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Query: [H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNINRLPPLSLYIHIPWCVQKCPYCDFNSHAQKGHIPEQDYIAHLLQDLHQDRQRFQDSIQDRSLHSIFIGGGTPSLFSAEGIHTLLSGVAQCLPFQPDIEITLEANPGTAEAERFKGYVQAGVTRISMGIQSFNDDKLVRLGRIHNAQEAKSAVGFAKLSGLKSFNLDLMHGLPNQTLEEALSDLQQAIALEPPHLSWYQLTIEPNTMFAYRPPVLPDDDALWDIFEQGHQLLTEAGYVQYETSAYAKPAFQCRHNLNYWRFGDYLAIGCGAHGKITQPNGEIKRYSKTKHPKGYMRGDYLYEEKTVATEDLAFEFFMNRFRLLEAVPKTDFTRLTGLCEESIQPQIQWALAKKYLVETEVAWQVTEQGKLFLNELLAEFLPKLast
1 -126.000[H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases  ali  100  1MNINRLPPLSLYIHIPWCVQKCPYCDFNSHAQKGHIPEQDYIAHLLQDLHQDRQRFQDSIQDRSLHSIFIGGGTPSLFSAEGIHTLLSGVAQCLPFQPDIEITLEANPGTAEAERFKGYVQAGVTRISMGIQSFNDDKLVRLGRIHNAQEAKSAVGFAKLSGLKSFNLDLMHGLPNQTLEEALSDLQQAIALEPPHLSWYQLTIEPNTMFAYRPPVLPDDDALWDIFEQGHQLLTEAGYVQYETSAYAKPAFQCRHNLNYWRFGDYLAIGCGAHGKITQPNGEIKRYSKTKHPKGYMRGDYLYEEKTVATEDLAFEFFMNRFRLLEAVPKTDFTRLTGLCEESIQPQIQWALAKKYLVETEVAWQVTEQGKLFLNELLAEFLPK 384
2 -58.700[KB] COG1243 Histone acetyltransferase  ali follow..  14  10.MLSGVTIVSIMTHPHSCPHKCVFCPGGVDVDTPQSYYG-REPTLMRAIENDYDPFHQVQSTPSKVELIIMGGTFLSLPIDYQDWFVTYAKNEKAEVRCVGMTIETKPDWAKEWHADQMLRLGATKVELGVQTVYDDILKFTNRGHTVKDSIESTRILKDSGF-KVVYHVMLGLPKSDPDKDLEAFKTIFSFRPDMLKIYPTLVVETAPLARGLYKPYGTETLIELISEMYRYIPKWMRIQRDIPANVILDGNKKGNLRELVEKKVLEKGIKINEIRFREVGMMWQHRGLLPDHTKIHLEASEGTEIFLSFEDEKEILIGYLRLRITSNKAHRKEIDGKTLHVYGIEVPIGSWDELLLSEAEKIAREEFDMRKISVL....... 447
3 -44.000[BK] KOG2535 RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase  ali follow..  16  103.............HINMTGNICVYCPGGPDSDFEYST-QSYTGYEPTSMRAIRSRYDPFLQSVDKVEFIVMGGTFMCLPEEYRDYFIRNLHDALSGHSSANITIETRPDYCLKRHISDMLSYGCTRLEIGVQSVYEDVARDTNRGHTVRAVCESFQLGKDAGY-KIVTHMMPDLPNVDFERDIEQFIEYFEFRSDGLKIYPTLVIRGTGLYEGRYKSYPPSMLVDLVAKILALVPPW-VYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGTTCRDV-----RTREVGIQEIHNKVRPYEIEWETFLSYEDPEQDILVGLLRLRKCSPDTFRPELKGEC-----SIVRELHVYGSVVPVNARDPTKFQHQGFGMLLMEEA... 507
4 -31.500[R] COG1242 Predicted Fe-S oxidoreductase  ali follow..  11  29.....QKTYKVALDGGFCPNRCTFCSAAGSGDFAGNRALDLKVQFQQVRDKMQTKWKDG-------IAYFQAFTNTHAPVAELREKFETVLNEPGV---VGLSIATRPDCLPDDVLAELNERTYLWLELGLQSAHDETGRLINRAHDYDCYLEGVRKLQKHNI-RICTHIINGLPKETPEMMMETAQKVVESGVDGIKIHLLHLLKGTPMVEGDLEFLTRDGYVNLVADQLEILPP.................................................................................................................................................... 266
5 -24.700[R] COG1244 Predicted Fe-S oxidoreductase  ali follow..  12  12...EPGKVLYVILPTIGCYRYCYMCSYPAQAPKKTSQER-----ILSHFLEAVHKIKGKDDRFSI-RIFTSGSDSAEVRRDTRIRIFREISKLDNVY---EVVVETRSEIIREDWVRELAEMKWFEVAIGLESANDDIADVINKGSTFNDFVRASEIIHNAGA-KVKTYLLLKPIFLSERDAIEDVKFSIEPYTDTFSINLTNIQKGTLYERGEYRTPWLWSVVEVLRWAKKKFPHK................................................................................................................................................... 253
