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Query: [S] COG1470 Predicted membrane protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNRYLALLLVLLLLTPSIKLSTAKEVNIVIFKGRILPQERLIIGNYTITVEFGIDNFPYVIVSNGTSKLVIERAEFGASITIENLSITIGSYNARKGLFIVASWSSEGEKHVAKVGRYFEGFEVITVTNSSVTLKRGITTIEVPKDKLILYGRYGIRYSNGTIFLYKLPSVEVKKKEERELVVFYPYSEVTTEVNRSIMLPLTIFNNGTETVNVTFSVVNAPKDWDVKFYYQGIEIKKLKLREKESITLQLKVLPSSAGSHVVKFSINGDIYSFYVNVVQPKMEALKITAPILVQEAEAGSKVTFSVLLSAGEDSVISMDVREPRDWKACILVDGVRAQEIYLRRGETKVVNLILEIPRNASLGYYESKISFTVRKSNGEVIKNETITLGVNIYKTYKGQKATLKLILVDDTGSPVPKALVKVGNESYATDSTGTLEVEMNPGKYVITIEKEGYETKKEEVELGDGEKKELKLLLVREPYYFNVEAQSDIYPIVMEGLSRPFTIVIENLGKSDDEYKLEIRGIPENWNAFFTESAEGNIEVTKVKVKSGETKTVYLKVYPSLNAMPGTYNATITVISSSGIKKEIPVKIKLIGSYNMNVNLLNYRLTITAGEEKTAMMDIFNFGNAPLTNLKITVKGPQGWDVKVDPSQIPSLSPKGRERVTITVKVPEGTPAGDYRVQITVKADQAEWQDTLRVVVRQRSTSTYIGVLILIISFALVLFMMRRIGRRLast
1 -158.000[S] COG1470 Predicted membrane protein  ali  100  1MNRYLALLLVLLLLTPSIKLSTAKEVNIVIFKGRILPQERLIIGNYTITVEFGIDNFPYVIVSNGTSKLVIERAEFGASITIENLSITIGSYNARKGLFIVASWSSEGEKHVAKVGRYFEGFEVITVTNSSVTLKRGITTIEVPKDKLILYGRYGIRYSNGTIFLYKLPSVEVKKKEERELVVFYPYSEVTTEVNRSIMLPLTIFNNGTETVNVTFSVVNAPKDWDVKFYYQGIEIKKLKLREKESITLQLKVLPSSAGSHVVKFSINGDIYSFYVNVVQPKMEALKITAPILVQEAEAGSKVTFSVLLSAGEDSVISMDVREPRDWKACILVDGVRAQEIYLRRGETKVVNLILEIPRNASLGYYESKISFTVRKSNGEVIKNETITLGVNIYKTYKGQKATLKLILVDDTGSPVPKALVKVGNESYATDSTGTLEVEMNPGKYVITIEKEGYETKKEEVELGDGEKKELKLLLVREPYYFNVEAQSDIYPIVMEGLSRPFTIVIENLGKSDDEYKLEIRGIPENWNAFFTESAEGNIEVTKVKVKSGETKTVYLKVYPSLNAMPGTYNATITVISSSGIKKEIPVKIKLIGSYNMNVNLLNYRLTITAGEEKTAMMDIFNFGNAPLTNLKITVKGPQGWDVKVDPSQIPSLSPKGRERVTITVKVPEGTPAGDYRVQITVKADQAEWQDTLRVVVRQRSTSTYIGVLILIISFALVLFMMRRIGRR 728
2 -53.900[M] COG1361 S-layer domain  ali follow..  12  1MKKAM-ALILGLILGSLVQPSLAQGPEL-LYEGYMNKGDYLLVGKWKGVFDPQKVRTLLQNQTFLRAMAETLGYNPDNPIEYAEFLRWLSTASQMEIWNAIVKTIDEHPELGIRLEDISKPYYVPNARPVGVNETIKIEY------RGKTVYITVLSAYPNGVKVSISGPIQWRASMVQGLLLSKIDVKGTIKPGQYFTVEVHLKNIGSRKRFVTAVLSPTPV--QGTLYPVESSVKFILIEPGEDKVIKFLYENAKPGDYPLYLTVIQRTLYDTAVVTVARDYEANFIVQNVPRIVHPGEDFTINVTFKNMGEDPVRGTLILEDITGRVFTPVSPSNFYRFVDPGMEFNETFKLHVSESAKTGTYTFKIRLKYYSGNSNQEKTQDFTISTTVEKIEPGTTFNITLRLRNVGEGYAKGLEVRIVNQTIEIHFTLKANERLENNIYPIKIEIKYLSSPD---DKLISDERIIGIDVTGSEKLVISSISTSPSRILPGTSNVEISFKIENVGDGKADYIIIMPNPQFPFKLSETSDQIINVG----SLGKGDSAQASFKVDVDENAKSGRYLIPLTIETGKFRQIEVNIPVIIAEKPKLVITDVRFGEKPVQGKDVNIYITVKNVGGEQAESVVIEGVVRSSQPFTLVKRTIGTLNPNQTGEGVITLSIEKDAVPKVYNILIRMRDNVYVFEGTIKVPVKENTESK-IGAGILAIVITLLTYFKRR.... 898
3 -15.700[S] COG4885 Uncharacterized protein conserved in archaea  ali follow..  12  44...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NDSHAVVTFVTEVRKENVEEFAIKAKIYDIQTDLLLNELEET-------SPESRFTAELTIPFE-----KTRDYKIVLYLQVGDRIYDSYRLTLRNLRNLEASLVDSDFLLTSVKNGSVGFVARFYVESVKDYDVARIKVLQADSNVLVGESWKNVTLQKGKTNIVSAEFEVPDD---YNYVVKLDVWRNGKSWADVLNLA-KSGGVPGF-EVVFALMALAGVALWRKA--RR 301
