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Query: [O] COG0464 ATPases of the AAA+ class, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTEEDKSTIKLKVAEADQRDVGKGIVRIDERFREKLGLKPFDVVEIKGGKSTSALIGRPYPSDAGLDIIRMDGLIRTNAKTSIGEYVDIRKADWKEAKSVTFAPVAQGMQIYAPSETLKAVFMNRTVSKGDFISTTSLRRSRERETFGKGVMFEDFFQDFFGQGFGPSFGLGEIKLQVVSTAPAGIVKITDMTQVELLPEAMEIISEQNIPTVMYEDLGGLKDAISKVREMIELPLKHPELFDRLGIDAPKGVLLQGPPGTGKTMLAKAVANESDAYFISINGPEIMSKYYGESERAIREIFEDAEKNAPAIIFLDEIDSIAPKRAEVTGEVERRVVAQLLSLMDGLKARKNVIVIGATNRPEALDIALRRPGRFDREIELRVPDTEGRLEIFQIHTRGMPLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKINLNEPEISKEILDALQVTREDFENALKDVQPSAIREILIEVPNVSWEDVGGLERVKELLKEVVEWPLKNPESYRDIGVEAPKGVLLYGPPGTGKTLLAKAIAHESDANFITAKGSDLLSKWYGESEKRIAEVFTRARQVAPSIIFLDELDSLAPIRGTSVGEPQVTARILNQLLSEMDGLEELRAVVVIGATNRPDIIDPALLRPGRFDELILVPVPDEGARREIFRVHTKNMALAEDVDIEKLVSFTDQYTGADIAAVCKKAGRHALREDLHAKKVRQKHFLQAIEETGPSVTPDTMKYYEAIKGELRKRKSKEIENPYYVLast
1 -174.000[O] COG0464 ATPases of the AAA+ class  ali  100  1MTEEDKSTIKLKVAEADQRDVGKGIVRIDERFREKLGLKPFDVVEIKGGKSTSALIGRPYPSDAGLDIIRMDGLIRTNAKTSIGEYVDIRKADWKEAKSVTFAPVAQGMQIYAPSETLKAVFMNRTVSKGDFISTTSLRRSRERETFGKGVMFEDFFQDFFGQGFGPSFGLGEIKLQVVSTAPAGIVKITDMTQVELLPEAMEIISEQNIPTVMYEDLGGLKDAISKVREMIELPLKHPELFDRLGIDAPKGVLLQGPPGTGKTMLAKAVANESDAYFISINGPEIMSKYYGESERAIREIFEDAEKNAPAIIFLDEIDSIAPKRAEVTGEVERRVVAQLLSLMDGLKARKNVIVIGATNRPEALDIALRRPGRFDREIELRVPDTEGRLEIFQIHTRGMPLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKINLNEPEISKEILDALQVTREDFENALKDVQPSAIREILIEVPNVSWEDVGGLERVKELLKEVVEWPLKNPESYRDIGVEAPKGVLLYGPPGTGKTLLAKAIAHESDANFITAKGSDLLSKWYGESEKRIAEVFTRARQVAPSIIFLDELDSLAPIRGTSVGEPQVTARILNQLLSEMDGLEELRAVVVIGATNRPDIIDPALLRPGRFDELILVPVPDEGARREIFRVHTKNMALAEDVDIEKLVSFTDQYTGADIAAVCKKAGRHALREDLHAKKVRQKHFLQAIEETGPSVTPDTMKYYEAIKGELRKRKSKEIENPYYV 764
2 -145.000[O] KOG0730 AAA+-type ATPase  ali follow..  42  55..ERKKSPNRLVVDEAIN--DDNSVVSLHPTTMEKLQLFRGDTILIKGKKRKDTVCIALADETCEEPKIRMNKVVRSNLRVRLGDVISVHQ-----------------------------------CPDVKYGKRVHILPVDDTVEGVTGNLFDAYLKPYFLEAYRPVRKMRSVEFKVIETDPAEYCVVAPDTEIFCEGEPVKREDEERLDEVGYDDVGGVRKQMAQIRELVELPLRHPQLFKSIGVKPPKGILLYGPPGSGKTLIARAVANETGAFFFCINGPEIMSKLAGESESNLRKAFEEAEKNAPSIIFIDEIDSIAPKREKTNGEVERRIVSQLLTLMDGLKSRAHVIVMGATNRPNSIDPALRRFGRFDREIDIGVPDEIGRLEVLRIHTKNMKLAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVIDLEDDSIDAEILNSMAVSNEHFHTALGNSNPSALRETVVEVPNVSWEDIGGLENVKRELQETVQYPVEHPEKFEKFGMSPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVREIFDKARQSAPCVLFFDELDSIATQRGNAGDAGGAADRVLNQLLTEMDGMNAKKTVFIIGATNRPDIIDSALLRPGRLDQLIYIPLPDEDSRLNIFKACLRKSPVAKDVDVTALAKYTQGFSGADITEICQRACKYAIRENIEKSEIRAAHFEESMKYARRSVSDADIRKYQAFAQTLQQSRGFGS...... 807
3 -141.000[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  37  17......................................................................HERLVSLKDTIQQTEIEEWPVSTRRAIQFVQERDMSLRRIKKPILEKVVEKVLDTLKAEVELASSQDLVLVDSDMEEQSDSNLMEVKDTNVINKSITSLWSSPNLKEIDGEDEKSAKRKDRRSKTNGSKRQKAEANREPPSDISLSDIGGLDDCINELLELVAMPIKHPEVYQYTGIHPPRGVLLHGPPGCGKTMLANALANELGVPFISISAPSIVSGMSGESEKKVREVFEEAKSLAPCLMFIDEIDAVTPKRESAQREMERRIVAQFLTCMDELSFEKPVLVIGATNRPDSLDSALRRAGRFDREICLTVPSQDAREKILRTMAKGLKLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPHPDPLSPEELEPLAICPQDFIEALAKVQPSSKREGFATVPGVSWNNIGALKSIRVELQMAIVQPIKRPELYQSVGISAPTGVLLWGPPGCGKTLLAKAVANESKANFISIRGPELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMVPRRDDS--LSEASSRVVNTLLTELDGLSDRSGVYVIAATNRPDIIDPAMLRPGRLDKTLLVDLPDAHERVEILKTLTKQTPLHEEVNLDVLGERCSNFSGADLAALVREAAVTALRSAVFAIRVTNADFELAFKNIKPSVSDRDRQKYQRLAKRWSSASTNDAD..... 779
4 -112.000[O] KOG0741 AAA+-type ATPase  ali follow..  23  2......AGRSMQAARCPTDE----LSLTNCSVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFDKAKQ-CIGTMTIEIDFLQKKSNDSNPYDTDKMAAQQLVFSFNEKLFGLLVKDIESMDPSILKGEPATGKRQK------IEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINFEKMGIGGLDKEFSDFRRAFAFRVFPPEIVEQMGCIHVKGILLYGPPGCGKTLLARQIGKMLNAREPVVNGPEILNKYVGESEANIRKLFADAEESGLHIIIFDEIDAICKQRGSGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAST--KVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTK---NSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPI---GPRFSNLVLQALLVLLKKAPPQRKLLIIGTTSRKDVLQEMEML-NAFSTTIHV--PNIATGEQLLEALELLGNLK-DKERTTIAQQVKGKIGIKKLLMLIEMSLQMDPE------YRVRKFLALLREEGASPLDFD......................... 744
5 -102.000[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  24  177...............MGQQLLDQEVAYLSPMLAFNLSLHISCLKSLVHRGNGVLEKYFEAKCDEEFIGKSAEDGSKIGLDLGYASHLRVSFVKIPECGTIPSLKVNSSFEAEERQGLIDSALQKRQLSRGDIFRIYIDWNCGSSICNPCSQRLCSESDDYIYFKVI----------AMEPSNERFLRVNHSQTALVLGGTVSSGLPPDLLVYRSKVPMPLQEETVNILASVLSPPLCPSA----LASKLRVAVLLHGIPGCGKRTVVKYVARRLGLHVVEFSCHSLLASSERKTSTALAQTFNMARRYSPTILLLRHFDVFKNLGSQDGSLVSFEIASVIRELTEPVSNGDQVLLIASAESTEGISPTIRRC--FSHEIRMGSLNDEQRSEMLSQSLQGVSISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETKKINQASQIDNSTEKLTAKEDFTKALDRSKKRNASALAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLFSS-GLRKRSGVLLYGPPGTGKTLLAKAVATECSLNFLSVKGPELINMYIGESEKNVRDIFEKARSARPCVIFFDELDSLAPARGASGDSGGVMDRVVSQMLAEIDGLDSSQDLFIIGASNRPDLIDPALLRPGRFDKLLYVGVADASYRERVLKALTRKFKLSEDVSLYSVAKKCSTFTGADMYALCADAWFQAAKRKVSSVVVEYVDFIKAMDQLSPSLSITELKKYEMLRDQFQGR........... 971
6 -87.500[O] KOG0737 AAA+-type ATPase  ali follow..  22  45...................................................................................................................................................................................................KIEQELVRQIVDGRESSVTFDEFPYYEKTRLLLTSAAYVHLKQSDISKHTR-PGSKAILLSGPADTEQVWMRQERTWTLRRHTSGNDLHSRGFDVTSQPPQSLYKVLVSISETNPIIIYLRDVEKLCQSE---------RFYKLFQRLLTKLSG--PVLVLGSEDDCQEVGEGISA--LFPYNIEIRPPEDENQLMSWKTRFEDIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHILNILQEGQGCFEDSLKLDTNIDSKEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVG-EHEAMRKIKNEFMTHWDGLMSNAGILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKT-ENLDFQELAQMTDGYSGSDLKNFCTTAAYRPVRELIKQECLSMEDMKVAKSQVAASFQWNDLYGEGGSRKK--EQLSYFL...... 726
7 -72.600[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  33  1................................................................................................................................................................................................................................................................................................................................................MASAAVASMVLDPKASP-ALMDLSTAD-EEDLYGRLKSLERQLEFTDIQEEYVKDEQKNLKRELLRAQEEQFMEMVDQNNGIVGSTTGSNYYVRILSTINR-------------ELLKPSASVALHRHSNALVDVLPPEADSSISEKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQIGIDPPRGVLLYGPPGTGKTMLAKAVANHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEVDAIATARFDAQTGADREQRILMELLNQMDGFDQTVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEDYVSRPDKISAAEIAAICQEAGMHAVRK--NRYVILPKDFEKGYRANVKKPDTD.......................... 403
8 -72.100[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  32  1...................................................................................................................................................................................................................................................................................................................................................................MTVTNRMEIESAYHKGEGFRSEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNIDINDTPNCRVALRNESYTLHKIDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE--RRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK................. 405
