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Query: [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLEGTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTGASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHVVKDLEEVEILast
1 -124.000[R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III  ali  100  1MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLEGTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTGASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHVVKDLEEVEI 309
2 -61.400[R] KOG2121 Predicted metal-dependent hydrolase (beta-lactamase superfamily)  ali follow..  21  486.EIVILGTGSSQPSKYRNVSAIFIDLF--SRGSLLLDCGEGTLGQLKRRYGLVRKLRCIWISHIHADHHTGLARILALRSKLLKGTHEPVIVVGPRPLKRFLDAYQRLEDLDMEFLDCRSTTAASLESGGEAEGSLFTQGSPMQSVFKRSDISMDNSSVLLCLKNLK---------KVLSEIGLNDLISFPVVHCPQAYGVVGEQILGWKMVYSGDSRPCPETVEASRDATILIHEATFEDALIEEALAKNHSTTKEAIDVGSAANVYRIVLTHFSQRYPKIPVID-----ESHMHNTCIAFDLMSINM 797
3 -54.300[R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I  ali follow..  19  22FRVKIWGARGTLPVSGENTICIEVRC---GDHVLLFDAGSGLHPAGLALRAEGITDVNLFFSHCHYDHIVGFPYFKPFYN-----SSNDVAIWSGHTTREMLKDFMSPPWFPVPLEICCAKIA-KAGDVLDVHPGLSIRTGMLNHPGNAIGYRLDW--------------------------------------------------EGKSLAIITDTEIDETVLDLIRDVDLFLYDAMFTDEEMGLYRGYGHSSWQQAIRLAKLADAKNVGFIHHAPSRSDEELDDIEKQAKAEFNGAFAAMDGQVIEI 292
4 -35.700[T] COG5212 Low-affinity cAMP phosphodiesterase  ali follow..  10  25FTLYSLGQNGGPLE--SCCSSHLIS-DGAFQEIISLDGGSHNESYAKAWHLSEQRIKTFLITHCHLDHIYGAVINSAMFG-----PQNPRTIVGLNYVIDTLKKHV-WPSLDKAGFINFQVVEPSMYTSL--TTTLSILPFPVNHGLKSSAFLFRNN------------------------------------------------LSDRYFLAFGDVEPDMVASEAQRKLSHILIECSTPDIPDTLL--FGHFCPRHLVNYGVIMPTLTCLLTHLKSHPLQNPADVILEQLESLSSTFKILQRGQFYKF 346
5 -28.300[R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)  ali follow..  14  46MKVIPLASESL-----VRSLALFLKI---GKVGILIDPGKALSLAREKIQEYAKKAQIVTISHYHYDHHTPFFEGIYESS----SVEKAREIYAGKLLIKHPTENINNSQKKRAHEFLKNAKEIAKDIKFADSQSFDFGSFTIEFSPP------------------------VPHGREGSKLGYVLMVLVDDG--------------KKSVLHASDTQLINDKAVIEKNPDILIAGGPPTY-LAHRVGNVKEIGMKNINRIISETNAKIVLDHHIIRD------KGYERFFSELDERPLTFAEFLGKES 319
6 -15.500[A] KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit)  ali follow..  13  4IKITPLGAGQDV-----GRSCLLLSM---GGKNIMLDCGMGYNDEIVPEGPITSHIDCVIISHFHLDHCGALPYMSEIVGYTGP-------IYMTHPTKAIAPILLE-------------------------------DMRKVAVERKGESNFFTTQMIKDCMKKVIPVTLHQS------MVDTDLEIKAYYAGHVLGAAMFWIKVGSQSVVYTGDYNMTPDRH--KCRPDLLISESTYATTIRDSKRCRERDFLKKVHECVAKGG--KVLIPVFALGRAQELCILLETYWERIYFALGLTEKANTY.. 278
7 -15.300[R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II  ali follow..  14  6VKVTIVFENHAGYRKGLIGYHGFSALVESNGYKVLVDTGKVLLNNMHELGIDANDIDVLFITHGHYDHTGGLKEFLKERSEP---------------------------------IEVYAHPGIFDERIALKPRKRDIGIPFQRKELEELGARFNLSPEPLEFLPGFISSGEIKRVTWDRAVGYFPDGRKDP---VRDDMALIVEGSKGLVVISGCGH--SGIINIARHAMELRGSKIAALIGGFHLRGAKKELLDDVVTNMKELGVNALYPGHCTG-------IEEFSYLWSKLDNVEGIYVGKEIKI 272
8 -14.900[A] KOG1137 mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit)  ali follow..  18  22LIVTPLGAGSEV-----GRSCVYMSF---RGKNILFDCGSGMAALPYFDEIDPSSIDVLLITHFHIDHAASLPYFLEKTTFNGR-------VFMTHATKAIYKLLLT--------------------------DYVKVSKVSVEDMLFDEQDINKSMDKIEVIDFHQTVEVN------------GIKFWCYTAGHVLGAAMFMVDIAGVRILYTGDYSREEDRH--QFSPDICIIESTSGVQLHQSRHIREKRFTDVIHSTVAQGG--RVLIPAFALGRAQELLLILDEYWANIYYASPLAKKCMAV.. 291
9 -14.300[J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing  ali follow..  15  2..................LSVISSEI--GVISKKLIDLGVLALRQRNSRG-KQPQPDAYLITHAHSDHHGKSAMLSPR-------------AVCTDKTATALEIRH--------------------------DRKYVGSMCRLGDEIEIEGVRVK---------------------------------TYPTAHTAGAAAFYWENDVGTRILVTGDVKNASKLPP----CDVLITEANYGDESMKCALFESGPVAFGAYEFGKAQRAVELM...................................... 216
