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Query: [C] COG1038 Pyruvate carboxylase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVLLLYSAVQQNSVLACGETVLKISKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLSLHRFKADESYQVGRGPHLAKDMGPIESYLSIEEVIRVAKLSGADAIHPGYGLLSESPEFVEACNKAGITFIGPTPDTMRQLGNKVAARNLAISVDVPVVPATNPLPDDIAEVERMAEEIGYPVMLKASWGGGGRGMRAIRKKEDLAREVTEAKREAKAAFGKDEVYLEKLVERARHVESQILGDTHGNVVHLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYIGAGTVEYLMDADTGKFYFIEVNPRIQVEHTVTEVVTGIDIVKAQIHILEGAAIGTAESGVPKQEDIRLNGHALQCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTSYTGAVITRYYDPLLVKVTAWAPEPDEAISRMDRALREFRIRGVATNLTFLEAIIGHDSFRNNTYTTRFIDSTPELFAQVKRQDRATKLLTYLADVTVNGHPETKGRAKPADKAAKPIVPYIDAPTPDGTKQLLDKLGPKGFADWMRNEKRVLVTDTTMRDGHQSLLATRVRTHDIARVASVYSKALPQLLSLECWGGATFDVSMRFLTEDPWERLSLIREGAPNLLLQMLLRGANGVGYKNYPDNVVKYFVRQAARGGVDLFRVFDCLNWVENMRVSMDAIAEENKLCEATICYTGDLLNSARPKYDLKYYTNLAVELEKAGAHIIAVKDMAGLLKPAAAKVLFKALREATGLPIHFHTHDTSGISAATVLAAVDAGVDAVDAAMDAFSGNTSQPCLGSIVEALSGSERDTGLDTEWIRRISFYWEAVRNQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLESRWHEVAQAYADANRMFGDIVKVTPSSKVVGDMALMMVSQDLTVADVENPDREVSFPDSVVSMLKGDLGQSPGGWPEALQKKALKGEKPYTVRPGSLLEDADLDAERKVIETKLERKVDDFEFASYLMYPKVFTDFALTAETYGPVSVLPTHAYFYGMEDGEELFADIERGKTLVIVNQASSGIDDKGMVTVFFEINGQPRRIKVPDRAHGASGSAVRRKAEPGNASHIGAPMPGVISRVFINQGQEVKAGDVLLSIEAMKMETALHAERDGKIAEVLVKPGDQIDAKDLLISYAELast
1 -241.000[C] COG1038 Pyruvate carboxylase  ali  100  1MVLLLYSAVQQNSVLACGETVLKISKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLSLHRFKADESYQVGRGPHLAKDMGPIESYLSIEEVIRVAKLSGADAIHPGYGLLSESPEFVEACNKAGITFIGPTPDTMRQLGNKVAARNLAISVDVPVVPATNPLPDDIAEVERMAEEIGYPVMLKASWGGGGRGMRAIRKKEDLAREVTEAKREAKAAFGKDEVYLEKLVERARHVESQILGDTHGNVVHLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYIGAGTVEYLMDADTGKFYFIEVNPRIQVEHTVTEVVTGIDIVKAQIHILEGAAIGTAESGVPKQEDIRLNGHALQCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTSYTGAVITRYYDPLLVKVTAWAPEPDEAISRMDRALREFRIRGVATNLTFLEAIIGHDSFRNNTYTTRFIDSTPELFAQVKRQDRATKLLTYLADVTVNGHPETKGRAKPADKAAKPIVPYIDAPTPDGTKQLLDKLGPKGFADWMRNEKRVLVTDTTMRDGHQSLLATRVRTHDIARVASVYSKALPQLLSLECWGGATFDVSMRFLTEDPWERLSLIREGAPNLLLQMLLRGANGVGYKNYPDNVVKYFVRQAARGGVDLFRVFDCLNWVENMRVSMDAIAEENKLCEATICYTGDLLNSARPKYDLKYYTNLAVELEKAGAHIIAVKDMAGLLKPAAAKVLFKALREATGLPIHFHTHDTSGISAATVLAAVDAGVDAVDAAMDAFSGNTSQPCLGSIVEALSGSERDTGLDTEWIRRISFYWEAVRNQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLESRWHEVAQAYADANRMFGDIVKVTPSSKVVGDMALMMVSQDLTVADVENPDREVSFPDSVVSMLKGDLGQSPGGWPEALQKKALKGEKPYTVRPGSLLEDADLDAERKVIETKLERKVDDFEFASYLMYPKVFTDFALTAETYGPVSVLPTHAYFYGMEDGEELFADIERGKTLVIVNQASSGIDDKGMVTVFFEINGQPRRIKVPDRAHGASGSAVRRKAEPGNASHIGAPMPGVISRVFINQGQEVKAGDVLLSIEAMKMETALHAERDGKIAEVLVKPGDQIDAKDLLISYAE 1174