9 -71.800[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  32  1..................................................................................................................................................................................................................................................................................................MGQNQSAQGGAGEKKDDK-------DKKKKYEPPIPTRVGKKKRRAAMKLPQVTPHTRCRLKLL------KLERIKDYLMMEDEFIRNQERLKPQEEERSKVDDLRGTPMSVG---NLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPG--------CSVLLNHKVHAVVGVLSDDTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRE--RRMKVTNEDFKKSKESVLYR.............................. 428
10 -71.400[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  29  2.....................................................................................................................................................................................................................................................................................................................................................................SLEELEAMDQS--NPGEFLERVREKIRMLNSETRILQISTKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVVNASTRMSSYLPITGLIPNSELHKDTNIVFEKLPPDYDMKVGGMVLKSDAKPDETYEDIGGLERQIEELNEAIVLSLTHPERFEKLNIKPPKGVLMYGPPGTGKTLMARACASKTNATFLKLAGPQLVQMYIGDGARLVRDAFALAKERKPTIIFIDEIDAIGAKRSDSDQTGDREQRTMLELLNQLDGFSSSEEVKIIAATNRVDILDPALLRSGRLDRKIEFPLPNTLGRKRILQIHARKMSVRDDVNFDELARSTEGFNGAQCKAVCVEAGMAALRK--EKTEISQNDFMDGIQEVLSRKKSK.......................... 396
11 -69.800[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  32  5...............................................................................................................................................................................................................................................................................................................................................................QFSNMVEPTGPAIVEDSYRRKLAECRDIEQKLKDLRKKESEMTKQFDK-----SENDIKSLQSVGQIVGEVLKQLSEEKFIVKATNGPRYVVGCRRSINKEELKQ-MTTLTIMRQLPREVDPLVYKMSHEDPGNISYSDVGGLAEQIRELREVVELPLINPELFKRVGITPPKGCLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRRFSEGTSADREQRTLMELLNQLDGFDSLGKVKVIMATNRPDTLDPALLRPGRLDRKIEIGLPNEQSRLEILKIHSNKITKHGEIDFEAVVKLSDGFSAADLRNVCTEAGMFAIRA--EREFVIDEDFMKAVRKVGDAKRLETKLDYKPV.................. 406
12 -66.600[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  31  2.........................................................................................................................................................................................................................................................................................................................................................................PDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARQVAPTDIEEGMRVGVDRNKYQIPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRA--RRKIATEKDFLEAVNKVIKSYA............................ 421
13 -64.800[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  30  21...........................................................................................................................................................................................................................................................................................................................................................................STEDITRATRLLDNEIRI--LKEDAQRTNLECDSYKEKIKENQEKIKLNKQLP-YLVGNIVEILEMNPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDSLKPEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKLGVRPPKGVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKAPCIIFIDEIDAIGTKRFDSEVSGDREQRTMLELLNQLDGFSSDERIKVIAATNRADILDPALMRSGRLDRKIEFPHPTEEARARILQIHSRKMNVHPDVNFEELARSTDDFNGAQLKAVCVEAGMLALRR--DATEVNHEDFNEGIIQVQAKKK............................ 417
14 -55.700[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  32  81...............................................................................................................................................................................................DSTIILVESDPRVIETEIVRDITLDDVVGQEEAKRKAKVILEY-LRNPEKF---GKWAPKNVLFYGPPGTGKTMMAKALSNEAKTPFLSVKSTKLIGEHVGDGARRVHELYERARQLAPCIVFLDEFDAIALDRGYQEIGDVSEIVNALLTELDGTNSNEGICTIAATNRVELLDASI--RSRFEEEIEFRLPSYEERLEILRRNLEEFPVPVKARLELVAAASEGFSGRDLVEKVIKASLHKAIA----------------EGKDKIETEDLLTAAEKVKMPSRQP.............................................................................................................................................................................................................................................................................................. 346
15 -52.200[O] KOG0739 AAA+-type ATPase  ali follow..  33  122..................................................................................................................................................................................................................PNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGK--TPWRGILLFGPPGTGKSYLAKAVATEANSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEAARAQMFRLHLGSTPHNTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMVCMSDMLRSLATTRPTVNADDLLKVKK--FSEDFG............................................................................................................................................................................................................................................................................... 434
16 -52.000[O] COG0465 ATP-dependent Zn proteases  ali follow..  25  136.......................................................................................................................................................................................................KSKARMLTEDQIKTSFADVAGCDEAKEEVSELVDY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLDTDIDASVIARGTPGFSGADLANLVNEAALFAARG-----------------NKRVVSMVEFEKAKDKIMMGAERRSMVQKESTAYHEAG---------HAIIGRLVPEHDPVHKVTIIPALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIEKVSTGASNDIKVATSIARNMVTQWGFSEKLGPLLYAEEEGEISDETARIIDQEVKLLVERNYQRARKLLLENMDVLHSMKDALMKYETIDAP............................................................................................................... 587
17 -51.100[O] KOG0740 AAA+-type ATPase  ali follow..  32  396..................................................................................................................................................................................................................PPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGL--GPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGASSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASARKQIVINLMSKEQCLSEEEIEQIVQQSDAFSGADMTQLCRGASLGPIRSLQT-----ADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYEN--WNKTFGCGK............................................................................................................................................................................................................................................................................ 674