4 -15.700[U] KOG3317 Translocon-associated complex TRAP, beta subunit  ali follow..  13  45.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FSTCLSEDETRARLLVSKQILNKYLVEKSDLLVRYTIFNVGSGAATKVRLVDSGFHPEAFDVVGGQVDRIAPQTNFTHVLVVRPKAFGYFNFTAAEVSYKAVEESETLQLAVSSEPGEGGAVMTLPSLAIPLALWHQSKSKY-KH 220
5 -14.400[R] COG2373 Large extracellular alpha-helical protein  ali follow..  10  403......VILNGLLRDADGKALPNQPIKLDVYHFTWPLDSNAATGMWHIRANTGDNQYRMWDFHVEDRMALNLTGEKTPLTPKDEVKFSVGAPANGNTLQGQLFLRPLGDIAAENLSRTLDEVQLTLDDKGRGEVSTESQWKETHSPLQVIFQGSLLESGGRPVTRRAEQAIQFASKSVYDYRTDSTVKQPIVDEGSNAAFDVYSDAQGVKKAVSGLQVRSEDEGWQSQFDQKDLIENEQTLDLKADET-GKVSFPVEWGAYRLEVKAPNEAVSSVRFWAGGAVRPDRVTLKLDKASYRPGDTIKLHIAAPTAGKGYADLTIPVDKTWNR----HDLYLSTLVVRPGDKSRLDLALETPAKMRPNQ-PLTVKIKASTKNGEKPKQVNVLVSAVDSGVLN-GQKRYGADIYDIYGQVIEGQGRLAALRFGGDGDELKRGGKPPVNHVNVTLNEQGEGSVTLPIGDFNGELRVMAQAWTADDFGSNVIAELNMPRFMASGDTSRLTLDITNLTDKPQKLNVALTASGL---------ELVSDSPAAVELAPGVRTTLFIPVRALPGYGDGEIQATISGLALPGETVDQHKQWKIGVRPAFPAQTVNYGTALQPGETWAIPADGLQNFSPVTLEGQLLLSGKPPLNIARYIKELKAYPYGCLEQTASGLFPSLYTNAAQLQALGIKGDSDEKRRASVDIGISRQRDNGGFAL---LTAYVMFLVRAGEQG.. 1268
6 -14.000[O] COG4934 Predicted protease  ali follow..  16 1228.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NASIPTPSLMLSSPSYYEHGNFSVSYKDNLNPNLTILNELYISYNGNIIASEPITTSSGVLQINGNDLPYGINLTFTIETANGQTNETSITVMNLPADEYYPTVNIIAPVTGSSQTGSLNITFTYTGFDDTVILYVNGSS---------NVITANVTGKNLYTITEGKG-SSSLPAGNYTVTVLVSKDGQVAKQSANFDIIEYLVIGIVGGLIV--SLAVVA-VMRRH... 1459
7 -13.700[M] COG4932 Predicted outer membrane protein  ali follow..  10 1110............................................................................................................................................................................TKKDSASHEVLADAEFELQNATGSKLKEKLTTDASGNIE-DYKLIETKAPTGYQL-----------------DATPVNFTIDFNQSEAAKVSKTNTAKTGTVMLTKKDSATNA---------------ELADATFELRNEDETLVRENLVTDDNGEISVA---------DLAPGDYKLIETKAPTGYQLDATPVNFTIDFNQSEVEKVSKTNTAKTGTVVLTKKDSATNAELAFELRNESDTLVR--------ENLVTDDNGEISVALAPGDYKLIETKADATPVNFTIDFNQSEAAKVSKINTAKTGTVVLTKKDSATNAELADATFELNLVTDDNGEIS-DYKLIETKAPTGYQL--------DATPVNFTIDFNQSEAAKVTKT--NKKKIGTIIVN-FIDVDGNQLNDKEVHTG---------NVGEEYSVKAKEIVGHTLVKDPANKKGMYK----ETSQEITFVYEKKAMPITVEPTEPSKPTEQLTESATVAEPKPIKQNIKTTNKSPNNKRKLPSTGDEFPYTMLFGLFVSVAG----VFFLRK--PK 1619