2 -120.000[IE] KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit  ali follow..  28  31.....REGKEIYTTVGIDYNEPKFDKILIANRGEIACRVIKTARAMGIKTVAVHSDVDSNSLHVKMADEAVCVGEAP-------TAKSYLRADRILQAVEDTGAQAVHPGYGFLSENTKFAAELEKAGAKFIGPNSKAILDMGDKIHSKKIATAARVSMIPGYDGEIADEDMCVKVSRDIGYPVMIKASAGGGGKGMRVAWNDKQAREGYRLSKQEAASSFGDDRMLVEKFIDNPRHIEMQVLCDKHGNALWLNERECSIQRRNQKVIEEAPSSFVPPEMRRKMGEQAVQLAKAVGYDSAGTVEFLVDSQ-RNFYFLEMNTRLQVEHPITECITGIDIVQQMLRVSYGHPLPI------TQEQVPLNGWAFESRVYAEDPYKGFLPSVGRLSRYVEPKHDGVRCDSGI-REGSEISIYYDPLICKLVTHGDNREQALNRMQEALDNYVIRGVTHNIPLLRDIVQEKRFRTGDITTKYLPEVYPEGFQGTSLSPKEQDVVIAFASALNARKLARANQFLNQNKQRSTHVASFS----KTYKFVSSLPVKEGERPTEHAVEVEFVEGSANKAQVRIGGKTVTISGDLNLSHPVNSIEVDGEHITTQIVGKRAGEITVLYKGTPFKVKVLPEQAVKYLQYMKEKAKVDLS-TVVLSPMPGAIKNVNVKPG-DMVSEGQELVVMEAMKMQNSLHAGKTGRVKAVNVKVGATVDEGEVLVELE........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 724
3 -108.000[I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit  ali follow..  37  1.......................MKKVLIANRGEIAVRIIRACRDYGLQSVAVYADPDQDALFVRLADEAYALEGVR-------PAETYLDISKLIAIAKRAGADAVHPGYGFLSERAEFAQAVIDAGLIWIGPDPDVIEALGDKVMARRIATGVGAPLVAGSDGPVSSAAEVTAFAEQHGLPVAIKAAHGGGGRGLKVAWKMEEIAELYESAVREATVAFGRGECFLERFLDRPRHIEAQVIADKHGNVLVLGTRDCSLQRRNQKLIEEAPAPFLSDEQRQKIHDAAKAICAAAGYSGAGTVEFLLGVD-GTISFLEVNTRLQVEHPVTEETTGIDLVIEQFRIAEGHKLRV-------LETPEPRGHSMEFRINAEDPGRGFLPTPGLISVFDAPSGPGIRMDSGV-ISGSSIPGVFDSLMAKLIVTGVDRDQVLRRARRALREFRIEGIATVLPFHRAAIETEDFIGTDVHTRWIETDFAAMPDAMERPAPADDPSITRTYLEIDGKRVSVGLPSILLSSLGTVSGGNASAP---------------------------------------------------------------------------------------------------------SAAVEKKEGEMTAPVSGTLQSFKVKDG-ETVSEGDLLAVMEAMKMETQIVATRAGKVR-LIVKEGDYLQAGATLIDIA........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 575
4 -99.900[I] COG0439 Biotin carboxylase  ali follow..  44  1......................MFKKILIANRGEIALRVIRTAREMGIQTVVVYSTADEKSLPVLLADESVCVGPPA-------SNQSYLNIPNILSAALMTGAEAIHPGYGFMAENPDFAEMCREHGIVFIGPTPESMRALGSKAGGREIAAQSNVPTVPGTGV-LESVDAALLAAKQIGYPVLLKASAGGGGRGQKVIRTQEELQKGFNQAQEEARLYFGDPAIIMEKFLEEFRHIEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEEAPST-LPESLRQEILAAGVRLAQFVNYAGAGTLEFIMDRD-GNYYFMEMNTRIQVEHCVSEMISSLDLVRLQIEIAAGLGLNI------QQDDVKLHGHAIECRINAEDPDKDFRPAAGKIDDAHFAGGAGVRVDTHV-YSGYSIPPHYDSLIGKLIVWHEDRDKAVSRMKRALEETVIQGPKTTIPLYIKIMDNPFYKRGAVMTNFLKTRMEM.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 445
