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Query: [R] COG1162 Predicted GTPases, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNNHSETESSGHNSVHGNNDNIPGWNEELELAFSAYKGLYLAGRISSRHKTVCEVLVPGAVVQAGISGALQRIGKQPVVGDFVVLLDQPETGSRMVVNILPRRTCLSRGAAGDGGGEQLIAANLDTIFIVTSVGKDLNLRRLERYLAIVYSSGASPVILLNKIDLADDPARLVEKIRDVTGDVPVIPLSALSKTGLDALGPYLNPGETVALVGSSGVGKSTLINAFLGETVQKTADIRKDDEKGRHTTTVRQMFLLPNGAVLIDNPGIREIQLGDSAEGLEKAFSEIVDAARNCKFKDCTHRNEPGCAVLQAVRDGIIPEERLESYHRLTDELSFQSKKAEIGLKRLEKERYREMAVNIKKYRKFTGKPLast
1 -116.000[R] COG1162 Predicted GTPases  ali  100  1MNNHSETESSGHNSVHGNNDNIPGWNEELELAFSAYKGLYLAGRISSRHKTVCEVLVPGAVVQAGISGALQRIGKQPVVGDFVVLLDQPETGSRMVVNILPRRTCLSRGAAGDGGGEQLIAANLDTIFIVTSVGKDLNLRRLERYLAIVYSSGASPVILLNKIDLADDPARLVEKIRDVTGDVPVIPLSALSKTGLDALGPYLNPGETVALVGSSGVGKSTLINAFLGETVQKTADIRKDDEKGRHTTTVRQMFLLPNGAVLIDNPGIREIQLGDSAEGLEKAFSEIVDAARNCKFKDCTHRNEPGCAVLQAVRDGIIPEERLESYHRLTDELSFQSKKAEIGLKRLEKERYREMAVNIKKYRKFTGKP 369
2 -16.700[R] COG1161 Predicted GTPases  ali follow..  23  76......................................................................................................DADFLRLLKEIGQHDALIVNVVDIFDFNGSLIPN-----LHKLT-----GGNDLLMVANKRDVLPKSLKVGKLTAWLREQAAILVTSAQNKDDVAELMEAIRRGRDVYVVGVTNVGKSTLINAIIKSASGSEDVITTSRFPG--TTLDKIEIPLDEDSALIDTPGI..................................................................................................... 240
3 -14.900[R] KOG2485 Conserved ATP/GTP binding protein  ali follow..  17  38..................................................................................................................RAIRNRLKLSDLVIEVRDARIPLSSADLQSQM-----SAKRRIIALNKKDLANPNVFFKWTRHFESSKQDCIAINAHSRSSVMKLLDLVEPTLLVMVVGVPNVGKSALINSIHQPVQERLKRATVGPLPG--VTQDIAGFKIAHR-YVLDSPGVLVPSIPDIETGLK-------------------------LALSGSVKDSVVGEERIAQYFLAILNIRGTPLHWKYLVEGINEGPHADCIDKPSYNLKDLRH. 284
4 -13.800[R] COG3596 Predicted GTPase  ali follow..  20  1.............................................................................................................................................................MVMKNFEVLQPLQNSLSGL-----------PLWVSERILQQINQLTHYEPVIGIMGKTGAGKSSLCNALFAGEVSPVSDVAA-------CTRDPLRFRLQIGEHIVDLPGVGE................................................................................................... 98
5 -13.300[R] COG0218 Predicted GTPase  ali follow..  17  28................................................................................................................................................................................................................IALAGRSNVGKSSFINTMLNRKNL----ARTSGKPGK--TQLLNFFNIDDKMRFVDVPGYGYARVSKKEREIEEYLTTRENLRAVVSLVDLRHDPS------------ADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESAIKKKLN......... 166
6 -11.900[R] KOG2486 Predicted GTPase  ali follow..  17  138................................................................................................................................................................................................................FALVGRSNVGKSSLLNSLVRRKRL----ALTSKKPGK--TQCINHFRINDKWYLVDLPGYGYASAPHELKQTKDYFLNRSTLVSVFLLVDASIPKPIDLEYASWLGQNQVPMTLIFTKCDKRKKKKNGGKKPEANIKEFQD.................... 278
7 -11.800[R] KOG2484 GTPase  ali follow..  16  147.......................................................................................................................VIENADVVLEVVDARDPLGTREVERAVRGA-PGNKRLVLVLNKADLVPRENLNNWIKYFRRSGPVTAFKASTQDQGAELLMSMLGN--RVGVVGIPNVGKSSIINSLTRGRSCMVGST------G--VTKSMQEVELDSKIKLIDCPGIVFTSGGENSHAVLKNAQRVGDV------------KDPFTIAESVLKR-MYDITNYDTFEEFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNTGK...... 412
