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Query: [J] COG0173 Aspartyl-tRNA synthetase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRTNYCGLISEQYLDQTVTVKGWVHRRRDHGGVIFIDLRDREGIVQVVIDPDTPEAFAAADSSRNEYVLSITGRVRNRPEGTTNDKMISGKIEILAKEIEVLNAAATPPFQIDDENISENVRLTNRVIDLRRPVMQRNLRLRYQVAMGVRRYLDAQGFIDIETPMLTRSTPEGARDYLVPSRVHPGEFFALPQSPQLFKQLLMVAGFDRYYQITKCFRDEDLRADRQPEFTQIDLETSFLNEDEIMDITEGMAKQVFKDALNVDLGDFPRMPYSEAMFYYGSDKPDMRINLKFTELTDLMKTEEFKVFRGAADMKGGRVVALRVPNGAEFSRKEIDEYTKFVGIYGAKGLAYIKVNDVSNLSNGEDSGLQSPIVKYLSENALKEIIARTGAQNGDIIFFGADKAKVVNEAIGALRIKVGLEHGKDNGYFTDEWKPLWVVDFPMFEYDEEADRYVAVHHPFTAPKEGHEDLMVSDPANCLARAYDMVLNGWEIGGGSIRIHRADVQEKVFAALKISPEEQQEKFGFLLDNLKFGAPPHGGLAFGLDRLVTLMTGAESIRDVIAFPKTQRAQCLLTNAPNSVDDKQLRELSLRLRQKATETKEVLast
1 -217.000[J] COG0173 Aspartyl-tRNA synthetase  ali  100  1MRTNYCGLISEQYLDQTVTVKGWVHRRRDHGGVIFIDLRDREGIVQVVIDPDTPEAFAAADSSRNEYVLSITGRVRNRPEGTTNDKMISGKIEILAKEIEVLNAAATPPFQIDDENISENVRLTNRVIDLRRPVMQRNLRLRYQVAMGVRRYLDAQGFIDIETPMLTRSTPEGARDYLVPSRVHPGEFFALPQSPQLFKQLLMVAGFDRYYQITKCFRDEDLRADRQPEFTQIDLETSFLNEDEIMDITEGMAKQVFKDALNVDLGDFPRMPYSEAMFYYGSDKPDMRINLKFTELTDLMKTEEFKVFRGAADMKGGRVVALRVPNGAEFSRKEIDEYTKFVGIYGAKGLAYIKVNDVSNLSNGEDSGLQSPIVKYLSENALKEIIARTGAQNGDIIFFGADKAKVVNEAIGALRIKVGLEHGKDNGYFTDEWKPLWVVDFPMFEYDEEADRYVAVHHPFTAPKEGHEDLMVSDPANCLARAYDMVLNGWEIGGGSIRIHRADVQEKVFAALKISPEEQQEKFGFLLDNLKFGAPPHGGLAFGLDRLVTLMTGAESIRDVIAFPKTQRAQCLLTNAPNSVDDKQLRELSLRLRQKATETKEV 602
2 -150.000[J] KOG2411 Aspartyl-tRNA synthetase, mitochondrial  ali follow..  39  1......................................................................................................................................MQYNLRLRSQMVMKMREYLNLHGFVDIETPTLFKRTPGGAKEFLVPSR-EPGKFCSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSKPHGTVKAICIEGAKYLKRKDIESIRNFAADHFNQEILPVFLNA--------NRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRGVRDPTLFSFLWVVDFPLFLPEESPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLL---KEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRGHDLMSNTPDSVPPEELKPYHIRVSKPTDSKAE. 460
3 -93.300[J] KOG0556 Aspartyl-tRNA synthetase  ali follow..  21  94....QISDISAKNDGQTVLLRARVYTSRLQGKMCFFSLRQKYDTIQALAVVNSKQMVKWCGSISLESIVLVEGIVKKSPEIIKSATV--QDAEIHISSIYVISPIKKNLPDSKFVRVNLDTRLDNRVLDLRTPTNQAIFDIQAGICQAFREFLLSNSFNEIHTPKMSGASSEGGSNVFKIQYFKTDGF--LSQSPQLYKQMLIAADRERVFEIGPVFRAEDSNTYRHTEFTGLDLEMAFNEYHEVMEFIEKLFLYIFKTIREKPDADRIRFHFKDAVKLLKEAGYRKQLVPGQKVPEDEEFHYCEDPEFDDFSTP-------------------------------------------------------------------------------------------------------EERALGQIVREKYHTDFYVIDKYP------------SSVRPFYT--------MPDPEDPRYSNSYDFFMKGQEIMSGAQRIHDPELLVERMKALGVSPDVG---LQQYIDAFAIGCPPHAGGGIGLERVVMFYLNLPNIRLASSFPRDPKRLLP.............................. 580
