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Query: [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEIKLLast
1 -108.000[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali  100  1MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEIKL 331
2 -84.400[HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases  ali follow..  26  29.MAKVLVSDSIDQVGIDILKQVA---QVDVKTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQ--AGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKSVKESKWE-RKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQEDQIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTAIETAQIGGAALDVFAQEPL--------------GESRLREFSNVILTPHLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAVNI 340
3 -79.900[K] KOG0067 Transcription factor CtBP  ali follow..  25  32PRPLVALLDGRDCTVEMPILKDLATVAF-CDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFK--ALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRV-EVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPF------------SFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNC 356
4 -78.100[E] KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily  ali follow..  27  82.KPRILVTEKLGEAGVNLLREFG---DVDCSYDLSPEDLKKKVAESDALIVRSGTKVTREVFEA-AKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQADASIKAGKWE-RSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVFCEEPP-------------SKDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVAGALKGELSATAVNA 395
5 -68.700[C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)  ali follow..  23  312...................................RPEILEKIRGAHAVIWGGRDILNAEILDA-AGPQLKAVSTMSSGINNVDVPELKKRGIPLGSTPAMLTVAVADLTVGLLIAAARRFQEGRRKIDSDKWDKDHLMLGQDIRDSTVGFYGFGGIGQAVAKRLMGFDIKRMLYTTRQDIEERFNAKKVDFETLLAESDFLIIASPLTKETLGLFNATVFNKMKETAVLVNVGRGKIVNQDDLYEALKSNRIFAAGLDVMDPEP-------------LPSNDKLLTLDNVVVTPHVGYATRRTRVDAANLASRNVLKGLAGEPMLSPA.. 597
6 -13.000[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  18  182.......................................................AAEPGKWGKIAEAVKGVTEETTTGVHRLHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGINRA---------------TDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEADP-QALMDGYSVVTVDEAIEDADIVIT----ATGNKDIISFEQMLKMKDHALLGNIGHFDNIDMHSL....................................................................................... 356
7 -12.600[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  15  87.....................AKAGISASTGIPVLPLPRLACLEGRNRRGVPVTGDLTNLIHSQLLLSFRGISKETTIGVHNLKMMVNGILKVPAIDVNDSATKSKFDNLYGCGIKQA---------------------TDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKTDPIKALQAGYEVTTMDEACQEGDVFVT----TTGCVDIILGQHFEQTKDDTIVCNTGYFDVMDVKWLNKNTVEKVNVKLQVDPYR..................................................................... 310
8 -10.800[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  18  1..................................................................................................................................................MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGELRELSQRLSAPRVVWVMVPAGNITTAVIE-ELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGT....................................................................... 121
9 -9.980[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  13  1.........................................................................................................MANYFNTLNLRQKLDQLGRCRFMDREEFADEANF----LKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIATENGFKVGTYEELIPTADLVVNLTP--DKQHSKVVADVMPLMKKDSAFGYSHGFNIVAPKCPGTEVREEYKRGFGVPTL...................................................................... 174
10 -9.880[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  20  6..................................................................................................................................................PSIAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIALGAVPSTADQAVKDADIVFLAVPLHK-------RSVNPATLEGKIVIDTMN................................................................................................ 95
11 -9.550[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  12  365..................................................................................................................................................LKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFSDFEEHPEVIILCTSI-LSTEKVLESLPFQRLKRSTLFVDVLSVKEFPRNLFLQTLPQD------FDILCTHPMFGPESGKNG-----NNLAFVFDKVRIGMDDRRKSRCNSFLDIFAREGCRMVEM............ 530
12 -9.070[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  14  2..................................................................................................................................................ETIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLLKTVSGHAAVAKAADIIITMVPDTPQVADVLDNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPV....................................................................... 121

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.