18 -48.900[O] KOG0743 AAA+-type ATPase  ali follow..  20  207.....................................................................................................................................................................................................................TFDTLAMDPNAKKKIIDDLERFLKRKEFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSIYD------NGELKRVLLSTTNR--SILVIEDIDCNAEVRDREAENQEDETLSGILNFIDGLWSSDERIIVFTTNHKERLDPALLRPGRMDVHINMSYCTGLGFRTLVSNYLGLDGLNHPL-CEEIEALVDSVTPAELAEEL-DVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGHPSTFETLAMDPGAKKKIIDDMERFLKRREFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSI------YENAQLKSILLSTTNR--SILVIEDIDCSSAEVVDREADEYQEYETLSGLLNFVDGLWSSDERIIVFTTNHKERLDPALLRPGRMDMHINMSYCTGLGFRTLVSNY-----LGLGGLNHPLCE--------EIEALIDSTEVTPAE--LAEELMQEDDTDVVLRGVVSFVENRKVEISKTKELEGSTC........... 962
19 -46.500[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  27  300...................................................................................................................................................................................................NIGKATITRADKHSKNKIYFKDVAGCDEAKQEIMEFVHF-LKNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESGVPFLSISGSDFMEMFVGVGPSRVRHLFQEARQAAPSIIFIDEIDAIGRARGRGGNDERESTLNQLLVEMDGFGTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFKIYLKKIKLDHEYYSQRLAALTPGFAGADIANVCNEAALIAARH-----------------EGATVTMAHFESAIDRVIGGLEKKNRVERRTVAYHESG---------HAVVGWFLEHAEPLLKVTIVPAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVL---IGKISTGAQNDLEKVTKMTYAQVFSDKVGLLSFPPRDDGYSNKTGAIIDEEVRDWVAKAYERTVELVEEHKVKVAEIAELLLEKEVLHQD............................................................................................................... 749
20 -45.800[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  26  266.......................................................................................................................................................................................................GLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVD-----------------GKEMVTMKELEFSKDKILMGPERRSVENKTITAYHESG---------HAIIAYYTKDAMPINKATIMPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMT--SDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAK............................................................................................................... 702
21 -27.600[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  14  50...............................................................................................................................................................................................................PDPHTFPLVRLAGVGRQTELLVRNTEQFIVG---------RPANNVLMSGARGTGKSSLVKALLHEYADKGLRL---EVDKSDLIGLPYLLTLL---KECPEKFIVFCDDLSALKTALDGGLSQRCANVLRRHLMPEYFDENAGTTGMRGEIHQKEAVEEKISLSDRFGLWLSFYPFDQNDYLAAVQNWLEDFGVPYDETAQMAALQRGSRSGRSAWQFACDWAGRLPKQ....................................................................................................................................................................................................................................................................................................................................... 284
22 -22.100[K] COG1224 DNA helicase TIP49, TBP-interacting protein  ali follow..  11  28..................................................................................................................................................................................................................ENLRAKDVADGLVGQKRAREAAGVIVR----LIKSGKMAGRGILMAGPPGTGKTAIAVAISKELGKDFVQVSASEFYSAEMKKTEALIQAMRKAVRIRETRTVLEGEVVGLDYNMVPNPYNPTQKIPESATLTLATKDEKRGRLAMQFFTQGIEVGDVIVI--DKETGRIGKLGRSEKAKKKYDLGDDEVVPVPSGKVEKEKEFTYVVTLHDLDEANARRTSIFSLFSPPSREIDN------------EVREAVDEQVKRLVEEGRAELVPGVLFI--DETHLMDIELFAFMNRAMESEMAPIIISNRGFSRIRGTDIVAPHGIPLDLLDRLLSREEIKTIIEIRAAESGIMLSNEAMEKLTD-IGEKTSLRYAVQLLAPAYEFAKMRNSGKVELEDVERAASIFADVSQSSA............................................................................................................................................. 437
23 -20.100[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  18  175.....................................................................................................................................................................................................................KLDPVIGRDEEIRRAIQVLQRRTKN-------------NPVLIGEPGVGKTAIVEGLAQRKNKRVLSLDMGALIAKYRGEFEERLKAVLNELSKEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLA-------RGELHCVGATTLDE--DAALER--RF-QKVFVGEPTVEDTIAILRGLKERYEIHHHVQITDPAIVAEAASSIRMEIDSKPQPLDRLERRIIQLKLEQQALQKEDDDASRKRLAMLEKELGEKEREYAKEKLLRMEEELHKRVIGQHEAIEAVSNAIRR--------SRAGLSDPNSFLFLGPTGVGKTELCKTLANFLENAMVRIDMSEFMEKYVGYEEG---GYLTEAVRRRPSVILLDEVEKAHHD-------------VFNILLQVLDDVDFRNTVVIMTSNLGSHLIQENSTLDYPSMKELVMSVVGQHFRPEFIN------RIDETVVFHPLGKE-------NIREIA-TIQLARLIKRMESHGYQL-HFTDACLDFIGEVGYDPVYGARPLKRAIQQEIENPL...... 827
24 -17.000[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  18  179.....................................................................................................................................................................................................................QLDPVIGREDEIRRTIRVLSRRTKN-------------NPVLIGEPGVGKTSIAEGLARRSNCKLLSLDVGSLVSKFRGEFEERIKSVLKEVEESTPIILFVDEMHLLMGAGSGGEGGMAANLLKPMLA-------RGKLHCIGATTLAE--DAAFER--RF-QIILVKEPSIEDTISILRGLKEKYEVHHGVTISDRALVTSRRLPDSAIDLVDEAALDNLERKLRQLRVEIRALEREKDEASKERLKAARKEAEQVGPDQINEIVARWTGIPVTRLKGQNEAVTAVANAIRAGLSDPN-------QPIASFLFCGPSGTGKTLLTKALASFMENAMIRIDMSEYMEKYVGHEAG---GQLTEQLRRRPSVILFDEIEKAAPE-------------VLTVLLQVLDDVDAKNAVIIMTSNLGAEYLTTD--------NESDDGKIDSTTREMVMNSIRGFFRISSIVIFNRLRRV-------DIRNIVENRILEVQKRLQSNHRSIKIEVSDEAKDLLGSAGYSPAYGARPLNRVIQNQVLNPM...... 850
25 -16.900[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  14  897............................................................................................................................................................................................................................................................ILIQGPTSSGKTSMIEYVAKKTGHKFVRIN-QEYIGTYVTDDNGSLEGVLVEALRNGYWIV-LDELNL-----------APTDVLEALNRLLDDVKPHPEFMLFATQNPPGVLSRAFRN--RF-LEIHFDDIPENELETILHKRCKIAPSYAAKIVQVFRELSLRRQTTRIFE--QKNSFATLRDLFRWAFREAVGYQQLAENGYMLDQKDKLAVQEVIEKVMKVKIDTDGNLDSMEIFQDMSLKEGPLSKVVWTRPMIRLFCLWRCLLAKEPVLLVGDTGCGKTTVCQILAECLHKELHIINAHQ-NGDIIGAVNYSLHSQLCEKFNVQESLDSIDDLIEKFEKLSSSEKNDNLSNLIERQIIKLVTAMKQGDFFLLDEISLADDSVLERLNS---LELSRTLTLVEHSNAAVSLTA-------KDGFAFFATMNPGGDYGKKEL----SPALRNRFTEIWVPPMVDTEDILKIVEGKLHNNKIELARPLVEYAKWHANEYL......... 1427
26 -15.700[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  17  5................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DRLISAAVINDEESIDRAIRPKLLTEYVGQPHVREQMEIFIQAAKQRGDALDH--------VLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVL--------EKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGSLTSPLR--DRFGIVQRLEFYQVADLEHIVSRSAKCLGLELTPEAHQLARRSRGTPRITNRLLRRVRDFAEVRADGAINGEVAMKALDMLNVDAEGFDFMDRKLLLAVIDKFMGG........... 279
