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Query: [L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERMIRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLNRASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKAFFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPFYQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSELYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKSLAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSEAARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAEPLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQAELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSPFKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVAVALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGDRSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANLRVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARGLSEQEDVVRLMTIHSSKGLEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMRRELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQARTYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKSERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYSGRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHRLYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAHEADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLYTKAVEQIAKTKVKGCALYFFDGGHILTLLast
1 -325.000[L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)  ali  100  1MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERMIRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLNRASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKAFFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPFYQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSELYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKSLAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSEAARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAEPLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQAELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSPFKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVAVALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGDRSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANLRVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARGLSEQEDVVRLMTIHSSKGLEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMRRELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQARTYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKSERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYSGRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHRLYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAHEADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLYTKAVEQIAKTKVKGCALYFFDGGHILTL 1232
2 -81.400[L] COG0210 Superfamily I DNA and RNA helicases  ali follow..  24  7.........GMNDRQAQAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLI--DEKFVNPWNILAITFTNKAAREMKERALALNPAT-----------------KDTLIATFHSMCVRILRREADHIGYNRNFTIVDPGEQRTLMKRILKQL-------------------NIDPKKWNERSILGTISNAKNDLLDEKGYEAQAADMYS--------------------------------------------------------------------------------------------------------------------------------------------QIVARCYKAYQEELRRSEALDFDDLIMMTLRLFDAN--------PDVLAYYQQRYQYIHVDEYQDTNHAQYQLIKLLASRF---KNICVVGDADQSIYGWRGADMQNILDFEKDYPDA-----KVVLLEENYRSTKKILQAANDVINNNRNRRPKKL----------------------------TQNADGEQLVYYRANDERDEAVFVASTISNMSQEL------------GKNFKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDLIAYLTIVANPADNISFERIVNEPKRGVGPGTLDKLRAYESDQSLLEAASN-LLMSPLKGKAAQAIMDLANILGQLRQDLDQMSITDLAEALLEKTGYLDSLRL-LESQARIENIEEFLSVTKNFDESS-DRLGRFLNDLALIADTDD-------SQAEAAEVTLMTLHAAKGLEFPVVFLIGMEEGV------------------------------------LSRASEDPDELEEERRLAYVGITRAEEVLFMT............................................................................................................................................................................................................................................................................................................................................................... 616