6 -20.700[S] COG1856 Uncharacterized homolog of biotin synthetase  ali follow..  12  70.................CELMCDHCASKILWHMIPATTPEELVKVGEDLK-----------KKGIEGVLISGGS-DKNGFVPLWDFFDAMKY---LKEELGFLLTCHVGLVDEDYVEKLKEANVDAVLLDIIGDNETIAQVYKPHKSVEDYDRSLRLLKEAGL-RIVPHVIIGLHYGKIKGEYNAIDMIAKYEPDALVLVVVMPYYGKAKFQLLPPPSSEESAQVISPVVIGCARPAGADRVKLDAYS........................................................................................................................................ 294
7 -18.600[R] COG2516 Biotin synthase-related enzyme  ali follow..  9  37.................CINDCKFCAQARSSRANLEMLSRVVWP-----AFELETVLKNFSKGNFKRICLQTIDYP--MLSDVFSLLEELSK-------LNVPISLSITPVPRSELEEFSTLGVDYIGVGLDAASERVYKDVISRYSWDDMWKFFDDVLSVFGKRAVVHLIVGL-GETDKEIVETIGEVYKKGG-IVSLFAFTPIKGTQMENFSPPPLERYRKIQVAHYLIK........................................................................................................................................................ 238
8 -17.700[R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme  ali follow..  13  34.....VRGEKLVLFVT-CPRNCFYCPLSPWRRKDVVYANERPVRSEKDIIEEAKIQD-------ARGAGITGGDP-LARLSRTVEYIRLLKEEFG--KKFHIHLYTTGILASEEALEKLYDAGLDEIRFHPDLFQ-------PNSKFFEREIENMKKAFDFG---WDVGGEVPAVPGFEDRIKWFASLLDKLGAKFLNINELEFSETN................................................................................................................................................................................ 217
9 -16.500[H] KOG2900 Biotin synthase  ali follow..  11  69.................CTEDCKYCAQSSRYNTGVK------ATKLMKIDEVLEKAKIAKAKGSTRFCMGSAWRDLNGRNRTFKNILEIIKEV----RSMDMEVCVTLGMLNEQQAKELKDAGLTAYNHNLDT-SREYYSKIISTRTYDERLNTIDNLRKAGLK-VCSGGILGLGEKKHDRVGLISLATMPTHPESVPFNLLVPIPGTPVGDAVKERLPIHPFLRSIATARICMPKTIIR----AGRNTCSESEQA----------LAFMAGANAVFTGEKMLTTPAVSWDSDSQLFYNWGLEGMQSFEYGTSTEG.................................................................... 344
10 -15.900[C] COG1031 Uncharacterized Fe-S oxidoreductase  ali follow..  11  170....NFPHVICEIEV--CERRCSFC---TEPLLHGRLKSRDVQAILKEIESLYRAGCRAFRFGRAANIFGSDRNGGKPSPEILEELYSGTREVAPHLEVLHTD-NANPSYLVTETIVRYNTPG-DVFSFGVESFDENVLKKNNVQGSPEEFLKAIAVVNEIGGVRPGVNLIFGLPGETEETLKKNYSYLKRILDERINIRKLLAYPGTPVYEYLKNKK-HRIKSYLHDQWKRRIREEIDREMLKRVFPAGTVLKKVIVEYREGKTSFGRQLGSYPILVGIPGNHSGVLDVV-----VVSHGERSVTALPYPSFINSMSLEELTAIPGIGSALARKIILNRPFRSWEDLKKVVPAETANFLRNLGISLQQ............... 550
11 -15.700[H] KOG2672 Lipoate synthase  ali follow..  11  131.................CTRGCRFCSVKTSRRPGPLDPNEPENT------------AEAIKQWNLGYIVLTSVDRDDLTDLGANHIAKTIQKIKEKAPHILVEALTPDFSGRMDLVEIVAKSGLDVFAHNVETVEELTPFVRDRRATYRQSLSVLKHVKKTCPH-TKTSIMLGL-GETDAEILTTLKDLLEHNVDVVTFGQYMRPTKRHLKVQEYVHPKK------FEYWKEVAEKLGFLYVASGPLVRSSYKAGEYFMENLIKKRSGNPASMSV............................................................................................................. 370
