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Query: [J] COG0050 GTPases - translation elongation factors, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAFDQIDNAPEEKARGITINTSHVEYDTPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEGEAEWEAKIIELAGYLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTVKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREDIERGQVLAKPGSIKPHTTFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNINMIVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVIALast
1 -127.000[J] COG0050 GTPases - translation elongation factors  ali  100  1MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAFDQIDNAPEEKARGITINTSHVEYDTPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEGEAEWEAKIIELAGYLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTVKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREDIERGQVLAKPGSIKPHTTFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNINMIVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVIA 394
2 -111.000[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  61  42ADEKVFVRKKPHVNIGTIGHVDHGKTTLTAAITKCLSDLGQASFMDYSQIDKAPEEKARGITISSAHVEYETANRHYAHVDCPGHADYIKNMITGAATMDGAIIVVSATDGQMPQTREHLLLARQVGVKQIVVYINKVDMV-EPDMIELVEMEMRELLSEYGFDGDNTPIVSGSALCALEGREPEINSITKLMEAVDSYITLPERKTDVPFLMAIEDVFSISGRGTVVTGRVERGTLKKGAEIEIVGYGSHLKTTVTGIEMFKKQLDAAVAGDNCGLLLRSIKREQLKRGMIVAQPGTVAPHQKFKASFYILTKEEGGRRTGFVDKYRPQLYSRTSDVTVELTHPDSDKMVMPGDNVEMICTLIHPIVIEKGQRFTVREGGSTVGTALVTELL. 438
3 -83.400[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  28  2.......KNQSEINIGLVGHVDHGKTTLTKALSGV-------------WTDTHSEETKRGISIRLGYADITFRKRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCQPQTKEHLMALDVIGVKDVIVVQNKIDIV-SKERALESYREIKEFVKGTCAEDAPIIPVSAQQGANID----------ILIETIEERIKTPKRDVDKPARMYVARSFDINKAGGVIGGSLVQGRLRVGDEIEIRPGIQVLHSTITGLVAGGEEMEEVGPGGLVGVGTLALTKADSLSGSVAGEPGTLPPVHSFTMETHLLERVVGTKEEPIKTGEPLMINVGTTTTVGVVK---------SARADDADVVLKLPACAEEGQRIALSARWRLIGYGII..... 407
4 -82.500[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  22  32..SHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVR-GYANAKIYQLDDPSCPRPECYRSCGSSMPDEFPVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCQPQTSEHLAAIEIMKLKHILILQNKIDLV-KERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIE----------VVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKKGGVAGGSILKGVLKVGQETEVRPGIKSIFSKIVSLFAEHNDLQYAAPGGLIGVGTKTLCRADRMVGQILGAVGALEIFTELEISYFLLRRLLGAKVQKLSKNEVLMVNIGSLSTGGRV---------SAVKADLGKIVLTNPVCTEVGEKIALSKHWRLIGWGQIRRGVT 464
5 -76.000[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  33  2...KIMASQKPHLNLITIGHVDHGKSTLVGRLLYEHGQKGKATFEFAWVMDRFKEERERGVTIDLAHRKFETDKYYFTLIDAPGHRDFVKNMITGTSQADAAILVISAREGVMEQTREHAFLARTLGVPQMVVAINKMDATSSEKRYNEVKADAEKLLRSIGFKDISFVPISGYKGDNVTKPSPNWYKGPTLLQALDAF-KVPEKPINKPLRIPVEDVYSITGIGTVPVGRVETGVLKPGDKVIFLPADK--QGDVKSIEMHHEPLQQAEPGDNIGFNVRGIAKNDIKRGDVCGHLDTPTVVKAFTAQIIVLN-----HPSVIAPGYKPVFHVHTAQVACRIDEIEKPDFIKNGDVAIVKVIPDKPLVIEKVGRFAVRDMGQTVAAGQCIDLE. 425
6 -74.500[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  26  1............MIIVTSGHVDHGKTALLKALTGT-------------STAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLIVAADEGVAVQTKEHLAILRQLQFHEIIVVITKADRT-NSAQIESLIQTIKQDYS--FLRNANYFVTSAETGQGISELRHYLANL------------AELADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKVNDEIYLSTG---QKIRIKAIHAQNTSSEQGIAGQRLALNLNALDRTPMKRGDWLLQNEPLPPTDRISVQILAEV--------PLNESQPVHIYHGASRTTGKLTLLQG-KNAAKNDRTLAEIILDSPLFLAFGDKLILRSGDTLIAGARVLEINS 345
