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Query: [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSDTIESILQEERLFDPPTEFSERAYVRSGREYEQLYSRAASNPEKFWGELAEQELHWFKKWDQVLDWQPPFAKWFVGGQLNISHNCLDRHLTTWRRNKAAIIWEGEPGDSRIITYAQLHREVCQFANALKSLGVQKGDRVAIYLPMIPEAAITMLACSRIGAPHSVVFGGFSAEALRDRLVDAEAKLVITADGGFRKDKAIALKQEVDKALEHGAPSVENVIVVQRTKADVTMTAGRDHWWHELQPQQSAHCPAEPIDSEDMLFILYTSGSTGKPKGVVHTTGGYNLYTHMTTKWIFDLKDTDVYWCTADVGWITGHSYIVYGPLSNGATTVMYEGVPRPSNPGCFWDVIERYGVNIFYTAPTAIRAFIRMGEAVPNARDLSSLRLLGTVGEPINPEAWMWYHRVIGGGKCPIVDTWWQTETGGIMLTPLPGAIPTKPGSCTKPFPGIVAEIVDLDGNPVESDQGGFLVIKQPWPSMIRDVYGDTDRFRHTYWEHIQPKEGQYLYFAGDGARRDKDGYFWVMGRVDDVINVSGHRLGTMEIESALVSHPLVAEAAVVGRPDELTGEAIFAFVSLEGNAEPSEELKKDLVKHVTEEIGAIARPAEIRFTDVLPKTRSGKIMRRLLRSLASGQEISGDTSTLEDRTVLDKLREGLast
1 -199.000[I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases  ali  100  1MSDTIESILQEERLFDPPTEFSERAYVRSGREYEQLYSRAASNPEKFWGELAEQELHWFKKWDQVLDWQPPFAKWFVGGQLNISHNCLDRHLTTWRRNKAAIIWEGEPGDSRIITYAQLHREVCQFANALKSLGVQKGDRVAIYLPMIPEAAITMLACSRIGAPHSVVFGGFSAEALRDRLVDAEAKLVITADGGFRKDKAIALKQEVDKALEHGAPSVENVIVVQRTKADVTMTAGRDHWWHELQPQQSAHCPAEPIDSEDMLFILYTSGSTGKPKGVVHTTGGYNLYTHMTTKWIFDLKDTDVYWCTADVGWITGHSYIVYGPLSNGATTVMYEGVPRPSNPGCFWDVIERYGVNIFYTAPTAIRAFIRMGEAVPNARDLSSLRLLGTVGEPINPEAWMWYHRVIGGGKCPIVDTWWQTETGGIMLTPLPGAIPTKPGSCTKPFPGIVAEIVDLDGNPVESDQGGFLVIKQPWPSMIRDVYGDTDRFRHTYWEHIQPKEGQYLYFAGDGARRDKDGYFWVMGRVDDVINVSGHRLGTMEIESALVSHPLVAEAAVVGRPDELTGEAIFAFVSLEGNAEPSEELKKDLVKHVTEEIGAIARPAEIRFTDVLPKTRSGKIMRRLLRSLASGQEISGDTSTLEDRTVLDKLREG 653
2 -168.000[I] KOG1175 Acyl-CoA synthetase  ali follow..  50  33.....SLASEENDLVFPSKEFSGQALVSSPQQYMEMHKRSMDDPAAFWSDIASEQKWGDQVFSENLDVRPISIEWFKGGITNICYNCLDKNVEAGLGDKTAIHWEGELGVDASLTYSELLQRVCQLANYLKDNGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNAVKRGPKTINLKAIVDAALDQSSKDGVSVGICATTRENTKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMIYTATTFKYAFDYKSTDVYWCTADCGWITGHSYVTYGPMLNGATVVVFEGAPNYPDPGRCWDIVDKYKVSIFYTAPTLVRSLMRDDDKFVTRHSRKSLRVLGSVGEPINPSAWRWFFNVVGDSRCPISDTWWQTETGGFMITPLPGAWPQKPGSATFPFFGVQPVIVDEKGNEIEGECSGYLCVKGSWPGAFRTLFGDHERYETTYFKPFA-----GYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKGQGIYAFVTLLEGVPYSEELRKSLVLMVRNQIGAFAAPDRIHWAPGLPKTRSGKIMRRILRKIASRQLEEGDTSTLADPSVVDQLIAL 690
