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Query: [F] COG0209 Ribonucleotide reductase, alpha subunit, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDTPDTSLIREREAEAVQGAPEPVAMTAGKPAKSSDGLDYHALNAMLNLYDEDGKIQLDCDRQAARQYFLQHVNQNTVFFHNLREKLDYLVAEGYYEQTVLDQYSFNFVRDLFDEAYARKFRFPTFLGAFKYYTSYTLKTFDGKRYLERYEDRVCMVALTLARGDEQLARDLVEEIISGRYQPATPTFLNAGKKQRGELVSCFLLRVEDNMESIGRSINSALQLSKRGGGVALCLTNLREAGAPIKQIENQSSGIIPVMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIMRFLDTKRENADEKIRIKTLSLGVVIPDITFELARNNEDMYLFSPYDVQRVYGVPLTEISVTEKYREMVNDAQIAKKKINAREFFQVLAEIQFESGYPYIMFEDTVNRANPIDGRITMSNLCSEILQVSEASLFHEDLSYEYLGKDISCNLGSLNIAAAMDAPDFGKTIETSIRALTAVSDMSHIGCVPSVARGNAESHAIGLGQMNLHGYLARERIFYGSEEGVDFTNIYFYTVAYHAVRASNRIAVETGKSFKGFEKSKYASGEYFDKYTDQAWAPATEKVRRIFEDAGIAIPTQDDWCALKKAVMEGGLYNQNLQAVPPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAAFMTNDNLEYYQDAYEIGPEKIIDTYAAATQHVDQGLSLTLFFRDTATTRDINRAQIYAWKKGIKTIYYIRLRQMALEGTQVQGCVSCALLast
1 -208.000[F] COG0209 Ribonucleotide reductase, alpha subunit  ali  100  1MDTPDTSLIREREAEAVQGAPEPVAMTAGKPAKSSDGLDYHALNAMLNLYDEDGKIQLDCDRQAARQYFLQHVNQNTVFFHNLREKLDYLVAEGYYEQTVLDQYSFNFVRDLFDEAYARKFRFPTFLGAFKYYTSYTLKTFDGKRYLERYEDRVCMVALTLARGDEQLARDLVEEIISGRYQPATPTFLNAGKKQRGELVSCFLLRVEDNMESIGRSINSALQLSKRGGGVALCLTNLREAGAPIKQIENQSSGIIPVMKLLEDSFSYANQLGARQGAGAVYLHAHHPDIMRFLDTKRENADEKIRIKTLSLGVVIPDITFELARNNEDMYLFSPYDVQRVYGVPLTEISVTEKYREMVNDAQIAKKKINAREFFQVLAEIQFESGYPYIMFEDTVNRANPIDGRITMSNLCSEILQVSEASLFHEDLSYEYLGKDISCNLGSLNIAAAMDAPDFGKTIETSIRALTAVSDMSHIGCVPSVARGNAESHAIGLGQMNLHGYLARERIFYGSEEGVDFTNIYFYTVAYHAVRASNRIAVETGKSFKGFEKSKYASGEYFDKYTDQAWAPATEKVRRIFEDAGIAIPTQDDWCALKKAVMEGGLYNQNLQAVPPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAAFMTNDNLEYYQDAYEIGPEKIIDTYAAATQHVDQGLSLTLFFRDTATTRDINRAQIYAWKKGIKTIYYIRLRQMALEGTQVQGCVSCAL 738
2 -170.000[F] KOG1112 Ribonucleotide reductase, alpha subunit  ali follow..  22  16KEDVHFDKITSRIQKLSYGLVDPVAVAIKVISGLYKGVTTVELDNLAAETAASTTQHPEYALLAARIAVSNLHKKTNKVFSEHEFHHPHTGKHAPMISDETWAIIEKNADKLNSAIVYDRDYSYTYFGFKTLERSYLLKIN--KEIVERPQQMLMRVSIGIHGDDITSAIETYNLMSERYMTHASPTLFNSGTC-RPQMSSCFLLTMEDSILGIYDTLKQCALISKSAGGIGLNVHKIRATGSVIAGTNGTSNGLIPMLRVYNNTARYVDQGGKRPGAFAIYLEPWHADIFEFVSLRKNTGPEEERARDLFLALWIPDLFMKRVEKDQEWSLMCPCECPGLDDCWGEEFE---ALYAKYEAEGRVRKTVKARKLWEHIVSNQIETGLPYITYKDAANRKSNQQNTIKCSNLCTEIIEYSAPDE------------IAVCNLASIALNRYFDFVKLAEVTKVITRNLNKIIDVNYY-PVEEARNSNMRHRPIGLGVQGLADCFMLMRYPFTSAEARDLNKRIFETIYYAALEASCELAELNGP-YSTYEGSPVSKGQLQFDMWGVT------------------PTDQCDWATLRKKIAKHGIRNSLLMAPMPTASTAQILGNNESIEPYTSNIYSRRVLSGDGSIQNIDGIPSDIKELYRTVWEISQKDIIEMAADRGAYIDQSQSLNIHMA-KPSYAGITSMHFYGWKKGLKTGMYYLRTKPAVNAVQFEGCLMCS. 787
