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Query: [R] COG0523 Putative GTPases (G3E family), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTPIAVTLLTGFLGAGKTTLLRHILNEQHGFKIAVIENEFGEVSVDDQLIGDRATQIKTLTNGCICCTRSNELEDALLDLLDSRDRGDIAFDRLVIECTGMADPGPIIQTFFSHDVLCERYLLDGVIALVDAVHANEQMNQFTIAQSQIGYADRILLTKTDVAGDSEKLRERLARINARAPVYTVVHGDIDLSQLFNTSGFMLEENVLASQPRFHFIADKQNDVSSIVVELDYPVDISEVSRVMENLLLESADKLLRYKGMLWIDGEPNRLLFQGVQRLYSADWDRPWGDETPHSTLVFIGIQLPEDEIRAAFVGLRKLast
1 -105.000[R] COG0523 Putative GTPases (G3E family)  ali  100  1MTPIAVTLLTGFLGAGKTTLLRHILNEQHGFKIAVIENEFGEVSVDDQLIGDRATQIKTLTNGCICCTRSNELEDALLDLLDSRDRGDIAFDRLVIECTGMADPGPIIQTFFSHDVLCERYLLDGVIALVDAVHANEQMNQFTIAQSQIGYADRILLTKTDVAGDSEKLRERLARINARAPVYTVVHGDIDLSQLFNTSGFMLEENVLASQPRFHFIADKQNDVSSIVVELDYPVDISEVSRVMENLLLESADKLLRYKGMLWIDGEPNRLLFQGVQRLYSADWDRPWGDETPHSTLVFIGIQLPEDEIRAAFVGLRK 318
2 -85.000[H] KOG2743 Cobalamin synthesis protein  ali follow..  29  40.AKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQEEWLELRNGCLCCSVKDNGLRAIENLMQKKG----KFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEENEATRQVALADIILINKTDLVPEEDKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLETPVSWKDTERTNRLVLIGRNLDKDILKQLFIATV. 377
3 -23.000[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  16  1MKRPLIIGVGGPVGAGKTMLIERLTRYTKGYSMAAITNDIYTKEDARILLNTPADRIAGVETGGCPHTAIREDASMNFAAIEEMCDKHPDLQLLFLESGGDNLSATFSPDLV-----------DFSIYIIDVAQGEKIPRKGGQG---MIKSDLFIINKVDLAPNVEVMKADTLKSRGNKDFFVTN.................................................................................................................................... 181
4 -18.500[R] COG2403 Predicted GTPase  ali follow..  14  135.LEKPSLKILGTGRIGKTAVSAYAARHERQYNPCVVAMGRGGPEVHGDRIEITPEFLMEQSDGCRRCGGGITNMKRGAETANRLDA-----DFVILEGSGAAIP---------------PVKSNRHIVLVGANQPLINIKNFFGPF-RIGLADLVIVTMCEEPEKVREIVDFIESINPEAEVITTVFRPKPLGEIEGKNVLFATTAPDSVKDLLVEYLESEYSCRVVGTTPHLS-NRPLLQRDIERYIEDADVMLTELKAAAVDVAT................................................... 416
5 -12.600[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  15  44......IIVVGMAGSGKTSFLHRLVC-FDSKSHGYVVN---GANIDIRDTVKYKEVMKQYNNGGILTSLN--FATKFDEVVSVIEKRADQLDYVLVDTPGQIE---ITEAFASTFPTVVTYVVDTPR-SSSPITFMSNMLYACSILYKTRLPLVLAFNKTDVADHKFALE.................................................................................................................................................... 223
6 -12.000[H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein  ali follow..  15  1...MNIFGITGWKNSGKTTLTEKLVAVRRGWKVSTVKHAHHDFDIDK----PGADSFRHRQAGATEVAIVSGNRWALMHELRGEDEPPAPCDIVLVE--GYKRRKIETRRLEAKDRTPLSAGDPNIVAIAADFAVTDKSLPAFDLDDVKSIVDFIE.................................................................................................................................................................. 160
7 -11.700[R] KOG2486 Predicted GTPase  ali follow..  16  133.DGLPEFALVGRSNVGKSSLLNSLVRR---KRLALTSKKPGKTQCINHFRINDKWYLVDLP-GYGYASAPHELKQDWNKFTKD--------------------------------YFLNRSTLVSVFLLVDASIPVKPIDLE-SWLGQNQVPMTLIFTKCDKRKKKKNGGKKPEA............................................................................................................................................... 271
8 -11.600[R] KOG1533 Predicted GTPase  ali follow..  15  36......VLVIGAPGAGKSTFCAGLTD-SQTKRPFLTIN---APDVNITEMITVNDVMDRLGNGALKYCIE--LGANCNWLLQKIEANHK--KYLIIDCPGQLE---VIRFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMVTMEMPQVNCLSKADLFSEDGTYD.................................................................................................................................................... 214
9 -11.200[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  17  89FDAKPMILLVGQYSTGKTTFIRYLLEEPTTDRFIAVMHGDEEGSIPGNALVVDAKALSGFGNAFLCSTLPNQVLESVT----------------IVDTPGILS-TGVLEWFAE--------RVDRIILLFDAHKLDIS-DEFKRCIEALAGNERIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPE................................................................................................................................... 282
