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Query: [C] COG1140 Nitrate reductase beta subunit, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKIRSQVGMVLNLDKCIGCHTCSVTCKNVWTSREGVEYAWFNNVETKPGQGFPTDWENQEKYKGGWIRKINGKLQPRMGNRAMLLGKIFANPHLPGIDDYYEPFDFDYQNLHTAPEGSKSQPIARPRSLITGERMAKIEKGPNWEDDLGGEFDKLAKDKNFDNIQKAMYSQFENTFMMYLPRLCEHCLNPACVATCPSGAIYKREEDGIVLIDQDKCRGWRMCITGCPYKKIYFNWKSGKSEKCIFCYPRIEAGQPTVCSETCVGRIRYLGVLLYDADAIERAASTENEKDLYQRQLEVFLDPNDPKVIEQAIKDGIPLSVIEAAQQSPVYKMAMEWKLALPLHPEYRTLPMVWYVPPLSPIQSAADAGELGSNGILPDVESLRIPVQYLANLLTAGDTKPVLRALKRMLAMRHYKRAETVDGKVDTRALEEVGLTEAQAQEMYRYLAIANYEDRFVVPSSHRELAREAFPEKNGCGFTFGDGCHGSDTKFNLFNSRRIDAIDVTSKTEPHPLast
1 -164.000[C] COG1140 Nitrate reductase beta subunit  ali  100  1MKIRSQVGMVLNLDKCIGCHTCSVTCKNVWTSREGVEYAWFNNVETKPGQGFPTDWENQEKYKGGWIRKINGKLQPRMGNRAMLLGKIFANPHLPGIDDYYEPFDFDYQNLHTAPEGSKSQPIARPRSLITGERMAKIEKGPNWEDDLGGEFDKLAKDKNFDNIQKAMYSQFENTFMMYLPRLCEHCLNPACVATCPSGAIYKREEDGIVLIDQDKCRGWRMCITGCPYKKIYFNWKSGKSEKCIFCYPRIEAGQPTVCSETCVGRIRYLGVLLYDADAIERAASTENEKDLYQRQLEVFLDPNDPKVIEQAIKDGIPLSVIEAAQQSPVYKMAMEWKLALPLHPEYRTLPMVWYVPPLSPIQSAADAGELGSNGILPDVESLRIPVQYLANLLTAGDTKPVLRALKRMLAMRHYKRAETVDGKVDTRALEEVGLTEAQAQEMYRYLAIANYEDRFVVPSSHRELAREAFPEKNGCGFTFGDGCHGSDTKFNLFNSRRIDAIDVTSKTEPHP 512
2 -59.400[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  30  2...TTQYGFFIDSSRCTGCKTCELACKDFKDLGPEVSFRRIYEYAGGD--------------------------------------------------------------------------------------------------------------------QEDNGVWHQNVFAYYLSISCNHCDDPACTKVCPSGAMHKR-EDGFVVVDEDVCIGCRYCHMACPYGAPQYNAEKGHMTKCDGCYSRVAEGKQPICVESCPLRALEFGPIEELRQKHGTLAAVAPLPRAHFTKPNIVIKPN................................................................................................................................................................................................................ 186
3 -47.400[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  16  2.......................................................................................................................NRFVIADSTLCIGCHTCEAACSETHRQHGLQSMPRL---------------RVMLNEKESAPQLCHHCEDAPCAVVCPVNAITR--VDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRAIAVKCDLCSFDEQG---PACVRMCPTKALHLVDNTDIARVSKR-------KRELTFNTDFGDLTLFQQAQSGEAK...................................................................................................................................................................................................... 203
4 -29.800[C] COG1036 Archaeal flavoproteins  ali follow..  17  99.........................................................................................................................TSNTVSKIAYGIADSLVTNAVAQAVKGKVPVYVVPVDI--------EGSIISEMPYNIDRKQCRHCETCPPRENCPHGAIT-EKNGVTDQIELLKCKGCGICKELCPYNAIKGGPVEVLVRDVDMRNVEIVKGLQGITVLESPEAILEL.................................................................................................................................................................................................................................................. 238
5 -22.300[C] COG1146 Ferredoxin  ali follow..  18  20..............................................................................................................................................................................................RDLSKVPWWGVDRKEIEWYPTIDYDKCVTCGICFVTCGRRVFDFDKKEGKVNCMVAC---------QTCMNLCPTGAISFPDASYIKKLVAQIKPLLAEDHLSPKETETKPEP................................................................................................................................................................................................................. 139
6 -21.300[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  12  46.................................................................................................................................QSQCGQCGYPGCRPYAEAISCNGEKINR-EPQPLDGEAQELTPARMVAVIDENNCIGC---KCIQACPVDAIVG-ATRAMHTVMSDLCTGCNLCVDPCPTHCISLQPVAETPDKWDLN---------TIPVRIIPVEHH.................................................................................................................................................................................................................................................... 191