27 -15.700[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali follow..  16  462.......................................................................................................................................................................................................TSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKI-------LCFHGPPGVGKTSIAKSIATALNREYFRFS-AEI-RTYVGAMPGKMIQCMKKVKTENP-LVLIDEVDKIGGAGFHGDPA------SALLELLDPEQNASRVLFICTANEISKIPGPLR--DRME-MIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERI-FRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYE---VTPPGVLAWTAMG-GSALYIETVLKRPVDLTNDKDGSIETTGNLGD-------VMKESVRTALTVA--AHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEIS----LTGKVLPVGGIREKV------AARRVGAKRVFL---PNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQ..................................................... 971
28 -14.800[O] COG0466 ATP-dependent Lon protease, bacterial type  ali follow..  18  308.......................................................................................................................................................................................................EEKKSIDIDEARRVLESNHNGLEKVKERIIQHLAVMKLKKEKQGSI-------LLLTGPPGTGKTSLGKSIADALGREYVRISLGGVRDEYIGALPGRIIQGMRKAGTKNP-VFILDEVDKLSTSYAGDPASA-------LLEVLDPEQNNSEVFFIATANSLASIPWPLL--DRME-TIEISGYTKNEKLAIAKDHLLPCILEEHGLDADKLKIEDEALKGIIDKYTREAGVRGLKKQLARTFVSEKIVSGKTDLPYVVRADMLKEVLGKEIIRQEEARKENVPGVAWTPVGGDILFIEGTF-----------------MPGNGKLTLTGQLGDVMKESAQISLSLVRSRLASTENSFNFTAS--------------------------DVHIHVPSGATPKDGPSAGVTLFTALTSLITGKAVDPKLAMTGEITLSGAVLPAAHRAG---KKVILPKENERDLEDVPEEVRNELKFVPVETIEEVLKEA.......................................................................... 772
29 -14.100[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  14  382.......................................................................................................................................................................................................KAKATLLLATRP----KSLPCRSKEMEEITAFIKGSISDDQ-------CLGRCMYIHGVPGTGKTISVLSVMKNSPYCFVEINGLKLASPEWKKALQSLNERFAEGENEKPCILLIDELDVLVTRNQS--------VLYNILD-----KPNSKLVVLGIANTMDLPEKLLPRSSRMGQRLCFGPYNHRQLQEIISTRLEGINAFEKTAIEFASRKVAAISG-DARRICRRAAEVADYRLKKSNISAKSQ---------LVIMADVEVAIQEMFQAPHIQVMKSVSGMAETSFDRVATTVSSICLTNGEFPGWDILLKIGCDLGECRIVLCEPGEKHRLQKLQ----------LNFPSDDVAFAL--KDNKDLPWLAN............................................................................................................................................................................................ 769
30 -14.000[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  16  251..................................................................................................................................................................................................................................................................................................................................................................ILETLTRQEATDLIKQYGGKVVRTDFILLGENAGPRKVETIKQHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKKEQEEKKILETVARMDDSNKKESQPSQI--------TSKYAPT------------SLKDICGNKGVVQKLQKWLQ--KSNFNKPGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASD-------RSKRLLDEQLFGVTDSQRLVLIMDEIDGMSSG----------DRGGVGQLNMIIKKSMI-----IICICN--DRAHPKLRPLDRTTFDLRFRRPDANSMRSRIMSIAYREGLKLSPQVDQLVQGTQS----DMRQIINLLSTYKLSCSEMTPQNSQAVIKNSEKHIVMKP............................. 614
31 -13.200[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  15  124.......................................................................................................................................................................................................................STILCREDEQIRIFEFVKGCIDQ---------QKAGSLYICGCPGTGKSLSMEKVVQQVPVDTLSVNCTSLSKTT-SSPLQHLQNLFSQSSSSRMMLIIADEMDYLITKDRG--------VLYDLFM-----LPFSRCILIGVANAADRFLPKLKSLNCKPMVITFRAYSKDQILRILQERLRVLVAFQPKALELCARKVAAASG-DMRKVCRSALEILEIETRGSTGPESQGPTPDDS---VVRMDHMAAALSKTFKSPVVETIQSLPSKKDATVGELNKLYLEICKSWMIPAGITEFTNMCTVLNDQGILKVGQARRDKLKRVS----------LRVDESDITFAL--QVNSLFILFFAN........................................................................................................................................................................................... 506
32 -12.900[DL] KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component  ali follow..  12  99.....................................................................................................................................................................................................................TQHELAVHKKKIEEVETWLKAQVLERQPKQGGSI-----LLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKDDFKAVFKEFLLRATKTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPL--------IFIISDSLSGDNNQRLLFPKEIQEENISFNPVAPTIMMKFLNRIVTIEANKDKTSLELLCQGCSG----DIRSAINSLQFSSSKGENNLRPRKKGMSLKSDA--------------VLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRAL--------------------GKILYCKRASLTELDSPRLLSEYERDTLLVEPEEVVEMSHMPGDQNYIDFFMEIDDIVRASEFLSFADILSGDWNTRSLLREYSTSIATR------GVMHSNKARGYAHCQGGGSSFRPLHKPQWFLIN------KYRENCLAAKALFPDFCLPA----LCLQTQLLPYLALLTIPMRNQAQISFIQDIGR................................................. 586
33 -12.400[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  13  355.....................................................................................................................................................................................................................................ENFTISAKGNDLFVNANLLIAHGYGLVGPNGHGKTTLLRHIATRAFAIPPNIDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEKQFVAGDLTVQEELNDTFAELTNKFSGGWRMRVSLARALYLEPTLL--MLDEPNHLDLNAVIWLDNYSHDQSFLDNVCNEIIHLDQKKLQYYKGNYSMFKKMYVQKR-QEKRLRELKAHGQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYIKFRFPEPSQLQPPILGVHNVTFAFPSQKPLFIKVDFGIDLTVAIVGPNGVGKSTFLKLLLGELEPQEGEQSAAEYLQRLFNLPHEKARKALAELCLSAPDVLILDELD-------------------IESIDALAEAINEYEGGVIIVSHDE-----------------------------RLIRETGCTLYVIEDQTINEIVGEFDDYRKEVLDSLGEVVNNPSVVANAAVLQ.............................................. 901
34 -12.200[R] COG1204 Superfamily II helicase  ali follow..  8 1377......................................................................................................................................................................................................................................................YKTNDSVFIGAPNGSGKTVCAQEIVDRRYEEW-LIQVADLIFCTPSQWDSLSKRWRSMRSIQKVDFYICDELQLLGGFY----GPLYEIVISRIRYMAVQLEKNIRVVGLSVS-----------------------VANARDLGEWLGTSPQCI-FSPKDRPNPLTIHLQSFSITHFPSLMLAMSKPIYRSLKNFISQRKSTIV------TPDRKVAKQLAFDLVTFSMADEDEYLFSLMENEAFNKVED--AALQQSLKHGI-----YISEITSSNDQNIVQYLYRHGLIKVLIASRDKAKSNAVIVMGTQYYDGKEHRPISELLQMLGFTASELSQVILMTVTTKKEYYKKFLNEPLPMESHLQVWLHDAFVS-----EISTQTIESKQDAVD-LVANPAYYGLQDITHESVSEFLSDLVETTMNDL---SEARLITVDDEDDSCVALNLAMIASH--------------ITYITMQTFALSLSERTKMKGL----EIVTSAAEYEQLPIRKYE.. 1900
35 -11.900[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  13  18.....................................................................................................................................................................................................................................................................................................SGANNEERFHRLLDAVRKAVICDCVVLMSLHNDTLTPLAMQGLTRDTLGRRFVVSEHPRLAQICSADLPVRFAADCPLPDPFDGLLLDSEDDLPMHSCMGLPLHFGEQLLGILTLDSLKPDAFDHLSPRSLEILAAIAAATLKMTLTFSEL---------------------ENQAKQTQLRLEELNQEAWSRDSVEIIGNSGPMLAMKADID-------------APSQFNILIHGETGVGKELVARTISNRKRQPLVYVNCSELFGHVKGAFTGADRARMGKFALADGGTLFLDEI-------------GELPLSAQSKILRALQNHEIQPDVRILAATNR--DLKKEVEA-GRFRADLPIYVPPLRERKG------------------------------DLSLLAGY-----VEQARRKLGITQLKLHGDVLSQLIQYPWP--GNVRELEHVINRAA.......... 422
