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Query: [EH] COG0059 Ketol-acid reductoisomerase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKESLGFLYYKHMDDIISGHFSATMMADWANGDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRDVNDAIRNHPVELIGQELRGYMTDMKRIAVAGLast
1 -116.000[EH] COG0059 Ketol-acid reductoisomerase  ali  100  1MANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKESLGFLYYKHMDDIISGHFSATMMADWANGDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRDVNDAIRNHPVELIGQELRGYMTDMKRIAVAG 492
2 -33.000[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  11  1..................................MENQKIGFIGAGKMGSALMQGTIKAGIVTPENIGASDVYEPFLKDLQAKLGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEITSEKLVIIAAGVPLSTYEDALLEGTRVVRVMPNIAA-------TVSEAAS---GIAPGKNATPEDLKAALEIFSAVGTA------VQVPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEIRAAFMNAVIRASERS..................................................................................................................................................................................... 264
3 -29.400[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  1.....................................MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVCAAGVTISSVEKKLMPAPKVIRCMTNTPV-------VVQEGATVYAT---GTHALVEDGQLLEQLMSSVGFC------TEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESFRSLLINAVEASCIRT..................................................................................................................................................................................... 265
4 -18.300[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  10  1..................................MSTMKVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAEAASEAEIAVLFTPGKKTFEIAKNITNHLPEGAVIANTCTVSLERELRRDRKDLGIASMHPAAVPGTPQHGHYVIGG----HSSSELDIATDEQISRCVELAESCGKV---AYVVPADVSSAV-ADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRSAKS---------------MHLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVAAQALAKEIKNLMGGKAA--GTIRRCMRKMFE...................................................................................................................... 344
5 -15.900[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  10  51...................................PPLRIAIIGFGNYGQFLAETLISQGHILFAHSRSDHSSAARRLGVSYFTD-----LHDLCERHPDVVLLCTSILSIENILKTLPQRLRRNTLFVDVLSVKKTLLLQYLPEDFDILCTHP-GPQSVSSNHGWRGLRFVYDKVRIGEERLRVSRCESFLEIFVREGCE---MVEMSVTDHDKF---------AAESQFITHTLGRLLGMLKLISTPINTKGYEALLDLAENICGDSFDLYYGFVYNNNSLEVLERIDLAFEALRKELFSVRKQSFEGEAKKVHVFPNCGENDASLDMMRSEDVVVKYEYNSQVSGSVNDGSRLKIGIVFGNFGQFLGKT---MVKQGHT-------LAYSRSDYTDEAAKLGVSYFSDLDDLFEEHPEVI-------LSTEKVLESLPFQRLKRSTLFVDVL---------SVKEFPRNLFLQTLPQDFDILCTHPMFG 483
6 -15.400[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  13  4...................................TKPSIAILGAGRVGSSLARSAVAAGYEVKVAGSGA--VDKIALTAEILMPGAVPSTADQAVKDADIVFLAVPLHKFRSVNPAT---LEGKIVIDTMNHWVPV------NGELEEIDQDPRSTSEIIAEFFAGSTMVKSFNHIGYHATDDVDAGAQVAQLIKSFG..................................................................................................................................................................................................................................................................................................... 170
7 -15.300[S] COG5495 Uncharacterized conserved protein  ali follow..  10  10...................................ARLNIAILSTGRVGVALER----ADQVVV------AVSHASRQWVQFRLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTPRPGTIVAHTSWNGVGILAQLGKDGCIPLAIHPAMMFSGSDEDLSQCQLRDTYFGI---TKTDDVGYAIAQSLVLEMGGEP-----FCVVEYARILYHSVSPHVGNHIVTVLADALEVRRSALRGSELLGLGVPPACRGEVVDDQLDVIVEARAACENTLQRGQAGLTKLVARGDLDALAGHLVALMR....................................................................................................................................................................................... 277
8 -13.900[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  13  2.....................................ETIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLAD------VAKGLKTVSGHAAVAKAADIIITMVPDTPQVADVNGVASGLTRGKLVIDMSSIS--------PIETKVFAGKINELGCDYLDAPVSGGEVGAKAALTIMVGGEEKAFERAKPVFEKMGKNITLVGPNGVGQTTKV----ANQIVVALTIEAVAEALVFASKAGADPARVRQALMGG........................................................................................................................................................................................................................................... 209
9 -13.700[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  1MIDMKLAIGITNFSRACEVAEMVGKPEIAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIVAKELPKPPEGAIHFTHPEDLGFEITDDREAVADADFIMTWFPKGDMQGIIDKFIDDIKPGAIVTHACTIPTTKFYKIFPETLNVTSYHP-----------GAVPEMKGQVYIAEGYA-SEEAINTLFELGQKARGNAY----RLPAELLGPVCDMCSALTAITYAGILSYRDSVTQVLGAPAGFAQMMAKESLEQITALMEKVGIDKMEEHLDPGALLGTADSMNFGAS--ADILPTVFEILEKRK..................................................................................................................................................................................... 346