8 -11.300[R] COG1160 Predicted GTPases  ali follow..  18  12............................................................................PNVGKSTLFNRLTRTRDALVADFLTRDRKYTEEGVEEKMAEQSLLAIDEADIVLFLVDARAGLTAADIGIALRQRQNKITVVVANKTDGIDADSHCAEFYQ------EIEQIAASQGRGVTQLMEQVLA--KIAIVGRPNVGKSTLTNRILGEDRVVVFDMPG-------TTRDSIYIPMERDGTLIDTAGVRKLLTIDARENISDQDLSLLGFI-----------LNAGRSLVIVVNKWDGLDQDVKDRVKLDRRLDFIDFARVHFISALHGSGVGNLFDSIKEAYACATQ. 390
9 -11.000[R] KOG2423 Nucleolar GTPase  ali follow..  19  169.......................................................................................................................VIDSSDVVVQVVDARDPMGTRHVEEFLRKE-KPHKHLVTVINKVDLVPTWVTRKWIGELSKEMPTIAFHASINNSFGKGAVINLRPQISVGFIGYPNVGKSSLVNTLRKKKVCKTAPI------G--ETKVWQYVMLMRRIYLIDSPGVTQIILKGV-ENVKDPENHVQGVLDRCQYGIPEFTDVDDFLTKIAIKQGRLLKGGDPDIVAVSKVV.................................... 403
10 -9.910[E] COG4917 Ethanolamine utilization protein  ali follow..  40  2..............................................................................................................................................................................................................KRIAFVGSVGAGKTTLFNALQ----------------GNYTLARKTQAVEFNDKGDIDTPG...................................................................................................... 46
11 -9.620[EJ] KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b  ali follow..  15  22...................................................................................................................................................................................................LNKTNLRLLKGHRYGLCGRNGAGKSTLMRAIANGQLDGFPDVGSLSGGWKMKLELARAMLQKADILLLDEP-TNHLDV-SNVKWLEEYLLEHTDIT-------VSHDSDTVCTDIIHYENKKLAKGNLAAFVEQKPEAKSYYTLTDSNAQMRFPPPGILTGVKSNTRAVAK... 248
12 -9.500[I] KOG0064 Peroxisomal long-chain acyl-CoA transporter, ABC superfamily  ali follow..  12  392.........................................................................GSDVGLGTVPNTAISESRVSERTQYLTTARNLLISRLMSSYKEIVSLAGYTFRVAGMMDVFEETALGVYCKTSVMESNQSNGIIEFRNGKPIAKGRIIYSDDPKNMSISLRAVPVVTPNCD-VPKLTLCIEPGVHLLITGPNGCGKSSLFRILSGLWPIYAGELH----IPRPVKDVPCMFYIPQRPYMSIGSLCDQIIYPDTREDMKRKHITENELRSILKMVSLEHIAQRD---KDILSGGEKQRMAIARLFYHRPRYALLDECTSAVSIDVESSIYEIAKGMGITLLTITHRP 695
13 -9.470[R] KOG1424 Predicted GTP-binding protein MMR1  ali follow..  18  138................................................................................EWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCED-----LECYVKEM-DANKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWSALAGASKQELLELFKE--TVGLVGYPNVGKSSTINTIMGNKKVSVSAT------GH--TKHFQTLYVEPGLCLCDCPGL--------------VMPSFVSTKAEMTCSGIDQMRDHVPPVSLVCQ--NIPRHVLEATYGINIITPREDEDPHRPPTSEE-----TAYGYMRGFMTAHGQP 526
14 -9.090[J] KOG1191 Mitochondrial GTPase  ali follow..  18  213..............................................................................TREDV-VELQCHGSEVCLRRVLRTEAGARLAEPGEFTLRAFLNGRLDLVEKLISAKSSAAADAALEGICIELLTEIEARLDFEDEMPPLDIESVINKITSMSQDVESALDTANYD-------KLLQSGLQIAIVGRPNVGKSSLLNAWSKSERAIVTEVA-----G--TTRDVVEANVTVRGVLLDTAGIRETNDIVEKIGVERSETAAKV................................................................................ 432
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Liu T, Rojas A, Ye Y, Godzik A. Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family. Protein Sci. 2003 Sep;12(9):1872-81.