36 -11.900[T] COG0467 RecA-superfamily ATPases implicated in signal transduction  ali follow..  12  1............................................................................................................................................................................................................................MIDQETDGIEKLETGIPGFDFLSDGGLPLGRATLIAGTAGSAKTIFASQFLVEGGENGVFVTFEEPPKALRKNMGALIARIEHAVRKYKASRISLDSLGAIFSHLSDSAQ------VRSDLFRLASALRELGVTAI-MTAERVEEYGEISRYGVEEFVAD-----------------------------------------NVVIVRNVLADEKRRRTIEILKYRGTDHQKGEFPFTIINKKGIVIIPLSAIELEQKSSDIRIT----SGSEELDRMCG-------------------GFFRDSIILVSGATGTGKTLMVTEFMDG-GERCLVFAFEESREQLIRNAENHLIMMKDIIQEFKPNRVAVDSLSAL-----ERVSTLKSFREFIIGLTSFIKQQEIGGLFTSTTPNLLGGASITDAHISTITDSIILLRYVEMYGEMRRGITVLKMRGSMHDKDIREFSIDHQGM....................................................................... 469
37 -11.700[LO] COG1474 Cdc6-related protein, AAA superfamily ATPase  ali follow..  19  40........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DLLLHRNEQINSLATILVSALRG---------ETPSNVLIYGKTGTGKTAVTRYVGKELFCSVVYINCEVIDTQYTGWPTDQVFMKFKEAARDQVIIIILDEIDKLIKKGDD----------VLYNLSRINTDLRK-AKVSMIGVSNDTEFLDPRVKSS---EEELIFPPYDAEQISDILKQRAKMAYNDGVLGIPLCAAFAAQEHG-DARDLLRVSGEIAERE--NQPQVLEEHVRRAQEKIEIDRVVEVVRTLPTQSKLVLYSI.......... 317
38 -11.600[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  14  72...................................................................................................................................................................................................................................................................................................................................................................................................................................................RPNPKTQIHVAADDSNKRHKLSSSSHRQHQPLSERMRPR------------TLDDVVGQDHLLSPLRSAVE--------------NRLPSIVFWGPPGTGKTSIAKSLINSSKYRFVSLSAVT-------SGVKDVRDAVESAKRLKRTVLFMDEVHRFNKSQQD----------------TFLPVIEDGSILFIGATTENPSHLITPLLS-----RVLTLNPLKPNHVETLLRRAVDDSERGDDSVIEFLANNCDG--ARVALNALEISATMATTRAGTDAVVSIDDAKEALQ--CKHLAYDKAGEQHNLISALHKSMR......... 358
39 -11.600[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  18  14......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLQDVVGQEHITKTLQNALVQ-------------KFSHAYLFSGPRGTGKTSAAKIIAKAINVDVMEIDAAS------NNGVDEIRDIRDHVK-FAPSVYIIDEVHMLTTG-------------AFNALLKTLE--EPPSHAIFILATTEPHKIPLTIIRCQRFDFK-RISNDALVGR---MKEILTHEGIEAEDELVLVARAAEGGM-RDSLSLLDQAI------SFADERVTVEDVLAITGAVSHEVLTQVVESA--QKGETAEALQ......... 266
40 -11.600[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  13  3...........................................................................................................................................................................................................................................................................................KTVAFGFVGTVLDYAGRGSQRWSKWRPTLLVIDRLELLHDARSRSLFETLKRDIASVSPETEVVSVEIELHNPWDFEEVYACLHDF---------ARGYEFQPEKEDYLIHIT----------------------TGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGPGEVTIIDLDLSRYNAIASRFAEERQQTLDFLKSGIATRNPHFNRMIEQI----------EKVAIKSRAPILLNGPTGAGKSFLARRIRHQFSGAFVEVNCATLRGDTA-MSTGHVKGAFTGARESREGMLFLDEI-------------GELGADEQAMLLKAIEEKTFYPDFQLIAGTVR--DLRQLVAE-GKFREDLTFTLPGLRQRQENLDYEVERHASLTGDSVRFNTEARRAWLARELSASVTRMATFA-----TSGRITLDVVEDEINRLRYN.............................. 446
41 -11.500[S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain  ali follow..  9  6.......................................................................................................................................................................................................TLGDVFKTVGLPPYTYVKPKHFGEVRADISQ------------------VGKHLLIEGPSGIGKTCVVFKVFEELQWSQRDFTYVGCRDQNAEQIIDDFLKNAAAGNALSPCVLVIDDFHLLSQAKRMEIGSTLKRLSDRAFEQAEPAK----VILIGIPTAGVSLAYDLG--PRL-GSYALTRASDVEIDKLISEGEQALAVLFE-DRDVLLAESAGNFW--AQYVCNKVCAIEVYETQDDAKILTFDILGIRGRLMAELTQRYLPIARTFAKGKRRPGGNKPYLEILLALCKIQDSVVTFDQLLQLVSERRRPGLKAVRTRISEVIFD----PDHGTDLRKQIAFEADSGFSIEDPDIGFSFAGEARRLVELVNAEMKAEDIVTFY------------DFDQQAILLAMDLQDILGKVYGESCRYYLVFLDKNYREKV---------RFEKDV---MTNGKRIDHIVPIVIDDEGAS------------------GTVGISNTIGRIDLKDVWAQIQKAGKISTDDVNTIKNRCVLEKIGAVA.................... 521
42 -11.400[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  13  550........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IPLVGHMDEQTKLYQWVRQTIVLGE---------GNSVIIVGPRGSGKSVLVDDILSRAKSYVVRLNGREISRQLFSDTLTKLLATLSHPTTSAAVIFVLEEFDLFVQHSRQ------------MLLYNLFDIAQSRKPILIIGLTTRYDCSESLEKRKSRFSMVIPMRPPSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTRSHLHVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICA.......... 859
43 -11.300[O] COG4930 Predicted ATP-dependent Lon-type protease  ali follow..  12  192.......................................................................................................................................................................................................TARTHFNRDQWIDVLLRSVGEPANIEQRTKWHLITRM----------VENNYNVCELGPRGTGKSHVYKECSPNS----LVSGGQTTVANLFYNMASRQIGLVGM-------VVAFDEVAGITFKDKDGVQIMRDSIEGKASMVFVGNINQSVETLVKTSHLLAPFPAAMIDTAFFDR-FHAYIPGWEIPKMRPEFFTNRYGLITDY-LAEYMREMRKRSFSDAIDKFYKLGNNLNQRDVIAVRRTVSGLLKLLHPNGSYSKEDVRVCLTYAMEARRREQLKKLGGLEFFDVNFSYIDNETLEEFFVSVPEQGGSELIPAGMPKPGVVTQAESG-MTGLYRFETQMTAGNGKHSVSGLGSSTSAKEAIRVGFDYFKGNLSRVSATAKFSEEYHLHVVELHNTGPSTATSLAALIALCSVLLAKPVQEQMVVLGSMT----LGGVINPVQDLAASLQLAF--DSGAKKVL------LPMSSAVDIPTVPAELFTKFQVSFYSEPVDAVYKAL...................................................... 691
44 -11.300[KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  14  7......................................................................................................................................................................................................................................................................................LNDDKPVIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKLANERCDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGV-IPALVAFQKTFNLRLDQRSYITEEDARGQINELKA-NGTEAGLITDLAEEAGMTGIFIYSAATVRQAFSDALDMTRMSLRHNTHDATRNALRT---------RYVLGDMLGQSPQMEQVRQTIL-------------ARSSAAVLIEGETGTGKELAAQAIQGKKSHPFVAVNCGAI-GAFTGSRRGGRAGLFEIAHGGT---LFLDEI-------------GEMPLPLQTRLLRVLEEKEVTRDVRVISATHC--NLEEDMRQ-GQFRRDLRLQLPPLRERVA------------------------------DILPLAESFLKVSLAALSAPFSAALRQGLQASETVLVHYDWP--GNIRELRNMMERLA.......... 459
45 -11.200[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  10  48......................................................................................................................................................................................................................................................IAEIPCLVLLGEPGVGKTHELEKLQRFTEET--ICEYSKVLGLNLRTFTNLKEDLFRDKEGHYHLHLFLDSLDEGLLN----VKSLAIGLVDEFKKPKYRSHINRLHLRLTCRTLPSILEEALKAESNFAIYELAPLRRIDVINAVEAEGFSSDDFLKAINQRDIVPLAI--KPISLGFLLNQKRYESYLEGCKCLCEEVSKCRHALKETGNLDIDQRLIVAARIAAVTIFANRFAVWI---VEQGQVPAEDVPRQKLCFGYEESNGREFEITQEVIQEVLLFSSRGLHRMGWAQTYAEFFAAWYLTIDLSKIKTLLYSSADST-DNVFQEIIKTDPDVLLQTDVANLLMQYEEEKKHSGLAEQLKVYICDSSKKEDTRRIAIDIAIECNLSELQGDLAK------RAISSIGDQSTRLKLKSLALNVLPEDEQDELKAYALKARQLTAEELFQALTPGMHRYFLESELVPQLDSEDLVIALDWLKTQGVRCFGHPFEELGDAILLKAWEHVNVPGVL 648