10 -13.600[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  10  2....................................SADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSSNRRYEELKKKGILFVGS-------------VSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKSDGEPCCEWVGPAGAGVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPGPEVPKDAVKDREQFVDQALYASKIISYAQ-GFMLIREA--AATYGWKLNNPAIALMWRIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAIALATTYGSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPEC............... 460
11 -13.300[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  10  1.....................................MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTT-GVASLRELSQRLSAPRVVWVMVPANITTAVIEELANTLEAGDIVIDGGNTDLRHEKLLFKKGIHLLDC-------------TSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETA........................................................................................................................................................................................................................................... 228
12 -13.100[E] COG0287 Prephenate dehydrogenase  ali follow..  12  2...............................MGDIMFERIALIGIGLIGSSIARDVRELGLARHV-----ISTRSEDTLKRAEELALYTVSAAEAVKDADLVIVSVPVGASESVAQQIAPYLKPSAIVTDVGSTKIAQMAPHMPENVHFIPGHPLAGTEKSGPDAGFAG--ERWCIFTPLPGTDAAALERLKDFWRALGSRVDEMDAEHHDKVLAIVSHLPHIIAYNIVGTADDLETVKYSASGFDPTMWRDVCLHNKDAILEMLAR--FSEDLASLQRAIRWGEGDKLFELFSRTRSIRRSIIEA.......................................................................................................................................................................................... 292
13 -12.900[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  2.....................................SKLLMIGTGPVAIQLANICYLKSDYIDMVGRASTSEKSKRLYQAYKKEK-LYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKH--------------------VILISPTFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEAP---------NHVLTTGVKKKLYMGSTHSNSTMCQRISALAEQLVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVYKLFPEGPITMTLIREMRLMWKEMMAILQAFRV-NLLQFMVKENVRPETLDEGDIEHFEILPDILQEYLLYVRYTAILIDPFSQ--GHYFDFSAVPFKQVYKNEQDVVQIPSEDYYRTAMIQHIGKMLGIDQFLTRYEASCQ-QDQQLSSQFNTNLFEGDKALVTKFLEINRTLS......................................... 433
14 -12.300[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  11  1.................................MSVKGDIGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGDVVEALLPHLEEGDIIIDGGNSN--------YPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGNQEAWQYVKPIFQAISAKT--CDWVGGEGAGHFVKMVHNGIEYGDMQLICEA-YQFLKEGLGLSYEEMQAIFAEWKNTELDSYLIDITTDILGYKDASGEPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESFARCVSSFKDQRVAANQLFGKTITPVEGDKKVWIEAVRKALLASKIISYAQ-GFMLIREASEQFGWDI-----NYGATAL-LWREGLGNIRDAYEANPNLVFLGSDSYFKGILENAVAKSIEVGTFLDGYTSARLPANLLQAQRDYFGAHTYERTDKPRGEFF.......... 466
15 -11.800[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  18  2.....................................LKIGIVGCGFIGGQICRAIDGGEVSAELALCDSSESKALELAASLKTCKPSYMKIEELIRGVDLIIESASQNAVRFIVPQA---LKAGCDVMILSVGALA................................................................................................................................................................................................................................................................................................................................................................... 99
16 -11.600[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  10  2....................................KQHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRISPNLSFTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQITDLSVFVITSKGIEQNTGLL-----LSEIMLEVLGDSVTPYLGYLSGPSIAKEVLNGSPCSVSAYDSQTLKQIHEAFSLPTFRVYPNT-------DIKGAA--LGGALKNVIAIACGIAEGLSFGNNAKAGLVTRGLHEMRKLAAIMDCKPEFSESSRNLRFGHLLAQGLTFEQAKAKIGMVVEGAYTALSAYQVAKHHKIDMPITTGIYRVLNLDLKEGIALLLQRNTKEEFL......................................................................................................................................... 334
17 -11.500[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  15  222AMNVNDAVTKSKFDNKYGTRHSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVT------EADPINALQALMDGYSVVTVDEAIEDADIVITATGNKDI--ISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRDDVTRTTIKPQVDEFRSIIVLSEGRLLNLGNATGHPSFVMSNSFADQTIAQI...................................................................................................................................................................................................................................................................................................... 416
18 -11.400[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  11  164......AIDVNDSATKSKFDNLYGCGIKQATDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIIT------KTDPIKALQAAMEGYEVTTMDEACQEGDVFVTTTGCV--DIILGQHFEQTKDDTIVCNTGYMDVKWLNKNTVEKVNVKLQVDPYRLKNGRGIILLAEGRLVNLACAMGHPSFVRSNSFTSQVMAQI...................................................................................................................................................................................................................................................................................................... 351