4 -84.700[J] COG0017 Aspartyl/asparaginyl-tRNA synthetases  ali follow..  23  9..........KDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEEEVFKLAKEIAQESSLYVTGTITEDNRSD-------LGYEMQVKSIEVISEAHDYPITPKN--HGTEFLMDHRHLWLRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAF--LSQSGQLYLEAA-AMAHGKVFSFGPTFRAEKSKTRRHIEFWMIEGEMAFTNHAESLEIQEQYVTHVVKSVLENVATPFPRISYDDAIEFLKAEFDDIEWGEDFGAPHE-------------------------------------------------------------------------------------------------------------------------------TAIANHYDLPVFITNYP------------TKIKPFYM--------QPNPENEETVLCADLIAGYGEIIGGSERVDDLELLEQRVKEHGLDEEA----YSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAPFPRLLN.................................. 426
5 -81.500[J] COG1190 Lysyl-tRNA synthetase (class II)  ali follow..  21  42.RENLSDQLHAEALNIDVTVAGRMMTRRIMGKASFVTLQDVGGRIQLYVSRDEGVYNEEFKKWDLGDILGARGKLFKT---------KTGELSIHCSELRLLTKALRPLPDKFHGLADQETRYRQRYLDLANDESRHTFKVRSQVMSGIRSFMVEKGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIVLTEELFRTLTETILGSSVVQYGEQTF------------DFGKPFAKLTMKEAICKYR-----------------------------------------------------------------------------------------PETNVADLDDMDKAVAIAESLGIKVEKSWGLGRIQCE-------------IFEETAESHLIQPTFITEYPAEVSPLARRNDDNPFITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQVSGDDEAMFYDEDYITALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK................................ 505
6 -79.400[J] KOG1885 Lysyl-tRNA synthetase (class II)  ali follow..  17  101.VDISLTDFIQKYTDITLKVAGRIHAKRASGKLIFYDLRGEGVKLQVMANSREEEFIHINNKLRRGDIIGVQGNPGKT---------KKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLLNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSY-----KVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFE------------------------------------------------------------------------------------TEETRKILDDICVAKAVECPPPRTTARLLDK-------------LVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV............ 597
7 -77.700[J] KOG0555 Asparaginyl-tRNA synthetase  ali follow..  26  117..........VQHRDQRVSIKAWVHRLRRQGKLMFLVLRDGYGFLQCVLNDKLCQS-YDAVTLSTETSVQVYGIIKALPDG----KSAPDGHELTVDYWEVIGKAPAGIDNVLNESAGVDVMLDNRHLVIRGENASRILRIRAAATRAMRDHFFAAGYTEVAPPTLVQTQVEGGSTLFGLDYY--GEPAYLTQSSQLYLE-TCNAALGDVYCISQSYRAEKSRTRRHSEYQHVEAECAFITFDQLMDRIEALVCDTVDRLLADPARPFKRMPYKEAIEWLQKNDVRNEMGEKFVYGEDIAEAAE-------------------------------------------------------------------------------------------------------------------------RRMTDTIGVPILLNRFP------------HGIKAF---------MPRCADDNELTESVDLLMPGVEIVGGSMRIWKEDQLLAAFEKGGLDSKN----YYWYMDQRKYGSVPHGGYGLGLERFICWLTDTNHIRDVCLYPRFVG.................................. 541