3 -14.200[F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase  ali follow..  11  12KAPFNRDRIQAAVESAAEHADQEIA---------------------------------IYALNVALAVELKLRDYDEVHITEIQTLVENELMQGPYKA---LARSYIEYRHDRDVAREKQSKLTKEIEGLIQESNADLLNENANKDGKVIPTQRDLLAGIVA--KHYAKTRILPRDVVQAHESGDIHYHDLDYAPFFPMFNCMLIDLKGMLTHGFKMGNAEIDTPKS--------TATAVTAQIIAQVASHIYGGTTINRIDEVLAPYVTASYEKH--LEIAREWDIHSPEAFAKARTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQQSILKNRIAGLGKNRKTAVFPKLVFAIKDYDIKQLALECASKRMYPDILNYDKVVEVTGS----FKTPMGCRSFLNPYEENGELIHEGRNNLGVVSLNLPRIALQAKGDINKFYALLDDKLKLARRALDTRINRLENVKARVKHGRASISLGYIGVHETIMAL---YDDVQLREEAVKIIQHLR----NAVEQWKKETGYAFS--------------------------------------------------------------LYGTPSENLCS---------------FCRIDAKQFGVVEGVTD-----KGYYTNSFKVNPYDKIDFEMPYPEISSGGFICYGEFPNMQRNVEALENVWDYSYHRVPYYGT---------NTPIDECYECG. 648
4 -6.820[R] KOG4331 Polytopic membrane protein Prominin  ali follow..  6  206IRKLLIDDYQVLNSTITKQLST---AGYNVVDRVKKLTGAHVIDVFMNISKVAQEMHDGLESVHGKV-LNEEGSRFEAEFSRLRNTANEELVKCLENELEPVRSMCAKAERLLESLAVTQFKIDQKFLPDATETGL-IVNANITQVLAASNNQFEQLESRIQHEIDKETYSAQNMLKQIGDDLFL-VAETISTQLRKVTFEALYSTVSYVSDPKKTPTLKYMQYSWYASGVLYGICGRRPTYYNDDCCVRSTGGKFVFLAVGTSALMFAVGNFSNLVCQPMRNPLSHPESLSLADLWKANHTPENDIEVTLQSKSPAEIIRACSRNETLYNFYGFDKKYHLNKL---------------QDFEKDAYNQLQISLRTTMENMPEIRPLDAFISRSELRDLEKLASVNVSKVSQQGLNAIKHAMDELDLASKTREFEESLDANSGRPKAVTLVLEQIRELEIQFAKPLRSRLEALYSNITSLDEKLSQLQVPVS-KLQHAQALLAENMREHFGRAAKEEFQQMVNNIDQYIVHVKSQMESEVTSCQPLTQ.............................................................................................................................................................................................. 771