5 -50.900[EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)  ali follow..  12  2..................PKRTDIQKIMVIGSGPIIIQACLSLKEEGYEVVLVNSNPATIMTDKEIADKVYIEPITL----------EFVTRILRKEGPDALLPTLGGQTGLNMAMELSKNGILDELGVELLGTKLSAIDQAEDRDLFKQLMEELEQPIPESEI--VNTVEEAVAFAATIGYPVIVRPAFTLGGTGGGMCANEKELREIT----ENGLKLSPVTQCLIERSIAGFKEIEYEVMRDSADNALCNMENFDPVGIHTGDSIVFAPAQTMSDYENQMLRDASLSIIRALKIEGGCNVQLALDPNSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEV------INPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERRLGTQMK------------------ATGEVMAIGRNIEESLLKACRSLEIGEIAELTKIDIFYLDKLLHIFEIEQELGAHPQDLEAELWGTTDDKVRQLRLENKIVPVYKMVDTCAAEFDSETPYFYSTYGWENESIRSDKESVLVLGSGPIRIVHSVKAIQAAGY-EAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDLEQFGGQTAKAGVTILGTQV-TNEEEAALAARKIGFPVLVRPSYVLGGRAMEEDLRSYMRTAVKASPDHPVLVDSYIVGQECEVDAI-LIPGIMEHIERAGVHSGDSMAVYPPQTLSQKVQETIADYTKRLAIGLHCLGMMNIIKDEKVYVIEVNPRASRTVPF---LSKVTNIPMAQVATKLILGQSLSELGYQN----GLYPESTRVHIKAPVFSFTKLAKVDSLLG------------------------------------PEMKSTGEVMGSDATLEKLYKAFEASYLHLPTFGNVVFTIADDAKEEALNLARRFQNYGILATEGTAAFFAS............................................................................................................................................................................................................................................. 976
6 -45.400[C] COG5016 Pyruvate/oxaloacetate carboxyltransferase  ali follow..  36  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TTQNKKIAITDVVLRDAHQSLFATRMRLDDMLPIAHELDQI--GYWSLEAWGGATFDACIRFLGEDPWVRLRELKQAMPNTPLQMLLRGQNLLGYRHYADDVVDRFVERSVKNGMSVFRVFDAMNDPRNMKQALQAVKRNGGHAQGTLSYT------TSPVHNLETWLEITEQLLEIGVDSVVIKDMSGILTPVEAYKLVSEIKKRYDVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGTYGHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQVPGGMLTNLESQLKQQNASDKLDEVLKEIPRVREDLGFIPLVTPTSQIVGTQAVINVLMGER............................................................................................................................................................................................................................................................. 361
7 -35.300[F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)  ali follow..  19  2.............TTIGTPLTPKATKVMMLGSGELGKEVVIELQRLGVEVIAVDRYANAPAQQV--AHRAYTI--------------SMLDGEALKALVEKEKPDYIVPEVEAIATAT--LVELEQAGFT-VIPTAKATQLTMNREGIRRAAEELGLPTSNYQF--VDNFDDFKRAVEKIGIPCVVKPIMSSSGHGQSILKSVEQIPSAWEYAQQGGRA--GAGRVIVEGFVKFDYEITLLTVRHVHGTSFLAPIGHIQIDGDYRESW--QPQA-MSAVALEKAQAIAEKITGALGGRGIFGVEMFVCGD--EVIFNEVSPRPHDTGMVTLISQELSEFALHARAILGLPIP----------DITLISPSASKAIVVEGKSTQ--VVFGQLAEVLAEPHTNLRL-----FGKGEVDG--HRRMGVILARDISVEKALEKARRAYDKLEIA.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 392
