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Query: [HI] COG1154 Deoxyxylulose-5-phosphate synthase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGNAQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLALast
1 -175.000[HI] COG1154 Deoxyxylulose-5-phosphate synthase  ali  100  1MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGNAQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA 620
2 -90.800[G] KOG0523 Transketolase  ali follow..  15  57...NRSLRPLVRAAAVETVEPTTDSSIVDKSVNSIRFLAIDAVEKAKGHPGLPMGCAPMAHILYDEV-FNRDRFVLSAGHGCMLLYALLHLAGYLKQFRQWGSTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAADHYTYAILGDGCQMEGISNEACSLAGHWGLGKLIAFYDDNHISIDGDTEITENVDQRFEALGWHVIWVK-NGNTGYDEIRAAIKEAKTVTDKPTLIKVTTTIGYGSPNKANSYSVHGAALEKEVEATRNNLGHFSSHWSRHTPEGATLESDWSAKFAAYEKKYPEEASTYTPESPGDATRNLSQQCLNALAKVVPGFLGGSADLASSNMTDFQKATPEERNLRFGVREHGMGAICNGIALHGLIPYCATFFVFTDYMRGAMRI-SALSEAGVIYVMTHDSILGEDGPTHQPIEHIASFRAMPNTLMFRPADGNETAGAYKIAVTKRKTPSILALSRQKLP-HLPGTSIEGVEKGGYTISDDSDVILIGTGSELEIAAQAAEGKTVRVVSFVCWELFDEQSDE-LPSDVSARVSIEAAS-TFGWGKIV---------GGKGKSIGI-NSFGASAPAPLLYKEFGITVEAVVDAAKSFF. 754
3 -89.400[G] COG0021 Transketolase  ali follow..  16  1...........................MSQLANAIRFLSADAVQKANGHPGAPMGMAEMAETLWTKF-YNRDRFVLSNGHASMLLYSLLHLTGDLKNFRQLHSTPGHPEYGYTDGVETTTGPLGQGIANAVGMALAEKILAADHYTYVFMGDGCLMEGVSHEACSLAGTLGLGKLIVLYDDNNISIDGKVDFTENIPQRFESYGWHVVPNV--NGHDTAAIQAAIEAARAETGKPSIICCKTLIGKGSANKEGSHKTHGAPLADEIEATRKHLGQEIYDAWNAKEQGAKLEAEWNELFAQYQTKYPAEAAEVCAKAETIATRKASQNSIEILAKELPELVGGSADLTPSNNSVSVTRDKGGNYIHYGVREFGMGAIMNGLVLHGVKPFGATFLMFSEYERNALRM-AALMKINPVFVFTHDSILGEDGPTHQPIEQTATLRLIPNMDVWRPCDTAESLVAWAEAVKAADHPSCLIFSRQNLKFQSEQQLNDIKRGGYVISEGNAQAVIIATGSEVELALEAQKNIAVHVVSMPSTNVFDRQDTAAVLPESLPRIAVEAGHADG-----------YKYVGLNGAVVGI-NRFGESAPADLLFKAFGFTVDNVVDTVKSVL. 659
4 -83.500[G] COG3958 Transketolase, C-terminal subunit  ali follow..  27  5......................................................................................................................................................................................................................................................................................................................APAGLKDDIEMRKVYAGFIAGQIEAGSPIIALEADLMSSMAMDSVARDYPQHVINCGIMEANVIGTAAGLALTGRKPFVHTFTAFARRCFDQLFMALDYQRNNVKVIASDAGVACHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFADILRQLMDL-DGFYWLRTIRKQARSI-YAPGSTFTIGKGNVLREGDDITLIANGIMVAEALEAARGVSAAVIDMFTLKPIDRMLVKNYAEKTRRIVTCENHSIHNGLGSAVAEVLVENC-PVPMRRVGVKERYGQVGTQDFLQKEYGLTAEAIVEAAKSLL. 317
5 -78.100[C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component  ali follow..  14  82.......................DQEIEHRIRSFTRWNAMAMVANKDTNVGGHISSFASAATLYDVGDKHGGDMVFVQGHSAPGVYSRAFLLGRLSSFRQEVDISSYPHPWMPDFWQFPTVSMGLGPIMAIYQARFTKYNFENRKVWAFLGDGETDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPGKIIQELESEFRGAGWNVIKVWGSRWDQLL--------ARDTKGLLMSRMMECVDGEYQTFKSKRGGHDPHKIFAAFKSATEHKGPTVILAKTIKGYGMGEAGEAMNIAHQQKKMPVDA-LKATGEGREVSTTMAFVRILNILLKDKKHVVPIVPDESRTFGMEGLKESQTGQVLQEGINEAGAMCDWIAAATSYMIPFYIYYSMFGIQRIGDLCWAAGMRSRGFLLGGTAGRTLNGEGLQHEDGHSHVYHAAIPNCISYDPTFQYELAVVMQDGLRRMYVEYYLTVMNENYEHPEMPAGAEYLFKKGVENSNAPRVQLLGSGTIFREVIAAAEGVESDLWGCPSFTELAREGNAAARWNLHPTDAPRESHVEKMLKGVRGPVIASTDVPRRYVVLGT-DGFGRSDTREKLRHFFEVDRYWVTVASLKALA 867
6 -66.400[G] COG3957 Phosphoketolase  ali follow..  11  1..........MSTVPAKGPLTPQQLSLINRYWRAANYLSVGQILMKNPLLREPLQPEHIKPRLLGHWGTANVIYICGPGHGGPGMVANTYLEGTYSEFSFPGGIPSHAAP-ETPGSIHEGGELGYALVHAYGAA----FDNPDLVVACVVGDGEAETGALWHSNKFLNPARDGAVLPILHLNGYKIANPTVLADDLDNLFRGYGYEPFFVEGSEPADMHQKMAATLDTIFQRPRWPMIILRSPKGWTGPKTVDMKSYDPSDLFDEKGALKPELRALAPKGEARIGANPHANGGLLRKELHMPDFRQYAVNVTEPGAIEAQSTKILGDFLRDVMKLNENFRIFGPDETASNRLGSVDHLAADGRVMEVLSEHLCQGWLEGYLLSGRHGFFSCYEAFIHIIDSMFNQHAKWLQVSLNYLLTSHVWQDHNGFSHQGFVDLVANKSADIARVYFPPDANTLLWVGDHCLKTWNRVNVIVAGKQPEPQWLTMAEAEKHCEAGLGIGLEPDIVMACAGDPTMETLAAVDLLRVNVVDLMVLQSPHQHPHGISDEEFDRMFTTNRPVIFAGYPYLIHRLVYKRTNHSNFHVRGF-IEQGTTTTPFDMTVLNELDRFHLAMEAVERLP 749
