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Query: [F] COG0151 Phosphoribosylamine-glycine ligase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNILIIGNGGREHALAWKVAQSPLADKVFVAPGNAGTALEHKVENVNISATDIPALVKFAQDKQIGLTIVGPEAPLVIGVVDAFREAGLKIFGPAKAAAQLEGSKAFTKDFLARHKIPTAEYQNFTEVEPALTYLREKGTPIVVKADGLAAGKGVIVAMTLQEAEDAVRDMLSGNAFGEAGSRVVIEEFLDGEEASFIVMVDGKNVEPMASSQDHKRVGENDTGLNTGGMGAYSPAPVITPEIHSRIMKEVIYPTVNGMAAEGNVYTGFLYAGLMIMPNGQPKVIEFNCRFGDPETQPIMLRLKSDLVELCLKACDGKLDEVISQWDLRASLGIVLAAEGYPKDYRKGDEISGLPKSAVKNEKVFLAGVAEQEGKLVTNGGRVLCVTALGESVFEAQQKALKLAEQIQWSGRFYRRDIGYRAVERELQKLast
1 -116.000[F] COG0151 Phosphoribosylamine-glycine ligase  ali  100  1MNILIIGNGGREHALAWKVAQSPLADKVFVAPGNAGTALEHKVENVNISATDIPALVKFAQDKQIGLTIVGPEAPLVIGVVDAFREAGLKIFGPAKAAAQLEGSKAFTKDFLARHKIPTAEYQNFTEVEPALTYLREKGTPIVVKADGLAAGKGVIVAMTLQEAEDAVRDMLSGNAFGEAGSRVVIEEFLDGEEASFIVMVDGKNVEPMASSQDHKRVGENDTGLNTGGMGAYSPAPVITPEIHSRIMKEVIYPTVNGMAAEGNVYTGFLYAGLMIMPNGQPKVIEFNCRFGDPETQPIMLRLKSDLVELCLKACDGKLDEVISQWDLRASLGIVLAAEGYPKDYRKGDEISGLPKSAVKNEKVFLAGVAEQEGKLVTNGGRVLCVTALGESVFEAQQKALKLAEQIQWSGRFYRRDIGYRAVERELQK 429
2 -107.000[F] KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS)  ali follow..  45  4IIALLIGNGGREHTIAWKLCESPLISKVYVAPGNGGTASNGAMENVNIGVCDFEQLVKFALDKDVNLVIPGPELPLVEGIEGHFRRVGIPCFGPSALAARMEGSKVFSKDFMHRNNIPTAVYKSFSNYDHAKSFLDTCTFDVVIKADGLAAGKGVIIPKTKKEAFEALESIMLNEEFGSAGKNVVIEELLEGEELSILTFSDGYTCRSLPPAQDHKRAFDGDKGPNTGGMGCYAPTPVASPKLLETVQSTIIQPTIDGMRHEGYPLVGILFTGLMLTPS-GPRVLEYNVRFGDPETQAVLPLLESDLAEIILACVNHRLDAIDIVISRKFSCAVVCVAGGYPGPYNKGDIITFDALK-DKNTRIFHAGTSIRDGNVVTNGGRVLAVEATGDSVEAAVRLAYEGVKTVHFDKMFYRKDIAHHALNPKRKT 433
3 -22.500[F] KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase  ali follow..  12  5.TVGILGGGQLGRMIVEAANRLNIKTVILDAENSPAKQISNSNDHVNGSFSNPLDIEKLAE--KCDVLTIEIEHVDVPTLKNLQVKHPKLKIYPSPETIRLIQDKYIQKEHLIKNGIAVTQSVPVEQASETLNVGRDLGFPFVLKSTLAYDGRGNFVVKNKEMIPEALEVL--------KDRPLYAEKWAP-KELAVMIVRSVNGLVFSYPIVETI---------HKDNICDLCYAPARVPDSVQLKAKLLAENAIKSF-----PGCGIFGVEMFYLETGELLINEIAPRPHNSGHYTIDACVTSQFEAHLRSILDLPMPKNFTSFSTITTNAIMLNVLG--DKHTKDKELETCERALATPGSSVY-------GKESRPNRKVGHINIIASSMAECEQRLNYITGRTDIPIKISVAQKLDLEAMVK... 402