8 -31.900[F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)  ali follow..  18  2..............TKNVMAKTNNLTIGIIGGGQLGRMLAMAAARLNHRTIVLEPQADCPAAQV--CNDQIVA--------------EYDDEKALAELASRCDV------VTYEFENVPVAAAEKLSASVPVYPPAQALSASQDRLTEKRFLNGCGIPTADFRA--VDSQDELEAALTAFGGKGVLKTRRMGDGKGQRLFRGGENL--------TGAFAALGGVPLILESFVAFEREISIIAARFQDGTVTC-YDPAENVHLNGILHTSTVPAA-LSDAAKAVAVQSAEKLLAALEYVGVIGIEFFVLPD-GSLVANEMAPRVHNTGHWTEAACAISQFEQHIRAVSDLAPGSTD................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 308
9 -30.200[F] KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase  ali follow..  13  1.....................MDSRTVGILGGGQLGRMIVEAANRLNIK-TVILDAENSPAKQISNSNDHV--------------NGSFSNPLDIEKLAEK--CDVLTIEIEHVDVPT-LKNLQVKHPKLKIYPSPETIRLIQDKYIQKEHLIKNGIAVTQSVPVEQASETSLLNVGRDLGFPFVLKSRTLADGRGNFVVKNKEMIPEALE--------VLKDRPLYAEKWAPFTKELAVMIVRSVNGLVF-SYPIVETIHKDNICDLCYAPAR-VPDSVQLKAKLLAENAIKSFPGCGIFGVEMFYLET-GELLINEIAPRPHNSGHYTIDACVTSQFEAHLRSILDLPMPKNF-----TSFSTITTNAIMLNVLGDKHTKDKELET--CERALATPGSSVYLYGKESRPNRK--------VGHINIIASSMAECEQRLNYITGRTDIMGSDSDLPVMSAACAVLKDFGVPFEVTIVSAH----------RTPHRMSAYAISASKRGIKTIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSCLDGVDSLHSIVQMPRGVPVATVAINNSNAALLAVRLLGAYDSSYTTKMEQFLLKQ-KLETVGYEAY..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 567
10 -19.400[R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase  ali follow..  17  1....................MSKMEEILVI--GVNTRPVVESAFRLGYRVYSAGYYCTADF--KHYTERRCIL--------------RERSGESCGRFHENFSQEKLLEAASDFIERADLTGAPPLPGEKVLGN--SRVDHVEDKYRLYRRI-RNSYPTPETH--LISDPAEAMEIVAAGEKKYIAKPVSGAGGFGVTEFREGDG-------------------EFLLQEYIEG-VPVSASVLSTGEDAITVLTSRQIIDRGVPGFEGQFVYAGNMTPGPSGEIEDLASDLILDLSLRGSNGVDLIMRDS--ELYVIEVNPRIQGTFECAEASLGINMVDAHIRACMGELIEKPDPVSYAVKRI-------------------YAPARCRVGEIKTMGVHDLPVPGTIIEEGEPL--------LTVLASHNSMEAAENLASNICSRVKKE.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 363
11 -17.700[R] COG3919 Predicted ATP-grasp enzyme  ali follow..  16  1.....................MTIPGVVIIGGAHGTLALARSLGVLNVPVYYL-THDSPLPGWSRFVRETIRWAGPHD--------DGAMAFLREMAEKPGLKGCLLVP---LVSQHRE------SALYKIILPEWTNLQWLCEKPLLYKRAAELGVS-IPRT--ALTSAADIDGL--DVMFPVILKPHMGGGNTSIARADDREELKAAFVDASGEI----GPDNVVVQELIPGGESQFSYAALWLNGEPIAEFT--------ARRARQYPVSTRVEVVDNRQAIEAARKILKSAGHSGLVEVEFKLDGRDGALKLLDVNPRPWSWFGLC-SAAGINLGGLLWRVANDMPTG...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 316
12 -16.800[R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)  ali follow..  10  2.........................KLFLFEFATCGERIEDSTAVEGLAMFSAFDGFKNYYEITGFVRPEFSCLFTLPVD----------SMDSMEKYLEKSDAFLI---APEDDFLLYTLTKKAEKYCENLGSSSRAIAVTSDKWELYKKL-RGEVQV-------------PQTSLRPLDCKFIIKPRTACAGEGIGFSDEVPD-------------------GHIAQEFIEG-INLSVSLAVGEDVKCLSVNEQIINNFRYAGAVVPAR----ISDEVKREVVEEAVRAVECVGLNGYVGVDIVYS---DQPYVIEINARLTTPVVAFSRAYGASVADLLAGGEVKHVRR...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 277