8 -76.800[J] KOG0554 Asparaginyl-tRNA synthetase (mitochondrial)  ali follow..  21  90.KKLRIAEVKLSRVGQSLNIMGWVRTLRSQSSVTFIEINDGSCLLQCVMTSDAEYDQVESGSILTGASVSVQGTIVASQGTKQK-------VELKVEKIIVVGEC-DSSYPIQKKRVSREFLRTKAHLRPRTNTFGAVARVRNTLAYATHKFFQESGFVWVASPIITASDCEGAGEQFCVTTLIPGKPAFLTVSGQLNGE-TYATALSDVYTFGPTFRAENSNTSRHAEFWMIEPELAFADLDDDMACATAYLQYVVKYVLDNCKEDMEFFDTWIEKGIIRRLSDVAEKEFLQLGYTDAIE-----------------------------------------------------------------------------------------------ILLKANKKFDFPVKWGL---DLQSEHERYITEEAFGGRPVIIRDY---------------------PKEIKAFYMRENDDGKTVAAMDMLVPRIELIGGSQREERLEVLEARLD----ELKLNKESYWWYLDLRRYGSVPHAGFGLGFERLVQFVTGIDNIRDVIPFPRTPASAE............................... 566
9 -64.400[J] COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)  ali follow..  18  2.........................................................................................SQLSLAFCSERV--QFVISVSCDEPPMTNSDWM---------PTASISQLKQRATLLRQIREFFAERNVLEVETPAMSHATVHTFKTEFVGPGYAKGSALHLMTSPEFHMKRLLAAGSGCIYQLGKAFRNEENGRYHNPEFTMLEWYRIGFDHHALMDEMDALLQLVLRCG------SAERMTYQEAFLNVLGVCP-----------------------------------------------------------------------------------------------------------------------------LEEEMRELKQVAATLGLSDIAEPEEDRDTLLQLLFSIGIEPKIGQITPAFDFPASQAALAKINPADPRVADRFEVYFKGIELANGFHELDNPAEQLARFKADNAMGLTEQPIDYHLIAALEAGLPECAGVALGIDRLIMLALGEDHIDKVTAFPFPRA.................................. 349
10 -44.200[E] COG2502 Asparagine synthetase A  ali follow..  13  1...............................................................................................................................MKKTFILQQQEIFVKNTFTQNLIEQL---GIIEVQGPILSQVGNGMQDNL-VNVKCIPNAVFEVVHSLAKWKRHTLAEDEGLFVHMKALRPDEDSLDPTH-YVDQWDWEKVIPEGRRNFAYLKETVNSIYRAIRLTLPKQITFVHSEDLVKRYPDLSSKERENAICKEYGAVFLIG-------------------------------------------------------------------------------------------------------------------------------------------KLSDGKPHDGRAPDYDDWTTESENGYKGLNGD----ILVWNDQLGKAFELSSMGIRVDESALRLQ----VGLTGDEDHLKMDWHQDLLNGKLPLTIGGGIGQSRLAMLLLRKKHIGEVQSWPKEMLE................................. 324
11 -12.400[S] COG3111 Uncharacterized conserved protein  ali follow..  22  48....TVESAKSLRDDTWVTLRGNIVERISDDLYVF---KDASGTINVDIDHKRWNG----VTVTPKDTVEIQGEV----------DKDWNSVEIDVKQIRKVNP.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 130
12 -12.400[J] COG0442 Prolyl-tRNA synthetase  ali follow..  13  19..................................................................................................................EVISHQLMLRAGMIRKLASGLYTWLRVLKKVENIVREEMNNAGAIEVSMPVVQPAD-EQYGPELLRFVDRGERPFVLGPTHEEVITDLIRGEINSYFQIQTKFRDE-----RAREFLMKDAYSFHTTQESLQETYDAMYTAYSK---------FSRMDLNFRAVLADTGSIGGSASHEFQVLAESGEDDIVFSTGSDYAANIEFAEALAPTEPRAPATEELRIVDTPNAKTIAELVEQFKLPIEKTVKTESGHKLVALLVRGDHDLNEIKAEKLPQVAKPLTFASEEEIRAAIGAGPGSLGPVNLSLPVIADHSVAVMSDFG--------NIDGKHYFGINWERDLALPLVADLRNVVEGDISPDGKGTLQIKRGIEVG------HIFQLGTKYSEVMKATVQGEDGR-----QVMTMGC-----YGIGVSRVVAAAIEQNHDDRGIIWPDAIAPFQVAILPMNMHKSFRVKELAEELYTTLRSHG.. 504