3 -72.400[Q] COG1021 Peptide arylation enzymes  ali follow..  22  26.....................................................................................PLTDILTRHADSDKTAVIEGE-----RAFSYRQLNQAADNLACSLRRQGIKPGETALVQLGNVPELYITFFALLKLGVAPVLALFSHQRTELNAYAMQIAPTLVIADRQHTLFA-----GEDFLNTFVAEHRSVRVVLLRN---------DDGDHSLDAAMRQAAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDY-YYSVRRSNEICGFNEDTRFLCAIPAAHNYASSPGALGVFLAKGTVVLATD----PSATLCFPLIEKHQINATALVPPAVSLWLQAIQEWGGNAPLASLRLLQVGGARLSATLAARIPAEIG---CQLQQVFGMAE-GLVNYTRLDDSPERIINTQGRPMPDDEVWVADADGNPLPPGEIGRLMTRG--PYTFRGYFNSPLHNASAF-------DANGFYCSGDLISIDQDGYITVHGREKDQINRGGEKIAAEEIENLLLRHPVVIHAALVSMEDELLGEKSCAYLVVKEPLRAVQ-----VRRFLREQVAEFKLPDRVECVASLPLTPVGKVDKKQLRQRLASRS.................... 534
4 -70.700[IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II  ali follow..  20  10...........................................................................................AQYRYGAGKNCI---EDINFTPDTYRKLLTKTLFVGRILEKYSV-EGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADV-------------TPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKS-ILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLY---PSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARF----ANPYDFYRLRYVVAGAEKLQESTKQLWQDKFG---LRILEGYGVTECAPVVSINVPMAA--KPGTVGRILPGMDARLLAVPG----IENGGRLQLK---PNIMNGYLRVEKPGVLEV-ENSRGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTT-------SELTREKLQHYAREHIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE................ 516
5 -65.800[I] KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter  ali follow..  17  78.....................................................................................ILFASTVRR-HPDKTALIFEGTD---THWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGS---------EMASAICE-VHASPDPSLSLFCSGSWEPGAVPPSTEHLD-PLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRY-YRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKK-----SASRFWDDCIKYNCTIVQYIGELCRYLLNQ--PPREAENQHQVRMALGNA--SGSPSGPTFPAAST---YPRWLSSTGPECNCSLGNFDRILSFVYPIRLVRVNEDTMELIRGPDGVPCQPGEPGQLVGRII--RRFDGYLNQGANNKKIAKDVFKK--GDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLE---RFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRK.......................... 602
6 -61.700[I] KOG1176 Acyl-CoA synthetase  ali follow..  20  51................................................................................................RGKTAFI---DAATDHRISFSDLWMAVDRVADCLHDVGIRRGDVVLVLSPNTISIPIVCLSVMSLGAVLTTANPLNTASEILRQIADSNPKLAFTTPELAPKIASSGISIVLERVEDTLRVP--------------RGLKVVGNLTEMMKKEPSGQAVRNQVHKDDTAMLLYSSGTTGRSKGVNSSHGN-LIAHVARYIAEPFEQPQQTFICTVPLFHTFGLLNFVLATLALGTTVVILPR-----DLGEMMAAVEKYRATTLILVPPVLVTMINKADQIMKKYDVSFLRTVRCGGAPLSKEVTQGFMKKY--PTVDVYQGYALTESNGAGASIESVEESRRYGAVGLLSCGVEARIVDNTGQVMGLNQTGELWLK---PSIAKGYFRNEEEIITS----------EGWLKTGDLCYIDNDGFLFIVDRLKELIKYKGYQVPPAELEALLLNHPDILDAAVI............................................................................................... 478