13 -16.500[M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes  ali follow..  14  2.........................KIAVLYGGEVSLSIMEALKANGHEVIGIDFHPDQVRDLVDLDVDLVFI--------------------------------GLHGRLG---EDGKVQALLDLLNIPYVGTGVQGSALAMDKAKAKLFFEKAGIRVAEEV--LHSFTYDANAFNFTGTYPVVVKPNQEGSTIGLTVAETEEELLQGIEEAFRH------DDTILIEEFIAG-TEVTVAVLGNKGERSLPVVE-DYESKYAPGMSEHIVPAR-ISEEHTAYVQQAAVRAHQALGCDVYSRVDFIVPNDGSDPVILKVNT------PDAAKGVGMEMIQTFVNLS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 302
14 -16.100[R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)  ali follow..  12  17........................DKITIGVIGS-ALDIADGAKEEGLPTLVVAQRGRHRTYEKYFRMRKTRDGLVKGFIDEVIVLDKFAQIIEIQEELRKRNV--IFVPNRSFVVYTGIDRVENEFLVPMFGTRSLRTEERSEEKSYYWLLEKAKLPY--------PEPVSPEEIDDVGLVIVKLPHAKKRLERGFFTAASYKEFKEKSEKLIRLGVIT-DLAKARIERYIIGPVF-NFDFFYSPIDGEIEL----LGIDWRFETSLDGH-SSTLRESLLEKVFDMAEKYVEATGIIGPFTLQTAVDKD-LNFYIYDVAPRTGGGTNIH-MAMGHPYGNSLWRMSTGRRIALEIKRAIELDELE......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 376
15 -15.600[F] KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS)  ali follow..  12  5.........................IALLIGNGEHTIKVYVAPGNGGTASNGAESKMENVNIGVC-------------------------DFEQLVKFALDKDVNLVIPG---LVEG--IEGHFRRVGIPCFGPSALAARMEGSKVFSKDFMHRNNIPT--AVYKSFSNYDHAKSFLDTCTFDVVIKADGLAAGKGVIIPKTKKEAFEALESIMLNEEFGSAGKNVVIEELLEGE---ELSILTFSDGYTCRS----LPPAQDHKRAFD-APTPVASPKVQSTIIQPTIDGMRHEGYPLVGILFTGLMLTPSGPRVLEYNVRFDPETQAVLPLLESDLAEIILACVNHR---------LDAIDIVISRKFSCAVVCVAGGYPGPYNKGDIITFDALKDKNTRIFHAGTSIRDGNVVTNGGRVLA-VEATGDSVEAAVRLAYEGVKTVHFDKMFYRKDIAHHALNPKTYENSGVSVDNGNEFVQRIKDLVKSTRRPGADADIGGF---------------------------DLKQAGWNDPLLVSATDGVGSKLLIALSLNKHDTVGID----LVA--------MNVNDLVVQGAEPLIFLDYFATGSLDL----------KVSTSFVEGVVKGCKQALVGGETSEMPGLYHDGSVGAVSRDDILPKPESFSKGDILLGLASYSLVRKIVEYSDLEYTSVCPWDKNVRLGDSLLIPTRIYVKPLLHVIRKNI----VKGMAHITGGGLVENVPRMLPSHLNAIIDVDTKDAGNVPISDMARTFNMGIGMV---------AVASEDAEETMKELTSVGETV.................................................................................................................................................................................................................................................................................................................................................................. 761