4 -20.600[F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)  ali follow..  14  14.KVMMLGSGELGKEVVIELQR---VEVIAVDRYANAPAQQVAHRAYTISMLDGEALKALVEKEKPDYIVPEVEA-IATATLVELEQAGFTVIPTAKATQLTMNREGIRRLAAEELGLPTSNYQFVDNFDDFKRAVEKIGIPCVVKPIMSSSGHGQSILKSVEQIPSAWEYAQQGGRAGAG--RVIVEGFVK-YEITLLTVRHVHGTSFLAPIGHIQI------------RESWQPQAM--SAVALEKAQAIAEKITGALG-----GRGIFGVEMFVCGD-EVIFNEVSPRPHDTGMVTLISQELSEFALHARAILGLPIPDITLI---SPSASKAIVVEG-KSTQVVFGQLAEVLAEPHTNLRLF-------GKGEVDGHRRMGVILARDISVEKALEKARRAYDKLEIA................... 392
5 -19.400[R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)  ali follow..  14  1MKLFLFEFATCGERIEDSTAVEGLFDGFKNYYEITGFVRPEFSCLFTLPVDSMDSMEKYLEKSDAFLIIAPEDDFLLYTLTKKA-EKYCENLGSSSRAIAVTSDKWELYKKL-RGEVQVPQT-----------SLRPLDCKFIIKPRTACAGEGIGFSDEVPD-------------------GHIAQEFIEGINLSVSLAVGEDVKCLSVNEQ----------------INNFRYAGAVVPARISDEVKREVVEEAVRAVECVEGLNGYVGVDIVY--SDQPYVIEINARLTT-PVVAFSRAYGASVADLLAGGEVKHVRRQMVRKSKSAEKPYVSVGDY......................................................................................... 296
6 -19.200[R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase  ali follow..  17  6.EILVIGVNTR--PVVESAFRLGYRVYSAGYYCTADFKHYTE-RRCILRERSGESCGRFHENFSQEKLLFIERADGIIPLTGAPPLPGEKVLGNS--RVDHVEDKYRLYRRI-RNSYPTPETHLISDPAEAMEIVAAGEKKYIAKPVSGAGGFGVTEFREGDG-------------------EFLLQEYIEGVPVSASVLSTGEDAITVLTSRQI------DRGVPGFEGQFVYAG-----NMTPGPSGEIEDLASDLILDLSL--RGSNGVDLIMR-DSELYVIEVNPRIQG-TFECAEASLGINMVDAHIRACMGELIEKP-DPVSYAVKRILYAPARCRVGEIKTMGVHDLPVP----------------GTIIEEGEPLLTVLASHNSMEAAENLASNICSRVK..................... 361
7 -17.900[EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)  ali follow..  16  9.KIMVIGSGP-DYAGTQACLSLKEEGEVVLVNSNPATIMTDKVYIEPITLEFVTRILRKEGPDALLPTLGGQTG-MAMELNGILDELGVELLGTKLSAIDQAEDRDLFKQLMEELEQPIPESEIVNTVEEAVAFAATIGYPVIVRPAFTLGGTGGGMCANEKE----LREITENGLKLSPVTQCLIERSIAGKEIEYEVMRDSADNALVVCNMEN----FDPVGIHTGDSIVFAPAQTMSDYENQMLRDASLS------IIRALKIEGGCNVQLALDPNSF-YVIEVNPRVS--SSALASKATGYPIAKLAAKIAVGLTLDEVINPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERR-------------GTQMKATGEVMAI---GRNIEESLLKACRSLE........................ 401
