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Query: [R] COG1161 Predicted GTPases, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYCIGCGAKIQTEAKNALGFLPAGALKKKIAERDQMEAVQAGDEGSEASIKTEDLYCQRCFRLRHYNEIAPTSLTDADFLRLLKEIGQHDALIVNVVDIFDFNGSLIPNLHKLTGGNDLLMVANKRDVLPKSLKVGKLTAWLREQAASRSLKPKDILVTSAQNKDDVAELMEAIEYYRRGRDVYVVGVTNVGKSTLINAIIKSASGSEDVITTSRFPGTTLDKIEIPLDEDSALIDTPGIIHRGQIAHYLEPEDLKYVSPRKEIKPKTYQLDPEQTLFFGGLARFDFISGERQGMTAYFDNEINVHRTKLEGATEFYEKHKGELLAPALVGAKLVRREFKITDKSDIVFSGLGWVRVPQKAVVAAWVPEGVDVVVRKALIGLast
1 -116.000[R] COG1161 Predicted GTPases  ali  100  1MYCIGCGAKIQTEAKNALGFLPAGALKKKIAERDQMEAVQAGDEGSEASIKTEDLYCQRCFRLRHYNEIAPTSLTDADFLRLLKEIGQHDALIVNVVDIFDFNGSLIPNLHKLTGGNDLLMVANKRDVLPKSLKVGKLTAWLREQAASRSLKPKDILVTSAQNKDDVAELMEAIEYYRRGRDVYVVGVTNVGKSTLINAIIKSASGSEDVITTSRFPGTTLDKIEIPLDEDSALIDTPGIIHRGQIAHYLEPEDLKYVSPRKEIKPKTYQLDPEQTLFFGGLARFDFISGERQGMTAYFDNEINVHRTKLEGATEFYEKHKGELLAPALVGAKLVRREFKITDKSDIVFSGLGWVRVPQKAVVAAWVPEGVDVVVRKALIG 381
2 -35.600[R] KOG2485 Conserved ATP/GTP binding protein  ali follow..  17  3.............................................MMLKKTVKKGLIGGMSFAKDAGKINWFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNVIRFFKWTRHFESSK---QDCIAINAHSRSSVMKLLDLVELKEPTLLVMVVGVPNVGKSALINSIHQPVQERLKRATVGPLPGVTQDIAGFKIAHRIYVLDSPGVLVPSIPDIETGLKLALSGSVKDSVVGEERIAQ............................................................................................................. 241
3 -27.500[R] KOG2484 GTPase  ali follow..  15  72..........QRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAVTKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVGNKRLVLVLNKADLVPRENLNNWIKYFRRSLGRRKLREMKTEKAMQGSVCIGAELLMSMLGNYKTSIRVGVVGIPNVGKSSIINSLTRG-----RSCMVGSTPGVTKSMQEVELDSKIKLIDCPGIVFTSGGEN--------------------------SHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFEEFFAKKAARMGKFLKKGVPDVVAAARSVLNDWGKI.......................... 413
4 -26.600[R] KOG2423 Nucleolar GTPase  ali follow..  17  89.......VHVTETESFEYTFGKKSLRKKAKLTEASLEEMSKSAEDRDVKYKPELDL-KELGDRPENMNPLFRAGQSNRVWGELYKVIDSSDVVVQVVDARDPMGTRCRHVEEFLPHKHLVTVINKVDLVPTWVTRKWIG-ELSKEMPTIAFHASINNSFGKGAVINLLRQFAKLHPDRPQISVGFIGYPNVGKSSLVNTLRKK-----KVCKTAPIAGETKVWQYVMLMRRIYLIDSPGVVYPQ--------------------------GDSETQIILKGVVRVENVKDPENHVQGVLDRCKPEHLRRQYGIPEFTDVDDFLTKIAIKQGRLLKGGDPDIVAVSKVVLNEFGKL.......................... 412
5 -21.900[R] KOG1424 Predicted GTP-binding protein MMR1  ali follow..  12  115..........................RRPNWNQNTTPEELKQAEKDNFLEWRRQLVRLE----EEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKEKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWSAQKRQIHNFSHLVSKQELLELFKELHTGRKVGLVGYPNVGKSSTINTIMGN-----KKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAE-------------------------MTCSGILPIDQMRDHVPPVSLV--------------CQNIPRHVLEATYGINIITPREDEDPHRPPTSEELLTA--GFMTAHGQPDQP----RSARYILKDYVSG 542
6 -17.900[R] COG0218 Predicted GTPase  ali follow..  17  27.....................................................................................................................................................................................EIALAGRSNVGKSSFINTMLNRK----NLARTSGKPGKTQLLNFFNIDDKMRFVDVPGY--SKKEREKWGCMIEEYLTTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESAIKKKLN........................................................... 166
7 -17.600[R] COG1160 Predicted GTPases  ali follow..  20  69...........................................................................EEKMAEQSLLAIDEADIVLFLVDARAGLTAADIGIANYLQNKITVVVANKTDGIDADSHCAEFYQ----------LGLGEIEQIAASQGRGVTQLMEQVEEQDKNIKIAIVGRPNVGKSTLTNRILGE-----DRVVVFDMPGTTRDSIYIPMGQQYTLIDTAGVRKRGKVHLAV--EKFSVIKTLQAIQDANVVL-----LTIDARENISDQDLSLLGFILNAGRSLVIVVNKWDGLDQDVKDRVKSEL........................................................ 351
8 -17.400[R] COG1084 Predicted GTPase  ali follow..  20  54...........................................................................RDRLKMIIQRIPDIESLPEFYIDVTVGVDELKKSLGAL-AVGILNQLESDYMARIKRSKPSDASHLRREAFGRISSVIKRIEGDLDFLDFAKNKLRNMPTVDLDAFTVVIAGFPNVGKSTLLRTLTGAE------PEVADYPFTTKGIQIGHLEKRIQVIDTPGLLDR.......................................................................................................................................... 222
9 -16.600[R] COG1162 Predicted GTPases  ali follow..  23  103...........................................................................RTCLSRGAAGDGGGEQLIAANLDTIFIVTSVGKDLERYLSGASPVILLNKIDLADDPARLVEKIRDVTGDVP--------VIPLSALSKTGLDALGPYL---NPGETVALVGSSGVGKSTLINAFLGETVQKTADIRKDDEKGTTTVRQMFLLPNGAVLIDNPGI............................................................................................................................................. 268