13 -11.100[J] KOG1936 Histidyl-tRNA synthetase  ali follow..  12  5........................................................................GLLPRRAWASLLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPATLTEKYGEDSGLMYDLKDQGGELLSLYDLTVPFARYLAMNKVKKRYHVGKVWRRETIVQGRYREFCQCDFDIPMIPDAECLKIMCEILSGL----LGDFLIKVNDRRIVDGMFAV-CGVPESKFRAICSSIDKLDKMAWKDVRHEMVVKKG-------------LAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLS-------------------------------------------------------------------------------------------LARGLDYYTGV-----------IYEAVLLQTPTQAGEEPLNVGSVAAG--PCVGLSIGVERIFYIVLWDSGIKAEMLYKNNPKLLTQLHYCESTIGEQELKEGVIKIRSVASREEV. 488
14 -10.000[J] COG0124 Histidyl-tRNA synthetase  ali follow..  9  1..........................................................................................................................MAIQIPRGTQDILPGDVETWQWIEQKAYDLCRRYNYQEIRVPMFEHTTTDIVQKEMYTFEDRGGRSLTLPEGTASVTRAYVSNKL-KLFYIGPMFRYERPQSGRMRQFVQFGVEADPAIDAEVLALVMRFYEELLKLVINSLGDTDSRLAHREALVNHFKPRIH-------------------------------------------------------------------------------------EFCNDCQDRLEKNPLRILDCKKDRDHELMGTAPSIHDYLSTESKAYFEKVQSYLTAL--------------------------NIPFVVDATLVRGLDYYNHTAFEVMVDGEGFGAITTLCGGG--------------------------RYNGLVEEIGGPETPGIGFALSIERAIMALEAQNQAIDCYVVTLGEAAKDKGVELVYQLRNAGIS................ 358
15 -9.930[E] COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis  ali follow..  10  11...................................................................................................................................ADVLPTNARQLESAREQLLALFRVHGYELVQPPLMTHIDAGLSLKTILVTDRLSGRQLGIR--ADITPQVARIDAHLRLCYAGPVLHAQSDGLLNMREPLQAGAEMDIRGDIELIDLMLKSMKIA--------------------------------------DMGKVLLSLGHIGIFRALSDAAHLDAGQSATLLALMQDKDTETVEAQVKAWKLDGMWAKAFSLLPRLYGGREVLSDARGRLPDLSAVGGALGE-----------------------LQAVCDAFPDCEIHIDLSELRVDNYHTGLLYAAYAADF----------------------------------------HDAVARGG-------------------------RYDGLGGYFGRARPA--GFSFDLRSFIGRLPAIERQPAVLVDAEDAEAAHEAV--------EALREQGQCVVIDYGIGHNV 363
16 -9.550[J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit  ali follow..  16  3.........................................................EQLEALRDDAIKKIEQAQEKKVVQEIRVKYKKGPVTEVLRGMGKLSPEERPVILANDVREAIGKAIESKMEALEQAEIHRKLQEETATITEVEDLFIGLGFSVAEGPALNLPKDHPARDMQDSFYFTDELLLRTQTSPVQARTMEKYKG--KIICPGKVFRRDDDDATHSHQFMQIEYVDHGVRMSDLKGVLQAFAKSFFGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERSIRLRPSFFPFTEPSVEVDVSCGICHGDGCRVCKQ---GWIEILGAGM------VHPRVLEMSGFNPNE--------YSGFAFG--------MGVERLSMLKYGIDDIRHFYT........................................ 332
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Damiano JS, Stehlik C, Pio F, Godzik A., Reed JC. CLAN, a novel human CED-4-like gene. Genomics. 2001 Jul;75(1-3):77-83.