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Query: [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst ETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTKTLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENSRGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHELast
1 -144.000[IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II  ali  100  1ETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTKTLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENSRGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE 516
2 -98.700[Q] COG1021 Peptide arylation enzymes  ali follow..  17  25VPLTDILTRHAD--SDKTAVIEG--ERAFSYRQLNQAADNLACSLRRQGIPGETALVQLGNVPELYITFFALLKLGVAPVLALFSHQRTELNAYAMQIAPTLVIADRQHTLFAGEDFLNTFVAEHRSVRV--LLRNDDGDHSLDAAMRQAAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSNEICGFNEDTRFLCAIPAAHNYAMSSPGALGVFLAKGTVVLATDPSATLCFPLIEKHQINATALVPPAVSLWLQAIQNAPLASLRLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTLDDSPERIINTQGRPMPDDEVWVADADGPGEIGRLMTRGPYTFRGYFNS----------PLHNASAFDNGFYCSGDLISIDQDGYITVHGREKDQINRGGEKIAAEEIENLLLRHPVVIHAALVSMEDELLGEKSCAYLVVKELRAVQVRRFLREQGVAEFKLPDRVECVASLPLTPVGKVDKKQLRQRLASRSP... 535
3 -96.500[I] KOG1176 Acyl-CoA synthetase  ali follow..  22  38.SLDITTFISSQTYRGKTAFIDAATDHRISFSDLWMAVDRVADCLLHD--RGDVVLVLSPNTISIPIVCLSVMSLGAVLTTANPLNTASEILRQIADSNPKLAFTTPELAPKIASSGISIVLERVEDTLRVP-RGLKVVGNLTEMMKKEPSGQAVRNQVHKDDTAMLLYSSGTTGRSKGVNSSHGNLIAHVARYIAEPFEQPQQTFICTVPLFHTFGLLNFVLATLALGTTVVILPRF-DLGEMMAAVEKYRATTLILVPPVLVTMINKADKYDVSFLRTVRCGGAPLSKEVTQGFMKKYTVDVYQGYALTESNGAGASIESVERRYGAVGLLSCGVEARIVDPNGLNQTGELWLKGPSIAKGYFRNEEEI------------ITSEGWLKTGDLCYIDNDGFLFIVDRLKELIKYKGYQVPPAELEALLLNHPDILDAAVI.......................................................................... 478
4 -87.800[I] KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter  ali follow..  16  74RTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQARGLSGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASPDPSLSLFCSGSWEPGAVPPSTE-PLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKF-SASRFWDDCIKYNCTIVQYIGELCRYLLNQPEAENQHQVRMALGNA--SGSPSGPTFPAASTYPWLSSTGPECNCSLGNFDSQVGAYPIRLVRVNEDTMELIRGPDGPGEPGQLVGRIIRRFDGYLNQ----------GANNKKIAKDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVTGNCDLERFAQVLEKE-LPLYARPIFLRLLPELHKTGTYKFQKTELRKEAFDPAIVKT 612