10 -15.700[R] KOG2486 Predicted GTPase  ali follow..  14  137.....................................................................................................................................................................................EFALVGRSNVGKSSLLNSLVRRK----RLALTSKKPGKTQCINHFRINDKWYLVDLPGY--PHELKQDWNKFTKDYFLNRSTLVSVFLLVDASIPV-----------KPIDLEYASWLGQNQVPMTLIFTKCDKRKKKKNGGKKPEANIKEFQDLIQGFFETTPPWIVTNQGRDEI........................ 304
11 -15.500[R] COG3596 Predicted GTPase  ali follow..  19  16..............................................................................................................................................................LSGLPLWVSERILQQINQLHYEPVIGIMGKTGAGKSSLCNALFAG-----EVSPVSDVAACTRDPLRFRLEHFMTIVDLPGVGESGVRDTEYAALYREQLPRLDLI..................................................................................................................... 120
12 -13.200[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  12  7.......................KRITVVPNGKEFVDIILSRTQRQTPTVVHKGYKINRLRQFYMRKVKYTQTNFHAKLSAIIDEFPRLEQI--DLLHVLYNKDHYKLALGQVNTARNLISKISKVKLLKYGDSLYRCKCLKVAALGRMCTVLKRITPSLAYLEQIRQHMARLPSIDPNTRTVLICGYPNVGKSSFMNKVTRAD------VDVQPYAFTTKSLF----YLRYQVIDTPGILD........................................................................................................................................... 227
13 -12.200[R] COG1163 Predicted GTPase  ali follow..  14  5...................................................................................................................VEKIKAIEDEMARTQKNKATSFHLGQLKAKLAKLRRELLTSASSGSGGGAGIGFDVAR----TGVASVGFVGFPSVGKSTLLSKLTGTE------SEAAEYEFTTLVTV----GAKIQMLDLPGIIDGAKDGRGRGKQVIAVARTCNLL..................................................................................................................... 146
14 -12.100[E] COG4917 Ethanolamine utilization protein  ali follow..  11  50..........................................................................NHPRWYHALITTLQDVDMLIYVHGANDPESRLPAGLLDIGVSKRQIAVISKTDMPDADVAA------TRKLLLETGFE-EPMFELNSHDPQSVQQLVDYLASLTKQEEA...................................................................................................................................................................................................... 151
15 -12.100[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  15  1................................................................................................................MGIIERIKEIEAEMARTQKNKATEYHLGQLKAKIAKLRTQLLEPPKGASGGGEGFE-------TKYGHGRVALIGFPSVGKSTLLTMLTGTH------SEAASYEFTTLGVIHYN-DTKIQLLDLPGIIEGASEGKGRGRQVIAVAKSSDLV..................................................................................................................... 143
16 -11.600[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  14  5...................................................................................................................LAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDV-----AKTGDARIGFVGFPSVGKSTLLSNLAGVY------SEVAAYEFTTLTTV----GAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLI..................................................................................................................... 145
17 -11.200[R] COG0486 Predicted GTPase  ali follow..  15  134......................................................................................LAQAEAIADLIDASS-EQAARSALKSLQGEFSNKVNQLVDSVIYLRTYVEAAIDFPDEEIDFLADGKIEAHLNDIITQ--LDHVRSEAKQLREGMKVVIAGRPNAGKSSLLNALAGR-----EAAIVTDIAGTTRDVLREHIH-PLHIIDTAGLREATDEVERIGIVRAWSEIEQADR..................................................................................................................... 309
18 -11.000[R] COG1159 GTPase  ali follow..  17  7..................................................................................................................................................................................YCGFIAIVGRPNVGKSTLLNKLLGQK-----ISITSRKAQTTRHRIV---PYQAIYVDTPGLHMEE-----------KRAINRLMNKAASSSIGDVELVIF--VVEGTRWTPDDEMVLNKLRDGKAPVILAVNKVDNVQEKVDLLPHLQFLASQMNFLDIVPISAETGMNVDTI--------GIVRKHLPEAIHHFPEDYITD 187
19 -10.900[J] KOG1191 Mitochondrial GTPase  ali follow..  17  261......................................................................................LSQAENVEKLISAKS-SAAADAALEGIQGGFSSLVKSLRAQCIELLTEIEARLDFEDEMPPLDIESVINKITSMSQDVESALDTANYDKLLQSGLQIAIVGRPNVGKSSLLNAWSKS-----ERAIVTEVAGTTRDVVEANVT-PITLLDTAGIRETNDIVEKIGVERSETAAKVADV..................................................................................................................... 435
20 -9.160[K] KOG2906 RNA polymerase III subunit C11  ali follow..  13  4..CPTCGNLLRYEGGGNSRFIQRQVEIKKKQLLVKKSIEAVVTKDDIPTAAETEAPCPRC----GHDKAYFKSMQIRSADEPES......................................................................................................................................................................................................................................................................................................... 91
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.