7 -47.100[G] COG3959 Transketolase, N-terminal subunit  ali follow..  19  11...........GGGSDGTPISIEELDKLRQVAEKARRNVIKMLFYDQIHVGSSLSSIEILTTLIFKHLVNKDWLILSKGHAAPALYAVLAEKGYIKRIQDITGLQGHPET-FIPGVDMSTGSLGQGLSFGIGVATGIKMANGTGRVYVIMGDGEQDEGEIWEAMTHAVVRNLDNLIAFIEMNNFQLDGSTDEINFLPKVWEAVGWKVLNCDGHDFIS----ITNAVNEAYKASKPVVIFAKTVRGKGFPPIENTHKQRSSPDDAR................................................................................................................................................................................................................................................................................................................................................................... 275
8 -35.000[C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit  ali follow..  20  1..................................................................................................................................................................................................................................................................................................................DPDIPEGTEMVMTTVREALRDAMAEEMRADEKVFVMGEEVAEYQGAYKITQGLERRVIDTPITEHGFAGIGVGAAMTGLKPIVEFTFNFAMQAIDQIVNSAA--GAPMVFRGP-SGAAARVGAQHSQCYA-AWYSHIPGLKVVMPYTAADAKGLLKAAIRDPNPVIFLENEIGQSFEVPKLDDFVLPIGKARIHRKGKDATIVSFGIGMTYAIKAVAGIDVELIDLRTIRPMDLPTVIESVKKTGRLVTVEEGFPQSSVGDFIANQVMRAALDAPILTIAGKDVPMPYAA--NLEKLALPNVDEVVQAVKTVCY 334
9 -34.600[C] KOG0524 Pyruvate dehydrogenase E1, beta subunit  ali follow..  20  29.....................................................................................................................................................................................................................................................................................................................SSSSNGVKEMTVRDALNSAMEEEMKRDDRVFLIGEEVAQYNGAYKISRGLPKRVIDTPITEMGFTGLATGAAFAGLRPICEFTFNFSMQAIDHIVNSAA--ACPIVFRGP-NGPAAAVAAQHSQHFA-PWYGSIPGLKVVSPYSAEDARGLLKAAIRDPNPVVVLENKTFPISKEALSEDFVLPFGLAKVERPGKDITIVGESISVVTALEAADGVEAEVINLRSIRPLDINTIAASVKKTNRIVTVDQAYSQHGIGSEIAAQIMESDLDAPVERVSMADVPMPYSHPVE--AASVPNADVVVAAAKKCLY 364
10 -18.200[C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit  ali follow..  11  8.ALGLTDQEAVDMYRTMLLARKID----ERMWLLNRSGKIPFVISCQGQEAAQVGAA-------FALDREMDYVL--PYYRDMGVVLAFGMTAKDLMMSGFAKAADPNSGGRQMPGHFGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQGDFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVENISDRAIGYGMPGVTVNGNDPLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKK----SDPLLTYQAYLKETGL--SDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK................................................................................................................................................................................................................................................................................................. 330
11 -16.100[C] KOG1182 Branched chain alpha-keto acid dehydrogenase complex, alpha subunit  ali follow..  10  103...RIPCYRVLDRIIPDSDFIPVSEKLAVRMYEQMRQGRISFYLTSVGEEAINIASAAAL--------SPDDVVL--PQYREPGVLLWRGFTLEEFANQCFGNKADYGKGRQMP----ISSPIATQLPQAAGVGYSLKMDKKNACTVTFIGDGGTSEGDFHAGLNFAAVMEAPVVFICRNNGWAISTHISFRSDGIVVKGQAYGIRSIRVDGNDALAVYSAVRSAREMAVTEQRPVLIEMMTYRVGHHSTSDDSTKYRAADEIQYWKMSRNPVNRFRKWVEDNGWWSEEDESKLRSNARKQLLQAIQAAEKWEKQPLTELFNDVYDVKPKNLEEQELGL......................................................................................................................................................................................................................................................................................... 455
12 -15.900[C] KOG0225 Pyruvate dehydrogenase E1, alpha subunit  ali follow..  14  48..............EGPPVTTVLTREDGLKYYRMMKADQLYKQKIIRGFCHLCDGQEACCVGLEAGIN-PTDHLI--TAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYANGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQW......................................................................................................................................................................................................................................................................................... 383