10 -11.100[K] KOG1534 Putative transcription factor FET5  ali follow..  17  1MVKVAAFVC-GVASSGKSTFCGALMS-KSVGRSCHLVN---EPTVDIRDLISIDDVMEELDNGGLIYCFE--LMENLDWLNEEIGDYDE--DYLIFDMPGQIE-VPILPALIRHLQVTLNFRP-CAVYLLESTKFFAGVLSAMSAMVMMEVPHINLLSKMDLLKDNNNIT.................................................................................................................................................... 185
11 -11.000[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  15  53.TKSNTVLLSGLSGSGKTVLFYQLRDGSSHQGAVTSMEP----------------------------------EGTFVLHNENNTKKGKVKPVHLIDVPGHSRLISKLEEYLPR--------AAAVVFVVDALEFLPNIRAASEYLYDILTNALLCCNKTDKVTTKEFIRKQMEK............................................................................................................................................... 196
12 -10.900[R] COG1084 Predicted GTPase  ali follow..  17  160.LDAFTVVIAGFPNVGKSTLLRTLT----GAEPEVADYPFTTKGIQIGHLERKWKRI------------------------------------QVIDTPGLLDRPVEDMNNIELQAMVALENIDVIMFIFDASE-ESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVEDPLKVSAFEGRGVS............................................................................................................................... 315
13 -10.700[E] COG4917 Ethanolamine utilization protein  ali follow..  19  1MKRI---AFVGSVGAGKTTLFNALQGN---------------------------------------------------YTLARKTQAVEFNDKGDIDTPGE-----FNHPRWYHALITTLQDVDMLIYVHGANDPESRLPA-GLLDIGVSKRQIAVISKTDMPDDVAATRKLLLETGFEEPMFELN.................................................................................................................................... 128
14 -10.700[R] COG3596 Predicted GTPase  ali follow..  14  39....PVIGIMGKTGAGKSSLCNALF----AGEVSPVSDVAA--------------------------CTRDPLRFRLQ----------GEHFMTIVDLPGVGESGVR-DTEYAALYREQLPRLDLILWLIKADDRALATDEHQVIGEAYRHKMLFVISQSDKAEPTSG...................................................................................................................................................... 165
15 -10.400[J] KOG0469 Elongation factor 2  ali follow..  16  16KRNIRNMSVIAHVDHGKSTLTDSLVSK-----AGIIAGSKAGETRFTDTRKDEQERCITIKSTAISLFFELE-NQFETVEVDGKKEKYNGFLINLIDSPGHVD--------FSSEVTAALRVTDGALVVVDCVSGVCQTETVLRQAIAERIKPVLFMNKMDRAELFQTFQRIVENIN............................................................................................................................................. 198
16 -10.400[R] COG1159 GTPase  ali follow..  14  7..YCGFIAIVGRPNVGKSTLLNKLL----GQKISITSRK----------------------------TTRHRIVGIHTE---------GPYQAIYVDTPGLMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNKLRDGKAPVILAVNKVDNVQEKVDLLPHLQFLA............................................................................................................................................. 143
17 -10.100[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  17  59........VTGTPGAGKSTFLEAFGMLREGLKVAVIAVD-GSILGDKTRMNDLARAEAAFIRPVPSSGHLGGASQRARELMLLCEAAG--YDVVIVETVGVGQ---------SETEVARMVDCFISLQIAGGGDDLQGIKK-------MEVADLIVINKDDGDNHTNVAIARHMYES............................................................................................................................................. 219
18 -9.970[R] COG2262 GTPases  ali follow..  16  195.ADVPTVSLVGYTNAGKSTLFNRITEAR---------------------------------------VYAADQLFATLDPTLRRIDVADVGETVLADTVGFIRHLPHDLVAAFKATLQETRQATLLLHVIDAADVQENIEAVNTVLEEIDAHELLVMNKIDMLEDFEPRIDRDEENKPIRVWLSAQTGA................................................................................................................................. 348
19 -9.920[R] COG2229 Predicted GTPase  ali follow..  14  1MRENKI-IFTGPVGVGKTTAIAAI-TDASASDMTLDRKRNTTVAMDYGAISLDEDTKVHLYG-----TPGQERFNFMWEILSQGSMGLV----LLLDNARTNPLKDLEFFLHSFRGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAKHNLNVPVFEIDARKEDDVKQLVSAMLFSIDPGLEV........................................................................................................................................ 178
