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Query: [H] COG0499 S-adenosylhomocysteine hydrolase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAQVMDFKVADLSLAEAGRHQIRLAEYEMPGLMQLRKEFADEQPLKGARIAGSIHMTVQTAVLIETLTALGAEVRWASCNIFSTQDEAAAAIVVGSGTVEEPAGVPVFAWKGESLEEYWWCINQIFSWGDELPNMILDDGGDATMAVIRGREYEQAGLVPPAEANDSDEYIAFLGMLREVLAAEPGKWGKIAEAVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDGYSVVTVDEAIEDADIVITATGNKDIISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRDDVTRTTIKPQVDEFTFSTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFADQTIAQIELFQNEGQYENEVYRLPKVLDEKVARIHVEALGGQLTELTKEQAEYIGVDVAGPFKPEHYRYLast
1 -116.000[H] COG0499 S-adenosylhomocysteine hydrolase  ali  100  1MAQVMDFKVADLSLAEAGRHQIRLAEYEMPGLMQLRKEFADEQPLKGARIAGSIHMTVQTAVLIETLTALGAEVRWASCNIFSTQDEAAAAIVVGSGTVEEPAGVPVFAWKGESLEEYWWCINQIFSWGDELPNMILDDGGDATMAVIRGREYEQAGLVPPAEANDSDEYIAFLGMLREVLAAEPGKWGKIAEAVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGINRATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDGYSVVTVDEAIEDADIVITATGNKDIISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRDDVTRTTIKPQVDEFTFSTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFADQTIAQIELFQNEGQYENEVYRLPKVLDEKVARIHVEALGGQLTELTKEQAEYIGVDVAGPFKPEHYRY 478
2 -92.200[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  43  2......SDKLPYKVAAWGRKALDIAENKMPGLMRIWERYSASKPLNGARIPGCLHRTVETAVLMSLITLGTEVQ-WSSCNIFSTQDHAAAAIAK--------AGISASTGIPVLPLPRLACLEG--------------------------------------------RNRRGVPVTGDLTNLIHSEYSQLLLSFRGISKETTIGVHNLYKMMVNGILKVPAIDVNDSATKSKFDNLYGCG------IKQATDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKTDPIKALQAAMEGYEVTTMDEACQEGDVFVTTTGCVDIILGQHFEQTKDDTIVCNTGYFDVEMDVKWLNK-NTVEKVNVKLQVDPYRLKNGRGIILLAEGRLVNLACAMGHPSFVRSNSFTSQVMAQIKLWTHPDKYPVGVHFLPKKLDESVAEAHLGKLNMKLTKLTEKQAQYLGMSCYCPFKPDHYRY 413
3 -13.000[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  18  56.....................................................................................................................................................................................AMEDEVYDYMGACKLKVLSTRTAGFDMY-NATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYP----DAAKEWLTYVSMDELLSTSDVISLTKDSHHLINAKTIAQMKDGVYLVNTARGAV-IDSQAL.......................................................................................................................... 244
4 -11.800[K] KOG0067 Transcription factor CtBP  ali follow..  13  72...........................................................................................................................................................................VLNEAVGAMMYHTITLTREDLEKFLRVIVRIGSGYDNV-DIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLNEHNHHLINDFTIKQMRQGAFLVNAARGGL-VDEKALAQALKEGRIR---------------------GAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAIT---SLRNCVNKEFFVTSAPWSVIDQHPELNGATYRY 387
5 -11.500[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  15  1.............................................................................................................................................................................................................................MANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYAAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHVVADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEV-----REEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAAT.............................................................. 198
6 -11.300[HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases  ali follow..  16  66...........................................................................................................................................................................IVPEYDAIMLRSATKVTEKIIQA-LKIIGRAGVGVDNI-DVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDAIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDP--ISQERADQIGCTLVDLDLLFSEADFITLTPETANLINAETLAKMKPTARIINCSRGGI-IDEEALVT-AIETAQIGGAALDVFAQEPLGESRLREFSNVI--HLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAVNIPGLTPDVMEKLRPKLAETLGTLVGQLAGGRIDRLTVCLQG......... 382
7 -10.900[E] KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily  ali follow..  15  119...........................................................................................................................................................................KVAESDALIVRSGTKVTREVFEAALKVVGRAGVGIDNV-DLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQAVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDP--APADRARALGVDLVSFDQAISTADFVSLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVFCEEPPSKDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVAGALKGELSATAVNAPMVAPEVLSELT-VLAEKLGRLAVQLASGGKG................. 429
8 -10.200[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  21  6..................................................................................................................................................................................................................................................................PSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIALTAEGAVPSTADQAVKDADIVFLAVPLHKF--RSVNPATLEGKIVIDTMN.................................................................................................................................... 95
9 -10.100[C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)  ali follow..  9  154.........SVIGFFGFGGISQAIAKRDVAKIIYHTRTRKENDGDFKAEHVSFEQLLQESDFLVVAAPLTNETREKFNGKAFNLMKRSSVFVN------VARGGLDVTTPEPLPANSPLLNVPNCEGLKMSTTKPFKVLIAHTDVPPEGIEILKEQCEILQVINEPPKNRPEILEKIRGAHAVIWGGRDILNAEILDAVSTMSSGINNV-DVPELKKRGIPLGSTPAMLTVAVADLTVGLLIAAARRFQEMLGQDIRDSTVGFYGFGGIGQAVAKRLMGFDIKRMLYTRNRVSQDIEERFNAKKVDFETLLAESDFLIIASPTLGLFNATVFNKMKETAVLVNVGRGKI-VNQDDLYEALKSNRIFAAGLDVMDPEPLPSNDKLLT-----NVVVTPHVGYATRRTRVDAANLASRNVLK.......................................................... 586
10 -9.910[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  10  1....................................................................................................................................................................................................................................................MIEVAEFIAREVKKGKVIEVGIGF-YTRIAKRLKELGFDVLAIDINKDAVVNAKNSGLNIFNPNISLYMGAKAIYSIRPTPEMMLKISKAVKVPAYIVPLTGDPVP................................................................................................................................ 113
11 -9.540[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  9  119..LSIENILKTLPFQRLRRNTLDVLSVKEFAKTLLLQYLPEDHPMFGPQSVSSNH-VSRCESFLEIFVREGCEMVEMSVTDHDKFAAESQFITHTLGRLLGMLKLISTPINTKGYEALLDLAENICG--------------------------DSFDLYYGLFVYNNNSLEVLERIDLAFEALRKELFSRLHGVVRKQSFEGEAKKVHVFPNCGENDASLDMMRSEDVVVKYEYNSQVSGSVNDGSRL-----------KIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFSDLDDFEEHPEVIILCTS-EKVLESLPFQRLKRSTLFVDVLSVKEFP-RNLFLQTLPQDFDILCTH-ESGKNGWNNLAFVFDKVRIGMDDRRKSRCNSFLDIFAREGCRMVEMSCAEHDWHAAGSQFITHTVGRLLEKLSLESTPIDVENTAGDSFDYYGLFLYNPNAMEQLE. 601
12 -9.050[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  11  1..................................................................................................................................................................................................................................................................MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGED-SLRELSQRLSAPRVVWVMVPAGNITTAELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPI............................................................................... 149
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zmasek CM, Zhang Q, Ye Y, Godzik A. Surprising complexity of the ancestral apoptosis network. Genome Biol. 2007 Oct 24;8(10):R226 [Epub ahead of print]