5 -6.630[C] COG1151 6Fe-6S prismane cluster-containing protein  ali follow..  10  79....................................GPDAMAMRNFLLKNIMGAGTYSHHAYEAYRTLKATAEGRTPFKITDENKLKWMCEKLGIDTAQSINDMAFELAVILEDQQRIGVEDQNVMVEAFAPKKRIEAWKKLGIYPAGTVHEEQNCVASCLTNVDGSHTQIGLEMVQDILFGTPTPHEVNMDLGIMDPEYVNIVFNGHQ-GAATILKAKEIQDMAKQAGAKGLRVVGSIETGQELLQRFPVDEVFVGHMGNWLAIEPLLATG----DIFAMEENCSPPAIDMYAEKYQVTLAAVSTIIDLPGVNYKFPYDPAQADETAQRLIELGIENFKKRKERQIKPHVPQKIQKAIAGFSTEAVLGALGNKLDPLVDVIAKGQIKGVVALANCSTLRNGPQDWVTINLTKEL-IKRDILVVSGGCGNHALEVAGLCTLDALSFGTCTDTGRISMLVTALAEHLNVDVP-----PIAVTAPEWMEQKATIDGIYGAYTHLSPTPFMTGARQLVDLLTNKAEDVTGGKIALGDDPMKVANDIEDHIMRKRKELG....................................................................................................................................................................................... 637
6 -6.420[O] COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family  ali follow..  8  31...................................................................................................................................................LSLMDLLSVSEALNAAGQQAAAAELYKTWVA--FNDNNPAYFNYAV----------MLNQLGDRAGAVQAFRACLKANPEFAPGHINLGRALEDAGLIGHAVEQWSHYAEVHMTLQNMGRVLEGAGKLEEAETALLRPELPEAGQHWSLRQRQCKWPVLAPSNHISPRKMLDAMSSLTL----YADDPMFQLAKAYRLSKTLIGARPDLSRFPRRSPKQKSGTGQRLRVGYLSSDLRDHAVGFALCEVLELHDKDSLEVFAYYCGNV----RGTDSTQERIKAAVHCWRDIHGVDDATAASQIIADE-----------IDILIDVNGYTKDARAKIFAYRPAPVIVSFCGYPGSMGSPFHQYPPENEIYYSEKVLRIACDQPLDRKRPVAAEDAFVYASFNGMQKITENCFARWMTILSETPGSLLWLLTGDDDVN-------QRLRDLAEKSGVASERLVFAPKAQNPQHIAAHSTASDPVLTMYGKTFAARFCGSIVTAAGVPESPEDYVARAIGFERD---QSLLEVRESIARQRETSVLRDIPALARRLEELFWQMQGECERG........................ 624
7 -5.850[O] COG4930 Predicted ATP-dependent Lon-type protease  ali follow..  8  5......HDLPVPAVSEGELVAEGYDLDALLNQHFRGRVVRKDLTKQLKEGANVPVYVLEY--LLGMYCASDDDQIVEQGLQNVKRILADNYEAEKVKSLIRERGSYKIIDKVSVKLNQKKDVYEAQLSNLGIKDA-LVPPQMVKDNEKLLTGGIWCMITVNYFFEEGQKTSPFSLMTLKPIQMPNMDMEEVFTARTHQWIDVLLRSVGMEPANIEQRTKWHLITRMI----NYNVCELGPRG----------TGKSHVYKECSPNSL-LVSGGQTTVA----------------NLFYNMASRQIGLVGMWDVV-----------------------------------------------------------AFDEVAGITFKDKDGVQIMKDYMASGSFSRGRDSIEGKASMVFVGN-----------------------NQSVETLVKTSHLLAPFPAAMIDTAFFDRFHAYIPGWEIPKMRPEFFTNRYGLITLAEYMREMRFSDAIDKFYKLGNNLNQRDVIAVRRTVSGLLKLLHPNGSYSKEDVRVCLTYAMEARRRVKEQLKKLGGLEFFDVNFSYIDNETLEEFFVSVPEQGGSELIPAGMPKPGVVHLVTQAESGMTGLYRFETQMTAGNGKHSVSGLG-SSTSAKEAIRVGFDYEHEYHLHVIALCSVLLAKPVQEQMVVLGSMTLGDLAASLQLAFDSGAKKVLLPMSSAVDIPTVPAELFTKFQV 677