3 -66.900[L] KOG2108 3`-5` DNA helicase  ali follow..  18  246.........SLNDRQRDAASNISTPLMVIAGPGSGKGLL-----------------PSNILAMTFTKAATSEMRERIGKSAGKKAAKD---------------ITISTFHSFSLQLCRMHADKLQRTSEFSVYGHGQQRRAIIEAVRLY----------------------------------------------------------------------------------------------------------------------------------------------------------EEEKKNGSKTSVPCESGEGLNGAGAGAGKASGKSPEQCRKMGNEIGAKILGNYNDILKACDALDYHDLISCSVTLLSDF--------PEVFKECQDTWKAIIVDEFQDTSTMQYKLLRMLGSH----NHITIVGDDDQITVKECHNE------------AQCAYVIDKIIEITNDGSTPCCSHGDI------------------------------------------------------------------------------------------------AILYRRQVSGKVFQNAFRQRKIP-FNVHGVAFYRKKVVQVILAMLKTTFSECDDASYRRVFKALLPEEKKRIIEHIESTSRKCSFISAASDIFNAKDMVAKLVDREQSLSAVVTCVANMIPQKYLLEQRAVVDNDGGKLLNEDNRSVLQYLMDDVAEFISTHCTTEKKGCNQLHSFINYISERE----TENFRSRRRDNENSVTLTTIHQANENEIPLLHESNG------------------------------------------NASESGTSLEEERRLLYVAMTRARKKLFFL............................................................................................................................................................................................................................................................................................................................................................... 801
4 -38.800[L] COG3857 ATP-dependent nuclease, subunit B  ali follow..  12  5..........................IIAGKAGTGKTTHLMDEVGEKIKKTSKTY----IFIV--PDQMTFQMETSFLNKQNLA----------------MLGTQIFSFSRLAWKILQET------GLSKTFLSQTGIEMVIRKAALDQKDK------------LKIFSRATSKKGFYSELAKLFKEMKQEEISVDELEKSAANLS---------------------------------------------------------------------------------------------------------------------------------TSVSSKVHDISLIYQKYEELL-----AGKFLENEDYLRLLADKIIESDYLNQ--------------TEIIIDGFTSFSKQELTVIEKLMQK---CDKVTVSLTLNVPEIHKGLEDFSMFKASTEAYFA------------LEMAKLNKIQVEPEKILLENKRANSDSLAFLANAWGDNKYSSYEGGANDLTIH---------------QANNRRAEMEGVAREIRQLALNG-------------YRYRDIAILTRNIGDYDILCEVMESFDIPIFIDKKRAMAKHPFIEFIRSSIDAILFNWKYEPIFQAVKTEFFFDVAENATIMRRKADILENYGLSTNVLPQTDEELATQSVINEMRNLINNITKAKTGIEFAMALYHYLEQVKAVEHLESWRQVAEENGYLELLLDEFVEVLGEEELDVNSFSEIITT----GLDALEFSLLPPSLDQVVLADMENAKLLNMKVIFAIGMNDGVMPLRQKDKGILSDQ--------------DRDSLRVENSNKPSAKNNIGEEDLLAYKIMSLPSDKLFLSYPAADEEGKVLSESNYLRKIKGQFKNLNESVYLT------------------DPSLLNDKEQSSYIRSKQATLGLLTSQLQMYKRGYPLSNVWWDAYNSYFEDSKESEAAKQVLSSLYYENKTKPLQETTAKASVSRMEKFFSCEFQHFAQYGLKLEER----------AHYKLQAVDMGEIFHGAMEWI---GNLTEEECRQMAKLAMTF-LAPKIQHEILLSSKRMEYIQYKLLQIITRARPIGLEVDFGLKGDIPPLKIPLQ-SDSELLLQGRIDRIAEQDDRLRIIDYKSS--------SHDLALTEVYYGLALQMLTYLDIVQKMIGKTAEPAGVLYFHMHNQY.. 1008
5 -35.900[R] COG3972 Superfamily I DNA and RNA helicases  ali follow..  14  196LAKLESEIANFDQKQRRAALVIDGPQRIRGLAGSGKTVILAMKAAHLHMTRPN----DKILVTFFTKSLRSPIKDLVTKFYRHYKEIDPDWNNI----------HIRHGWGGSNSSGTYA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------DACRRSGRMPRSYSSARDAAPRGVEPFSFACEELIN--------------------------------------------------------------------SAQSLEYYDHILIDEGQDFPDGFYKLCFELAKGDRDKKNIVWAYDELQNILNVKMRSPAELISLARAEKNLPPGATNDTVLSKCYRNQREVLVAAHALGFGIYSNIVQLLESPDHWRDVGYDVLTPDFQVGNDIEILRPVENLPPLIGNFIASSFEKEISWITKEIINFLDMG-------------LLPEDIIVVALDDRHMRNYFRYLSESLASHEISVNN-------------------------------------------------------------------------------------------------------------------------------------------------------------HADPYSEPPFSISGKITLSTVYRAKGNEAAVVFALGVDA---------------------------------------------SLRLRADRNKIFAAFTRTKAWLRVSGLGDSARRVAVEIDTALRN............................................................................................................................................................................................................................................................................................................................................ 651