7 -72.400[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  31  1.....MGKEKVHINIVVIGHVDSGKSTTTGHLIYKCGEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYITIIDAPGHRDFIKNMITGTSQADCAVLVVACGTGEFEQTREHALLAQTLGVKQLIVACNKMDSTESEARFTEITNEVSGFIKKIGYNPKAVPFVPISGFNGDNMLEVSNASGKTLLEALDSI-IPPQRPTDRPLRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPQNV--TTEVKSVEMHHESLPEAVPGDNVGFNVKNVSVKDIRRGSVCSDSKQAKEARTFHAQVIIMN-----HPGQISNGYTPVLDCHTAHIACKFNELDFPKFLKSGDAGIVELIPTKPLCVESFGRFAVRDMRQTVAVGVIKSVEK 443
8 -69.300[R] COG5258 GTPase  ali follow..  22  96LRAVSREEPPPTVTVVALGNVDAGKSTLVGVLTTGRLDDGKGLARSY--ASRYKHEVLTGRTSAVSLRLLKRSDKLVLLVDVGGHERYLRTALRGLFSPDYVMLVVAANSGVQKMTKEHLGIAVAIGIP-VFVVVTRIDIT-PSEVFQKTVEEVVRILKMPGVSKAPVFYVSSVTGHGLD----------LLLRFLSLLPRRRRWDYGGEFLMYISDIYLVKGVGVVIGGLVEKGILHVGDRVWLGPYGKWMQTVVKSIHFNRTPVESAKAGSFITVALDKVEK---VEKGMVLSARPLKAVREVTADVLVLRHP-----TVIRAGFSGVFHYKAVRTGGYIKEIDK-GELMVGDSGVVKIELSRPWHIDSG-VFVFRN-GPTRILGRIIGTDG 513
9 -66.900[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  22  17.AWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLVDSEETFTRIREDYLTFAGQLPGN-LDIRFVPLSALEGDNVASQSWYSGPTLLEVLETV-EIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGV--ESNVARIVTFDGDREEAFAGEAITLVL--TDEIDISRGDLLLAADELPAVQSASVDVVWMA------EQPLSPGQSYDIKIAGKKTRARVDGIREVENLPLNGIGLVDLTFDEPLVLDRYGGLIFIDSNVTVGAGMVHEPVS 439
10 -64.500[J] KOG0458 Elongation factor 1 alpha  ali follow..  23  157.ISAFVKSALPHLSFVVLGHVDAGKSTLMGRLLYDLNTMGKSSFKFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNAFEQTKEHMLLASSLGIHNLIIAMNKMDNVDSQQRFEEIKSKLLPYLVDIGFFEDNINWVPISGFSGEGVYKIEWYNGPNLMSTLENAAENEGINKDDPFLFSVLEIIKTSNDLALVSGKLESGSIQPGESLTIYPSEQ--SCIVDKIQTNHEETDVAIKGDFVTLKLRKAYPEDIQNGDLAASVDYIHSAQCFVLELTTFD-----MNRPLLPGTPFILFIGVKEQPARIKRLKKIRHLGSKQRAFVEIELKRWIPLLTAGRVVLRKDGRTIAAGKISEITQ 611
11 -62.900[J] KOG0459 Polypeptide release factor 3  ali follow..  27  90AEDVAEANKKRHLNVVFIGHVDAGKSTIGGQILFLSGDKSRESWYMAYIMDTNEEERLKGKTVEVGRAHFETESTRFTILDAPGHKSYVPNMISGASQADIGVLVISARKGEFEQTREHVQLAKTLGVSKLIVVVNKMDDPTSKERYDEIEQKMVPFLKASGYNTKDVVFLPISGLMGKNMDQRMWWSGPSFFEVLDSI-EIPPRDPNGPFRMPIIDKF--KDMGTVVMGKVESGSIREGDSLVVMPNKE--QVKVVAIYCDEDKVKRAGPGENLRVRITGIEDEDILSGFVLSSIVNVPAVTEFVAQLQILE-----DNAIFTAGYKAILHIHAVVEECEIIELKKVLFVKNGAAVVCRIQVTNSICIEKFGRFTLRTEGKTIAVGKVTELLS 527
12 -34.700[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  25  7.............NIAIIAHVDHGKTTLVDKLLKLSGTLDRKEAESERVMDSNDQEKERGITILAKNTAIKWNGYNINIVDTPGHADFGGEVERVMSMVDSVLLVVDAQDGPMPQTRFVTQKAFKAGLR-PIVVVNKIDRPGAR--PDWVIDQIFDLFDNLGATDEQLPIVYASALNGIAGLEKMDDNMDALFQAIIDHVPAPVVDTEGPFQMQISQLDYNSFLGVIGIGRITRGKVKSNTPVVAISDDGSKRNRILKIMGHHGLQRVEVAEAEAGDIVCVSGMEELFISDTLCDPQNVEALPPLTVDQPTVS................................................................................. 308
13 -34.500[M] COG0481 Membrane GTPase LepA  ali follow..  20  6.............NFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEA-QVLDSMDLERERGITITLNYKAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMNLE-VVPILNKIDLPAAD--PERVAEEIEDIV---GIDAMEAVRCSAKTGVGIE----------DVLEEIVHKIPAPEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGTLRKGDKIKVMSTGQSYNVRLGIFTPKQVDTTILNCGEVGWVVCAIKDILGAPVGDTLTSHNN................................................................................................ 279