7 -56.500[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  13  19.................................................................................DTPIARLLKNAKE-TPDHRFISVYNERGIVAKYTYTELLRRVNTIAKFCDDLGL--GKTVGIHMGHELDFLCSIFALWATGRTCVIFNQIWSQQVVRVLVKRLNISDLLYHE----------------YKPKFEVDTLNATSL-------------------ASLPLDIDAPCIRAGLEPEVALINHSSGSTGVPKSMPFLMKK-YALGYDYGTPEFMNHLSTPMVMATSFALTTLS---WINALYCNGNLLYATCTSEAERLAWNVYYALRAGCERLIILPNLLVLTLQIMPDKEEC--FPACKLVAAGGEMVPANMYHTCKRVL--PNATIYPQYGTTESGLVSFLAYNGKDTLHNKEPGKTVKKLMLVTEDNEAVPEKIGCEGFVCVVT--DVQSEPYVGDDAETIQSRNSTFINYDGQPAVRFADLAVWNSKLGITIKGRLGRRVKRNGVFFDLKYFDQVVVGLKEVKDAFSF----FIFNRFVLVYVPAYNGVDPV-----TLKQKLNKELRDHHLFSSCFPLADIPRNAAGKVDLKSIETYASKCLSVEDQRLPVLLNPVAI.... 542
8 -50.400[I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  18  28..............................................................................................KERPNEVYLKQIINRQFVEFTYAEVADKALRLVSALRALGADPGDKVALISKNCAEWFICDLAMMLGDYISVPIFPTAGSETIDYCLEHSESKILIVGKLDDNKA----------AHVLAERPNLISISLPYPSAAK------CQYEFQTLIKQHQPSEERPTHFDEKLMSIVYTSGTSGQPKGAMLTYGA-FTWSAQQLINHIGIEENDRLFSYLPLAHITERVYIFGSSIIGGVLTAFPE------SLDTFIEDVKMHRPTLFISVPRLWTLFQQR-RKLADGLGLDQARVLGCGSAPVSPALLEWYRSV----GLNITEAWGMTESFAYSTLNYPF-RADKIGTVGNAGPGIELKIAED----------EEILVRS--KGLFAGYYKNDTATAESF-------NDDGWLHTGDIGSLDSEGYLTIQGRKKDTFKTAGKFVAPVPIEKKLFEYSRVEMMCLIG---SGLPAPILLAVPHNFPHFDRARYERTTQKVIARINSELESHEQIKGVLMIKDTPTLKIKRHVLEK.......................... 544
9 -49.000[Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins  ali follow..  19  393.................RSDLFRRATMESLGELVALLEKIVERPE---LPLDRQSLVSGNHQKRLRQWNETDAEFQPQRRC--LHDFVTASAET-SPQAIAVTDQDR-----SLSYAELDWRADRLASGLVAAGIGRGKRVGIRLERSVELVVAILAVLRTGAAYVPLDPRYPADRIEFIAADADLALILV-----------------TTENDISTIGQNFRCMTP----------------GMVENLAGGAVPTPVTSGADLAYLIYTSGSTGRPKGVAIEHRN-AVAFMQWCMHAFTKDQLSGVLASTSICFDLSIFE-IFATLAAGGRIFMVD------DLFAFPSAPFAGEVTLVNTVPTPMSELLKLGPL------PQNVKTVCLAGEPLPRELVARIYAND--QVECLYNLYGPSED-TTYSTVAPVPPSGEWFGIGVPIANTRAYVLDGEMNEVPVGVPGELFLS---SGLARGYWNRPGQTAERFLPN-DCSQHRVMYQTGDIVRRRDDGGLDYMGRADRQLKLNGFRIEPGEIEAVLLQQEGVHEAVAGLWRDAANHPRLAMWIAGDPALEIT-----KLVATLRQRLPEHFIPVLATRLDALPRLPNGKLDRSALPDPAAYGERATETASLLND......... 954