10 -14.000[R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain  ali follow..  13  178VRVTFLGGSREV-----GRSCYLLQT---PESRILIDCGSSTPYLYVPEVQPLDALDAVVITHAHLDHCGLVPLLYKF---------------GYRGPIYLTPPTRDLMVLLQLDFLEVAGREGTNPPYSSNLIREALKHT-----------------------------ITLDYGVVTDISPDVRLTFYNAGHILGSAIAFHIGEGHYNIAFTGDFKFEKTRL--FPRLEALVMEATYGGPNDFQPSRKEAEERLIEVINRTLDRGGKVLIPTFAGRSQEVMIVLEEAMREKRLRETYVYLDGMIYEA 447
11 -12.500[A] KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit)  ali follow..  12  5IKLKVFSGAKDE-----GPLCYLLQV---DGDYILLDCGRFGLQYFEELKPFIPKISAVLISHPDPLHLGGLPYLVSKCGLTAP-ATVPVYKMGQMFIYDMVYSHLDVEEFEHTAFEKVEQVKYNQTVVLKGDSGVHFTALPAGHMLGGSIWRICRVT-------------------------------------------------GEDIVYCVDFNHKKE-FDNFNRPHLLITGAHHISLPQMRRKDRDEQLVTKILRTVRQ-KGDCMIVIDTAGRVLEL-LDQLWSNADAGLSTYNLV........ 266
12 -12.500[R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase superfamily)  ali follow..  12  84LFATWLG------------ATVLVDL---EGVKFVTDAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDH------LDADAVKRITNLNPQIKWFVPLGLKKWMKNQ----GIGADGSNTVTELN-ESSEFVKNGKTITIWCLPAQH--------------------------------SGQRGLSDHNHRLWSGWAVIG--------ENRRFYFPGDTGFCKKIGEKLGPFDLAIPIGAYEPR----FMKSHHINPDEAVEVHKLVRARNSIGIHWGTEYYLEPRDKLKELMDA................ 333
13 -12.400[R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily  ali follow..  14  4IKITPLGGVREF--------GKNMYLVEVEEQIFVLDAGDFVIPDITYLLENADRVAGIFLTHGHADSIGALPYIVSELK---------VPVFGSELTIELAKINVK----NYADSRKFNDFHVVTEDTEIDFGKAVISFFSTTHTIPE---------------------------------SLGIVISTNDGNIVYTGDFRFDPAV-----AKGYRTNMRRLAEIGSGVLALLSSSP---NALSTMQSASEHEIYEKIYDYIDDNEGRVIIACNAGNLGR--IQQTIDAAIKLGRRVAFT........ 252
14 -12.000[R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold  ali follow..  16  103DSLTWFG------------SAFLLNV---DNKQLLID---GRNRIMLHLIDEMPPIDAVLITHDHYDHL--------DYRSIVKLNNKVSHFFVPLGCSAHLI----------RWGIPEEKITELNWWEETEYQGLTVALTPSRH--------------------------------SSGRNPFNIDTTLWGGWVILG--------NKTRVYTSGDSGYGPHFKQIGDKYG--FDITLIEGAQYDRNWPDLHMVPEQAIQANLDVGGKTMMLMHWGA---NEPIERALKEAKIREVNIIAPMIGETVLL 359
15 -9.660[R] KOG0813 Glyoxylase  ali follow..  11  13.SVIRILGCNPSAMTLQGTNTYLL---GSGSRRILIDTGDEDVPQYIAHLGDVASIDTILLTHWHHDHVGGVKSIVGTKLAEKDCRVFKFGRTDAPDVCP-------------------EIPTDIKLHPLAHNQEFTTEGANVRHTTDHVVLAMNE-----------------------GTLFSGDCILGEGTAVFEDKSLEKILDIKPQRIFPGHGNVIEEPIGKIE--YYINHRNQREQQILQ-FFVQRPNENLQAMDVVKVV-AAYNVNHHLSKLEKEGKLRVSKSADEEFY.............. 284
16 -9.460[L] KOG1361 Predicted hydrolase involved in interstrand cross-link repair  ali follow..  16  153..............................GTPFTVDA----------RYGCVQGCSAYFLTHFHADHYIGL-----------TKAWSHGPIYCSSLTSRLLRLSLSVNPSS---------IHPLELDVEYTINGIKVTLIEANHCPGAALIHFRLLD-------------------------------------------------GTCYLHTGDFRASKQMQTFNQRVHVLYLDTTYCNPRYKFPSK--EDVLSYVVRITKDFLRKQIVVGSYSIGKECV----YLAIAKALGVKIFANASRRRI.. 353
17 -9.260[S] KOG4736 Uncharacterized conserved protein  ali follow..  12  275.NVTVLQAGSVRPLRDGQVEAVGITLVNDNGYIVLIDTGASSDTSLAKESVTLDQIDSVVITHASPGHMGNM--------------------------NFFAQKPILYHSMEYIGRHVTPTELKERPYRKLSGNVEVWKT----HTQHDLSVLVHNVAGYGTM--------------------------AIVGDLIPSEHLLSEKRDVMIEEGVWDNAIKQNANLIVCMADWIVHGQPFRVLPNYRQKAGCTRLLAQRHLLNQAF-LSFIISLPFHFCLQNFPLRKTVSRFKQLFNS............ 540

FFAS is supported by the NIH grant R01-GM087218-01
1 3 9 8 0 4   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53.