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Query: [E] COG0169 Shikimate 5-dehydrogenase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASQIDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEGALLast
1 -106.000[E] COG0169 Shikimate 5-dehydrogenase  ali  100  1MASQIDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEGAL 278
2 -14.400[H] COG0373 Glutamyl-tRNA reductase  ali follow..  16  51..NRTEIYCD----VRSASKNKVIEWLSQFHQVSLDELKPSLYVHEEQAAIRHLMRVA-CGLDSLVLGEPQILGQVKQAYAEARENHAVNPATEKSVAKRVRTETEAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERALSLAQQFGADV-IALNEIPDYLAQADIVISSTASP-KGMVESALKARRHQPMLLVDILYSVDDLQSIVDSNIEQRKVEAIQAEAIVSEESATFMSWLQAVDSIRDYRKQANEAREELL 358
3 -10.900[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  20  2..........................................................................................................................KKNVLIIGAGGVAQVVAHKCAQNSLGDIHIASRTVDKCRKIVESVREKKALDALDVEATKAGSQIVINVGSAFVN---MSVLRACMDTGVAYMDTAYGNYEWKRAAECKEKGITAILGGVNAYARLAKDEYF........................ 168
4 -10.300[E] KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase  ali follow..  14  366....MTECTTIEHPF-CMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFG------DMLYPYVEEMIL-ATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRES-AQSLSMGTRRKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSQEEKLGFLVAKQDLVISLLPYVLH---PLVAKACITNKVNMVTASYTPALKELEKSVEDAGITIIGEGLDHMLAMETESYISYCGGLPAPEHSNNPLRYKFS... 651
5 -10.300[H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase  ali follow..  13  40.........LVGADPASQIYVGNKRKSCEEVGILSKSYDLTTTQNELLAIIDQLNAKNIDGILVQLPLPKQINA--EAIIERIDPKKDVDGFHPYNVGRLCQRIPT-YGVMKLLETTGIDLHGKHAVIVGASNIVGRPMSLELLLAGATVTVTHR------------------FTKNLENHVRQADILVVAV-----GKPNLISGDWIKESAVVIDVGINRVDGKLVGDVEFDKAAEKAAGVGMLMSNTLYAYE........................ 279
6 -10.200[H] KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase  ali follow..  11  68.........LVGENPASHSYVLNKTRAAAVVGINSETIMKSISEEELLNLINKLNNDNVDGLLVQLPLPEHIDE--RRICNAVSPDKDVDGFHVINVGRMCLDQYS-WGVWEIIKRTGIPTLGKNVVVAGRSKVGMPIAMLLHTDGAHERPGGDATVTISHR---------YTPKEQLKKHTILADIVISAA-----GIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGITPVPGGVGMLMKNTIIAAKKVLRLEEREVLKSKEL........ 339
7 -9.800[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  10  1......................................................................................................................MKMTNNTVLITGGAGIGLELAKRLLELG-NEVIICGRSEARLAEAKQQLPNIHTKQYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELFVDGDEIELNFQAPVHALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALHSFSLTLRHHVRDT. 173
8 -9.770[R] COG5322 Predicted dehydrogenase  ali follow..  12  6.APKTMKFGFIAHPTSVALKRHVKIVDLLE--RDDRWQWRNLVPFADFGRIVSAQGAVCEGILHYMPL-VDAVESLKDQGAQVVGLGGFTAIVGNRGLQTLERTTTGRNVLESMDRLGVEPADTEVAVVGYPGSIALVIAKLLAGHGCRLCLVHRGSEAQGRQGLAYLPEPMRLSNDIEHCYEHVQFYVAATSTG-----GLIDPYRLRPGSVVVDAAL---PRDVKPYRKDRNDILIIDG-GLVSASSALRFGAESMGLAPKKFLNGCLAETLILGL 313
9 -9.310[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  15  3............................................................................................................................KIGIVGCGFIGGQICRAIDGVSAELYALCDSSESKALELAASLKTCKPSY-MKIEELIRGVDLIIESASQNAVRF---IVPQALKAGCDV--MILSVGALADEELRDTLFGLAKEHNCKLYFPSGAVV.......................... 126
10 -8.980[H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)  ali follow..  14  8......................................................................................................................LDLTNKPVLVVGGGEVACRKIDALLRADAKVTVISPQVAPALQAWIEQGKCHWIQHFYSSHWLDKRYVQVWATTD---NPELNHQVYKDAKEQGILVNVVDDQPYCDFITPS--------------MIERGRIQLAISSGGASPV--LIRNIRETLEAVL 148
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 9 3 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;