5 -76.200[I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  18  17PPPNEMLLRWAKERPNEVYLKQIINRVEFTYAEVADKALRLVSALRALGAPGDKVALISKNCAEWFICDLAMMLGDYISVPIFPTAGSETIDYCLEHSESKILIVGKL--DNKATAHVLAERPNLISISLPY-PSAAKCQYEFQTLIKQHQPSEERPTHFDEKLMSIVYTSGTSGQPKGAMLTYGAFTWSAQQLINHIGIEENDRLFSYLPLAHITERVYIFGSSIIGGVLTAFPE---SLDTFIEDVKMHRPTLFISVPRLWTLFQKLADGLGLDQARVLGCGSAPVSPALLE-WYRSVGLNITEAWGMTESFAYSTLNYPFRAKIGTVGNAGPGIELKIAED------EEILVRSKGLFAGYYKN----------DTATAESFDDGWLHTGDIGSLDSEGYLTIQGRKKDTFKTKGKFVAPVPIEKKLFEYSRVEMMCLIG-SGLPAPILLAVPHNFPHFDRARYERTTQKSELESHEQIKGVLMIKD--LTPTLKIKRHVLEKKYHDVGQN.. 552
6 -70.600[I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases  ali follow..  20  92.........LTTWRRNKAAIIEPGDSRIITYAQLHREVCQFANALKSLGVKGDRVAIYLPMIPEAAITMLACSRIGAPHSVVFGGFSAEALRDRLVDAEAKLVITADGGFRKDKAIALKQEVDKALEHGAPSVENVIGRDHWWHELQPQQSAHCPAEPIDSEDMLFILYTSGSTGKPKGVVHTTGGNLYTHMTTKWIFDLKDTDVYWCTADVGWITGHSYIVYGPLSNGATTVMYPRPSNPGCFWDVIERYGVNIFYTAPTAIRAFIRMPNARDLSSLRLLGTVGEPINPEAWMWYHRVIGCPIVDTWWQTETGGIMLTPLPGAIKPGSCTKPFPGIVAEIVDLDGSDQGGFLVIK-PSMIRDVYGDTDRFRHTY---EHIQPKEGQYLYFAGDGARRDKDGYFWVMGRVDDVINVSGHRLGTMEIESALVSHPLVAEAAVVGRPDELTGEAIFAFVS-SEELKKDLVKHVTEE-IGAIARPAEIRFTDVLPKTRSGKIMRRLLRSLASGQEISGD 637
7 -70.200[I] KOG1256 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  18  82LTTYSGIRRGPTVLGKRVMKDGKLEWEWISYDQAFETSDHASQAIRKLGIEESKIGIYSNNRPEWILSEMAIHNFSNVSVPLYDTITNDDMHYITNLCEISLMFVDAEIKTKQLIRDKSYLSSLKYIVQFNECSDDIKEMARENDFMGKKQKHRPHVPPTPETLATISFTSGTTGRPKGVMLTHLNMCSATMSCEEFENAGVQDAYLSYLPLAHIYERLCLLSN-FMIGSRIGFSRG--DPKLLVDDVQALAPRSFATVPRVIDKIHKAVMKQ--PNIRQLILGAAKSDVSAMRFARGAFGVEVLEGYGQTETSGPTTLQLVGDTRIGCVGPPMACAMIKLIDVPELGNGGEVLVKGHNVTSGYYKN----------PEATASSFEDGYMKTGDIGRFTAEGSLQIIDRRKNVFKMPGKFVAPDLTESLYTSSSFVQQIYVHG--DMEKPWLVAIVVPDADDVLRQFVELTEEDKRPRYEGVYGVHLTPV--TTPTLKNKRNAIAQFFKAEIDG.. 685
8 -64.800[I] KOG1175 Acyl-CoA synthetase  ali follow..  19  125.........VEAGLGDKTAIHELGVDASLTYSELLQRVCQLANYLKDNGVKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNAVKRGPKTINLKAIVDAALDQS-ENTKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGMIYTATTFKYAFDYKSTDVYWCTADCGWITGHSYVTYGPMLNGATVVVFPNYPDPGRCWDIVDKYKVSIFYTAPTLVRSLMRDVTRHSRKSLRVLGSVGEPINPSAWRWFFNVVGCPISDTWWQTETGGFMITPLPGPQKPGSATFPFFGVQPVIVDEKGGECSGYLCVK-PGAFRTLFGDHER--------ETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKGQGIYAFVT-SEELRKSLVLMVRNQ-IGAFAAPDRIHWAPGLPKTRSGKIMRRILRKIASRQLEE.. 671