14 -33.300[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  19  44.............NFGIVAHVDHGKSTLADRLLEMCGAVPPGQKQM---LDKLQVERERGITVKAQTAALRHRGYLLNLIDTPGHVDFSAEVSRSLAVCDGILLLVAANQGVQAQTIANFWLAFEKNIQ-IIPVINKIDLPGAD--IKSVETQLKNLF---EFNPEECLHISAKSGLNVD----------KVLEAIIDRVPAPTAIIDAPFRSMIFDSYFDHFRGAIAHIMVKEGSVKKGDKIQSYQNEKVYDVSEVGVMVKCTELRAGQVGYLVCN-MRTVN--EAVVGETLFAETTSRDSVKTFAEIKGVKPTVYAGLFPVETSDYESLKQAVERLCLNDPSVTVIPDSSKALGLGWRIGFLGVLHMEVFGARLSQEYDASVILC....... 399
15 -28.700[J] KOG0469 Elongation factor 2  ali follow..  18  10..RALMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGETRFTDTRKDEQERCITIKSTAISLKYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKP-VLFMNKMDRAIKKDKTAALVEKLGIKLANDEKDLEGKPLMKVFMRKWLPAGDT-------MLQMIAFHLPSPVTPNGPLMMYISKMVPTSDKGRFYAFGRVFSGKVATGMKARIQGPNDLYEKTIQRTILFIEPIEDIPSGNIAG--LVGVDQYLVKGGTITTYKDAHNMRVMKFSVSPVVRVAEAKNPADLPKLVEGLKRLAKSDPMVQCIFEESGEHIIAG-AGELHLEICLKDLEEDHACIPLKKSDPVVS......... 572
16 -28.200[J] COG4108 Peptide chain release factor RF-3  ali follow..  23  5.TTPYFGEVSKRRTFAIISHPDAGKTTITEKVIQVAGTVKGRGSNQHAKSDWMEMEKERGISVTTSVMQFPYGDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLMEVTRLRDTPI-VTFMNKLDREIRDEELELVLGASHEFDRELFLQGELTPVFFGTALGNF--------GVDHMLDGLTQWAPSPSEEKFTGFVFKIQANMDPKHRDRIAFVRIVSGTYKQGMKMNHVRLGKQVNISVTFMAGDRARAEEAFAGDIIGL----HNHGTIQIGDTFTQGETLK.............................................................................................. 388
17 -27.100[J] KOG0468 U5 snRNP-specific protein  ali follow..  18  133.............NVALVGHLHHGKTTFVDCLIRQTHPQFEMEERQLRYTDTLFTEQERGCSIKATPVTLKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAI-TVCINKIDRLDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFASCNRFMGDCSGFVDMCVEHIKSPLENQYGTLMVHSSKMYPNDDCFFQVLARIVSGTLHAGQEVRVLGENDSRILQVGRLWVYKVELNRVPAGNWVL--IEGIDQCIVKTSKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEESGEHVI-LGTGELYLDCVMHDLRKMYSE-----IDIKVADPVV.......................... 663
18 -23.100[J] COG0480 Translation elongation factors (GTPases)  ali follow..  24  12.............NIGIAAHIDAGKTTTTERILFYSGIIHKIGEVHEGTADWMDQERERGITITAAAISTSWKDYQINIIDTPGHVDFTIEVERSMRVLDGVIAVFCSVGGVQPQSETVWRQADRYKVPR-IAFINKMDRTGDDDLMSLTEEEIRSALRKGTIAGTIVPVLCGSAFKNK--------GVQLMLDAVVDYLPAPTRADDNEPLAALAFKIMADPYGRLTFVRVYSGVLKKGSYV--LNATKNKKERISRLVLDRQDVEELRAGDLGAA----LGLKDTLTGDTITDEGAPVILESLFIPEPVIS................................................................................. 406
19 -22.700[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  24  182.............VVTIMGHVDHGKTTLLDKFRKT----------------QVAAVETGGITQHIGAFLVSLPSGEITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAQVP-IILAVNKCDKAEAD---EKVKKELLAVVCEDYGGDVQAVPVSALTGDNLMALAEATVALAEMLEL--------KADPNGPVEGTVIESFTDKGRGLVTTAIIQRGTLRKGSVLVA----GKCWAKVRLM-FDENGKTIDEAYPSMPVGITGWRDLPSAGEEILEVESEPRAREVVDWRKYEQEQEK.............................................................................. 455
20 -19.500[E] COG4917 Ethanolamine utilization protein  ali follow..  22  4..............IAFVGSVGAGKTTLFNALQG----------------NYTLARKTQAVEF-----------NDKGDIDTPGHPRWYHALITTLQDVDMLIYVHGAND---PESRLPAGLLDIGVSKRQIAVISKTDMPDAD------VAATRKLLLETGFE-EPMFELNSHDPQSVQQLVDYLASLTKQEE........................................................................................................................................................................................................ 150