6 -31.300[R] COG3973 Superfamily I DNA and RNA helicases  ali follow..  14  215............KEQNQIIRNEKSKLIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFS-PNFLFNSYVSSVLPELGE------------------ENMEQATFQEYIEHRLGR---------------------FKCESPFDQLEYCLTETKGGDFPTRLAGITWKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQ------------IQSYFYSLDQNHSIPNRMEQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQREQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWG--GKFQHEKMDAIGELTRSAFTDNKLLYEDAAPFL-----------YMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPA----ASMTVLGDINQSIYAHTINGDQRMDACF------EDEPAEYVRLKRTYRSTRQIVEFTKAMLQ--------------------------------DGADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKG---------------HETIAVICKTAHQCIQAHAHMSEYTDVRLIHKENQPFQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------KGVCVIPVYLAKGIEFDAVLVYDASEEHYHTE--------------------------------------------HDRRLLYTACTRAMHMLAVF............................................................................................................................................................................................................................................................................................................................................................... 753
7 -20.300[L] COG3893 Inactivated superfamily I helicase  ali follow..  10  10..........................VLTIAAGTPFLKTLAETLCDGRLDPTDPLSLASVTIYVPTRRSARVLRSEFVDLLGGRSAILP---------------LIRPLGETDDDSGFFDIENPEIMDLAPPISGTGRQIELARLILAWRNSLPDAIRAIHSDSPLVAPASPADAWLARALGEVIDAMDTEEKDWEALQHLDT------------------------------------------------------------------------------------------------------------------------------------GEHAQWWQLTADFLKIASVFWPARLAELNRSSAGRHRNAILRAEADR-------------ANLPDTGPIIVAGSTGSIPAAADLIAAVAA---PQGTVVLPG-----------LDLAMPEEQWQAIIEDPTDPSSRTHPQYGLYM---LLQKLGMSRDEVVQIGALDRDLEKRAAVFSAALAPAKSTSDWNGWREGRDPGFFDEAFAAEAANQREEATAIAVALRLALEAP-----------GPGRPSQAALITPDRGLARRVATELQRFGIEADDSAGTPLSATPQAGLTQLALEAILRPGDPVPIISLLKHPLARFGLSELIALRGGRVETEI-WRVALPEGSVDAARDLARRIAIATEPLGS-RAFTDKLPLSDWAGRTGRVIEAICADDSNDLAAEAGDKLSSLFAELMESGDILDADGPQWIDIFAALVAGE----SIKPRSMRHPRIFIFGALEARLQSVDTVVIGGLNEGLWPGQTANNPFLSRSMKTAIGLEPPERRIGQLAHDFEMANGTRQ------------IFYTRALRQ................................................................................................................................................................................................................................................................................................................................................................... 713
8 -18.100[L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits  ali follow..  12  367.....PGEYILDSSQLKAYQSTKRLSIIQGPPGTGKSFVTL-KAIETLLENTHSHV-LPILVACQTNHAVDQILIRLLHQGASVM---------------------------------------------RLGSRTKDPEIAAVTIFQKAKHTKHSFKAAYNEI---------RHKKQRLIKQITNIMHNFNLEFVTLSYLHSKGIITTSQLESLRNNTEWISSVAENGEKTEEELISIWLG--DAKVELITPSEITDGFEEELQIDPEKLEEIQKEAEDSGALMEEELRGKFINLRCKYLFSKLTTLHEKEIDTLLTIPNIWDIPEYSRGIIYCRWLESAYAAAEKELNRLYRFYLKVDREIGFSNKRAAILLRGANVIGMTTTGLNKYRDILERINPKI--CFIEEAADV--LEGPIIPAVFPS----EQLVLIGDHKQGCSTYALRQDPFNLSI-SMFERLVENDMEYTRLTMQRRMHPQIRRLVSSVYEDLSDYE--------------ITKYWPSIPGMGEIRRFFLTHSRIEDNDGFASKINLFEAQMLVQFAVYLINNGV-------------EPQKITCLTFYAAQKDLIERLLSESLNREKHFIK---------------VATVDGEENDVVLLSLVRN--VGFSSPHRVCVSLSRARRGLF--IFGNAQLVAESNPLWWDAINTLMNDETIQGLGDHLPL.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 974
9 -16.200[L] KOG1803 DNA helicase  ali follow..  14  236.......PETLNPSQVAAVNTQRNLLCIQGPPGTGKTRVIAEIVHQLMKKKK------KVLVCAPTHVAVRNAMDATTGRMIEEMPEEKAEQQLCLLANTKDEFQN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKSASKLEEIKKQLSTMSTSDPLYKKMSYEYYLIRNSIFRSIFYPKLAVFSTLGTSSIQKLP-----------------------------------------EYHWNADVMIVDEAAQCTEPATWVPVLTTP---SCKKLILVGDQKQVVLSDKAMKGNFKLSLMEKLAEEFSSNNINILLNEQYRMNKKIMNWSNEVFYENQLTAHSTVSDITLRDICPNLPEDHVLNNPIMMINMENVKDRSHEEFESHSFTNTDELNLVTEYVNRLVVD-------------GINPKAIAVISPYYAQIEKLRRSIPFR---VDVNTVDAFQGHERQVVIFCLVR--DNDEGQIGFLNETRRLNVAVTRARRQFVLIGNKGNKHLLKLYKHLQSEK...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 668