8 -5.730[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali follow..  10  300......QQINLLLHPSQNVIDNPVYLCDLVATLV-QSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHR------------KYLLNEQLKVIKKELGIEKDEKTTI--IEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHY------GMKDVKERIMEFIAVNLLRKSIGKILCFHGPPGV------GKTSIAKSIATALNREYFRFSVGGMTDVA-------------------------EIKGHRRTYVGAMPGKMIQCMKKVK--------------------------------------------------------TENP-LVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRM---------EMIDVSGYLAEEKVEIAHQLRKDTSLATEQLKSALEELIKHYCRESGVR---NLQQHIERIFRKAALQIAEQQ-------NEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTKAHIHIHVSSLLSLALDRPVVQDMAMTGEISLT-IREKVIAARRVGAKRVFLPNENRRDFDDL.......... 946
9 -5.580[S] KOG2939 Uncharacterized conserved protein  ali follow..  7  124VSKKISTLIMQKSSSYTAQVGEMEKIRDEVGSVI----------NEILTIRKALALATSQTRTCLGLIAYKNKKIVLNQLKMTLTTIKGFHETEQHIRETIEEGNFPLAIQMLIETQIKAGGYAHFTCVNEVISK----------LAGMSCLLEAELSAQLSTIAVVFDSEKYRFVYT------AYEMLEKTEQVAEKLLTAFVEAIETTTSAVVLSKLKEEDFREMGFVLCRSFQAFHKILNFHSSESASEASQSIYKQLLASRTEVFLAATRRLQVLVESRDFVSLKFEHILDIKTYFASTHHQKLAESIEKRTETYFLSMFFENESFALCPVPFQFTIFDLQDFEFLKESVRIESSPKSREESENSEEETVELIGN----DWQNPFCQ-QKSERSYSTSSAATEIQNENYNPNLTKQESFSEDPLDEPSGVPPPNLCNTALNLLRFFG-ALLPTLCSKSAPAIIDLYEFFFAS-GSEGAEFVGRIPRLVACLDGISRKFTKDEKANSPFRKVFQKDGDFLSGKMYPSLSPAVQIAFIDNLYGACERIIAVNSIEFVARQLDLIRPVIESLLLEDTREHLSTILDAFYTQVLPCQAD--ARILIVDASASKSLIDSVTSVNAYVDLLVQDYELFSIRITAIKETAPVNLSEAMEKFWERAIYYSFKALVQGYGDGGKCSTEG-------------RALMQLDFQMILMKVYPNCGKKIQKKTSEKGNIHLC..... 891
10 -5.440[J] KOG1148 Glutaminyl-tRNA synthetase  ali follow..  9  17...LNETTVKDTLKN--KKLSSSLNKVIEETNVGSSGCDRTIGNLLFTLANASLKQKDPKSNAHEAFIASKIVSGDLKTNLQVNAAITYCKDKDTIDESEFDKETGVGVVLTPEQIEQLVGDYVAENKSKILEQRYQLLNPSASALRQHALLKWAPQLEVKQTLD----RKFLELLGPKTEQDAAAGKKKGAKAKNSKQKT--VDSGKAKEQKIVSEQSKKYNMFEEGAKLHKPGGNTQLIPERMKEHLQATGGGV-VTRFPPEPNGYLHIGHSKAI------------AVNFGFARYHNGVCYLRFDDTNPE---EERYFESIKDLVAWLGFQPYKITYSSDYF-AEIKKARGGEERGPRYACVHRDRPIEEEFRNMRDGKYQPKEAILRMKQDLSDGNPQ--TYDFTHCLVDSFENISHSLCTTEFILSRVSYEWLCNALEVYCPAQREYGRLNVGTLMSKRKIMKLVKEGYVHGWNDPRLYTVALRRRGVPPGAILEFVSEVGVTTAVSEVARFENCVRKFLENSVPRLMFLPDPIK...................................................................................................................................................................................................... 585
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;