21 -19.200[J] KOG0465 Mitochondrial elongation factor  ali follow..  19  72.............NIGISAHIDSGKTTFTERVLYYTKRIKAGRDNVGAKMDSMDLEREKGITIQSAATYCSGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPR-VTFINKMDRMGDDEMAEMFTQQIKDAIRRSTIARSFTPVLMGSALANT--------GIQPVLDAIVDYLPNPSVPAVQQPFVGLAFKLEEGKYGQLTYVRVYQGRLRKGNYI--TNVKTGKKVKVARLVREMEDVDEVGSGE-----ICATFGIDCASGDTFTDGSVQYSMSSMYVPDAVVSLSITPNSKDASNFSKALNRFQKEDPTFRVKFDPESKETIISGMGELHLEI............................... 523
22 -18.600[R] KOG2486 Predicted GTPase  ali follow..  16  138..............FALVGRSNVGKSSLLNSLVR--------------RKRLALTSKKPGKTQCINHFRI---NDKWYLVDLPGYNKFTKDYFLNRSTLVSVFLLVDASIPVKPIDLEYASWLGQNQVP-MTLIFTKCDKRKKKKNPEANIKEFQDLIQGFFETTPPWIMTSSVTNQGRDEILLHMAQLRN........................................................................................................................................................................................................... 313
23 -18.100[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  20  447.............VVTIMGHVDHGKTTLLDRFRES----------------RVTEGEAGGITQHIGAYQIKANGKKITFLDTPGHEAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAAGVP-IIVAINKIDKPGNPQRVTQELTEHGVFPVAWDPENGSEFVISAKFNQNLDELLDTVLLVAEVQEL--------KADPTVRAIGTVVEARLDQGKGAIATLLVQQGTLHVQDPIVV-----NTYGRVRTM-TNDLGRRIKEAGPSTPIELTGLS----QAGD----------------HFAVFEDEKAARA--AGEERAKRAQLIKRQNTRRVNLDNLFDTLKEGQTKSVNIIIKADVSAEALAASLQKIEVEGVAVGAISE... 786
24 -17.100[R] COG3596 Predicted GTPase  ali follow..  14  27ILQQINQLTHYEPVIGIMGKTGAGKSSLCNALFA----------------EVSPVSDVAACTRDPLRFRLQIGEHFMTIVDLPGDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYQVIGEAYRHKMLFVISQSDKAEPTSGGNILSTEQKQLLHELFQPVHPVCAVSVRLQWGLRVMAERMIK.............................................................................................................................................................................................................. 214
25 -16.800[R] COG1084 Predicted GTPase  ali follow..  13  153..RNMPTVDLDAFTVVIAGFPNVGKSTLLRTLTGA----------------EPEVADYPFTTKGIQIGHLERKWKRIQVIDTPGNNIELQAMVALENIADVIMFIFDASETCGYTLESQYSLYLGI--IPVVTVFNKMDLAENVKYLEEYINMVEDPLK-----------VSAFEGRGVSKIIKKLEGLYE........................................................................................................................................................................................................... 326
26 -16.000[R] COG0218 Predicted GTPase  ali follow..  13  28..............IALAGRSNVGKSSFINTMLNRKN---------------ARTSGKPGKTQLLNFFNI---DDKMRFVDVPGYGCMIEEYLTTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIV-ATKADKIPRGKWNKHES-AIKKKLNFD--PSDDFILFSSVSKAGMDEAWDAILE.............................................................................................................................................................................................................. 193
27 -13.300[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  11  170.............TVLICGYPNVGKSSFMNKVTRADVDVQPYAFT----------------TKSLFVGHTDYKYLRYQVIDTPG---ILDRPFEDRNIIEAVLFFLDISGSCGYTIAQQAALFHSIK-KPLVIVCNKTDLMPMENISEEDRKLIEEMKSEA--EEQVLLKMSTLTDEGVMSVKNAA................................................................................................................................................................................................................ 345
28 -12.900[R] COG1159 GTPase  ali follow..  13  11..............IAIVGRPNVGKSTLLNKLLG-------QKISITSRKAQTTRHRIVGI--------HTEGPYQAIYVDTPGNRLMNKAASSSIGDVELVIFVVEGTR----WTPDDEMVLNKLR-APVILAVNKVDNVQEKVDLLPHLQFLASQ-----MNFLDIVPISAETGMNVDTIAGIVRKHLPEAIHH-----PEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVTNERGGYDINGLILVEREGQKKMVIGNKGAKIK-TIGIEARKDMQE......................................................................................................... 267