8 -17.500[M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes  ali follow..  18  1MKIAVLGGTSAER-------------EVSLSSGKGIMEALKANGHEVIGIDFHPDQVRDLVDLDVDLVFIG-EDGKVQALLDLL---NIPYVGTGVQGSALAMDKAKAKLFFEKAGIRVAEEVVLHSFTYDANAFFTGTYPVVVKPNQEGSTIGLTVAETEEELLQGIEEAF------RHDDTILIEEFIAGTEVTVAVLGNKGEERSLPVVEPKNKLYDYESKYAPGMSEHIVPA-----RISEEHTAYVQQAAVRAHQALGC--DVYSRVDFIVPNDGSPVILKVNTLPGMTPTSLYPDAAKGSYEEMIQTFVNLSLKK............................................................................................................ 305
9 -16.200[R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)  ali follow..  11  18.KITIGVIGSHSALDIADGAKEEGLPTLVVAQRGTRDGLVKGFIDEVIVLDKFAQIIEIQEELRKRNVIFVPNRSFVTGIDRVENEFLVPMFGTRSLRTEERSEEKSYYWLLEKAKLPYPEPVSPEEIDDVGLV------IVKLPHAKKRLERGFFTAASYKEFKEKSEKLIRLGVITREDAKARIERYIIGPVFNFDFFYSPIDGEIELLGIDWRFETSLDGHVRLPAATVCGHASSTLRESLLEKVFDMAEKYVEATKKYPPGIIGPFTLQTAVDKDLNFYIYDVAPRTGGGTNIHMAMGHPYGNSLWRKPMSTGRRIALEIK........................................................................................................ 367
10 -16.000[I] COG0439 Biotin carboxylase  ali follow..  15  2FKKILIANRGEIALRVIRTAREMGIQTVVVYSTADEKSLPVLLADESVCVGNIPNILSAALMTGAEAIHPG------PDFAEMCREHGIVFIGPTPESMRALGSKAGGREIAAQSNVPTPGTGVLESVDAALLAAKQIGYPVLLKASAGGGGRGQKVIRTQEELQKGFNQAQEEARLYFGDPAIIMEKFLEEFEVQVMGDGQGHVIHICSIQRRNQKLIEE------------APST-LPESLRQEILAAGVR------LAQFVNYAGAGTLEFIMDRDGNYYFMEMNTRI-QVEHCVSEMISSLDLVRLQIEIAAGLIQQDDVKLHGHAIECRINAEDPDKDFRPAAGKIDDAHFAGGAGVRV-DTHVYSGYSIPPHYDSLIGKLIVWHEDRDKAVSRMKRALEETVIQGPKTTIPLYIKIMDNP... 427
11 -15.700[F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)  ali follow..  17  12LTIGIIGGGQLGRMLAMA-AARLNHRTIVLEPQADCPAAQVCNDQIVAEYDDEKALAELASR--CDVVTYEFENVPVAAAEKL---SASVPVYPPAQALSASQDRLTEKRFLNGCGIPTADFRAVDSQDELEAALTAFGGKGVLKTRMGYDGKGQRLFRGGENLTGAFAAL--------GGVPLILESFVA-REISIIAARFQDTVTCYDPAENVHL----------NGILHTSTVPAALSDAAKAVAVQSAEKLLAAL-----EYVGVIGIEFFVLPDGSLVANEMAPRVHNTGHWTEAACAISQFEQHIRAVSDLAPGSTDRH---SDCVMTNLIGDDINDVPAW---------LSKKDCLVHLYGKTE-----ARPGRKMGHVTELLHTGKA.................................. 363
12 -15.600[I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit  ali follow..  15  3.KVLIANRG----EIAVRIIRA-QSVAVYADPDQDALFVRLADEAYALEGVDISKLIAIAKRAGADAVHPG------AEFAQAVIDAGLIWIGPDPDVIEALGDKVMARRIATGVGAPLGSDGPVSSAAEVTAFAEQHGLPVAIKAAHGGGGRGLKVAWKMEEIAELYESAVREATVAFGRGECFLERFLDRRHIEAQVIADKHGNVLVLGTRDNQKLIEE------------APAPFLSDEQRQKIHDAAKA------ICAAAGYSGAGTVEFLLGVDGTISFLEVNTRL-QVEHPVTEETTGIDLVIEQFRIAEGH--LETPEPRGHSMEFRINAEDPGRGFLPTPGLISVFDAPSGPGIRM-DSGVISGSSIPGVFDSLMAKLIVTGVDRDQVLRRARRALREFRIEGIATVLPFHRAAIETE... 427