12 -15.600[R] COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif  ali follow..  12  31.................CIYDCAYCINRSSSNVERARFTA------EEV---VWLTLEFYRRNYIEGLFLSSGIIR--TMEEMVRVARELRVTHGFR--GYIHLKSIPE--ASPRLIEEAGLYADRLSINIELPTDSGVSRFAPEKQPANIRRSMADIRLKIEEGQSTQMIVGADGADDSTILSTSARLYGYGLRRVYYSAFSPIPDSSKNL--PLIKPPLMREHRLYQADWLYRFYGFDIGEITAIGGDG..................................................................................................................................... 269
13 -15.400[H] COG2896 Molybdenum cofactor biosynthesis enzyme  ali follow..  17  26...........YLRVSVCDFRCTYC------MAEHMTFLPKKDLLTLE---ELDRLCSVFIEKGVRKLRLTGGEPLV---KNIMHLIGNLSRHLKSGALDELTLTTN-GSQLARFAGELADCGVRRINVSLDTLNPEKFRTITRWGDLSRVLEGIDAAQKAGIHKINAVALKDFNDAEIPELIR-WAHGRGMDVTLIETMPM...................................................................................................................................................................................... 207
14 -15.400[H] COG0502 Biotin synthase and related enzymes  ali follow..  11  66.................CPEDCSYCPQSARYHTG---VQNQQLLDVDEIVAKAKI----AKARGAGRFCMGAAWRGPKP-KDIEKVTEIIKAV----KSLGLETCGTFGLLQDGMAEDLKEAGLDYYNHNLDT-APEHYAEVIGTRRFDDRLSTLGKVRKAGLK-VCCGGIVGMNETRKERAGLIASANLDPQPESVPINQLVKVEGTPLADAEELDWTE------------FVRTIAVARITMPKSYVRLSAGRSGMT--EEMQAMCFMAGANSIFYGDKLLVTDNPEEDGDQLLMAKLDLEPETAENKK......................................................................... 332
15 -15.100[R] KOG4355 Predicted Fe-S oxidoreductase  ali follow..  16  196LPKIRKNPLIEIISI--CLNACTYC---KTKHARGNLASYPIDELVDRAKQSFQ--------EGVCEIWLTSEDTGAYGRDNLPTLLWKLVEVIPEGAMLRLGM-TNPPYILEHLEEMAKILNHPRLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEK---TIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTP--AAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGE.......................................................................................................................................... 436
16 -15.100[HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes  ali follow..  10  63.................CLSKCRFCAFYAREKGYVLSHEEILRKV------------GYAVKMGATQIMLQGGMNPDLGLEWFEELFRKIKARFSLSPPEIVFLAKLERSSIREVLDRLKAAGLDSLPGGGAEILVDSVKISPNKCSSDEWLRVMETAHSLNMP-TTATMMFGH-VESDGDIVEHLIKIRELQEKTGGFTAFIPWTFQPGNTELYAEIKRPVS------PLRYLQVLAISRIVLNNFR---NIQASWLTQGFEIATLSLFFGANDFVVRATGKDFRPAKIEEIVKAVKAVGRPVALRDTYYNILEWF................................................................... 355
17 -15.000[C] COG1032 Fe-S oxidoreductase  ali follow..  10  252.................CGVGCDFCEVTLRPLRYMP-----LNMIVDEIKINVAGGVDNAWLHSDEIFGYKHGHFFEPNEEALSELFSTVMSVPGVKTSNPTHGRISIPAGYPEMMEKLSKINWIGIQTGLETGSEELAKKHMP-SWQDIVWQGVFVETRNYW-RSAFTIQVGQEGETPEDLWETIALINKLSNSRPFEFTVTPLVNVPLGR............................................................................................................................................................................ 461
18 -14.800[H] KOG2876 Molybdenum cofactor biosynthesis pathway protein  ali follow..  13  71...........YLRISLCNLRCQYC-----MPEEGVPLTPKANLLTTE---EILTLARLFVKEGIDKIRLTGGEPLI---PDVVDIVAQLQRLEGLR---TIGVTTN-GINLARLLPQLQKAGLSAINISLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYNPVKVNVMRGLNEDELLDFAA-LTEGLPLDVRFIEYMPF----DGNKWNFKKMVSYKEMLDTVRQQWPELEKVPEEESSTAKAFKIPGFQGQ-----------ISF-ITSMSEHFCGTCNRLRITADGNLKVCLFGNSEVSLRDHLRAGASEQELLRIIG............................................................. 356