29 -12.800[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  15  48....RLFRRTKSNTVLLSGLSGSGKTVLFYQLR---------DGSSHQGAVTSMEPNEGTFVLHNENNTKKGKVKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALE-NIRAASEYLDILTNASVIKVLLCCNKTDKHTKEFIRKQMEKEIDKL............................................................................................................................................................................................................................................. 201
30 -12.400[R] COG1160 Predicted GTPases  ali follow..  11  5.............VVALVGRPNVGKSTLFNRLTR----------------RDALVADFPGLTRDRKYGHAHIAGYDFIVIDTGGEEKMAEQSLLAIDEADIVLFLVDARAGLTAADIGIANYLRQRQNKITVVVANKTDGIDADSHCAEF----------YQLGLGEIEQIAASQGRGVTQLMEQVLAPFAEKMENADENDRTSEEEQDEWEQE-LEEEQDKNIKIAIVGRPNVGKSTLTNR--ILGEDRVVVFDMPGTTRDSIYIPMERDGQQYTIDTAGVRKRGKVHLAVFSVIKTLQAIQDANVVLLTIDAREN-----ISDQDLSLLGFILNAGRSLVIVVNKWDGLDQDVKDRVKSELDRRLDFIDFARVHFISALHGSGVGNLFDSI. 381
31 -11.500[P] COG0370 Fe2+ transport system protein B  ali follow..  14  2..........SQNTYCILGNPNTGKTSLFNALTGSYEYVGN------------------GVTVEKKVGTLR--SKTGKLIDLPGDETVVTRFLLE-EKFDCMLNIVDSSQ-----ERNLNLTVQLLEYGPVVMGLNMIDVAAGRG-IHLNIQNLAKKL------RIPILPVVARSGKGTEDILSTLSEKHV........................................................................................................................................................................................................... 162
32 -11.300[R] COG2229 Predicted GTPase  ali follow..  14  2..........RENKIIFTGPVGVGKTTAIAAIS----DEALVQTDASASDMTLDRKRNTTVAMDYGAISLD-EDTKVHLYGTPGQERF-EILSQGSMGL--VLLLDNARTNPLKDLEFFLSFRGLLEKAPVVVGITKMDIRSQPG--------IDVYHKYLAKHNLNVPVFEIDARKEDDVKQLVSAMLFSIDPGLE..................................................................................................................................................................................................... 177
33 -10.700[T] KOG3886 GTP-binding protein  ali follow..  12  30.LGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLTFDVEHSHVRFLGNVLNLWDCGGQDTFMENYFTSQRNVEVLIYVFDVESRELEKDMHYYQILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFER................................................................................................................................................................................. 269
34 -10.700[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  10  3MGVGDSSGSPKPIRIVVVGEKGSGKSSLIMAAAR----------------NTFHPNIPSLLPYTNLPSEFFPDRIPATVIDTSSRPEDKGKVVKEVRQADAIVLTFAFDR---PETLDRLSKYWLPLFRQIIVAGYEVDNKEAYNHFSIEQITSALMKQYREVE----TSIQWSAQRLDQAKDVLYYAQKAVIDPVGPVFDQENNVLKPRCIAALKRIFLLSDHN-------MDGILSDEELNELQKKCFDTPLVPCEIKQMKNVMQVTFP--------QGVNERGLTLDGFLFLNTRLIEEARIQTLWTMLRK................................................................................ 284
35 -10.500[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  14  64LSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWYLMTEGSDEKKSVKTVNQLAHKAGCLVRVFWPKAKCALLRDDLVLVDSPGLDSWIDKFCL---DADVFVLVANSESTLMNTEKHFFKVNEWLSKPNIFILNNRWDASASEPHMERCLHFLVEELKVANALEAQNRIFFVSAKEVLSARKQ.................................................................................................................................................................................................................. 294