7 -18.800[C] COG2440 Ferredoxin-like protein  ali follow..  16  22..........................................................................................................................................................................DPGRPHIKVRPHERPSANLLALTHICPAKCYELN-DKGQVETTSDGCMECGTCRVLCEASG......................................................................................................................................................................................................................................................................................... 81
8 -18.400[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  23  6..........................................................................................................................GKAKEEARVISPKSVDEYPEA--------------PITLGTTLVNFTGDWRTFMPVIDESKCVKC---ICWKFCPEPAIYI-KEDGFVAIDYDYCKGCGICANECPTKAITMVREE.................................................................................................................................................................................................................................................................................. 104
9 -17.900[C] COG0348 Polyferredoxin  ali follow..  18  197...............................................................................................................................................................................................CGHLCPIGAAYAKGLFRIKVEHRQQCDNCMDCYNVCPEPQVLRDPLHAKKSECISCGR---------CIDVCPEKVFIFTTRFNHSVNHSG...................................................................................................................................................................................................................................... 290
10 -17.700[C] COG1145 Ferredoxin  ali follow..  14  162ILPYEDAVKLVKERDYIAVGYC--PCRVMARLVGEGCRHSIENCIHMGSVGKYMVEHGLGRRISADEAIEILRQSNREGLVHLTERSKHVATICNCCSDCCVFFKAVHEAKHPNTIAHSSYLATVDTSRCIACG--------------------------------------------------------ICMLRCPMKAIKAKINREPASVDAEKCLGCGVCVPTCPMEAIELVERDELLE.............................................................................................................................................................................................................................................................................. 345
11 -15.600[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  19  113...................................................................................................................................................................................................................SGEERCIACKLCEAICPAQAITIEAEERAMTKCIYC----------FCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLL............................................................................................................................................................................................................................ 196
12 -14.800[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  17  19...................................................................................................................................................................................LVMIFGHAFRKRDTLQYPEEPVYLPPR-GRIVLGEERCVACNLCAVACPVGCISLQKAETEFSRCIFC----------LCEEACPTTAIQLTPDFEMGEFKRQDLVYEKHDLL............................................................................................................................................................................................................................ 140
13 -14.500[R] COG3383 Uncharacterized anaerobic dehydrogenase  ali follow..  10  23LDYLNAEGIQHP-HIC-SCDTCMCACSTN--LTDGME------IKTNSELAKDAQLEAMDRILENH-------LYCTVCDNNNGNCKVHNTTELLGVEKQDRPYR-----EKGYLNDFTHPFYRYDPDQCILCGRCVEAC----QQVQVNETLSIDWERSQPRVIWDDDRPANLSS-------CVSC---LCATVCPCNALMEKSMLGQAGFMTGL---CTFCGVGCTFEVWTKDRKEGPVNKFATCVKRITT---PLIREGNEFVPASWEDAIHLVATKLREIQAKYGNDSIGFISSSKTTNEENYLMQKLARQVFETNNIDNCSRYCQAPASDGLTRTVGIVEDIESAGLVIIV--GHPVLASRIKRAQKTRGQLIVSDLRKHEMAERSDLPKQGTDFVWLTAVAKYIIDQNWHDQVFMENRISEYAEKETGLPAETLKLVAEMIHEAD--TQNIAGSHTSSAIANLLLVTGNFG---GAGAYPLRGHNNVQGACDMGSLP......... 600
14 -13.800[R] COG2768 Uncharacterized Fe-S center protein  ali follow..  20  199...................................................................................................................................................................................................................IDEEKCTKCDECVKICPSNA--IEDYQINREKCVKCL---------GCSEACDYGAVKT---------FWVFGRDVSERIVECTKGVFKVQKNFAYL---------------------------NFLMDITPHCDCHPYSDLPVVPDL---------------GIMASKDILAIDRASVDLYRQAENLSGALLKDKK--------FWDWTDVEGMLNYAEKLELGTQN----YRLIEIS.............................................................. 363
