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Query: [H] COG0373 Glutamyl-tRNA reductase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLLAIGINHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVILSTCNRTEIYCDVRSASKNKVIEWLSQFHQVSLDELKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVKQAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEIGGSAVSVAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERALSLAQQFGADVIALNEIPDYLAQADIVISSTASPLPIIGKGMVESALKARRHQPMLLVDIAVPRDIEPQVGKLNDAYLYSVDDLQSIVDSNIEQRKVEAIQAEAIVSEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQGEPAKLAVIRQSLGLDDLNLast
1 -109.000[H] COG0373 Glutamyl-tRNA reductase  ali  100  1MSLLAIGINHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVILSTCNRTEIYCDVRSASKNKVIEWLSQFHQVSLDELKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVKQAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEIGGSAVSVAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERALSLAQQFGADVIALNEIPDYLAQADIVISSTASPLPIIGKGMVESALKARRHQPMLLVDIAVPRDIEPQVGKLNDAYLYSVDDLQSIVDSNIEQRKVEAIQAEAIVSEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQGEPAKLAVIRQSLGLDDLN 419
2 -20.500[R] COG5322 Predicted dehydrogenase  ali follow..  13  42................................................................RGYRDDRWQWRNLVPFADFGRIVSAQGAVCEGILHYMPLTAEEMLSQPRAIAQRVVDAVESLKDQGAQVVGLGGFTAIVGNRGLQTLERTGISLTAYAAYRNVLESMDRLGVEPADTEVAVVGYGSIALVIAKLLAGHGCRLCLVHRGSEAGLAYLPEPMHAQVRLSNDIEHCYEHVQFYVAATSTGG-LIDPYRLRP--------GSVVVDAALPRDVKPYRKDRNDILIIDGGLVSASSALRFGAESMGLAPKKFLNGCLAETLILGLEGRAEAFSIGR------ELPEDKVLEIGRIAELHGFSPSPMASYGEPVKDRHFAALRPFHRPRTQSPAG................ 376
3 -14.400[E] COG0169 Shikimate 5-dehydrogenase  ali follow..  16  3..................................................SQIDQYAVINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKL------DDGEILGDNTD--------GEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGVKAQAFEQLKQSYDVIINSTSAS-----DGELPAIDPVIFSSRSVCYDM-----------------MYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLW---RGLRPGTKQILRELRKNLEGAL............................................................. 278
4 -11.400[E] KOG3007 Mu-crystallin  ali follow..  15  116...................................................................................................................................................................TAAASALASSYLSKEDSTSLLIIGSGKVAEKLIHAHCSRPIRSVRIWNHRFESAKSLASRAQIDAVPIQNLENAVKCSDIISSATLSKKPIIVGSWI------NPGTHIDLVGGFTPHEADSKCIQISNVFVDTRKDLLTPIKEGLFSPNEVIADLFDLCNNKHSGRSQLKNPAEAITLFKSVGDSREDLAAASL............................................................. 321
5 -9.330[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  17  3.....................................................................................................................................................................................KIGIVGCGFIGGQICRAIDGVSAELYALCDSSESKALELAASLKTCKPSYMKIEELIRGVDLIIESASQN---AVRFIVPQALKAGCDSVGALADEELRDTLFGLAKE.................................................................................................................................. 113
6 -8.870[E] COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog  ali follow..  14  116.........................................................................................................................................................TALRTAATS------AVAAKYLAPRGARTMAIIGNGAQSEFQAIAFKAAGVDRLRLYDIDRSASLKCAKNLAGMGFDIETGQEAVEGAGIITTVTADKQTILTDNMV------GAGVHINAVGGDCPTELHRDILLRSDIFVEFPPQTRIEGEIQQLDPNHPVTELWQVVAAKV............................................................................................ 285
7 -8.020[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  12  2...................................................................................................................................................................................KKNVLIIGAGGVAQVVAHKCAQNSLGDIHIASRTVDKCRKIVESVREDALDVEATKALIVSSQIVINVGS---AFVNMSVLRACMDTGVA----YMDTAIHEEPNKICET------------PPWYGNYEWKRAAECKEKGITA----------ILGVGFDPGVVNA......................................................................... 158
8 -7.100[E] COG0686 Alanine dehydrogenase  ali follow..  12  1...MIIGVPKEIKNHE--YRVGMIPASVRELVSQVYVETNAGSGIGFSDDDYIAVGASILPTAADVFAK-MIVKVKEPQAIERAMLKEGQILFTYLHLAPDFPQTEELIKSKAVCI-----AYETVTDNMGRLPLLAPMSEVAGRMS------IQAGAQTLEKSRGGSGLLLGGVPGVAPAKVVVLGGGVVGANAARMAIGLRADVTILDRNIDTLRKEFQGRANVVYSTADAIEKYVLEADLVIGAVAAAPKLVTQQHIKRMKPGS-----AVVDVAIPTTHAEPTYIVDDVVHYCVANMPGAVART----------STFALNNATLPYIVKLANKGYQKAL--------------------------LEDAGFLKGLNVIHGKVTYKEVAENFGLDYVDPAKAIAMFN......... 374
9 -7.090[Q] KOG0024 Sorbitol dehydrogenase  ali follow..  12  69..........................................................................................GHEASGTVEKVGSSVKHLKPGDRVAIGRYNFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGH----KVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLS-KAKEIGADLV--ESPQEIARKPEVTIECTGAEASI------AGIYATRSGGTLVLVGLGSEMTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFP--------------LEKALEAFETFKKGLGLKIMLKCDPSDQN................................................ 356
10 -6.780[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  14  2................................................................................................................................................................................SHTKPSIAILGAGRVGSSLARSAVAAG-YEVKVAGSGAVDKIALTAEILMPGAVPSTADQAVKDADIVFLAVPLHKF---RSVNPATLEGK-----IVIDTMNH........................................................................................................................................... 96
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan;71(1):112-22. Epub 2006 Oct 17.