYPLVGILFTGLMLTPSGPRVLEYNVRFGDPETQAVLPLLESDLAEIILACVNHRLDAIDIVKFSCAVVCVAGGYPGPYNKGDIITFDALKDKNTRIFDGNVVTNGGRVLAVEATGDSVEAAVRLAYEGVKTVHFD. 414
15 -20.600[F] COG0151 Phosphoribosylamine-glycine ligase  ali follow..  14  2.............NILIIGNGGREHALAWKVAQ--ADKVFVAPGNAGTALEHKVENVNISATDIPALVKFAQDKQIGLTIVGPEALVIGVVDAFREAGLKIFGPAKAAAQLEGSKAFTKDFLARHKIPTAEYQNFTEVEPALTYLREKGTPIVVKADGLAAGKGVIVAMTLQEAEDAVRDMLSGNAFGEARVVIEEFLD--EEASFIVMVDGKNVEPMASSQDHKR----MGAYSPAPVPEIHSRIMKEVIYPTVNGMAYTGFLYAGLMIMPNQPKVIEFNCRFGDPETQPIMLRLKSDLVELCLKACDGKLDEVISQRASLGIVLAAEGPKDYRKGDEISGLPKSAVKNEKVFEGKLVTNGGRVLCVTALGESVFEAQQKALKLAEQIQWS. 410
16 -16.800[HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)  ali follow..  12  17.....RHYRRGFMRIAFFGPTFATGLLAMAALNRGHDVVYLTPGDDDTLAVHATVIRKGKYKKPEAFHAAMDVEEIDALMLRNDHAGILFGRLAEQRGVVVLNDPEGLALAQNKL----YFQSFPEIVRPTTLISRNVEEIRAFADTHPKGVIVKPLQGSGGKNVFKIGSSKETNLN---QIFEAVSLEGYLIAQAYLP-EGDVRFFMM---NGRPLMRDGQYAALRRVPAKGDLRSNIHAKVTDEIVELAEMMRPKLVEDGMFLVGLDIVGDKILEVNVFSPGGLSN--ILELTNVDFSDTIIEAVE..................................................................................... 350
17 -9.380[TU] KOG3895 Synaptic vesicle protein Synapsin  ali follow..  11  82....PAFSKDKYFTLLVLDDQNTDWSKYFRGRRLDFDIRVEQAERDITVVSSADTGPVVTMAAYRSGTRVARSFRPDFVLIR-----RSTILGLKYGGVPSINSLHSIYQFQDKPWVFSHLLQRDGFPLIEQTFFPNPRDLVSIRGMMKFPSVLKAGHCHGGVATARLENQSALQDAAGLVSGAGNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLTEKYKSWVDEIS----ELFGGMEVCGLSVVVAKDG-YIISA-----CDSTFALIGDTQEEDRRQIADLV..................................................................................... 447

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.