15 -13.400[Y] KOG2439 Nuclear architecture related protein  ali follow..  11  15.....................................................................................................................................................................................SPALACVK--PTQVSGGKKDTEPDQLEKVSITLSDCLACSGCITSSEEILLSSQSHSVFLKNW---GKLSQQQDKFLVVSVSPQCRLSLA------QYYGLTLEAADLCLMNFFQKHFQCK----YMVGTEMGRIISISKTVEKIIAHKKQKENTGADRKPLLSA--VCPGLIYTEKTKP-------------QLVPMLLNVKSPQQITGSLIAIARESFYHLSLKKLEASRPESLDDGIDCV----------ITPREIVTMLQELNL............................................................... 266
16 -13.000[C] COG1141 Ferredoxin  ali follow..  15  47.................................................................................................................................................................................................................VYVDEITCIGCKHCAHVAR-NTFYIEPDYGRSRVIR------AEEVIQEAIDTCPVDCIHWVDYTE............................................................................................................................................................................................................................................. 109
17 -12.000[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  16  39.....................................................................................................................................................................................QACYQC---TCTGSCPSGRRTSYRTRLIMVIKSDECTTCYTCYERCPRGVKIVDAVKAARNLA------AKKGYMAKAHRMVAMFVIKTGHAVPINDEIREVRKNIGLDEV............................................................................................................................................................................................................................ 154
18 -11.700[C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)  ali follow..  10  22LEACLSLGLDIP-YFCVGCRQCAVSCMT--PASDGTF------ISIDDEEAKQFRESVVEWLMTNHPHDCP---VCEEGGNCHLQDMTVMTGHSFR-----------RFTKRTHRNQDLGPFISHEMNRCIACYRCVRYY----KDYADGTDLGVYGAHDNVYFGRPEDGTLE----------SEFSGN--LVEICPTGVFTDKTHSERYNRKWDM---CQQCSIGCNISPRIENRYNGTVNHYFLCDDRPRQPV-----------QRRGDDFITLNQAMQGAADILRQSKKVIGIGSPRASVESNFALRELVGEENFYTGIAHGEQERLQLALKV-GIYTPALREIESYDAVLVL---GARVALAVRQAVKGKAREMAAAQKVADWQIAAILQRAKHPLFVTNVDDTRLDDIAAWTYRAPVEDQAPAVDGIEPELQSKIDVIVQALAGA--KKPLIISGTNAGSLEVIQAAANVAKALKGRGADVG-RSVNSMGLGIMGGGSLEEALT... 556
19 -11.100[R] COG4624 Iron only hydrogenase large subunit, C-terminal domain  ali follow..  11  13....................................................................................................................................................................................ADLPKDNKK--CIKIGSPLAL-----------SLSDCLACSGCVSADEAGALSEDLSFVLDLS-----PQTSFVLSPQSKINIFNLYREDGM-EFEAVLSSFLRSKFNIHRIVDTSYLRSKIYEETYREYMATNHLIVSACPGVVTYIERTAPYLIGYLSRVKSPQQMAFSLV-SVMPCQDKKLENGRDGVKFDFILTTLDSLGFRRPARAS-SSGGYAEFILGKHCVVETREIRNGIKEHLLDDGRTISQITGL--ENSINYFKSSKTKGPRHKMT----------EIFLCKNGC-----GGPGQ.......................... 315
20 -10.800[C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit  ali follow..  12  407.....................................................................................................................................................................................SECTDC---WCQRVCPNSAADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERCS-MAKEFLERNYIVVTTGCGAMSIGEYRDEDGQTLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQKPLEGNFEEIA-ILNRVGACGVAWGAYSQKAAAIATGVNRWGIPVVLGPHGSKYRRLFLGRADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENREEATIAKLCIRPTDTPKGRQMKLS--NYIDLHRKYTIPDDIDRFIIPIVYKRDVMKILEEKN...................................... 765
21 -10.700[C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit  ali follow..  12  8..................................................................................................................................................................................................................VIDYDVCAACGACEAVCPIGAVTVKKAAGIRQVCEGC----------TCSRVCP------------VVDGFIQDELTNVRKFFGARSKDNVGSQDGGVASGILKSLFKQGKIDCAVGITRNEKWEPEVVLLTSAEDVERTRGTKYTS----------------DPVLAALREAFEKYDRIAVIGVPCQAHAAHLIRENVNEKIVLIIGLLCMESFHHDVMLEKIIPEILKVKLEDIRKMEFTKGKFWVYTKDGEVHSVPIKDRNPCHHCCDYTSVFADISVGSVGAPDGWNS-VFIRTE... 287