13 -14.300[IE] KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit  ali follow..  16  51.KILIANRG----EIACRVIKTARTVAVHSDVDSNSLHVKMADEAVCVGEARADRILQAVEDTGAQAVHPG------TKFAAELEKAGAKFIGPNSKAILDMGDKIHSKKIATAARVSMGYDGEIADEDMCVKVSRDIGYPVMIKASAGGGGKGMRVAWNDKQAREGYRLSKQEAASSFGDDRMLVEKFIDNPEMQVLCDKHGNALWLCSIQRRNQKVIEE------------APSSFVPPEMRRKMGEQAVQ------LAKAVGYDSAGTVEFLVDSQRNFYFLEMNTRL-HPITECITGI---DIVQQMLRVSYGH--PLPITQEQVPLNGWAFESRVYAEDPYKGFGLPSVGRLSRYVEPKHVDGVRCDSG--IREGSEICKLVTHGDNREQALNRMQEALDNYVIRGVTHNIPLLRDIVQEK... 478
14 -13.800[C] COG1038 Pyruvate carboxylase  ali follow..  13  26.KILVANRS----EIAIRVFRA-KTVAIWAEEDKLSLHRFKADESYQVGRGSIEEVIRVAKLSGADAIHPGSESP---EFVEACNKAGITFIGPTPDTMRQLGNKVAARNLAISVDVPVATNPLPDDIAEVERMAEEIGYPVMLKASWGGGGRGMRAIRKKEDLAREVTEAKREAKAAFGKDEVYLEKLVERAESQILGDTHGNVVHLCSIQRRNQKVVE------------RAPAPYLSEAQRQELAAYSLK------IAAATNYIGAGTVEYLMDADTG-YFIEVNPRI-QVEHTVTEVVTGIDIVKAQIHILEGAPKQEDIRLNGHALQCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTSYTGAVITRYYDPLLVKVTAWAPEPDEAISRMDRALREFRIRGVATNLTFLEAIIGHD... 466
15 -13.500[R] COG3919 Predicted ATP-grasp enzyme  ali follow..  12  1MTVVIIGGAHGTLALARSLGVLN---PVYYLTHDSPLPGWSRFVRETIRWAGPHDEMAEKPGLKGCLLVPSGDGEVVSQHREELSAL-YKIILPEWTNLQWLCEKPLLYKRAAELGVSIPRTYALTSAADIDGL--DVMFPVILKPHMGGGNTSVIRADDREELKAAFVDASGE----IGPDNVVVQELIPGGGESQFSYANGEPIAEFT----ARRARQ----PVDFGYTSTRVEVVDNRQAIEAARKIL----------KSAGHSGLVEVEFKLDGRDG-KLLDVNPRPW--SWFGLCSAAGINLGGLLWRVANDMPTGQAVIARQGTSWSYLVRD........................................................................................... 333
16 -12.400[HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)  ali follow..  13  107..............................................................EEIDALMLRNDPSLDQTFGRLAEQRGVVVLNDPEGLALAQ-NKLYF---QSFPEIVRPTTLISRNVEEIRAFADTHPKGVIVKPLQGSGGKNVFKIGSSKETNLNQIFEAVSL-----EGYLIAQAYLKEGDVRFF-MMNGRPLMRDGQYAALRRVPAKGDLRSNIHANGTAEAVKVTDE-----IVELAEMMRPKLVEDGMFLVGLDIVG--------DKILEVNVF-SPGGLSNILELTNVDFSDTIIEAVETKVSMQA.......................................................................................................... 357

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.