10 -16.100[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  17  408.........QLNSSQSNAVSHQRPLSLIQGPPGTGKTVTSATIVYHLSKIHKD-----RILVCAPSNVAVDHLAAKLRDLGLKVVR----------------------------------------------LTAKSREDVESSVSNLALHNLVGRGAKG--------------------------------------------------------------------------------------------------------------------------------------------ELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKR--------------------------------------------LDTKFRTVLIDES--TQASEPECLIPIVK---GAKQVILVGDHQQ-------LGPVILERKAADFERLISLGHVPIRLEVQYRMNPYLSEFPSNMF------------YE--GSLQNGVTIEQRTVPNSKFMMFWANYGREEISANGTSFLNRIEAMNCERIITKLFRDG-------------VKPEQIGVI-----------------------------------------------------------TP---------------------YEG--------------------------------------------------------------QRAYILQYMQMNGSLDKDLYIK------------------------------VEVASVDAFQGREKDYIILSCVRAN------------QQAIGF-------------------------------RDPRRLNVGLTRAKYGLVILGNPRSLAR....................................................................................................................................................................................................................................................................................................................................................... 817
11 -15.800[A] KOG1804 RNA helicase  ali follow..  17  307.......NPVLNENQKLAVKRRPLPYILFGPPGTGKTVTIIEAVLQVHFALPD----SRILVCAPSNSAADLVCLRLHESKVLQPAT----------------------------------------------------------------------------MVRVNATCRFEEIVIDAVKP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------YCRDGEDIWKASRFRI------IITTCSSSGLFYQIGVR---VGHFTHVFVDEA--GQASEPECLIPLGLMSDISGQIVLAGDPMQSFLE-RLMSRPAYQRDENAFGACGAHNPLLVTLVKNYRSHEALLMLPSRLF------------YHRE----------------------------------------------LEVCADPTVVTSLLGWEKLPKKGFPLIFHGV-------------------RGSEAREGKSPSWFNPAEAVQVLRYCC------------LLAHSISSQVSASDIGVI------------------------------TPYRKQVEKIRILLRNVDLMD---------------------------------------------------------------------------IKVGSVEEFQGQEYLVIIISTV--------SNEDRFEDDRYFLGF-----------------------------SNSKRFNVAITRPKALLIVLG.............................................................................................................................................................................................................................................................................................................................................................. 712
12 -12.800[S] COG4343 Uncharacterized protein conserved in archaea  ali follow..  72.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VRGEESFPVSLGKAIHEAVAKA-IREAKSKNFSAEPPNYDNEMINVAVKAVWEYTMSLCQSSYLKVRSEQPYATEEGVLLTSMPFLV-------EHRMDGSLLGCSGLISVDCYDYLRNVVFDLKVGEFN---------------EEMRLYTTGYALVLESIHEIPVDVGCIISITFNG.... 227
13 -12.600[L] COG1330 Exonuclease V gamma subunit  ali follow..  7.................................SNQLDLLKALTTALIEREPLDNPFQQEVVLVQSPGMAQWLQMQLAQQFS-----------------IAANIVFPLPATFIWDMFTRVLPDIPKESAF------SKEAMTWKLMWLLPDLLENPLFSPMKRYLSDDGDRRKIHQLAARVADLFD--QYLVYRPEWLESWERGQLIEGLD--DAQQWQALLWVELTRYTRQ----------------------------------------------------------LEQPEWHRANLYQRFIHQLLKSDVCPQGLPKRVFICGISALPPIYLQALQALGKHIDIHLMFTNPCRY---------WGDIQDYTFLAKLQSRKRRHYRESIELSLFRHPQQAEQLFNTDGEQNLSNPLLASWGRLGRDHMYLLSQIDEIQEVHAFVDIEPDNLLHGIQH-------------------LELEDHAVIGTTPETLARSDQKRRLDLDDRSLSFHVCH-----------------------------SPQREVEVLQDHLLGLLAAD-----------PELTPRDIIVMVVDIDSYTPYIQAASERYLPFAISDRKASQAHPALHAFITLLDLPQSRFTAEQVLALLEVPAFGITEDGLRRLRAMDSTAGDWQGILPYDESSGLAAELAGQLADMLMHLSQWRQQLGQPRCRQLLDTFFDQDNDTEAA------VLIEQQWQKVIGYGIAAQYPDVVPLNLLRDELAARLDNERISQR-------AGPINFCTLMPMRSIPFKVVCL-----------------------LGMNDGVYPRTLPPQGFDLMAKKVRRGDRSRRDDDRYLFLALLSAQQQLYI------------SYIGRSIQDNSKRYPSVLVS--ELIEYVAQSYHLPGDEKLSADDSAQRVTQHLLCWHARMPFSAENFIKNSELQSYAAEWLPSAESKGHAHPNFNQPLQAEPLAEI----------------TLDELVRFYRHPVRAFFQLRLGVNFVIEETELPD--EPFTLDNLSRYQFNTQLLNAL-----INEDDINSVFARARAAGVLPYGSFGELYWESQQDEMV-PLAEQIRSERKENHSIELNIEFADITVTGWIHQVQDDGLVRWRPSILTAVDGLLLWLEHLV--RKGTAWRYAPMAADEARPYLQQLIKGYQQGLCEPLMLLSKSGWAWL......... 1047
14 -12.500[L] COG2887 RecB family exonuclease  ali follow..  17  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PAPPVAARPKHFSVTEIETLRRDPYAIFAKKILKLRPLEPL--------IRDPAAAERGTLFHDILGHFQAAIDPLAPDAAEKLMELGRILF-----ADMDLPLEIEAVWWPRFTALIPQFLQWERERAYKVQERFAEIASQKREVELGITLSGRADRI-MRDGTAEIIDYKTGSTP---------SPKQAHVLLSPQLALEAALLAR...................... 190
