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Query: [E] COG0137 Argininosuccinate synthase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGRAKKVVLAYSGGVDTSVCIPYLMHEWGVEEVITLAADLGQGDELGPIQEKALRCGAVESLVIDGKEEFVKEYAFRSIQANALYENRYPLSTALARPLIAKMLVEAAEKYGADAVAHGCTGKGNDQVRFDISIMALNPNLKVLAPAREWKMSREETIAYGERYGVESPVKKSSPYSIDRNILGRSIEAGPLEDPMTEPTEEIYLMTKAIADTPDEPEYVDIGFEKGIPVSLNGVMLDPVTLVERLNEIAGNHGVGRLDMVENRVVGIKSREIYEAPALLVLIDAHRDLESLTQTADVTHYKNTVEEIYSQLIYRGLWYSPLKEALDAFIVKTQERVTGMVRVKFFKGNANVAGRKSDYSIYDAELATYGMEDQFDHKAAEGFIYIWGLPTKVWAQKMRGLast
1 -127.000[E] COG0137 Argininosuccinate synthase  ali  100  1MGRAKKVVLAYSGGVDTSVCIPYLMHEWGVEEVITLAADLGQGDELGPIQEKALRCGAVESLVIDGKEEFVKEYAFRSIQANALYENRYPLSTALARPLIAKMLVEAAEKYGADAVAHGCTGKGNDQVRFDISIMALNPNLKVLAPAREWKMSREETIAYGERYGVESPVKKSSPYSIDRNILGRSIEAGPLEDPMTEPTEEIYLMTKAIADTPDEPEYVDIGFEKGIPVSLNGVMLDPVTLVERLNEIAGNHGVGRLDMVENRVVGIKSREIYEAPALLVLIDAHRDLESLTQTADVTHYKNTVEEIYSQLIYRGLWYSPLKEALDAFIVKTQERVTGMVRVKFFKGNANVAGRKSDYSIYDAELATYGMEDQFDHKAAEGFIYIWGLPTKVWAQKMRG 400
2 -112.000[E] KOG1706 Argininosuccinate synthase  ali follow..  40  1MSSKGSVVLAYSGGLDTSCILVWLKEQGYD--VIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYILGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSK 408
3 -35.000[J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain  ali follow..  15  21.NRKKKVICGMSGGVDSSVSAFILQQQGYQVEGLFMKNDYCTAAADLADAQAVCDKLGIKLHKINFAAEYWDNVFEHFLQEYKAGRTPNPD-ILCNKEIKFKAFLDYAEDLGADYIATGHYVR-DNNKDQSYFLYTLSKDQVAQSLFPVGEIEKPIVRAIAEDLGLATAKKKD---STGICFIGERKFKDFLARYLPAQPGEIRTVEGKVVGRHDGLMYHTLGQRKGLGIG-GEDPFYVVEKDLVNNVLVVAQGHDNSALLSSGLIASQLHWVDRQPRCTVKTRYRQEDIPCEIQPINDETIRVVFDEPQIAVTPGQ---------SAVFYQGEICLGGGVIETQIK..................................................... 383
4 -34.300[J] KOG2805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase  ali follow..  12  3.EKPLRVAVLLSGGVDSSVALRLLHAAGHSCTAFYLKINQCPWEDDLKYAKHVCEQVDVPLEVVHLTDEYWERVVSYIIEEYRCGRTPNPD-VLCNTRIKFGAFMDAISDMEYDYVGSGHYAK-DMVKDQTYFLSHLSQTQLKRLLFPLGCVKKDEVRKLATQFDLPNKDRKD---SQGICFLGKIKFSDFVCRHIGEMEGIILEASGDFLGNHRGFWFYTIGQRQG--LRLPGGPWYVVEKDTKNNVVFVSRNYYSIDKRRRIFRVGSLRWNSGKPELRCKVRHGPGFYSCSFEMEGDG-----------------------DVAVVHLDEDDQGLAAGQFAAFYEGTTCIGSGVILESWDDQCFKALQLAALEDKTKLGKPVKIMTMPTMSSVEADTG 410
5 -32.800[R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily  ali follow..  15  11IKSKKKLVVMFSGGVDSTLLAKLAREVLGKNAVALTIDSPVIPRKEIEEAKNLANLIGIRHEFIELNELKSRHL-----------IENPPDRCYLCRKLRDNIVKNWARENGFDVIADGLNFSDLQDYRPGVKAST---EDGIWHPFIDFEVTKEEIREYSKKLGLPTWDKPAMACLCSRFPYGFGLNEERVRMVEKAENRELGFREVRVRFFPYKTAVVEVGRDEMELLMGKRT-----DIVLALQKIGFSF................................................................................................................................................... 246
6 -25.900[R] COG1365 Predicted ATPase (PP-loop superfamily)  ali follow..  12  52DKINVKIAVAYSGGSDSSATVKILRWAGFDVVPITARL----PHISKEKLREETLFVEVPGYLEEMEKLIEKR----------------APICGRCHSMVMRAVEEKVRELKIRILATGDMLSI------GSGSIYEKENLVILNLPAFLSLNKVDLLSILGWEDYEFYGCPLWREAVKRVPIMKRFAIQRVLRELRT.......................................................................................................................................................................................................... 224
7 -23.800[J] COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain  ali follow..  9  2...LGDVYHLFSGGKDSSLAAWILRKLGYEVRLVTITF----VLDNWKYAKETADILGFEHEVVRLPRELLNMAVEMCIEDGKPGRA-----------------IQFLHEKALEYVASRSYVDDKVPFLDLRKARSLEDRFNVAYIRPLLGLGYKTIRELANSIFVIEERESEKLEKGD--------YEAELRYRERGINPKTIFPSRHMQSRVVGIKDDELGRS............................................................................................................................................................................... 206
8 -21.000[R] COG0603 Predicted PP-loop superfamily ATPase  ali follow..  16  1...MKRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRHRAEIDVARELALKLGARAHKVLDVVSSLTRDSIPVPDYEPEADGIPNT--VPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPNHAVSLGMAKDIRFETPLM--WIDKAETWALADYYGKLDLVRNET.................................................................................................................................................................................................................................. 185
9 -14.700[F] COG0519 GMP synthase, PP-ATPase domain/subunit  ali follow..  14  20..GSSKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDN--RLHEGDQVMAMFAENMGVKVIRANAEDKFLEEKRKIIGRTFIEVFDEEATKLQDVKFLAQGTIYPDVIESAGAKTGKAHVIK----SHHNVGGLPEDMQFELVEPLRE--LFKDEVRKIGLELGLP......................................................................................................................................................................................................................................... 188