16 -13.800[F] COG0151 Phosphoribosylamine-glycine ligase  ali follow..  13  2.........................NILIIGNGALAWKVAQS------LADKVFVAPGNAGTALEHKVENVNISAT--------------DIPALVKFAQDKQIGLTIVG----PEAPGVVDAFREAGLKIFGPAKAAAQLEGSKAFTKDFLARHKIPT--AEYQNFTEVEPALTYLREKGTPIVVKADGLAAGKGVIVAMTLQEAEDAVRDMLSGNAFGEAGSRVVIEEFLDGE---EASFIVMVDGKNVEP----MASSQDHKRVGEYSPAPVITPEIHSRIMKEVIYAAEGNVYTGFLYAGLMIMPNGQ--KVIEFNCRFDPETQPIMLRLKSDLVELCLKACDGK---------LDEVISQWDLRASLGIVLAAEGYPKDYRKGDEISGLPKSAVKNEKVFLAGVAEQEGKLVTNGGRVLCVTALGESVFEAQQKALKLAEQIQWSGRFYRRDIGYRAVERE.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 426
17 -13.000[I] COG0511 Biotin carboxyl carrier protein  ali follow..  25  96.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GAKIIDQKLAEVASPMVGTFYRAFVEVGDRIRQGQTVCIIEAMKLMNEIEADVSGQVIEILVQNGEPVEYNQPLMRIK. 180
18 -12.000[E] KOG2367 Alpha-isopropylmalate synthase/homocitrate synthase  ali follow..  13  57............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QKAPRWLSTDLRDGNQS-LPDPMSVAQKKEYFHKLINI----------GFKEIEVSFPSASQTDFDFTRYAVENAP--------DDVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMEAISKAVEATKLVRKLTKDDPSQQAEFSPECFSDTPGEFAVEICEAVKKAWPIIFNLPATVEVASPNVYADQIEYFSTHIKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSISEIVHRCNKIPIPPRAPYGGELV................................................................................................................................................................................................................................................................................................................................. 360
19 -10.500[HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)  ali follow..  13  1MSAWRKSGRDYQSPNWRHYRRGFMRIAFFVNSIE-TGLLAMAALNRGHD-VVYLTPGDFTLRSDDTLAVHATVIRKGKYKKPEAFHAALQDKALERITMDVEEIDAL-----MLRNDPSFGRLAEQRGVVVLN-DPEGLALAQNKLY---FQSFPEIVR-PTT--ISRNVEEIRAFADTHPKGVIVKPLQGSGGKNVFKIGSSKETNLNQIFEAVSL-----EGYLIAQAYLPAAKEGDVRFF----GRPLMRDGQYAALRRVPAK---TAEAVKVTDEIVE-LAEMMRPKLVEDGMFLVG-LDIVGD------KILEVNVFSPGGLSNILELTNVDFSDTIIE.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 347
20 -10.400[E] COG0119 Isopropylmalate/homocitrate/citramalate synthases  ali follow..  15  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MRDGEQT-PGVALTREKKLLIARALDEM----------RINVIEAGSAITSAGERESIKAVANAGLDAEICSYCRIVKMD-------------VDHALECDVDSIHLVAPVSDLTVRQIAAEVTEYAKDHGLIVELSGEDASRA-----DPEFLKAIYSDGIDAGADRLCFCDTVGLLVPEKTTEIFRDLSSSLKAPISIHCHNDFGLATANTVAALAAGAKQSHVTINGLGERAGNASLEEVVMSLE-YKYDTGIKHEQIYRTSRLVSRLKSTYEPMSPEYIGRQRQIVLGKHAGR--SSITLALKEMGLEADEAQTEEIFNRVKQM........................................................................................................................................................................................................................................................................................ 340