15 -12.100[S] COG4913 Uncharacterized protein conserved in bacteria  ali follow..  28........VNW-NTRVWCYTLGGRSGLLTGDIGSGKSTLI-DAITTLLVPAQRV---------AYNKAAGADARERLRSYVLGYYKSERNDATGTAKPVALRGTSNYSVKVITLAQVSFPPYGAWFRRRFGIQHEQALELFHQTVLTDFVCSHMLEPCDVGSRIEALICHFDDLDRAHQAVLTAKQQVKLLVPLVDDVQKHQTQLASIQALEAGRDTLRPYFAQLKGELLKHRLDALAAEAAQLTVEQHLEEQRKAADSEVTQLRQALRDNGG-KKSDRYQTLLTKIDETAPADAIGFLTQQQRFAQHTEELNAAIERLHNDKSEKDRADAREKHTTLLAEINSLQQRQSNISAAQIRIRHD-QVRKEDALHGFGLTLLVPDAKPESPHYTWLQQELQRRCNVVCCDTIEQFHCEARAITQA-DRHRIDDRSRYVLGHLEDSMGMLGQDIGTIIAGRKKEQEQLQATSNILQTLQQQLTAAQTQVSVLERKCKNAWHE--SQQKTAQQMWNQARSVWDDAPLSQAQITLLAGWRQQALGEHVLSVESCDNHEQQVRQWLQKRIDAENAHLRQLNDRITKAETVEMDADLAALPEYARMLNDLQKDDLPRFEARFKALLNVNTINEIASFNAQLNRERETIDINQSLHGIDYNQDRYINQSLHGIDSQKGRYITLLAQPSPDAEIRDFQQDLRACTEGTDEQYSDAKFLQVKRIIDRFRGRTDVRNWFSGGKSGGQKEKLAYTVLSLAYQFGLKWDEVRSESFRFV---------IDEAFGRGSDESAEYGLRLFQKLNLQ--LLIVTPLQKIHIIEPFVSSVGF........................................................................................................................................................................................................................................................................................................................................................................................................................ 1110
16 -11.500[S] COG3421 Uncharacterized protein conserved in bacteria  ali follow..  52.......KYPFFEWQKSALEN--THLLFNMATGAGKTMMMAALILYYFEKG-----YRHFLFFV---------QNNIVDKTENNFIDPAHAKFLFTEKILQGEIKFTSIQKLYNDIHTERENQTTLA--VMLGDEAH------HLNAQTKGKKQDELDLEVELKANAGNAEIERKGWEHMVLELLLNKNGNPGQNVLLEFTAT----PENADVQQKYADKIITKF----------GLKEFLQ-----KGYTKEINLVSSTLNKKERVLHALLFAWYRHQIALKYGIANFKPVESKADYSAFLNWAENVQADDFEFLDTFSGSLNNSDNEQGKTRTEQALKFMQDNKFGFAHLANWVKQNYQKHNVIITNS------------------ETNKNKTEKTDSETEKLLNNLEAADNPIRAIFTV---------DRLTEGDVLNDIVRLYEGQNGGGSNKKSGKTAAATVSEKQL-IGRGVRHELRILEELFYYTHDEQSRYISELKNELRKDGYLPEKDDDKVLATFKLLIWANKKIPNPNAKSNNADSLQANPQTLSFQVHGNQLLQETQFTADENDETARQIGTQNNFTQTIKMSEMERHIFNKA---KNSQSLFHFNRLQSKLDIQNRNELQNNLLKDWQIEFLGLGQDKQVRLDDKLAGCLKILEMVEKHLNESDMPFIGTKEFTPKKLWEIFGTPKQKWVKKDDVKTTIATQN--LEEALIQFISARLGDLKSKYDVHLIRNVFKLNNFADGEGFMDFILLLKD--------KQKSSSNGVKDFLHYQIFIEPKGEHL------------ETDGWKEEFLEAITVEYGMDKILQKDTPHYRLIGLPFFTDHQKNGQFTESFPLGAASLEKMK..................................................................................................................................................................................................................................................................................................................................................................... 940
17 -11.400[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  10  888................RACSTRMFPILIQGPTSSGKTS-MIEYVAKKTINNHEHTDLQEYIVLDELNLAPTDVLEALNRLLDDNIPETQVLVKPHPEFMLF----------ATQNPPGVYAGRKHLSRAFR-FLEIHFDDIPENELETILHKRCKIAPSYAAKIVQVFRELSLR-TLRDLFRWAFREAVGYQ---QLAENGYMLLAERARDQKDKLAVQEVIEKVMKVKIDTDGIYNLDSMEIFQDMSLKEGPLSKVVWTRPMIRLFCLVWRCLLAKEPVLLVGDTGCGKTTVCQILAECLHKELHIINAHQDTENGDIIGAQRPVRNRSAVNYSLHSQLCEKFNVQESLDSIDDLIEKFEKLSSSEKNDLSNLIERQIIKYRSLFEWHDGALVTAMKQG-DFFLLDE---ISLADDSVLERLNS----------VLELSRTLTLVEHSNAAVSLTAKDGFAMNPGGDYGKKELSPALRNREDILKIVEGKLHNNKIELARPLDVLSAVEFINACEILDLNLV-VSMVFIDALGSFTTFSLSNNLASLHAERQRCFAKLNELAGSNIMASKSADISIKVESDSTYSLHTDTTLMNASKVLRALQVLKPILLEGSPGVGKTSLITALARETGLLDE---SQSVLEGLNA----LDHRNEAYIPELDKVFKAHPNFRVFAAQNPQHKGLPRSFINRFSVV--YVEALKEKDMIEIAACNYHQEDWRLKIIKFMFRLQDNIEKDISFGSFGSPWEFNLRDTLRWLQLLNDAPKY-----TCVSPADYLEVMVLHRMRTVEDRVRTCELFKEVFDIDYEPRTIGFSLSSQCFKVGHSLLVRDVERQKTLLDSQNI-----LQSQLPVLESVITCIN-KKWPCILVGDTATGKTCILR--LLAAIAGAKIKEMAVNSDTDTMDLI........................................................................................................................................................................................................................................................................................................................ 1912