13 -13.300[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  14  16...................................................................................................................................................................................................................................................................................................................................LLGNEAIARGAIEAGIDVFAAGTPSSEIADTLSDACRL-YMEYSANEKVAFEVAVGASLAGKRAMATMKHVGVNVAADPLFS-FAYVGARGGFVL----VTADDPSMHSSQQDNRWYGKAAKLPVVEPSSVQEAKDYAKLCFDLSE-PMILRSYTHASGVVELGKIPEKEFSRVEWERHDGDVGIIACGLSYAYTKEALENLNLPVLKLSSMHPLPERLIENFVSQMKKVIVVEEV--DPFVELHVRAMGLAEVY----------------GKMNGYMPMNYYNVGRVETGIAKALG 348
14 -11.400[C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit  ali follow..  9  10.....................................................................................................................................................................................................................................................................................................................................NTAAAHISYAFTDVAAIYPITPSSPMAEHVDEWATQGRKNL--SEAGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYK-IAGELLPGVFHVSARALATHSLNIYGDHQDVMAARQT-GCALLAEGSVQEVMDLSAVAHLVAI-PFINFFDG-----RTSHEIQKVEVMDYEDLREDADRVIIAMGSICDTIEETAKGEKVGVLKVHLYRPFSVEHFLKIPKTAKKIAVLDRTKEAGSQAEPLYLDVVKAFYNSDVRPVIVGGRFGLGLKD--------TLPVHIYSVYENLKL 382
15 -10.900[C] COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes  ali follow..  11  175ITNTEEKRWIQQRIESVVGKPTFSDAEKRRFLSELAAEGLEPGAKRFSLEGGDSLVTMLKEMIRHAGKNGTREVVLGMAHR--------GRLNVLINVDLFDEFAGKHKEHLGTGDVFNPSHLEIVSPVVIGSVRARR-EARSNMVLPITGDAAITGGVVQETLNMSQGYEVGGTVRIVINNQTSNPLDARSTQYCTDIAKMVQAPIFHVNADDPEAVAFVTRLALDFRNTFKRDVMIDLVCYRRHGIKKHPTPRKIYADKLIEQNIASLEDATEMVNLYRDALDHGDCVVEEWRPEMQSRVAKIYSDRALMASGEKPFDWGGAETLAYATLVDEGIPIRLSGEDAGRGTFFHRHAVIHNQKVWDSVLSEEAVLAFEYGYATAEPRTLTAQFGDFANGA--QVVIDQFIRMCGLVMLLPH-GYEGQ-GPEHSSLERYLQLCAEQNMQVCIPSTPAQVYHMIRRQALRGRRPLIVMSPKSSLDELANGSFLPAIGEIDELDPKGIKRVVMCSGKVYYDLLEQRRK-DVAIVRIEQLYPFPHQAVQSVLEQYHDFVWCQEEPLNQGAWYCSQHNF--REVIPFGASLRYAGRPASASPAVGYLSVHQKQQQALVNDALNV.. 934
16 -9.520[R] COG4032 Predicted thiamine-pyrophosphate-binding protein  ali follow..  13  2............................................................................................................................................................................................................................................................................................................................YVVNPEEKVIEIMKQTG---DLAATLP-----CDRIKNLLPLVSENFPEIKLTEENGVGICAGIYLAGGKPMMLIQSTGLGNMINALESLNVTCKIPLPILASWRGVYKEGIEAQLGAHLPSILEGLTYTIIGETEKLPLLENVILDAFE-NSRPHIALVSPKQAAGMPIKPEIMERTCRFSLTSGTLKPFML............................................................................................................... 201
17 -9.460[C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit  ali follow..  16  67...........................................................................................................................GRTLPVATAAKLANH----SLHVIAVAGDGDCYGG--GNHFLHAIRRNPNITLIVHDNQIYGLTK------------------------GQASPTTAKGTRTKVQPSGVPAEPMNPLALAISQDCSFVARGFAGDPEYLKELMKAAITHKGFSLLDILQ.................................................................................................................................................................................................................................................................................................................................................. 196
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Jaroszewski L, Li W, Godzik A. A segment alignment approach to protein comparison. Bioinformatics. 2003 Apr 12;19(6):742-9.