9 -64.100[I] KOG1180 Acyl-CoA synthetase  ali follow..  19  89HDLGTQWEECVRRYGNQPCM-QMGDYHWRSYAQVDKRVNMIASGLTSLGQEKEPIILFAETREEWMTTALACMKMNFPIATMYATLGDEAVQFAINEVGAKTIFTSEALISKV-KKAMSNGATSIENIIFFDSVDPASRGESVREYCMLLGAYPVPTRSKKDDLAFIMYTSGTTGNPKGVMISHQNIVAVTAGQAFNIVLGPDDRYIGYLPLAHILEVCAEMVV-FTKGVRILFDRAPKIMKGEHGDCWVLQPTLMACVPAVMDRIFKAVIDE--GKVRQILSGGAPLSPETQRFMNICFCCPVVQGYGLTETCGGGTIADIHDLSTGTVGPPLTCCEILLQEWAEAGPQGEILISGPNVALGYFKNDEKTK------EEFVKVNGKTFFATGDIGEFREDGSLKIIDRKKDLLKLAGEYISLGKVETNLLTNPNVDNVCVYGVPNQ---KNLTQLASKAGASNDNFEKLCEASKLQRVEIPQKIFICHE--LTEALKLKRKNIEKAFRKELDE.. 723
10 -63.900[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  13  19DTPIARLLKNAKETPDHRFISERGIVAKYTYTELLRRVNTIAKFCDDLGL-GKTVGIHMGHELDFLCSIFALWATGRTCVIFNQIWSQQVVRVLVKRLNISDLLYHEYKPKFEVDTLNATSLASL----------------------PLDIDAPCIRAGLEPEVALINHSSGSTGVPKSMPFLMKKYALGYDYGTPEFMNHLSTPMVMAT----SFALTTSWINALYCNGNLLYPSSSI-LAWNVYYALRAGCERLIILPNLLVLTLQIDKEECFPACKLVAAGGEMVPANMYHTCKRVLNATIYPQYGTTESGLVSFLAYNGKDTLHNPGKTVKKLMLVTEDNEKIGCEGFVCVVTDVQSEPYVGDDAETIQSRNSTFINYD--GQPAVRFADLAVWNSKLGITIKGRLGRRVKRNGVFFDLKYFDQVVVGLKEVKDAFSFFIFNRF---VLVYVPAYNGVDPVTLKQKLNKE-LRDHHLFSSCFPLADIPRNAAGKVDLKSIETYASKCLSVED 530
11 -56.200[Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins  ali follow..  17  453RCLHDFVTASAETSPQAIAVTDQ--DRSLSYAELDWRADRLASGLVAAGIRGKRVGIRLERSVELVVAILAVLRTGAAYVPLDPRYPADRIEFIAADADLALILVTTENDISTIGQNFRCMTPG--------------------MVENLAGGAVPTPVTSGADLAYLIYTSGSTGRPKGVAIEHRNAVAFMQWCMHAFTKDQLSGVLASTSICFDLSIF-EIFATLAAGGRIFMVD---DLFAFPSAPFAGEVTLVNTVPTPMSELLKLGPL--PQNVKTVCLAGEPLPRELVARIYANDQECLYNLYGPSEDTTYSTVAPPPSGEWFGIGVPIANTRAYVLDGEPVGVPGELFLSGSGLARGYWNRPGQTAERFLPNPFADCSQHRVMYQTGDIVRRRDDGGLDYMGRADRQLKLNGFRIEPGEIEAVLLQQEGVHEAVAGLWRDAANHPRLAMWIAGDPLEITKLVATLRQR-LPEHFIPVLATRLDALPRLPNGKLDRSALPDPAAYGERATE 947
12 -26.300[H] COG1541 Coenzyme F390 synthetase  ali follow..  16  17....................................................................................EIQERKLKALVSTVYQYSPFYRQRFRETPDDIKSLNDLPKLPFTKKQDLRDT---------------YPFGMFCVPLSQVVRFHASSGTTGKPTVVGYTANDIVESLCRALVSCGVSSDDIMQIAYGYGLFTGGLGFHYAAERLGATVLPI-SAGNTARQIELMKDLGSTVMACTPSYMIYLAEYASQMGVDNLRAGIFGAEPWSEETRKRIEDKTGITAYDVYGTSELSGPLFTECTERQ-----GLHIDMFLIEIIDPKTEGEKGELVVTT---------------------KEALPLIR---WRTGDITYMETD-IMRILGRADDMLIIRGVNVFPSQIEHVLMQIPEVGEHYMIIVDRREDGLDELTVQVDTTGDILKLEKKIADKLKSVLNVWAKVEVVGTLQRF-EGKIDRRKI............ 433
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang B, Jaroszewski L, Rychlewski L, Godzik A. Similarities and differences between nonhomologous proteins with similar folds: evaluation of threading strategies. Fold Des. 1997;2(5):307-17.