36 -10.300[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  13  53FSDPFSTEVKPRILL--MGLRRSGKSSIQKVVFHKMS---------------PNETLFLESTNKICREDVSNSSFNFQIWDFPGQIDFFDPTFD--RGTGALIFVIDSQDDYMEALARLHLTVTRA---NFEVFIHKVDGLSDDETQRDIHQRANDDLADAGLEKIHLSFYLTSIYDHFEAFSKVVQKLIPQLPTLENLLNISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIYGLKEDGAGTPYDKESTAIIKLNNTTVLYLKEVTKFLA----CFVREESFERKGLIDYNFHCFRKA............................................................................... 363
37 -10.200[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  14  337.........KSIADLGLIGLPNAGKSTILNKISNAKPKIGHWQFTT--------------LSPTIGTVSLGFGQDVFTVADIPG-LEFLRHI----ERSNGWVFVLDLSNKDLQLLIEEVGTLEKVKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKS---QEWDCVPISALREKT........................................................................................................................................................................................................................ 499
38 -9.630[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  18  15.........SREMRILILGLDGAGKTTILYRL-------------------QVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSAD--IGISKDELLYMEELAGAILVVLANKQDMDG-----CMTVAEVHHALGLENLKNRTFQIFKTSATKG........................................................................................................................................................................................................................ 163
39 -9.610[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  16  15.........DQEVRILLLGLDNAGKTTLLKQL-------------------ASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSAD--FEETGQELAELEKLSCVPVLIFANKQDLLT-----AAPASEIAEGLNLHTIRDRVWQIQSCSALTG........................................................................................................................................................................................................................ 163
40 -9.570[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  20  10...DKLWGSNKELRILILGLDGAGKTTILYRL-------------------QIGEVVTTKPTIGFNVETLSYKNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTD--MSTASKELHLMEELQDAALLVFANKQDQPG-----ALSASEVSKELNLVELKDRSWSIVASSAIKG........................................................................................................................................................................................................................ 164
41 -9.550[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  16  14........AKKEMRILMVGLDAAGKTTILYKL-------------------KLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSND--VVEARDELHRMDELRDAVLLVFANKQDLPN-----AMNAAEITDKLGLHSLRQRHWYIQSTCATSG........................................................................................................................................................................................................................ 163
42 -9.550[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  17  14.........ERELRLLMLGLDNAGKTTILKKF-------------------NGEDIDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSAD--MQDCQRELQSLERLAGATLLIFANKQDLPG-----ALSSNAIREALELDSIRSHHWCIQGCSAVTG........................................................................................................................................................................................................................ 162