46 -11.200[L] COG0470 ATPase involved in DNA replication  ali follow..  17  23.....................................................................................................................................................................................................................TLDEVYGQNEVITTVRKFVD--------------GKLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLEL-NASDDRGIDVVRNQIKDFASTRQ-LIILDEADAM-----------TNAAQNALRRVIE--RYTKNTRFCVLANYAHKLTPALL--SRCTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRRVLNVL------QSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDDWGTAHYTLNKVRSAKGLALIDLIEGIVKIL................................................................................................................................................................................................................................................................... 285
47 -11.200[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  14  7....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DFSGDEDFRPLAARMRPQTVEQYIGQQHILGPLRRALE--------------GHIHSMILWGPPGTGKTTLAEVAANYANAEVERVSAVT-------SGVKEIRAAIEKARENRRTILFVDEVHRFNKSQQD-------------AFLPHIE--DGTVTFIGATTENPSFELNNALLS-----RVYKLTSLNQQEILQALHQAIADTERGADNVLDRLAELVNG--ARMSLNYLELLYDMAREDDQGRKQIDLPLLAEVAG--EKVSRFDNKGDIWDLISAVHKSIR......... 268
48 -11.100[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  13  55............................................................................................................................................................................................................................LREHRQQSEDLIAIARSGLENLFRQVAGQNYVLLLSDREGVTVEFLGDPLFGNSLRKAGLYLGSEWSEWRAGTCDHFDNTHTPLSCTAAP-LSAVLDISLLSSPILKASQNLALHLVSATVRRIELMAQARNQWVLRFSRSPEFLDVD--------------------PEAAISIDGLGRIAGMTHAGAKILARSTGLDWRDPQQLIGEPVSRFFDIEVDNLSDLTRRRPTRERLVFARDGNALFAHAIEPHSKVRAPLVSREQPPALRRLGGDAPVIAALQAKAAK------------ARTRLPILIQGETGTGKEHLARAIGSGLEGPFVAINCAAI-GAFTGASAKGRKGLIEQADG---GTLFLDEI-------------GDMPLALQSRLLRVLAEGEVLPRIRIVSASHR-----QTLVSQGAFREDLTLTLPALRDRPDFDWVL-GELILSPAALSALKAHDWPGNI-RELDNVIGVAAALAENGVVELGDLPDQLLANADTVGGNEASATLSLTLTACNWNISEAAR......... 604
49 -11.000[A] KOG0063 RNAse L inhibitor, ABC superfamily  ali follow..  12  72............................................................................................................................................................................................................................IINLPKDLAKDTTHRYGANGFKLHRLPIPRPGLGLVGTNGIGKSTALKILAGDWEEILTHFRGSELQSYFIRVVEENLKTAIKPQHVDYIKEVVRGNLGKMLEKLDERGLMEENQVLEREARQVSGGELQRFAIAAVFVKKADIY---------FDE------PDVRQRLKAAQVIRSLLRHDSYV-----------VVEHDLSVLDYLSDFVCC--------LYGKPGAYGVVTLPFSVREGINVFLAGFIPTENLRFRDESLTFRVSETTQENDGEVKSYARYKYPNMTKQLLEVMEGEFTDSIVMLGENGTGKTTFIRMLAGAFPREIRPLQIEQLMDQVVGEKQ---RVAITLCLGKPADIYLIDE------------PSAHLDSEQRITASKVIKRFILHAKKTAFIVEHDFIMATYLADR...................................................................................................................... 535
50 -11.000[R] COG1855 ATPase (PilT family)  ali follow..  15  5......................................................................................................................................................................................................................................................................RAITHASTGGWKEMKYVVDTSVVI--------SGRVTEMLESGEIKGTIIVVMAELEAQANFGKMTGFQGLSE-----IEKLTKLAKDKGFEVIFAGERPKLEHIRLAKGGEIDNLIREVAAEFDAVLVTSDRVQHLVARAKGIETIYVRPRVVRPENTRIMSFFTPDTASVHLREGVPPYAKRGRIGDLKLVKLDDRPMSYEELNEIANEILEAARQDEDSSIEIERRGADRMEITAVRPIAQVSIDEYGVSEEL-VERQRGILISGPPGAGKSTFAASVANFLLENGYIVKTME-EITQYAPLEGDMSLTSDILLLVRPDYTIYDEL------RRTSDFQVFADMRLA--------------GVGMIGVTHATRAVDAIQRMIGRVELGMIPQVVDTAGRIVKVYELSFTVKVPTGMTEADLARPVEIYTYGEQVVVMKAALEEKISKYVDDFEVEMVGRKAVIKVPEKHIPTLIGRKGRRIKNIEDEF........... 520
51 -11.000[P] COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA  ali follow..  12  11.....................................................................................................................................................................................................................................LQGTFRLSDTKTLQLPQLTLNAGWAFVGSNGSGKSALARALAGELPLL-RQSQFSHITRLSFEQLQKLVSDEWQRNNTDMLGPGEDDTTTAEIIQDEVKDAPRCMQLAQQF--GITPLLDRRFKYLSTGETRKTLLCQALMSEPDL---LILDEPDVASRQQLAERLAS---HQSGITLVLVLNRFD-----EIPEFVQFAGVLADCTLAETGAKEELLQQALVAQLAHSEQLEGVQLPEPDEPSARHALPANEPRIVLNNGVVSYNDRPILNNL------------SWQVNPGEHWQIVGPNGAGKSTLLSLITGDH-LDILGIDKRTADAPFHSLSWGQQRLAIVRALVKHPTLLILDE--------------QGLDPLNRQLIRRFVDVLISEGETQLLFVSHHAEDAPACITH...................................................................................................................... 475
52 -10.900[R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain  ali follow..  14  126......................................................................................................................................................................................................................................................ASQKSKVALWKCYDCGNLIEANT-CGSRNVHIVEIKGSTPASRF------LIFELVERQPFEPEVVVRVDPPVPLMHRK--ENVFSPEKELSELMKKCNSAASRIARVVVHPDYRADGLGILAVRT--IEERRVPEMRMRKHLVETIAQMARFNPFFEKAGFYYLWDTASG-----LYKPLSEEAERYIRKFLEEDEVARGHGGKLCVSRYGSVKPLEKLKFRNVSKLFASTLDLEKVSDEVRTVLESFGVRQRVVER--------YVLRDVNLEIKPGVAVVGASGSGKTTFLRLIVGEALLNRAGISDAVLYRARFNELSQKERFKLAACLAKKPSLMLVDE------------FAAHLDEMTAVRVARKISELAREAKITLIAVTHRKEVINALYVGYGGV-----TESP......................................................................................................... 620
53 -10.900[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  17  49......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLDDVAAHRDIIDTIDRLTN-------------------LLLYGPPGTGKTSTILAVARKLRNMILELNASD--DRGIDVVRQQIQD-FASTQSFSLGLVLLDEADAMTKDAQF-------------ALRRVIE--KYTKSTRFALIGNHVNKIIPALQRCTRFRFA---PLDGVHMSQRLKHVIEAERLVVSDCGLAALVRLSNGDMRKALNILQSTHMASKEITEEESKQITEEDVYLCTGNPLPKD............................. 274
54 -10.800[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  14  136.........................................................................................................................................................................................................................................................................................................................YVRHISTIFVSKLLEDQGPGDNISKIFATMIDNMDQ--GVLVVDDESRVQFVNQTALK---------------------------------------LGVVQNNIIGKPIRFRPLTFESNFTHGHMQHIVSWDDKSELIIGQLHNIQ-GRQLFLMAFHQSHTSFSVANAPDEPHIEQLVGECRVMRQLKRLISR------------APSPSSVMVVGESGTGKEVVARAISGRRNKPFIAINCAAI-GAFTGASANGKTGLIQAANTGT---LFLDEI-------------GDMPLMLQAKLLRAIEAREILPDIRIISATNQ--NLAQFIAE-GKFREDLFY-------RLNVI-----------PITLPPLRERQE-----DIELLVHY-----LHLHTRRLGSVYPGIAPDVVEILRKHRWP--GNLRELSNLMEYLV.......... 501