10 -44.800[I] KOG1256 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  16  80...............................................................................GVLTTYSGIRRGPTVGGKEMLGK-MKDGKLEWEWISYDQAFETSDHASQAIRKLGIEIGEKIGIYSNNRPEWILSEMAIHNFSNVSVPLYDTITNDDMHYITNLCEISLMFVDA---------EIKTKQLIRDKSYLSSLKYIVQFNECSDDIKEMARENWSFNEFVEKKQKHRPHVPPTPETLATISFTSGTTGRPKGVMLTHLNMCSATMSCEEFENEAGVQDAYLSYLPLAHIYERL-CLLSNFMIGSRIGFSRG-----DPKLLVDDVQALAPRSFATVPRVIDKIHKAVMKQVQDKPLKKIRQLILGAAKSDVSAMRFARGAFG---VEVLEGYGQTETSGPTTLQLVG--DTRIGCVGPPMACAMIKLIDPELGYSVDKNGGEVLVK---HNVTSGYYKNPEATASSF-------TEDGYMKTGDIGRFTAEGSLQIIDRRKNVFKMPGKFVAPDLTESLYTSSSFVQQIYVHG---DMEKPWLVAIVVPDEQLCNIPILADDVLRQFVEKRPRYEGVYGVHLTPV---TPTLKNKRNAIAQFFKAE..................... 682
11 -40.700[I] KOG1180 Acyl-CoA synthetase  ali follow..  18  117............................................................................................HKEKQSNGKIFEKWQMGDYHWRSYAQVDKRVNMIASGLTSLGQQEKEPIILFAETREEWMTTALACMKMNFPIATMYATLGDEAVQFAINEVGAKTIFTSE---------ALISKVKKAMSNGATSIENIIFFDSVDPASRGESVDVLSFDQLLSRGERE-VPTRSKKDDLAFIMYTSGTTGNPKGVMISHQN-IVAVTAGQAFNIVLGPDDRYIGYLPLAHILEVCAEMV--FTKGVRIGYSSAQTLFDRAPKIMK-CWVLQPTLMACVPAVMDRIFKAVIDEVNANS-GKVRQILSGGAPLSPETQRFMNICFC---CPVVQGYGLTETCGGGTIADIH--DLSTGTVGPPLTCCEILLQEWAEAGYSPKNDGEILIS---PNVALGYFKNDEKTKEEFVK-----NGKTFFATGDIGEFREDGSLKIIDRKKDLLKLAGEYISLGKVETNLLTNPNVDNVCVYG--DSNKSFLVALVVKLCEDKKVVEALQKELAQYGASKLQRVEIPQKIFICHE---TEALKLKRKNIEKAFRKE..................... 720
12 -25.700[H] COG1541 Coenzyme F390 synthetase  ali follow..  16  14..........................................................................................................................................................................................................ELEEIQERKLKALVSTVQYSPFYRQRFREAGVTPDDIKSLNDLPKRDTYPFGMFCVPLSQVVRFHASSGTTGKPTVVGYTANDIRNWVESLCRALCGVSSDDIMQIAYGYGLFTGGLGFHYAAERLGATVLPISAG----NTARQIELMKDLGSTVMACTPSYMIYLAEYASQMVDIAEDTNLRAGIFGAEPWSEETRKRIEDKTG---ITAYDVYGTSELSGPLFTECTERQGLHIWA-------FLIEIIDKTGEQVGEGEKGELVVTEALPLI---------------------------WRTGDITYMETD----ILGRADDMLIIRGVNVFPSQIEHVLMQIPEVGEHYMIIVDRREDGDELTVQVELSDKAEIDTKLEKKIADKLKSVLN-VWAKVEVVNPGTLQRF-EGKAKRVIDRRKI........................ 433

FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 6 0 4   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Nika K, Tautz L, Saito K, Cerignoli F, Friedberg I, Godzik A, Mustelin T. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. FEBS Lett. 2007 May 29;581(13):2527-33. Epub 2007 Apr 30.