43 -9.540[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  16  19.........NKEMRILMLGLDAAGKTTILYKL-------------------KLNQSVVTIPTVGFNVETVTYKNIKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSAD--ISEARQELHRIREMRDCLLLVLANKQDLPG-----ALSPAQITDVLQLDKLKDRLWNVQPTCALTG........................................................................................................................................................................................................................ 167
44 -9.520[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  14  67..............IGFVGFPSVGKSTLLSNLAGVYSEVAAYEFT----------------TLTTVPGVIRYKGAKIQLLDLPG-----RQVIAVARTCNLILIVLDVLKPLGHKENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDA.............................................................................................................................................................................................................................................. 202
45 -9.490[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  13  65..............VALIGFPSVGKSTLLTMLTGTHSEAASYEFT----------------TLTCIPGVIHYNDTKIQLLDLPG-----RQVIAVAKSSDLVLMVLDASKSEGHRTKELEAVGLRLNKTPPQIYFKKKKTGGISFNTTAPEKLCYQILHEYKIHNAEVLFRENATVDDFIDVIEGNRKYIKCVYVYNKIDVVGIDDVDRLSRQPVRVYSKPQGQQPDFDEPFVLSSDRGGCTVECNHVHRTLVKDMKYALVWGTSTR--HNPQNCGLSLEDEDVVQIKKERDEGGRGRFKSHSNAPARI-----ADREKKAPLKQ..................................................................... 399
46 -9.440[R] COG1163 Predicted GTPase  ali follow..  13  68..............VGFVGFPSVGKSTLLSKLTGTESEAAEYEFT----------------TLVTVPGVIRYKGAKIQMLDLPG-RGRGKQVIAVARTCNLLFIILDVNKPLHHKEKELEGVGIRLNKTPPDILIKKKEKGGISITNTVPLTHLGN.............................................................................................................................................................................................................................................. 203
47 -9.430[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  16  2.........KRPLIIGVGGPVGAGKTMLIERLTRYLSTKGYSMAAITNDIYTLPADRIAGVETAIEEMCDKHPDLQLLFLESGG-----LSATFSPDLVDFSIYIIDVAQGEKIPRKGGQGMIKS------LFIINKVDLAPYVGAVEVMKADTLKS------GNKDFFVTNLKTDEGLKSVADWIEKRLQLALLEE..................................................................................................................................................................................................... 206
48 -9.420[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  14  18.........QKEAKILFLGLDNAGKTTLLHML-------------------KDERLVQHQPTQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYD--FAESKRELDALEALATVPFLILGNKIDIPY-----AASEDELRYHLGLTNFTTGKVFMCSIVRKMGYGEGFKWLSQYIN........................................................................................................................................................................................................... 193
49 -9.360[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  15  18.........KEEMELTLVGLQFSGKTTFVNVIAS-------------------QFAEDMIPTVGFNMRKITRGNVTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAAD--LEASRNELHSLPQLAGIPVLVLGNKRDLPG-----ALDETGLIERMNLSSIQDREICCYSISCKEK........................................................................................................................................................................................................................ 167
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Godzik A. Fold recognition methods. Methods Biochem Anal. 2003;44:525-46. Review.