55 -10.800[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  15  46.....................................................................................................................................................................................................................KLNEIVGNEDTVSRLEVFAR--------------GNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLEL-NASNDRGIDVVRNKIKMFAQQKVTIIILDEADSM-----------TDGAQQALRRTME--IYSKTTRFALACNASDKIIEPIQ--SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFG-----------------------FINSENVFKVCDEPHPLLVKEMIQHCVN------ANIDEAYKILAHLWH-------------------------LGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTM........................................................................................................................................................................... 349
56 -10.700[L] COG1484 DNA replication protein  ali follow..  14  88............................................................................................................................................................................................................................TEGKPQAIKDAFECTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELYVPVIYFPFVEGFTD-LKNDFALLEAKLNRMKQAD--VLFIDDL-----KPVNGKPRATDWQLEQMYSVLNYRYLNHKPILLSSELTIEGLEALGTKIYEMCSDYLVIIKGAAYELN..................................................................................................................................................................................................................................................................................................................................................................................... 259
57 -10.700[L] COG0593 ATPase involved in DNA replication initiation  ali follow..  12  121..................................................................................................................................................................................................................TKHLFDNEGKSNQLARAVGQKLA---------QAPGEPSANPFFLYGGTGLGKTHLLHAIGNGINARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLD-ALLVDDIQFFAEK---------EKTQEEFFHIFNSLFETGRQIILTSDRYPKEIEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEEHNM-------NLPEEVAFFIAQRLRTNVRE-LEGALNRVKAMQDFKGGDIDIDFVRDT------------------------------------LKDILALQERLVTIENIQKVVAEYYRIKVSD---LKSKSRARSVTRPRQIAMALAKELTNRSLPEI-GRAFDRDHTTVLNACREVPKFREQ--IQEDWANLIRT....................................................................................................................................................................... 451
58 -10.700[F] KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response  ali follow..  20  4...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PNILLTGTPGVGKTTLGKELASKSGLKYINVG--DLA------REEQLYDGYDEEYDCP-----ILDEDRVVDELDNQMREGGV---IVDYHGCDFFPERWFHIVFVLRT--DTNVLYERLETRGYNEKKL-----TDNIQCEIFQVLYEEATASYKEEI-QLPSNKPEELENNVDQILK............................................................. 161
59 -10.600[R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase  ali follow..  14  54...................................................................................................................................................................................................................................................SFSIEPGKTLCVVGESGSGKSVTARSILQYITSGSIILNKADGSSVDLAKLDPRGRAI-RAVRGADIAMIFQEPMSSLSPVHLKMSKAQARAEAIELLRQYSGGMRQRAMIAMALACKPQLLDEP------------TTALDVTTQAEILDLISR---LQKAHGMAVL------FITHDMGVVAQIADDVLVMHHGVVKEYGTVE------QIFHKPQDPYTRMLIGSVLKLEQKAEIRLARPPLDQTAAPILEVKDLS----MHFGEMKALDGVSIKLLPGLGIVGESGSGKTTMGRSIMRLYRADGSVVDLSKIEGKELKAARRELRMVFQDPFGSNPRMTVAQVIEPLLVNGIAKGKELGLDPSGRERYPHAFSGGQRQRIGIARAITLRPRII----------EATSALDVSVRFQVLDLLMKLQDELGLA---DIGVIRYM------CDRVGVMYRGKLVEVGEAEKVCNAPDHPYTQALLSAIPRPD............................ 566
60 -10.500[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  17  77........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QYVIGQERAKKVLAVAVYNHYKRLNQRDKKD-LGKSNILMIGPTGSGKTLLAETLARLLNVPFTIADATTLTEAYVGEDENIIQKLLQKCEKAQMGIVYIDEIDKISRKSDNPSITRDVSGEVQQALLKLIEGVDTRNILFICGGAEPEDLVKFGLIPEGRLPVIATLDELDEAALMQILTEPKNAL----------TKQYAKLFEMEGVDLEFRPDALKAVARKALERKTGARGLRSILEGILLDTMY-EIPSQQDVSKVVIDE........... 400
61 -10.400[R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog  ali follow..  13  99............................................................................................................................................................................................................................................................TGILGPNGIGKSTSVQILSGTLVPNFGKGDWDTVLEHYAGTALHDYFKDVVDGKVQKPQYVDLIPKAFKGKTSELLEKTDERGFLDELIDRLRGVVERKISELSGGELQRVAIAACAARDAQF---YFFDEIDIYQRINVARLVQE---ISKDRAVLVVEH--------DLAILDMLTDVIHIAY--------GEPAGFGVITLPKSVRVGINQYLKGYLPEENIRIRPEAIRFEVHPPREDAQFQSMVSNSFSKQYGDGFSLKATGGSLREGLGIVGPNGIGKSTFVKVLAGEIKPDANPLQLERIYESLLGELQ---RVAIAACLSQEADLYILDE------------PSAHLDVEQRSMVTKVINRFAENNQKTAMVVDHDIYMIDMLSQR...................................................................................................................... 519
62 -10.400[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  14  75........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NLLFGQHLVKDVVVNSIKSHWYNEN-------RKPLVLSFHGYTGSGKNYVAEIIANNT-VATNDFPDKNKLEEYQVELRNRILTTVQKCQR---SIFIFDEADKLPEQ-------------LLGAIKPFLDGVDFRRSIFILLSNKGGGEIARITKESGYPREQLRLEAFERELMNFSYNELISNHLIDHFVPFLPLQRE-------HVRSCVGAYLRKRGRGDLVSNVDFVERVLNSLQYFPESSKAFSSSGCKRVDAKTDLEMA......... 341
63 -10.300[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  15  189.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARK------------AMLSAPLLITGDTGTGKDLFAYACSPRSAKPYLALNCASI-SELFGHAPEGKKGFFEQANGGS---VLLDEI-------------GEMSPRMQAKLLRFLNDGTFRRDVRVICATQK-----VELVQKGLFREDLTLNLPPLRDCPQ------------------------------DIMPLTEL-----VARFADEQGVPRPKLSADLSTVLTRYGWP--GNVRQLKNAIYRAL.......... 427
64 -10.200[R] COG4172 ABC-type uncharacterized transport system, duplicated ATPase component  ali follow..  13  31...................................................................................................................................................................................................................................................NIHVNAGETVAVVGESGSGKSQTMMAAMSLLASN-VDYRGRNLLTLSKSDLNAKISMIFQEPMTSDPLYSIGNQLIEPIRRHRGLNAAEAREEALKLLREMSGGQRQRVMIAMALANDPDILDEPTTA-------------DVTIQAQILMLLAE---LQRKLGMAIV------FITHDLGIVRRFADRVYVMRQGEVVEEGEAG------AIFANPQHAYTKMLLAAEPTGSKAAPPANAPVVLE-GRHVEVTFKIGGGFLAGEPLMLRAVDDISIRLQRNIGIVGESGSGKSTLGRALLRLLPSD-IRFGDRDISTQAMRPLRRQMQLVFQDPFGSSPRMTVGQVITEGLLVHEPNLSGKQRDQRAVEAL-HEFSGGQRQRIAIARAMILKPKMV----------EPTSALDRSVQKQIVELLRKLQADHELS---DLSVVRAM------ADYIIVMKQGKIVEEGPTEAIFSNPQHVYTQTLMAAAIDVT............................ 533
65 -9.940[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  16  55.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FPGVVGYDDTVIPQ----------------NALLARQNFILLGLRGQAKSRILRAITELLDPEVPVIDGADLIGDVDPIKAARLGTSLGDTRSMHFGIFAVNELADLSP-------------KVQVALFNILQPIRLELDVMLVFSANPEDKIVTPLK--DRIGSEIRTHYPDVQLGMDITAQEAVKEEAREDGRIDKLSGVSQRLPISLMELACANAERRSLVSG-DAPVVRVTDVYAGLPAITGKMELEYEGELKGADNVAKDLIR......... 381