8 -12.200[W] KOG4802 Adhesion-type protein  ali follow..  10  145.......................................................................................................................................................................................AACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYKGVPLK----------PRKELRFTELQSGQLEVKWSSKFNISYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKR-----RKTTDGFQNSVILE-------------------------------KLQPDCYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTRYHVRWFPEACAHNRTTGSEASSGMTHENYIILQ---DLSFSCYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKP----------------IGCLGEAGHVLSKVLAKPEN--------SASFIVQDVNITGHFSWKMAKANLYQPFQVTWAEVTTESRQNISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGE. 642
9 -11.700[S] COG4719 Uncharacterized protein conserved in bacteria  ali follow..  9  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FPGGTTVKTHLTLTALALTSVSFAAQAAPAATSP-SGATYSVAQVTENGKTTERLVDASGKGALPGSLLQMTQKVQNVSARSVNGLRLNMRVDPATIYTFSANPTKTVTVTENGKATQRTVPASPSEYTNVRWELPSLAASQTVNCNLRVRVK.............................. 176
10 -10.800[M] COG5386 Cell surface protein  ali follow..  10  1MKKLWKKGLVAFLALTLIFQLIPGFASAA-------DSRLKDGGEYQVQVNFYKDNTG-KTTKESSEADKYIDHTATIKVENGQPYMYLTITNSNYWQTMAVSKDGTRPAKPAQAEVYQDSYQDVQTVSTDAANNTRVEKFKLSSLDDIIYSYMHIKVDAISYDHWYQVDLTIDPSTFKVISEPAVTTPVTLADG-IYTIPFVAKKAND----------------------DSNSSMQNYFDNPAWLKV-------KNGKKTVAMTVNDNKTVTALKTQIS------------------GALQDVKVVSEDKDANTRIVEFEVED--------------------NQPLAAHVNYEAPFNGSVYKGQADFRYVFDTTKAQAASSYPGSDVTPPVDPGETNPPVTK----PDPDPGTTNPPVTTPPTTPSKPVVVDPKNLLNNHTYSIDFDV--------------------------------FKDGTNETSMMESYVMKPAIIKVEN-NQPYVYLTLTNSSWIKTFQYKQNGVWKDMEVVSG---INKNTRTVKYPVKDGTANTDVKTHVLIENMPGFSYDHEYTVQVKLDPASIKDITGKDVTLQEPVKNDDL------------------------------NTSNLANNNNAGPKLAKPDFDDTNSVQKTATTNNKAEKNAKTSDSSSM---------AWY--ITLFGASFLYLAYRLKR--KR 571
11 -10.200[R] KOG3515 Predicted transmembrane protein of the immunoglobulin family of cell adhesion molecules  ali follow..  9  2...........................................................................................................................................................................................EGQIIPAGSVQKLLCVSSG-GNPLATLT---------WYKNDKRINSVIRAADKSVSAEITIL-ANVSDNQAQYRCEASATEIPLFQSTTLSVHFAPET-VKIRIEPEELRPGMEATIICDSSS-SNPPAKLS------W----WKDGIPIEAIWQLEACPSQFAMDLPAPPVHFAGARRILCPCPPTGTPDMPQPTGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTR-----LHRDDAGIYSCSASNSGGATLNITVVVEYGTT------------KSVSENIVVNPGEDAMLYLHIKDAKREDVGNF--RCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFI-----------WDLPINRTYKYEVEERKIDSLTLIVDKVAPADYGAY--ECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTL......... 575