20 -9.890[M] COG0481 Membrane GTPase LepA  ali follow..  18  1MKNIRNFSIIAHIDHGKSTLSDRLIQTCG----GLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDGETYQLN----------------FIDTPGHVD--------FSYEVSRSLAACEGALLVVDAGQGEAQTLANCYTAIEMNLEVVPILNKIDLPADPERVAEEIEDI.............................................................................................................................................. 150
21 -9.830[H] KOG3220 Similar to bacterial dephospho-CoA kinase  ali follow..  13  6........VTGGIATGKSTIIAREIVEPGQPCWRQIREVFGD-EINRAVLGKEDKELRGKLNKITHPTIHRKIFWQVCKLLVTGHAWIVLDLPLLFETGVLMDFIHKIVCVTCDSDK----QLERLIA-LSESEARHRVDSQMPLDKKCEKSHFVIDNNGSVEEAESSAMSIYNLMRDSKQ......................................................................................................................................... 201
22 -9.810[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  14  11......VAILGGESSGKSTLVNKLANIFN----TTSAWEYGRDYVFSHLGGDEIA------------LQYSDYDKIALGHAQYIDFAVKYANKVAFIDTDFVTTQAFCKKYEGRQALIDEYRFDLVILL-DGLRSLGSSVDRKEFQNLLVEMEFVRVEEEDYDSRFLRCVELVREM.............................................................................................................................................. 182
23 -9.700[R] COG0218 Predicted GTPase  ali follow..  17  23.DELPEIALAGRSNVGKSSFINTMLNR---KNLARTSGKPGKTQLLNFFNIDDKMRFVDVP-GYGYARVSKKEREKWGCMI--------------------------------EEYLTTRENLRAVVSLVDLRHDPSADDVQ-EFLKYYEIPVIIVATKADKIPRGKWNKH................................................................................................................................................... 157
24 -9.630[R] COG1160 Predicted GTPases  ali follow..  16  2..ATPVVALVGRPNVGKSTLFNRLT----RTRDALVADFPG---------------------------LTRDRKYGHAHIAGY--------DFIVIDTGGIDGTEEGVEEKMAEQSLLAIDEADIVLFLVDARAGLTAADIGNYLRQRQNKITVVVANKTDGIDADSHCAE-FYQLGLGEIEQIAASQGRGVTQLME......................................................................................................................... 158
25 -9.380[H] COG0237 Dephospho-CoA kinase  ali follow..  17  7........LTGGIASGKSTVIAKQAVEKGMPAYRQIIDEFGE-DIDRKKLGATNEQKRLALNAIVHPAVRQEMLNRRDEAVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAV---SRIRSQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA............................................................................................................................................. 197
26 -9.280[J] KOG0468 U5 snRNP-specific protein  ali follow..  18  129.PLIRNVALVGHLHHGKTTFVDCLIRQTH------PQFETMEERQLRYTDTLFTEQ-------------RGCSIKATPVTLVLQDVKQKSYLLNIFDTPGHVN--------FSDEATAAMRMSDGVVLFIDAAEGVMNTERLLKHAVQERQAITVCINKIDRLDAYFKLKHIVEEVNGLLSTYGAPDDNLLVS............................................................................................................................. 304
27 -9.270[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  15  2IENLRNIAIIAHVDHGKTTLVDKLLKLSGTLD-----EAESERVMDSNDQEK--ERGITILAKNTAIKWNGYNIN-------------------IVDTPGHAD--------FGGEVERVMSMVDSVLLVVDAQDGMPQTRFVTQKAFKAGLRPIVVVNKIDR--PGARPDWVIDQIFDLFDNLGATDEQLDFPIVYASA....................................................................................................................... 167
28 -9.040[N] COG1419 Flagellar GTP-binding protein  ali follow..  16  174.....KVLFVGTTGVGKTTSLAKLAARDEKKRVAILTLDTYRIAAAEQLKIYAD----IMDIPMKIAYTPKEAEYEMMALKDY--------DIVLVDTAGRSH----DLQMSELRALSEAVKPNITFLVLSMNYKLDDMKRIVERFSAVKP-THIILTKMDETSVYGTFVNISEITG--LPIAFVTNGQRVPDDI........................................................................................................................... 349

FFAS is supported by the NIH grant R01-GM087218-01
1 3 6 3 0 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Veeramalai M, Ye Y, Godzik A. TOPS++FATCAT: fast flexible structural alignment using constraints derived from TOPS+ Strings Model. BMC Bioinformatics. 2008 Aug 31;9(1):35