66 -9.830[S] COG5324 Uncharacterized conserved protein  ali follow..  10  394............................................................................................................................................................................................................................................................IFPISVIGCGKTTTSQTLVNLFPDSWGHIQNDDITGK---DKSQLMKKSLELLSKKEIKCVIVDRNNHQFRERKQ-------EWLNELKEDYLVYDTNIKVIGVKLSEIRDITLQRVIKRGNNHQSIKWDELGEKKVVGIMNGFLKRYQ-----PVNLDKSPDNMFD-IELDFGQADSSLTNAKQILNEIHKAYPILVPEIPKD-----DEIETAFRRSLDYKPTVRKIVGKGNNNQQKTPKLIKPTYISAKIENYDEIIELVKRCIASDAELTEKF-------KHLLASGKVQKELHITLGHVMSSREKEAKKLWKSYCNRYTDQITEYN--------NNRIENAQGSGNNQNTQVKTTDKLNFRLEKLCWDEKIIAI---------------------VVELSKDKDGCIIDENNEKIKGLCCQNKIPHITLCKLESGVKAVYSNVLCEKVESAEVDENIKVVKLDNS.......................................... 816
67 -9.710[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  19  9..........................................................................................................................................................................................................................................................RTVAILGGESSGKSTLVNKLANIFNTTSAWEYGRDYVFSHLGGDEIALQQYIDFAVKYANKVAFIDTDFVTTQAFCKKYEGREHPFVQALID-----EYRFDLVILLENNTPWVADGLRSLGSSVDRKVRVEEEDYDSRFLRCVELVREM............................................................................................................................................................................................................................................................................................................................................................................ 182
68 -9.670[R] COG0714 MoxR-like ATPases  ali follow..  19  1............................................................................................................................................................................................................................MREQISVLTQNLSQTIVGKDEAIRVALLSGGHALLEDVPGVGKTLLAKSLARSINGKFQRVQGTNIWNPSSREFEFLPGPAFAN-------ILLADEINRATPR---TQAALLEVMEEKQVTVDGETRLVPHPFFVIATQNPIEYQGTFPLPDRFALSLSLGYPSEAEELKMLQRQQNP............................................................................................................................................................................................................................................................................................................................................................................. 187
69 -9.630[DL] KOG2035 Replication factor C, subunit RFC3  ali follow..  13  12......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DLLGKDGVDYHIEQANHL-----------KFLSADCMPHLLFCGPSGAGKKTRIKCLLRELSNYHIEMTPSDVGIYDRVVVQDLVKEMAQTSQIESTSVVVLCEADSLT-------------RDAQHGLRRTMEKYANNCKIVLS--CESLSRIIEPLQS-----IIINVPAPTDEDVTKVLRKVIERESFLPENVLQKIVEKSEGNL-RRAILMTEALRMENESGVAESVVIPVPEWEIYIQETARLILQKQSSDLLKVRERLYELLSRCIPPTVIF 295
70 -9.630[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  13  406............................................................................................................................................................................................................................FAQLNSSQSNAVSHVLQRP-------------SLIQGPPGTGKTVTSATI------------------------------------------------------------------VYHLSK-----IHKDRILVCAPSN---AVD------------------------HLAAKLRDLGLKVVRLTAKSREDVESSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKAD-CTCVGAGDKRLDTKFRTV--IDESTQASEPECLIPIVKG----------AKQVILVGDHGLKQSLFERLISLGHVPIRLEVQ-PYLSE-YEGSEQRTVPNSKFPWPIRGIPMMFWANYGREEISANGTSFLNRIEAMNCERIIT-------------------------KLFRDGVKPEQIGVITPYEGQRAYILQYMQMNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLR-DPRRLNVGLTRAKYGL----LGNPRSLARN............... 818
71 -9.520[U] COG3267 Type II secretory pathway, component ExeA (predicted ATPase)  ali follow..  19  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YLNFFGFDELPFSIVRYLYLSQRHQEAIVHLGLGDGGGAMLTGEVGTGKTTVARAILASLPGKT-TFSDLELLEAICDEFEVSYPKLLAEHAQGIQVLLMIDEAQHLAPDVLEQ--------RLLTNLETESHKL----KVLLIGQPELQEKLRLPQLRQ-RITGRYHLLPLNEEQTADYIRFRIENPELFNRKACQWIAEQTHG-IPRLINLVCDAALKQAYQA--GEPTLSLARIKLACQEVM................................ 266
72 -9.510[R] COG3903 Predicted ATPase  ali follow..  12  6......................................................................................................................................................................................................................................................LTNYRLVTLRGEGGVGKTRLAIQIAAASEVDLAPIADPGMVSTTAARPGSSTFDTLSHAIGNCHMLMVLDNCEHVL--------DACAELVVELLGACPELS-------ILATSR-----ESIGVTGEVTWVV-LSPANEAIQLFTERARLVQPNFEVADNFDAVSEICRRLDGMPLAIELAAARLRSL-----------------SPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWS------ALLTDTERIL---------FRRLAV-----------VGGFDLTAASEVAAAGGDD--FVERYSVLDQLTLLVDKSL--VVAEESRGSTRYRLLETVRQYALEKLNESEEIDGVRA-YATMAAGLNVPASTDYEQRLLQAEEIDNLRAAFRGNGDIAAALQLASA-REGLAWLESILEREGDNHLVPAGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALALARDGDCAVLARALVACGCGSGCDTEAAQPYFAEAIE......... 483
73 -9.450[F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)  ali follow..  14  3.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IAITGTPGVGKTTVAKLLAKKLNYEYV-------------------------------------SLKDFALEKGCGRRVNDEVEVEIDELAYFIERELKGKNAVVVVLRAHPKLIGERLRERGYDREKIG-----ENVEAELVDAV-----------LIEAIEEHENVIEVDTTNKSPEDVVEEIVSLINSGIKKRVGIVDWSEVYDEIIPYLRLGG...................... 179
74 -9.340[R] KOG0927 Predicted transporter (ABC superfamily)  ali follow..  14  77.....................................................................................................................................................................................................................................ANFSITFFGSELLQDTMLELNCGYGLIGLNGCGKSSLLAVLGGREVPVPPHIDIFHLTREIPASSKSALQCVMEVDEERIKLEKLAEELERLDDMSADLAEVKAARILHGLAKDFSGLFVKPHLLLLDETNHLDLLEEELKT---YKRILVLISHSQ----DFLNGVCTNIIHLTGKRLKYYTGNYEAFVRTRMELLENQMKQYNWEQDQISHMKNYIARFGHGSAKLARQAQSKEKTLAKMVAQGLTEKVSDDKVLNFYSCGKVPPPVIMVQNVFRYNDETPWIYKNLEFGIDLDLALVGPNGAGKSTLLKLLYGDLRIARYHQHLHELLDLDASPLEYRCRVVFAWLAWQVPHLLLLDELD-------------------METIDALADAINDFDGGMVLVSHDF................................................................................................................................ 563
75 -9.220[S] COG3854 Uncharacterized protein conserved in bacteria  ali follow..  13  120......................................................................................................................................................................................................................................................VETGKSILMLGRPGVGKTTIARVLADELHKRVVIIDTSEIAGD-VAHPELQHQVMIEAVENHMPEVIVIDEIGTVGTAHGNQIENLIKNPTLSDL-----VGGIQAVTLGDDEARRRGSQKTVLEADTVDTLLRGRQPSPQTRTVDEQGKVAITRQLSVVNGRGGQLATPEESFAPARPSNGWRASGQMLAIPSLPLERERISGQSEFDRLLDESFNYPEAIDFGSSARQPGPNGEDLPLHVYPYGVSRHQLEQVISVLTLPVVLTKDIDN------ADAILALRSHVKNHAKLRQMAKARHVPIHVIKSSTI-----PQITRGLRRLLNMEDPEVAD----RELQLFLHNGSDDEMDALEEARLAVEQIV----IPKGQPVELLPRSPQVRKMQHELVEHYRLKSHSFGEEPNR--RLRIY................................................................................................ 577
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Zhang B, Godzik A. Fold prediction by a hierarchy of sequence, threading, and modeling methods. Protein Sci. 1998 Jun;7(6):1431-40.