18 -11.100[R] COG1204 Superfamily II helicase  ali follow..  1364.........FFNKIQTQVFNSTNDSVFIGAPNGSGKTVCAELALLHHWSQEDY-----TAVYIAPIQEIVDRRYEEWYGKFSDVLVKLTGERSQDLKLIQVADLIFCTPSQW--DSLSKRWRSMRSIQKVDFYICDELQLLGGFLYEIVISRIRYMAVQLEKNI----------------VVGLSVSVANARDLGEWLGTSPQCIPKDRPNPLTIHLQSFSITHFPSLMLAMSKPIYRSLKNFISQRKSTIVFTPDRKVAKQLAFDLVTFSMA-DEDEYLFSLMENEAFNKVEDAALQQSLKHGIAYISEITSSNDQNIVQYLYRHGLIKVLIASRDVIYSLKAKSNVIVMGTQYYDGKE--HRYIDYPISE--LLQMLGFTASIGSSELSQVILMTVTTKKEYYKKFLNEPLPMESHLQVWLHDAFVSEISTQTIESKQDAVYRRLVANPAYYGLQDITHESVSEFLSDLVETTMNDLSEARLITVDDE--DSCVALNLAMIAGITYITMQTFALSLSERTKMKGLLEI------TSAAEYEQLPIRKYEDIVL-ERIHSRLPVRLSNPNYEDPHTK------SFILLAA---------HFSRFELPPGLVIDQKFILTRVHNLLGACVDTLSSEGHLIACIRPME......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 1980
19 -11.100[L] COG1111 ERCC4-like helicases  ali follow..  11  11....KPEKIEARTYQQLLAADRKGNSMIVAPTALGKTVVAVLVAAERLRKYRGS----KVLILSPSKPLAIQHEESFREFMLATCTSLTGSIKPEERKERWIKSQIATPQTVESDILAGRYDLRDV--SLIVFDECHRAV-GSYSYVFLASNYIQNARHPLILGLTA-SPGADEDKIKTVCENLFMNEVVVKTEGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLRKVLKNRLKMLKNLGVIDTISVGKKDLLKARGRVQNRIARSTSPPRACYRAISLLASINVEHALELLETQGIRPLHQYLLRLKEKKTKAAKGLLADPDFTRAMHLTRRAMMSGVEHPKLDRLMEILKRELKGDEAR--IIVFTQFRDTLEEIYSGEKGLTQKQQRDIIKSFRMGNHDVLLEEGIDIPSVDLVVIQRRGRTGRKRKGRMVVKTRDEAYYYSSIRKERSMKENLRGGSVNVEVNPIMEP....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 513
20 -10.700[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  49....................AEIPCLVLLGEPGVGKTHELAIGLVDEFKKPKYRSHINRLHLRLTCRTL--AFPSILEEALKALWEESNFAIY---ELAPLRRIDVINADDFLKAINQRDIVPLAIKPSLGFL-EQKRYESYLEGCKCLCEEVSKCRHAL--------TGNLDIDQRLIVAARIAAVTIFANRFAVWIDVEQGQVPAEDVPRQKLCFGYEESNGREFEITQEVIQEVLDTGLFSSRGLHRMGWAHQTYAEFFAAWYLTQRNIDLSKIKTLL----------YSSADSTPKLIPQLHETAVWLASMRDNVFQEIIKTDPDVLLQTDIPTDSELRA--TIVANLLMQYEEEKRNYAKLKHSGLAEQLKVYICDSSKKEDTRRIAILSELQGDLAKLTLCPSQPDQSTRLKLKSLALNVLPEDEQDELKAYALKALWPRQLTAEELFQALTPSKRINLLGMHRYFLESEPQLDSEDLVIALDWLKTQGVRCFGHPFEELGDAILLKAWEHVNVPGVLEGFTQVPSLQAQFQESLLGNNQKRYALIENLVESIAEKDEDEDFYFLTSSMTEPIISSNDVDWML------EKLQDSNHEKIQRAWAKIIEEVFDRRDTKQISEIIKATQ---NNSILSDVFSY----FTPIELDSEEVTQLRDHYLKMKNSWNKPDLLDPPPKERVIDCLEQLES----GDLSAWWRLNREMTLLPQ------SKRYGHNLKLDLTQLPGWKEAEQATKKRIIQGAIQYIQQQTNIDYSWIGTNTYNFSE-ALQLILTEAPRTLD--ILSVPNSFIDSNPRKNCRKLV-------------SLSYHHSPDEFLTTLLKLIDKENQDNNIFVIDRLEMCWDEKLNLTEKVKDSQLKPNVFRKLLEK---LIEQGAVQAKDIALSTIRNYTNSEFDSERQKALFAIKALITYSDPDSWNVI--WEKITADVQFGREAFELAASCNLSGIKFDLTEKQIADLYAWLVWQYPHYEDPDHRNEVMA-------------------------------YIVSPRDNIAFFRNNSLSQLRDKGTIEACAELERLIQELPHLYAQQNMRRETWRPFKPDKLLEFLIIPEPSNLDLSNQLSTIDKRTEKMEDEP-VTSNNVTCSSPEKQKRFNWEILFGVI-GVIATVVG-----NGIFNDVLKDSLNGSP---SKIEQQAMPK...................... 1318
21 -10.500[R] KOG0354 DEAD-box like helicase  ali follow..  10  67....YPINVSFRDYQFNIVQALFENVLVALPTGLGKTFIAAVVMMNYLRWFPKS----YIVFMAPTKPLVTQQMEACYKITGIPKSQGHVPVTTRNQYYQSRNVFFVTPQTILNDIKHGICDRTRI--SCLVIDEAHRST-GNYAYVEVVHLLSLSNKNFRILALSA-TPGNKLEAIQNVIDSL---------------------------------------------------HISRIEIRTENSIDISQYVQKKEVDFFPVDLSAEITDIRDRFSSILEPMKLNKGNYYRIQNAKDITSFTVVQAKQAFLAMSGQNFPANQKWDILNTFDALATFAYPLNLLLNHGIRPFYQKGRSGYKKRIINHENYRPLMDDIEILLRDQSFVGHPKL-----EHLERIVTEYFEKEQTKDTRIM------------IFVAEEILRFLGKFYNVRPAIFIGQSAVRKAAGMSQKLQNETVKQFQKGE-----VNTLIATSIGEEGLDIGYDASASPIRGRTGRKRKG---YIYMLLTRGKEEAKWERAKDAYRTLQDNIVSGRGLSLSEKSYRILPEK................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 587
22 -10.500[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  890...........INEKIKTIVGIEKMLLCGGAVKLGLPQILSFSLILATKEPEYSSIAGLSLLPPLFPYLEPQEAELVIQIFDFISSDTHKQGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTN-ENEPVCYLGLQKLELFFQAKVD----ELHDTLNLDISNEVLDQLLRCLLDCCVKYASTNMQISYLAAK-----------------AIDPSRAKAQHIIKETVVLDNFENGEESLKFILDFMQSQLIPAFLVTTDTKAQGFLAYALQEF---KSAVINKKKGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVTMQLFSLKLMEYAHSQNAEKKVVKDQELPFLVLNVILTESELE-------VNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVD-----VFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFP---SKTLGIVSLNCGFHARALFY------------WEQHIRNATAPYAALESDYR----------VLQEIYAGIDD-----DEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPE-------NKKAKIGLLNSMLQSGHYESLVLSLDSFIINDNHSKMLNLGIEAS----IDSLKKCLSKSNLES---------------------EAKLGSIFYQYLRKDSFAELTERLQ--PLYVDAATAIANTGAHSAYDCYDILSK-LHAINDFSRIAETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILSTHLVGYE----------KFENTKKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDEHAQWWW-AISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKGKVFLKLTK----WLGKA-LGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLSGELVTRIINGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYF-----------VALSQMISRVCHPNNKVYKILEHIIANV-----VASYPGETL---QLMATIKSTSQKRSLRGKSILNV-----------LHSRKLSMSSKVDIKALSQSAILITEKLILCNTRINS....................................................... 1996
23 -10.000[D] COG3096 Uncharacterized protein involved in chromosome partitioning  ali follow..  13........INWNGFFARTFDLDELVTTLSGGNGAGKSTTM-AAFVTALIPDLTLLHFRNYSMLDTINSRHQRV---VGVRLQQVAGRDRKVNELKDKLEAMEGVQFKQFNSYHSLMFDLGIIARRLRSAYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAAYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQQENEARAEAAELEV-----DELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADCAAEWLETFQAKELEATEKMLSLEQKMSMAAHSQFEQAYQLVVAINGPLARNEAWDVAR--VQPLRMRLSELEQREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSQCGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGNALAERFGGVLLSEIYDDVAIVVPDLSQVTEHLEGLTDCDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFG-RESRIESLHAERE-----VLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRNDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLA------DRVDEIRERLDEAQEAARVQQFGNQLAKLE-PIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALT-EVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREAL.................................................................................................................................................................................................................................................................................................................................................................. 1007
24 -9.880[U] KOG2081 Nuclear transport regulator  ali follow..  2....................................................DTYSVDVVAISALFQGNNPKEQEKANKWLQD-FQKSIYSWTIADE--LLHQKRDLHANYFAAQTMR-----NKIQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVAD---REPINDLLVTLAPHQCAIWPLLEVLKVLPE--EIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQRNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADA--QKPHYSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKRPHIERLISALFRHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGA--FHILQAPETTWESTEAALFIMQNVAKNILPDEILNMSEQTHIAVRYTANHPESLEAVLNFLLLQQKNGLAPAAAIALTSICSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAI------NDAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQILVDEFAKSSECIGGLLEMLQAFIELQSSLITPIFQCMKFFINLLVWGRSNNHSRNTECRPLVVELASQHGGALVMNLIQASVFQLHSYMLVDVAEVLH---------ELKQVVGNERMQPFLAQALEALPKKNSGQQQLDEFSSTVLRADTTKAISQALKT.......................................................................................................................................................................................................................................................................................................................................................... 908
25 -9.520[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  10  2..........................................................DDIPTLLARTLNPTTSKSAEEALKVWELQDSSFALKLLNIVAEDTVDINIKLAYFKNYIKKHWDSEEGASI--RISDEVAELIKREIINLMLK---------------------STTIIQVQLGEVIGYIANFDFPDRWDTLLPDLISKLSAVDMNTNIAVLSTAHAIFKRWRPLFRSDALFLEIKYVLDRFCEPFLALFVQTNNLLRNGPQDAESLNSLFQVILLECKLFYDLNCQDIPEFFEDHMSEFMTAFLNYFTYTNP-----SLEGDEGETNVLIKVKASICEIVELYTLRYEEVFT---LYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVIRIRKHAEFFQQDQVLQQFIELVVLP-------NICLRESDEELFE---DDPLEYVRRSNSDSRARSAIVLVRGLLDHFDQKSVVSTHINANLQQFSTNPSLEWNKKYVALQLFSAVTSINLMVDVVAFFENNIKPDLLQPAGVIHPMVLAEDIKYVFTFRNQLNSQQLI----PTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVHIFTSLLIAPHILPA-LNQLFLIVESASTPQKLAENDYLMKMRIIIMSQEAILPALLLQHLTKITEEVSKNPSNPKFNHYLFESIGALIRSLSK-SGPQTVSQLENALLPVFQNV-LSQLVEASGNEPLPDFVVNLIQPCLSPALWDSKGNIPALVRLLRAMIFRGPQ-----------------IFISNKFVEPVLGIFQKLISSKVNDHFGFDLL---------------------DRVFTVFNANILAPYINHIFFLLLSRLKNSRTERFV................................................................................................................................................................................................................................................................................................................................................................ 780