19 -14.600[R] COG2100 Predicted Fe-S oxidoreductase  ali follow..  12  116...........LIQVR-CNMRCIFCSVDEGPYSRTRKLDFVVDIDYLL---KWFDWVAKEKGKGLEAHLDAQGEPLL---PFIVELVQALREHPHVS---VISMQSNGVLLNDKLVEELAEAGLDRVNLSIHSLDPEKAKMLMGIYDLNHVLEMAEALVNAGID-VLIAPVI-MFGVNDDEAEAFIEFARRIGAG-KRWPALGFQNYIPYKFGRNPVIAKPVPKEFYRWLRELEEKTGMKPLILKP.......................................................................................................................................... 345
20 -14.300[R] COG0535 Predicted Fe-S oxidoreductases  ali follow..  15  1MVAFLRGPTHVDFNLT-CNLACSHCHSASGPKLDNELKTEEILQTIDALH-----------IIGALKIAFAGGEPFI---RDIFNILSHACSL----PGWGISVITNGFYLNSLTVEKLKACPNLSINISVDGSTPAGYSTLRKQLNRERVLSGIDNVVRSG---MSNSVNFTITKATLH----DIEATYELVVDRIGADNMVAIKFFPGGYGKEHLDLYEIPYDMWDEHFVALTRA................................................................................................................................................... 224
21 -14.100[J] COG0621 2-methylthioadenine synthetase  ali follow..  14  139LPPARVEGGAAFVSI--CSKYCSFC---VVPYTRGEEFSRPLNDVLTEIANLAQQ----------EINLLGQNVNAYMDDGEICDFATLLRIVHEIPGIERMRFTSHPREFTDSIIECYRDLPVSHLHLPIQSGSDRVLSAMKRGYTALEYKSIIRKLRAI---CLSSDFIVGFPGETEREFEQTLKLVKDIAFDLSFVFIYSPRPGTPAANLPDDTPHEEKVRRLEALNE......................................................................................................................................................... 367
22 -13.900[T] KOG2492 CDK5 activator-binding protein  ali follow..  13  217...VDSASKTAFISI--CDNMCTYC---VVPFTRGRERSRPIESIVEEVQ--------RLRDQGYKQVTLLGQNVNSYRDMTFTTLLEKVADAAPDI------TSPHPKDFPMQLIELIASR-CKQLHLPAQSGDDETLERMERGYTRDLYLRLVDDIRHV---SLTSDFIAGFCGETEQAHQNTLSLIRAVRYSFCFVFPYSMRGKTRAHHRLTDDVPEDVKARRHLDLTTVFREEALKLNQ............................................................................................................................................. 478
23 -13.600[R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)  ali follow..  11  12.................CNLKCDYCFYLSKENIFQHKGWMTEETLETFIERYISASGHDV------YFTWQGGEPTMAGLDFFEKAIQYQNRYKG-TKKIHNALQTNGILLDDAWCLFLRENHFL-VSIGPKELHDRYRVTRSGKGSFDKVMAGIEQLKKHQ---VEFNTLTVINRINVKYPLEVYRTLKSIGAKHIQF......................................................................................................................................................................................... 185
24 -12.800[H] COG0320 Lipoate synthase  ali follow..  13  94.................CTRRCPFCDVAHGRPVTPDANEPEKLA-------------QTIQDMGLRYVVITSVDRDDLRDGGAQHFADCISAIRAKNPTIKITLVPDFRGRMDRALDILTATPPDVFNHNLEN-VPRVYRQVRPGANYDWSLKLLERFKEAH--PTKSGLMVGL-GETNAEIVEVMHDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPAE------FDEMKAEAMAMGFTHAACGPFVRSSYHA.................................................................................................................................. 311