22 -10.300[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  24  275....................................................................................................................................................................................SENCTMCNE--CAFVCPHAAIRPILTN-RIQVSPMDCTGCNLCAETCPAKDKALVMKP.................................................................................................................................................................................................................................................................................. 353
23 -10.100[T] KOG4846 Nuclear receptor  ali follow..  7  151...............................................................................................................................................................................................CK-VCGDKASGYH---GVT-----SCEGCKRCLKQCEIKRESRN-------RCQYC--RFKK-----CLDS--------GMSKDSVRQMKFRNAMRDDKSPDSVFVPEISTLERQEEVDAVYEAVLRAHTTFSFYTDIKIRSIVARPFNVRINED----------SKMNRLNAWQIYAHEIDVDIKEVVNVKEIP---FNFINGNDKAVLLRKNAFPLYLLRIVRGMSNRGLMLRDAFANHIITIGCTDGDIALFIVLILCQPLTTEQQFSTFKSQLQLLE........................................ 427
24 -9.760[C] KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit  ali follow..  12  74...................................................................................................................................NCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLAPLDC-----PICDQGCDLQAVEDKNIGPLVKTIMTRCIQCTRCIRFAS-NDMQVGTYIEKMFMSELS------GN---IIDICPVGALTSKPYAFTARPWERKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGAEALVALKDLLNRVDSDTTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRN 484
25 -9.610[C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit  ali follow..  13  150....................................................................................................................................................................................................PAKEWKQSHEDRLKLDGLYECILCACCSTSCP-ERLDNLEDPFRLYRCHTIM---------NCAQACPKGLNPAKAIAEIKKMMVE...................................................................................................................................................................................................................................... 256
26 -9.370[C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain  ali follow..  19  311.......................................................................................................................................................................................................................RCIRCGACLNTCPYRQI--EEFKDLPSACSLC----------ACNQVCPVKIPLANLLLKHRRHIAESGMNPLAERL............................................................................................................................................................................................................................ 401
27 -9.140[C] COG0247 Fe-S oxidoreductase  ali follow..  9  276......................................................................................................................................................................................ACVECGR--CTNMCPATGTGKMLSPMDLILRLRSRSPWVPAAAFRHTRGNQLAAAEEEIWACTTC----------NCEDQCPVMNEHVDKIIDLRRYL--------------VLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKKEGKEFEYLF---VGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNPRRLGNEFLFQELAEKNISEFEKNDVKKIEVYHHTEVLAEL-VKNGKLRPQHPLHETITFHDREIIPGVQLVEMERSRETGMCCGAGGGLMWMEEETGNRINVARTEQALAVNPSV.... 656
28 -9.050[C] KOG3049 Succinate dehydrogenase, Fe-S protein subunit  ali follow..  11  167.....................................................................................................................................................................................................KQQYLQSIEEREKLDGLYECILCACCSTSCP-ERLAKLQDPFSLYRCHTIM---------NCTRTCPKGLNPGKAIAEIKKMMATYKEKKAS............................................................................................................................................................................................................................... 279
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.