19 -11.000[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  11  23...................................KLISVGIIGSGNWGTAIAKICGENAKQVHMWMYEEKIQHEGKECNLTEVFNFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLKKDAAISCIKGVSVTKDRVRLFSDIIEENTGMYCSGANIASEVAQEKFCETTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAVAAGIIDGL-DNTKSAVMRIGLLEMQKFGRMFFDCKPLTMSEESCGIADLITTCLGGRNHKCAVAFVKTVVEQELLDGQKLQGAATAKEVYEFLDNQN........................................................................................................................................................................... 345
20 -10.400[H] COG1893 Ketopantoate reductase  ali follow..  10  1..................................MEKPRVAVIGSGSIGLLLYAYLKLANWPALLVTN------RPEQADHLNKEGLTFVAKSFSAEEAEVGFITVKSFAVKALLPQLQR-KKWDGLVFFQNGMHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWIGDMVGDSKNFDPMWAC-----------------------------------------LHNAGLKAQKVTNWQDKMERKLIANAAINPLTGLFR-------------VKNGALIENQLFSLLLKELVKEACVTLGREAYTRAICDKTANNLSSMYMDLTHHRRTEIESITGYLIKEAAK............................................................................................................................................ 280
21 -10.300[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  16  3.....................................KTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEASDEDRKRALSLIKGSGDINDLAQADLVIEAVTETVKRKIYGQVCPVMRPDAILATNTSS-----------SITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEEETFKAAKEFVAHLD..................................................................................................................................................................................................................................................................................................... 174
22 -10.300[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  12  14............................STTAQLSKINNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSAAAQTALVSSVLDRIKMSTNVSDSVKDADLVIEAIVEDIKRKLFAEVEVAAKPTTLITTNTSS-----------RLADIGLNLKDKSRFGGLHFFNPVPMMKLLEVVRHTETSDATFNQLVDYGKTVG..................................................................................................................................................................................................................................................................................................... 200
23 -9.990[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  13  106IGEYALAAALQLTRHAREIETFVRKRDFRWQKPILRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDA---------AKEWLTYVSMDELLSTSDVISLHMPKDSHHLINAKTIAQMKDGVYLVNTARGAV---------------IDSQALLDSLDKGKIAGAALDAY.............................................................................................................................................................................................................................................................................................................................. 261
24 -9.880[R] COG2910 Putative NADH-flavin reductase  ali follow..  15  2.....................................AKIALIGAGNAGSRILKELSDRGHQVTAIARNPEKIAALPNVVAKKGDVFDQAALSELLKGHDAVISSVTASDPATLIEAVRASGVQRYLVVGGAGS...................................................................................................................................................................................................................................................................................................................................................................... 101
25 -9.800[C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)  ali follow..  10  151..................................IRDSVIGFFGFGGISQAIAKRLQCWDVAKIIY-------HTRTRKENDGDFKAEHVSFEQLLQESDFLVVAAPNETREKFNGKAFNLMKRSSVFVNVA-----------RGGLDVTTPEPLPANSPLLNV-------NCEGLKMSTTKPFKVLIAHTDVPPEGI--------EILKEQCEILQVINEPPKNRPEILEKIRGAHAVIWGGR---DILNAEILDAAGPQLKAVSTMSSGINNVDVPELKKRGIPLGTVAVADLTVGLLIAAARRFQEG--RRKIDSDKWDKDHLNWMLGQDIRDSTVGFYGF-----------------IGQAVAKRLMGFDIKRTRNRVSQDIEERFNAKKVDFETLLAESDF--LIIASPLTKETLGLFNATVFNKMKETAVLVNVGRGKIVNQ-----------DDLYEALKSNRIFAAGLDVMDPEPLPSNDKLLT 555
26 -9.370[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  13  10................................REVKKGKVIEVGIGF-YTRIAKRLKELGFDVLAIDINKDAVVNAKNSGLNAEVDDIFNPNISLYMGAKAIYSIRPTPEMMNYILKISKAVKVPAYIVPLTG....................................................................................................................................................................................................................................................................................................................................................................... 109
27 -9.050[I] KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase  ali follow..  10  353.....................................NEIAVVGAGFMGAGIANVTINKGIRTVLLDANQAGVERSKLEREKIYNHLVPTIDYSAMKNADVVIEAVFEPLKHKVIRQIENVVGPNTIIASNTSA-----------PIKDIAAASSRSDKVIGMHYFSPVEKMQLLEIITHDGTSKETLATAAQLGLKQG-------------KLVVVVKDCPGFFVVRCLSPMMSEIVRLLQEGVEPSELDKLTTK--VGAATLADEAGLDVAEHVARYLGT----ALGPRVHGGSVDLLSELVRAGHKGRKTSKGIFVYGDGAKGSKKVNQEAAKLFEKYKLTPIKSVSSPEDRQLRLVSRGVISSPSDGDIASVFGLGFPPFWG-----------FRFVDLYGAGKLVAAMDRFAGYESVQFEP.................................................................. 739

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.