12 -9.630[S] COG1572 Uncharacterized conserved protein  ali follow..  11  36..................................................................................................................................................................................................GTPEQDELIEITSGTVKGGLYVDGGE----------KKTPYVQEFNVPGDVVTWARVYV--TEEKTGTLDLTINGEEFESLDLEGKNDKGDDEDQNPAIYCTGHGVYWIAYDVG-TNISTGPVTVEAQTEGDIDGRVYG----ILAAVYEDKEGQSTKYWVELHGKGWSETLASTHDEGYADFSGKVDTDKYNTANLAVVYLCGTPGLDDSLYFNEEQLSDGENSNDIANSKSYFDFKFFDVLDLLEEDDNELKFQRDEEDYVHPVLAA---------TLGTGEEGTSDLIVSGLTVPLLYAGKDNTIKASIKNIGKDSA----------YGFQAALYADGEIVSTAPVSSLSSGKSKTIEFNWKP---AWDGEQALKVYVDYTNKKKETCEVNNWNSPFLAKVVDLTPPELEIDYPEDGARYLTVSGTIEDTNRNLTVDVNGQN------------ALISGESWSASVPVV------SGPNTIVVSAV-DGENNTGRELIVVEGKESS......................... 504
13 -9.570[U] KOG1631 Translocon-associated complex TRAP, alpha subunit  ali follow..  8  14............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IVICTFSAPNKFGAYAAEAVEDDLVDVEGEEGAVTGEDAEADEDSDTGSSSSPNADTYLLFTGQQLDLPGGKPVEFLIGFTNKGAEEFVIETVEASFPMDFNYFIQNFSAVEVKPGFESTVSYTFLPSDQFAGRPFGLNIALAYRDANGIQNETVLISEVDEETFFLYVLLAGIVVLLLVIGQQY... 220
14 -9.470[S] KOG3594 FOG: Cadherin repeats  ali follow..  10  75...........................................................................................................................................................FTVSPENGNLLVSDRIDREEICGKKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNPPTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRLKAPLDREEQPHHHLVLTAVDGGEPSRSC-TTQIRVIVADANDNRVNVAENLPAGSSV------LKVMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTIGVEAKDGGHYCKVQIDISDENDNA------------TLASESQHIQEDAELGTAVALIKT---------HDLDSGFNGEILCQLKGNFPFKIVQDTKNTYRLVTDGPEYNVTITATDKGNPPLSSSKTIT-----------------LHILDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASDPDGPNGLVSYYIVASDLEPRELSS---SVSARSGVAFELTLQARDQGSPTLSSLRVLVDDRND-----APLVLYPALGPEGSALFDMV--PRSAEPGYLVTKVVAVDADSGYNAWLSYHIVQASEPGLFGEVRT--RQRLLV-TVRDGGQ. 651
15 -9.120[R] COG3291 FOG: PKD repeat  ali follow..  11  387...............................................................................................................................GDGITSKHARTATHTFTNPGTYDVS-LTVTNAAGSSTVNKSNYISVTPPQAPVADFFSPEVNDLRDFGESIPINETVS--------FIDNSTGSPMSWLWDFGDGA-----------TSTARNPEHAYSARGGYTVNLTVTNSFGSNTVLVGVIDAPAIPAYFSSDVRSGNAPLTVTFVDDLDAESPNYPI-------WREWDFGDGVVQTYMVDDNDSATPYAMHVY-----KKPGKYTVTLYMDNRGGNSIITKYHYITVTVNFSANVSSGPAPLVVLFTDTSGPAPSSWLWDFGDGINSKHAMNATHTFTEPGNYTVSL----------TVENSAGNNTVTKTDYIVVTDPVATSSSGGSSHKSSGGSSGGGGGGSPEPAKNVEVKELSQVFITNGNEVKFD-----------------------------TKNATCVVYVGFDAKRTLGKTTTIVEQLKNSSSLVSELPEGEVYKSFNISSSKNIEIGFKVEKA----IQDKGIDQASISLNRYKDEKWEQFPASLSGE---KFLYFTAETPGFSSFAITGESKSTLGGSQEADPKESASLPGF-EMIYGMAGLLAVFLYRRK.... 957
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li Z, Ye Y, Godzik A. Flexible Structural Neighborhood--a database of protein structural similarities and alignments. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D277-80.