26 -9.400[L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member  ali follow..  14  3.......................................................................................................................................................................................................................................................................................................TCGRRLAARLTSFVGWPAKSALAPGGRILTLKVMQFAPQQDEALKAVSQWLKLARHFAENVDGEKAAQVLRSKGATNAKTIHIYRPRGEEEVEDEETGKTSIAPMFAIIIVDE---CSMVDEALGKDLMS---FGTPILVLGDPGQ---------PPV--------GGYFTNHEPDFLLTDIHRQARDIIQLAM--------------------QVREGKEIMHGDYGTAQVISKGQVTQPLVLEADQVLVGTNRTRRRYNQRLRELKGFTSEY----------PQSGDKLVCLRNDPAK--------------------------------------------------------GLLNGSLWQVMSSSKETVKPGINLMIRPEDDDMDRGAAKIKLLKAAFEDV------------------------------EGEIPWSTRKRYDEFDYGY---------------------------------------ALTVHKAQGSQWNNVVLFDESWAFRDT----------------------------------------------RERWLYTAITRAAERLTIV............................................................................................................................................................................................................................................................................................................................................................... 409
27 -9.350[R] COG1201 Lhr-like helicases  ali follow..  12  27...........TEPQERAFPHDGKHTLLIAPTGSGKTSAVLPVFNAILKKKPEKRSGISALYITPLRALNRDMLSRIEVMGKL--HGDTPQSERQRQSRNPPDLLITTPETLQAMFSGSRLRKNMETVTHVVVDE----------IHELASSKRGAQLAIGLERLVEISGEFQRIGLSATV-EIAKFLAGANRDFTVIEVALLK-EDREVMEIARTVGCEPEFASHLSLIRKIVEESQSTLIFVNTRQSAEALAAGFRKLGASIGVHHGSLSF-VEAEEAFKAGALRGLICTSSMELGIDIGNVDRVVQYGSPRQVSRLLQRVGRAGHRLHEVSRGTVLSMEADDTAESMAITKAALEGRVEDISPHVNSLDVVANQIAGMVMDFGEVGIEKIFRILRRAFRDLRPEELQRVGVLDEAFVVNFAE----PGAVFITKEVAQDVGKLRAEDEAVAEKLRLKYPVSRSAVLELIRLIRDQVEGDFPLPDAETIVDAVTLNACFGHNTNGTLARVLTSLLSARFGSSVAQEVDPYRIRLTLPRRVGPIQIRDMLLSLRPEHVEPIIEMTLKNTTLMKWKMVHVARKFGALLLEIYEGSSMYDEVVREI-----------FHDMLDVPRAKEVLTKLTA--GEIAVEVSGPTPIG-------SAGFAMKKDLVAPEKADRSIVLALKERIMNDNIILFCTTCKKWTSRRQVKNVPEEIICPVCDSRMVAALKPWEDEEIKLVRKQGKGVPVSAEEKKRIQRVYRNASIVNSQGKKAVIALASRGVGP-ETASRVIE........................................................................................................................................................................................................................................................................................................................................................................................................................................................ 927
28 -9.290[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  12  183...........DEEIRRAIQRTKNNPVLIGEPGVGKTAI-VEGLAQRIVNGEVPEGLKNKRVLSLDMGALGEFEERLKAVLNELSKEEGDAGNLLKPS--LARGELHCVGATTLDEYRQYIEKAALERRFQKVFVGEPTVEDTIAILRGLKERYE----------IHHHVQITDPAIVAAATLSHRYVSDRQLPDKAID----------------------LIDEAASSIRMEIDSKPQPLDRLER----RIIQLKLEQQALQKEDDDASRKRLAMLEKELGEKEREYAELEDVWKAEKAALSGTQHIKAELDSAKTQMEQARRASDFAKMSELQYGVIPALEKQLAQAESAEG--KEMTLLRYRVTDEEIAEVLSRATGIPVAKMMEGEKEKLLRMEEELHKRVIGQHEAIEAVSNAIRRSRAG----------LSDPNRPIGSFLFLGPT-LCKTLANFLFDDENAMVRIDMSE-FMEKHSV--------SRLVGAPPGYVGYEEGGYLTEAVRRRP------SVILLDEVEKAHHD---------------VFNILLQVLDDGRL----TDGQGRTVDFRNTVVIMTSNLGS----HLIQENSTLDYPSMKELVMSVVGQHFRPEFINRIDE--------TVVFHPLGKENIREIATIQLARLIKRMESHGYQLHFTDACLDFIGEVGYDPVYGARPLKRAIQQEIENPLAQQILSGK............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 835

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24