10 -14.400[R] KOG2840 Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily  ali follow..  14  47FRRGEKVAVAASGGKDSTVLAHVLKLHNYGLELVLLSID-GYRDDSLETVKQNRDDYQMPLKILSYEELY-------WTMDRIVAQIGRSNNCTFCGVFRRQALDRGAKLLGVDSIATGHNADDIAETVLMNVLRGGEDTIPRVKPLKY--SYEKEIVMYAHYKKLVYFSTE.................................................................................................................................................................................................................................... 232
11 -12.700[S] KOG2594 Uncharacterized conserved protein  ali follow..  13  56GRKSKRAMLAISGGISSMAMLETANYLSKYDELLAVHFQWGTDSAVAKTIEESISKNYPKCPFIATDSRGNIEINADNEKFNPEVISSLASRQDLLYRIRDKLLVSYARKANCDTIVFGDSGTTIAARVLELVAEGRGFAIFLLRPLRE--VLSSDLKSYMNIKGLAFCDSLIEARPNTI----HGVTESYFSSLNDTFPSLVSTVMSSKLHVPSTEAICTI.................................................................................................................................................................................. 309
12 -12.400[R] KOG2316 Predicted ATPase (PP-loop superfamily)  ali follow..  9  2.....RVAALISGGKDSCYNMMQCIAAGHQIVALANLRPAENQVGSDEAIDLYAEAMALPLYRRTIRGRSLDTRQVYTKCEGDEVED------------LYELLKLVKEKEEVEGISVGAILSDYQRIRVE----NVCKRLNLQPLAYLWQRNQEDLLREMISSNIQAMIIKVAALGLDPDKHLGKTLDQMEPYLIE........................................................................................................................................................................................................... 189
13 -12.000[H] COG0301 Thiamine biosynthesis ATP pyrophosphatase  ali follow..  16  206LGTQEDVLSLISGGFDSGVSSYLHIKRGSKVHYCFFNLGGPAHEIGVKQTAYYLWQKYVRFIAIDFAP----------VVAEILEKIDDGQMGVVLKRMFMRTAGMVAEKFGIQALVTGEAGQVSSQTLTNLRHIDNVTDTLILRPL---NWDKEDIIRLAREIGT.......................................................................................................................................................................................................................................... 365
14 -12.000[H] COG0171 NAD synthase  ali follow..  11  41....KSLVLGISGGQDSTLAGKLCQMAINELQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAV--LASEQALREAGIELSDFVRGNEKAR-ERMKAQYSIAGMTSGVVVGTDHAAE---------FFTKYGDGGTDINPL--YRLNKRQGKQLLAALACPEHLYKKAPTA............................................................................................................................................................................................................................... 212
15 -11.300[R] COG2102 Predicted ATPases of PP-loop superfamily  ali follow..  14  2.....RSAVLYSGGKDSTMALYHALQESEVEFLVSVISDNPES--NIHLTALLAEAVGIPLIESRTAGVEEEE------------------------VEDLAGTLKTLRERGVEAVYSGALYSEYQKSRID----SICRRLGLRSVAPLWHRDPLDYMEEIVDLGFRVMVTAVAAEGLDESWLGRIVDRKMIDELAD........................................................................................................................................................................................................... 169
16 -11.100[EH] COG0175 3`-phosphoadenosine 5`-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes  ali follow..  16  24AAEFANPVMLYSIGKDSSVMLHLARKAFYPLPFPLLHVDTGWKREMYAFRDRTANAYGCELLVHKNPEGVAMGINPFVHGSA-----------KHTDIMKTEGLKQALNKYGFDAAFGGAR-RDEEKSRAKERIYSFRGESIRVFPLSNW--TEQDIWQYIWLENIDI........................................................................................................................................................................................................................................ 205
17 -10.600[D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control  ali follow..  10  14TLKGATIIVGVSGGPDSMALLHALHTCGRSANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQL---------VCETAQINVTAYAQEKGLNKQAAARDCRYQFFEEIMSKHQADYLALAHHGDDQVET--GMQPVRRFGTGRIIRPF---TITKEEILHYCHENGLSYRTDESN---AKDDYTRNRFRKTVLPFLKQESPDVHKRFQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQ--------LALPMPLQRRGVQLILNYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKNVPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFIKAGDRIKLKGMNGSKKVKDI........... 410
18 -9.210[R] COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase  ali follow..  10  24LETLPRVCVSFSGGKDSGLMLHLTATLARKMKIHVLFIDWEAQSCTITYIESLREYYADV--IERFYWVALPLTTQNSLSQYQPEWQCWQPGTDWVRQPFVRDFADWFSEKRPAAMLVGIRSDESYNRFAAIANSH-KGHTWYIYPIYDW--KTADIWTWFAKTGKP......................................................................................................................................................................................................................................... 225
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24