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Query: [J] COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPETAAEMINTIKSSTEELIKSIPNSVSLRAGCDIFMRFVLRNLHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFIADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSKQGNQLYTLLEQKGIPVTLIVDSAVGAVIDKVDKVFVGAEGVAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMFPLSSDDLPMAGPPLDFTRRTDDLEDALRGPTIDYTAQEYITALITDLGVLTPSAVSEELIKMWYDLast
1 -101.000[J] COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family  ali  100  1MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPETAAEMINTIKSSTEELIKSIPNSVSLRAGCDIFMRFVLRNLHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFIADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSKQGNQLYTLLEQKGIPVTLIVDSAVGAVIDKVDKVFVGAEGVAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMFPLSSDDLPMAGPPLDFTRRTDDLEDALRGPTIDYTAQEYITALITDLGVLTPSAVSEELIKMWYD 305
2 -90.000[J] KOG1466 Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3)  ali follow..  39  59NEKSFNVIEEFNNWRKQPDLAEAVAAIRALAAVIRASEASTMMELEIELKKASDTLKSWDKTSISLTAGCDLFIRYVTRTSAEYEDFNSAKSRLLERAEKFGEISCKARRIIAMLSQDFIFDGCTILVHGLSRVVLEILKTAAQNNKLFRVLCTEGRPDGTGVLLSSELSKLDIPVKLLLDSAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAHSMNKPVYVAAESYKFARLYPLDQKDMAPALRPIEFGV-KIPTKVEVERSARDYTPPQYLTLLFTDLGVLSPSVVSDELIQLY.. 361
3 -83.600[J] KOG1465 Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7)  ali follow..  19  6LKEITQLIHAIKVGLVEGSYNITNKTLDIFKYIIMSKSWQNADALMQIVRDQCKILQAALPQETVTSNIARRILKLTRESVDYSVPQHGLREALLDHLQEVETELETSSENICVQAEEHIHSSEIILTLGHSRSVENFLKRAIKKRQFLTIIVAECAPACRGHNLAASANEKNVEIVVIPDAAIFAMMSRVNKVIIGTHSVLANGGLRAACGAYTVALAAKHYSVPVIVLAPMYKLSPLHLCEQDAFNMVGCAEDVIDSIPAREAKVYSPMFDYVPPELVTLFISNTGGHAPSYVYRLLTELYHP 347
4 -82.900[J] KOG1467 Translation initiation factor 2B, delta subunit (eIF-2Bdelta/GCD2)  ali follow..  21  143.PAVIRLGLKLANYKIFGSNQRCIDLLKTFKIVIQDYQTPYSRHLTTHINSQIAYLVSTRPLSISMGNAIRFLKLEISVL-DIDLTDDEGKELLLEKIDSYIDRIIIAGQVIVQAATEKIQDGDVILTYLHSSTVNDVLIHAKNVGKKFRVVVVDSRPEFEGRVCLKLLTEHGIECTYVMISALSYIMQEVTKIFLGGHAMLSNGALYSRAGTSLISLLGHESNVPVIACCESYKFTERIQLDSLVYNELAPGDQLVNWKSVKNLKLLSLKYDVTPPRLITVCVCEMGLLPSTSVPAIINEFK.. 463
5 -80.300[J] KOG1468 Predicted translation initiation factor related to eIF-2B alpha/beta/delta subunits (CIG2/IDI2)  ali follow..  20  30VRGVEDGWKVINKMQVRGAPAIAIVGCLSLAVEINPEDFENKKSLRQEIEGKLNYLVSARPTAVNMKIAADELITLANELYDEAIDVTQMKHRFLDATEAMLKKDIADNRAIGANAPAGSTGSVRVLTHCNTGTALGVVRQLAELGKLEHVYCTETRPYNQGARLTAELVHEKFPATLVLDSMVAALLRNVAAVVVGADRVASNGDTANKIGTYQIAVVAKHHDVPFYVAAPLTSIDLAIPGGDHIIIEERPDREMTHRIAAPGINCWNPAFDVTPASLITGIITERGVFKPAELKEAITKLLES 364
6 -75.400[J] COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family  ali follow..  22  32CKTHEEVAHAIKEMIVRGAPAIGVAAAFGYVLGLRDYKTG---SLTDWMKQVKETLARTRPTAVNLFWALNRMEKVFFENADR----ENLFEILENEALKMAYEDIEVNKAIGKNGAQLIKDNAGALATVDYGTALGVIRAAVESGKRIRVFADETRPYLQGARLTAELMKDGIEVYVITDNMAGWLMKLIDAVVVGADRIALNGDTANKIGTYSLAVLAKRNNIPFYVAAPVSTIDPTIRSGEEIPIEERRPEEVTHRIAPEGVKVLNPAFDVTENTLITAIITEKGVIRPPFEENIKKIL... 341
7 -8.340[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  16  10.............................ILEHLQKQGKCSVEELAQYFDTTGTTIRKDLVILENAGTVIRTYGGVVLNKEESDPPIDHKTLINTHK-----------KALIAAAAVKYIHDGDSIILDAGSTVLQ--MVPLLSRFSNITVMT-------NSLHIVNALSELDNEQTILM-SFHGQLAENFDKLFMGTDGIDLNVGVTTFNEVYTVSNAMCNAAREVILMADSSKFGRKS------------------------------PNVVCSLETVDKLITDAGI................ 234
8 -6.860[G] COG0120 Ribose 5-phosphate isomerase  ali follow..  13  6.....................................................................................................TSTDSPEKRAAGIAAAGLVSSGMLV---GTGSTVAYTIKELGRRVREEGLDILGVVTSYQSEMLAIEA---GIRLTTLAQ------HPELDLAIDGADQIDSELRAIKGGGAAHTR-IVSVSARRFVVVADESKTSKQL................................................................. 135
9 -6.560[S] COG2121 Uncharacterized protein conserved in bacteria  ali follow..  10  8.......................................................................................KNIVLKVVPRLAFGVLWLLHKTCKNRYFLAQDLKEKPFIVSCWHGELGMIGFAYLRLQKPSVYVIASQHF---DGSIAAGLFESFGFKNI--KKGGVKVLIEGLKRLKEGCDAITPDG--SIADGVIALAQKSGVGISACRVVCKNA....................................................................... 158
10 -6.500[R] COG0496 Predicted acid phosphatase  ali follow..  15  4......................................................................................................................LLTNDDGI----HAEGLASLERVARTLSDDVWVVAPEQDQSGYAHSLSKHFAVRGTPTDCVIMGVKKILPGAPDVILSGINSGANIADDVTYSGTVAGAMEGALLGIRSIALS.......................................................................... 124
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Jaroszewski L, Li W, Godzik A. A segment alignment approach to protein comparison. Bioinformatics. 2003 Apr 12;19(6):742-9.