21 -9.580[E] COG2902 NAD-specific glutamate dehydrogenase  ali follow..  13  732....................VNAIDATLRTNRDLLAFKFDPK-DPRPFREIFVYG-TEVEGVHLRFGKVA---GG------SDRGQDYRTEVLGLVKAQQVKNAVIVPVG-GFFGSRDEVFNAGREAYKTYI----RTLLSITDNIVDDAIVPPADT-VVAADKGTATFSDTANGLAHEAGFWL--DAFASGGSAGY----DHKKMGITARGAWETVKRHFREMDTDIQT--------PFTVAGDVFGNGMLLSEKIRLIAAFDHRDIFIDPDPDTDKSFAERKRLFELPRSSWQDYDSAGAMIISRSEKS-----VTLTPEAVAAIGLDSVATPFEIMTAILKIKAAVE-TNAEVGDRANDPIRVNATELRAKVIGEG-ANLGITQKGRIAY--ALAGGRCNSDAIDNSAGVNSSDV--EVNIKIALASAVNSGRLNQLLASMTPDVAQLVLRNNYQQSLAISLTE-RLGLANREELGRLMGALEATGQLNRKVETLAEFSERYASGKPLTRPEIGVLLSYAKLTLFDALVASPLPDEPYLQHLLLDYFPAKMQKNYANDIKAHRLH---REIVATALANAVVNRGGPGFVQKLA-----DASGLLAADVVKAAV-KRLWTEVDALDGKVGGQVQNGLYATIT---------RIFSDASRLYLQTGSAGAAAGDMATEIERLKTAIKTLSPAATKYRGVTEIDGVPSGLLEELDTLSLLVYVPEIMRIAESAGTTLARAAESYATVSSTFRVARLLDASQLRSQDQISSSRRRIVISALTEYAKEKDPVQAWYAA-----DRVRVNRIVSELGALSESGDTNLARLTVAAGLLGDI................................................................................................................................................................................................................................................................................................................................................. 1581
22 -9.260[Q] COG3321 Polyketide synthase modules and related proteins  ali follow..  11  164LGLHGPAMTFDTACSSGLMAVHLACRSLHDGESDLAL-LLEPHASVAASAQGMLSSTGRCKSFAADAD-GFVRSEGCAMVLLKRLPDALRDGNRIFAMILGTATNQDGGTETLMMPSEDAQVAVYQAALAVAGVEPETIGPIGDPIEYRSLARVYG-PCALGS------------AKSNMGH---STASAGTVG--IKAI-RNGLVPPLLHFDRLSDDLTEIETGLFVPQEVNTPKRVAVSSFG---GTNVHV-------------IVEEAPSEALSSTSIAALRETARQLATWVEEHQDSVPVWVFSGQGSQ--WASMGVQLLANEPVFAAT--ITKLEPVIAAESSFSV-TAPETVTGIDKVQPSVFAVQVALATTRPGAVIGHSMGESAAAVVAGALSLKLMNRVAGSGAMGSVELPAKQVNSELMARGIDDVVISVVASPQSTVIGGATETVRDLIAQWEQRDVMAREVAVDVASHSSQVDPILDDAAALADIAPMTPKVPYYSATLFDPRELPVCNGAYWVDNLRNTVQFAAAVQAAMEDGYRVFAELSPHPLLTHAVEQTARNLDMSLAGMRREQSMPYGLRGLLADLHSAGAALD-FAALYPAGRLLDAPLPVWTHPRLFIDTDGQ-------EQRAQGACTVTVHPLLGSHVRLLEEPERHIWQG-AALSWLADHQVHNVAALPGAAYCEMALAAAVEVFGEAAEVRAIAFEQML-------------------LLAAETPIDAIASVDAPGVINFVVQANQDGERNATATLHAAEDDCPPPAYDIAALLEAHPNSNGTDLRESFAERGVQLGAAFAGLATA........................................................................................................................................................................................................................................................................................................................................................ 1065

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.