25 -11.000[O] COG0602 Organic radical activating enzymes  ali follow..  12  23.........AIFIRLQGCPVGCAWCD-TKHTWDKLSDREVSLFSILAKTKESDKWGAASSEDYTARHVVITGGEPCIHDLMPLTDLLE--------KSGFSCQIETSGTHEVRCTPNTWVTVSPKVNMRGQALERANEIKHVGRVRDIEALDELLATLSDDKPRVIALQPISQKEDATRLCIETCIARNWRLSMQH............................................................................................................................................................................................ 217
26 -11.000[E] COG1509 Lysine 2,3-aminomutase  ali follow..  8  112..VHRYKDKVLLLATDRCPVYCRFCTRSYSVGLDTQSVLK--KKVSPFQSRWDTILAYLRVTPVIADVVVSGGDCFRLKPSRLLAIGMGLLS---IPSIRRIRFATKPMKITSDHSDAGRDQGV-EISFHTHFNHPREI--------TDYTIAAAELLFKRGIRMRNQSVLMAGVNDDPEVMKQLVKKLSDLHIQPYYVYTCDLVDGIEHMRCSV-----RLACQIEKAVRGITAGYNTPLFVVDTPGGGGK.................................................................................................................................... 356
27 -10.700[C] COG0731 Fe-S oxidoreductases  ali follow..  9  95.................CNQRCLFCWRPTEVPVPAPGEWDSPEKIVEESIACQRKLITGFGGSPNNVAISLSGEPTFYP--YLPELIEEYEKR-----GFTTFLVTNGTVPSM-----LAKVNPSQLYMSLDAPDLKTYLRVCQPKSPDRINESLDIMKDKCSRVIRTTLVKGENIFNPKGYAELIKRA---SPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVLEFSKELAKHLGYEIADESEISRVV........................................................................................................................................ 327
28 -10.600[R] COG5014 Predicted Fe-S oxidoreductase  ali follow..  14  85.................CKFLCAYC-WNYFRNLRPKRAGDFLSP-----EEVAERLLEISKKRKCDLFRISGAEP-ILGRRSAEHVRKVIEL-----VNNTFILETN-GLMFGFDPSLVDLFLNVLIRVSVKGWDEESFEKIASGEYFRYQLKALEHLHGK---HFWVAVVYDLREKGLKELEKRLPIPCRIEKEYLEMY........................................................................................................................................................................................ 257
29 -10.100[R] COG1964 Predicted Fe-S oxidoreductases  ali follow..  13  110.................CDLACWYC-FFYARRAGYVYEPTIEQ--IREMVRKAKNMKPI----GCNAVQLTGGEPTL---DDLIDIIRMIKEE------DHIQLNTNGIRLDPDFALRVRVAGVNTVYLSFDGVDEKTNPKN-----HHEIPKILENCRRAQLGVLVPTVIKGV--------DHQLGDIIRFAAENDIVRGVNFQPVSLVGSEQFRITIPDCIKAIEEQTNGEIGREDF................................................................................................................................................. 316
30 -9.770[L] COG1533 DNA repair photolyase  ali follow..  15  71...............PYCEHGCVYCDFETKL----FAKPDAARLLDKELSKEGYQ----------RTIAIGTNTDPYQPIEKQYRIMREILEVLARGHPVGIVTKSALVTRDIDILSRMAERGLAKVALSVTTLDRMLARTM-RASTPTKRLEAIRQLSDAGIP-TSVMVAPIIPGLTDQEMERILDSAYAAGAREAGYVVLRLPLEV................................................................................................................................................................................ 268
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.